Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10454
Gene name Gene Name - the full gene name approved by the HGNC.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TAB1
Synonyms (NCBI Gene) Gene synonyms aliases	3'-Tab1, MAP3K7IP1
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein inter

Show/Hide all(323)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047792	hsa-miR-30d-5p	CLASH	23622248
MIRT054555	hsa-miR-26b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	24565101
MIRT054555	hsa-miR-26b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	24565101
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652877	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT652876	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT652875	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT652874	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT652873	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT652872	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT652871	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT652870	hsa-miR-935	HITS-CLIP	23824327
MIRT652869	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT652868	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT652867	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT532650	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT532649	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT532648	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT532647	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT652866	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT652865	hsa-miR-1281	HITS-CLIP	23824327
MIRT652864	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT652863	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT652862	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT532646	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT652861	hsa-miR-4284	HITS-CLIP	23824327
MIRT652860	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT652859	hsa-miR-4279	HITS-CLIP	23824327
MIRT652858	hsa-miR-8057	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621909	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT621908	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT621907	hsa-miR-4736	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621903	hsa-miR-7150	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT532654	hsa-miR-4318	PAR-CLIP	22012620
MIRT532653	hsa-miR-892a	PAR-CLIP	22012620
MIRT532652	hsa-miR-6841-5p	PAR-CLIP	22012620
MIRT532651	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT532650	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT532649	hsa-miR-1915-3p	PAR-CLIP	22012620
MIRT532648	hsa-miR-6764-5p	PAR-CLIP	22012620
MIRT532647	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT532646	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT532645	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT532644	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT532643	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT532642	hsa-miR-4693-5p	PAR-CLIP	22012620
MIRT532641	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT532640	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652878	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT652877	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT652876	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT652875	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT652874	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT652873	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT652872	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT652871	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT652870	hsa-miR-935	HITS-CLIP	23824327
MIRT652869	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT652868	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT652867	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT532650	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT532649	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT532648	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT532647	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT652866	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT652865	hsa-miR-1281	HITS-CLIP	23824327
MIRT652864	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT652863	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT652862	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT532646	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT652861	hsa-miR-4284	HITS-CLIP	23824327
MIRT652860	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT652859	hsa-miR-4279	HITS-CLIP	23824327
MIRT652858	hsa-miR-8057	HITS-CLIP	23824327
MIRT621912	hsa-miR-3615	HITS-CLIP	23824327
MIRT621911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT621910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT621909	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT621908	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT621907	hsa-miR-4736	HITS-CLIP	23824327
MIRT621906	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT621905	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT621904	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621903	hsa-miR-7150	HITS-CLIP	23824327
MIRT621902	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT532654	hsa-miR-4318	PAR-CLIP	22012620
MIRT532653	hsa-miR-892a	PAR-CLIP	22012620
MIRT532652	hsa-miR-6841-5p	PAR-CLIP	22012620
MIRT532651	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT532650	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT532649	hsa-miR-1915-3p	PAR-CLIP	22012620
MIRT532648	hsa-miR-6764-5p	PAR-CLIP	22012620
MIRT532647	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT532646	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT532645	hsa-miR-6791-3p	PAR-CLIP	22012620
MIRT532644	hsa-miR-6829-3p	PAR-CLIP	22012620
MIRT532643	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT532642	hsa-miR-4693-5p	PAR-CLIP	22012620
MIRT532641	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT532640	hsa-miR-6836-3p	PAR-CLIP	22012620
MIRT1408119	hsa-miR-10a	CLIP-seq
MIRT1408120	hsa-miR-10b	CLIP-seq
MIRT1408121	hsa-miR-323-3p	CLIP-seq
MIRT1408122	hsa-miR-3609	CLIP-seq
MIRT1408123	hsa-miR-4725-5p	CLIP-seq
MIRT1408124	hsa-miR-504	CLIP-seq
MIRT1408125	hsa-miR-548ah	CLIP-seq
MIRT1408126	hsa-miR-548t	CLIP-seq
MIRT1408127	hsa-miR-1226	CLIP-seq
MIRT1408128	hsa-miR-1233	CLIP-seq
MIRT1408129	hsa-miR-125a-5p	CLIP-seq
MIRT1408130	hsa-miR-125b	CLIP-seq
MIRT1408131	hsa-miR-129-5p	CLIP-seq
MIRT1408132	hsa-miR-298	CLIP-seq
MIRT1408133	hsa-miR-335	CLIP-seq
MIRT1408134	hsa-miR-3670	CLIP-seq
MIRT1408135	hsa-miR-3678-3p	CLIP-seq
MIRT1408136	hsa-miR-4319	CLIP-seq
MIRT1408137	hsa-miR-450b-5p	CLIP-seq
MIRT1408138	hsa-miR-4733-3p	CLIP-seq
MIRT1408139	hsa-miR-4775	CLIP-seq
MIRT1408140	hsa-miR-507	CLIP-seq
MIRT1408141	hsa-miR-557	CLIP-seq
MIRT1408142	hsa-miR-590-3p	CLIP-seq
MIRT2122388	hsa-miR-1587	CLIP-seq
MIRT2122389	hsa-miR-1915	CLIP-seq
MIRT2122390	hsa-miR-1972	CLIP-seq
MIRT2122391	hsa-miR-299-3p	CLIP-seq
MIRT2122392	hsa-miR-3714	CLIP-seq
MIRT2122393	hsa-miR-3919	CLIP-seq
MIRT2122394	hsa-miR-3925-5p	CLIP-seq
MIRT2122395	hsa-miR-4286	CLIP-seq
MIRT2122396	hsa-miR-4456	CLIP-seq
MIRT2122397	hsa-miR-4492	CLIP-seq
MIRT2122398	hsa-miR-4493	CLIP-seq
MIRT2122399	hsa-miR-4498	CLIP-seq
MIRT2122400	hsa-miR-4640-3p	CLIP-seq
MIRT2122401	hsa-miR-4656	CLIP-seq
MIRT2122402	hsa-miR-4675	CLIP-seq
MIRT2122403	hsa-miR-4741	CLIP-seq
MIRT2122404	hsa-miR-4786-5p	CLIP-seq
MIRT2122405	hsa-miR-762	CLIP-seq
MIRT2344668	hsa-miR-1202	CLIP-seq
MIRT2344669	hsa-miR-1207-3p	CLIP-seq
MIRT1408127	hsa-miR-1226	CLIP-seq
MIRT2344670	hsa-miR-1286	CLIP-seq
MIRT2344671	hsa-miR-149	CLIP-seq
MIRT2122390	hsa-miR-1972	CLIP-seq
MIRT2344672	hsa-miR-22	CLIP-seq
MIRT2344673	hsa-miR-24	CLIP-seq
MIRT2344674	hsa-miR-3176	CLIP-seq
MIRT2344675	hsa-miR-3194-5p	CLIP-seq
MIRT2344676	hsa-miR-331-3p	CLIP-seq
MIRT2344677	hsa-miR-3620	CLIP-seq
MIRT2344678	hsa-miR-365	CLIP-seq
MIRT2344679	hsa-miR-3679-3p	CLIP-seq
MIRT2344680	hsa-miR-3684	CLIP-seq
MIRT2344681	hsa-miR-3692	CLIP-seq
MIRT2344682	hsa-miR-3922-3p	CLIP-seq
MIRT2344683	hsa-miR-3972	CLIP-seq
MIRT2344684	hsa-miR-4267	CLIP-seq
MIRT2344685	hsa-miR-4448	CLIP-seq
MIRT2122400	hsa-miR-4640-3p	CLIP-seq
MIRT2344686	hsa-miR-4650-5p	CLIP-seq
MIRT2344687	hsa-miR-4715-3p	CLIP-seq
MIRT2344688	hsa-miR-4722-3p	CLIP-seq
MIRT2344689	hsa-miR-4722-5p	CLIP-seq
MIRT2344690	hsa-miR-4729	CLIP-seq
MIRT2344691	hsa-miR-4763-5p	CLIP-seq
MIRT2344692	hsa-miR-4782-5p	CLIP-seq
MIRT2344693	hsa-miR-556-3p	CLIP-seq
MIRT2637927	hsa-miR-1229	CLIP-seq
MIRT2637928	hsa-miR-1273f	CLIP-seq
MIRT2637929	hsa-miR-1302	CLIP-seq
MIRT2637930	hsa-miR-1307	CLIP-seq
MIRT2637931	hsa-miR-135a	CLIP-seq
MIRT2637932	hsa-miR-135b	CLIP-seq
MIRT2637933	hsa-miR-147	CLIP-seq
MIRT2344671	hsa-miR-149	CLIP-seq
MIRT2637934	hsa-miR-18a	CLIP-seq
MIRT2637935	hsa-miR-18b	CLIP-seq
MIRT2637936	hsa-miR-1913	CLIP-seq
MIRT2637937	hsa-miR-219-5p	CLIP-seq
MIRT2637938	hsa-miR-2392	CLIP-seq
MIRT2344673	hsa-miR-24	CLIP-seq
MIRT2637939	hsa-miR-2467-3p	CLIP-seq
MIRT1408132	hsa-miR-298	CLIP-seq
MIRT2637940	hsa-miR-3064-5p	CLIP-seq
MIRT2637941	hsa-miR-3150a-3p	CLIP-seq
MIRT2637942	hsa-miR-3158-5p	CLIP-seq
MIRT2637943	hsa-miR-3175	CLIP-seq
MIRT2637944	hsa-miR-3183	CLIP-seq
MIRT2637945	hsa-miR-3187-3p	CLIP-seq
MIRT2637946	hsa-miR-3189-5p	CLIP-seq
MIRT2637947	hsa-miR-324-3p	CLIP-seq
MIRT2637948	hsa-miR-3605-5p	CLIP-seq
MIRT2637949	hsa-miR-3622a-3p	CLIP-seq
MIRT2637950	hsa-miR-3622b-3p	CLIP-seq
MIRT1408134	hsa-miR-3670	CLIP-seq
MIRT2637951	hsa-miR-3675-5p	CLIP-seq
MIRT2637952	hsa-miR-370	CLIP-seq
MIRT2122392	hsa-miR-3714	CLIP-seq
MIRT2637953	hsa-miR-377	CLIP-seq
MIRT2637954	hsa-miR-3911	CLIP-seq
MIRT2637955	hsa-miR-3926	CLIP-seq
MIRT2637956	hsa-miR-3973	CLIP-seq
MIRT2637957	hsa-miR-4265	CLIP-seq
MIRT2122395	hsa-miR-4286	CLIP-seq
MIRT2637958	hsa-miR-4296	CLIP-seq
MIRT2637959	hsa-miR-4298	CLIP-seq
MIRT2637960	hsa-miR-4303	CLIP-seq
MIRT2637961	hsa-miR-4322	CLIP-seq
MIRT2637962	hsa-miR-4327	CLIP-seq
MIRT2637963	hsa-miR-4417	CLIP-seq
MIRT2637964	hsa-miR-4435	CLIP-seq
MIRT2637965	hsa-miR-4445	CLIP-seq
MIRT2637966	hsa-miR-4474-3p	CLIP-seq
MIRT2637967	hsa-miR-4638-5p	CLIP-seq
MIRT2637968	hsa-miR-4651	CLIP-seq
MIRT2637969	hsa-miR-4659a-3p	CLIP-seq
MIRT2637970	hsa-miR-4659b-3p	CLIP-seq
MIRT2637971	hsa-miR-4685-5p	CLIP-seq
MIRT2637972	hsa-miR-4698	CLIP-seq
MIRT2637973	hsa-miR-4701-5p	CLIP-seq
MIRT2637974	hsa-miR-4723-3p	CLIP-seq
MIRT2637975	hsa-miR-4735-3p	CLIP-seq
MIRT2637976	hsa-miR-4749-3p	CLIP-seq
MIRT2637977	hsa-miR-4756-3p	CLIP-seq
MIRT2637978	hsa-miR-4758-3p	CLIP-seq
MIRT2637979	hsa-miR-4761-5p	CLIP-seq
MIRT2637980	hsa-miR-4773	CLIP-seq
MIRT2637981	hsa-miR-4782-3p	CLIP-seq
MIRT2122404	hsa-miR-4786-5p	CLIP-seq
MIRT2637982	hsa-miR-4794	CLIP-seq
MIRT2637983	hsa-miR-4796-3p	CLIP-seq
MIRT2637984	hsa-miR-4797-5p	CLIP-seq
MIRT2637985	hsa-miR-486-3p	CLIP-seq
MIRT2637986	hsa-miR-491-5p	CLIP-seq
MIRT2637987	hsa-miR-494	CLIP-seq
MIRT2637988	hsa-miR-508-3p	CLIP-seq
MIRT2637989	hsa-miR-520g	CLIP-seq
MIRT2637990	hsa-miR-520h	CLIP-seq
MIRT2637991	hsa-miR-544	CLIP-seq
MIRT2637992	hsa-miR-548s	CLIP-seq
MIRT2637993	hsa-miR-588	CLIP-seq
MIRT2637994	hsa-miR-603	CLIP-seq
MIRT2637995	hsa-miR-604	CLIP-seq
MIRT2637996	hsa-miR-605	CLIP-seq
MIRT2637997	hsa-miR-608	CLIP-seq
MIRT2637998	hsa-miR-644	CLIP-seq
MIRT2637999	hsa-miR-647	CLIP-seq
MIRT2638000	hsa-miR-769-5p	CLIP-seq
MIRT2638001	hsa-miR-939	CLIP-seq
MIRT2638002	hsa-miR-940	CLIP-seq
MIRT2692583	hsa-miR-1260	CLIP-seq
MIRT2692584	hsa-miR-1260b	CLIP-seq
MIRT2637933	hsa-miR-147	CLIP-seq
MIRT2344671	hsa-miR-149	CLIP-seq
MIRT2692585	hsa-miR-188-3p	CLIP-seq
MIRT2637934	hsa-miR-18a	CLIP-seq
MIRT2637935	hsa-miR-18b	CLIP-seq
MIRT2637936	hsa-miR-1913	CLIP-seq
MIRT2637937	hsa-miR-219-5p	CLIP-seq
MIRT2344673	hsa-miR-24	CLIP-seq
MIRT2637939	hsa-miR-2467-3p	CLIP-seq
MIRT2637940	hsa-miR-3064-5p	CLIP-seq
MIRT2692586	hsa-miR-3156-3p	CLIP-seq
MIRT2637945	hsa-miR-3187-3p	CLIP-seq
MIRT2637946	hsa-miR-3189-5p	CLIP-seq
MIRT2637947	hsa-miR-324-3p	CLIP-seq
MIRT1408134	hsa-miR-3670	CLIP-seq
MIRT2344681	hsa-miR-3692	CLIP-seq
MIRT2637954	hsa-miR-3911	CLIP-seq
MIRT2637955	hsa-miR-3926	CLIP-seq
MIRT2122395	hsa-miR-4286	CLIP-seq
MIRT2692587	hsa-miR-4292	CLIP-seq
MIRT2637960	hsa-miR-4303	CLIP-seq
MIRT2692588	hsa-miR-4308	CLIP-seq
MIRT2637962	hsa-miR-4327	CLIP-seq
MIRT2637964	hsa-miR-4435	CLIP-seq
MIRT2637965	hsa-miR-4445	CLIP-seq
MIRT2637966	hsa-miR-4474-3p	CLIP-seq
MIRT2637969	hsa-miR-4659a-3p	CLIP-seq
MIRT2637970	hsa-miR-4659b-3p	CLIP-seq
MIRT2637972	hsa-miR-4698	CLIP-seq
MIRT2637973	hsa-miR-4701-5p	CLIP-seq
MIRT2637975	hsa-miR-4735-3p	CLIP-seq
MIRT2637978	hsa-miR-4758-3p	CLIP-seq
MIRT2637979	hsa-miR-4761-5p	CLIP-seq
MIRT2637981	hsa-miR-4782-3p	CLIP-seq
MIRT2122404	hsa-miR-4786-5p	CLIP-seq
MIRT2637982	hsa-miR-4794	CLIP-seq
MIRT2637988	hsa-miR-508-3p	CLIP-seq
MIRT2637991	hsa-miR-544	CLIP-seq
MIRT2637992	hsa-miR-548s	CLIP-seq
MIRT2637993	hsa-miR-588	CLIP-seq
MIRT2637995	hsa-miR-604	CLIP-seq
MIRT2637998	hsa-miR-644	CLIP-seq
MIRT2637999	hsa-miR-647	CLIP-seq
MIRT2638000	hsa-miR-769-5p	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000185	Process	Activation of MAPKKK activity	IEA
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0001701	Process	In utero embryonic development	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0003007	Process	Heart morphogenesis	IEA
GO:0003279	Process	Cardiac septum development	IEA
GO:0004724	Function	Magnesium-dependent protein serine/threonine phosphatase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10094049, 11460167, 14743216, 16845370, 17620599, 19026643, 21900206, 21903422, 21988832, 22158122, 23818254, 25241761, 25260751, 27107012, 27505673, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006469	Process	Negative regulation of protein kinase activity	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS
GO:0007254	Process	JNK cascade	TAS
GO:0008047	Function	Enzyme activator activity	TAS	8638164
GO:0010008	Component	Endosome membrane	TAS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016607	Component	Nuclear speck	IDA
GO:0019209	Function	Kinase activator activity	IEA
GO:0030324	Process	Lung development	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0035904	Process	Aorta development	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0048273	Function	Mitogen-activated protein kinase p38 binding	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS
GO:0060976	Process	Coronary vasculature development	IEA
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS

MIM	HGNC	e!Ensembl
602615	18157	ENSG00000100324

Protein

UniProt ID

Q15750

Protein name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)

Protein function

Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with th

PDB

2J4O , 2POM , 2POP , 2YDS , 2YIY , 4AY5 , 4AY6 , 4GS6 , 4KA3 , 4L3P , 4L52 , 4L53 , 4O91 , 5DIY , 5E7R , 5GJD , 5GJF , 5GJG , 5J7S , 5J8I , 5J9L , 5JGA , 5JGB , 5JGD , 5JH6 , 5JK3 , 5NZZ , 5O90 , 5V5N , 5VVU , 7NTH , 7NTI , 8GW3 , 8XI8 , 9FPD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00481	PP2C	69 → 334	Protein phosphatase 2C	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12429732}.

Sequence

MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSEN
NCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLES
IDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYV
ANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQEST
RRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAH
GPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTL
LVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNG
AHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEP
YVDFAEFYRLWSVDHGEQSVVTAP

Sequence length

504

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway TNF signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Leishmaniasis Toxoplasmosis Hepatitis B Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Lipid and atherosclerosis		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Schizophrenia	Schizophrenia	GWAS
Diabetes	Diabetes	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Non Small Cell Lung	Associate	26884850
Cardiomyopathies	Associate	12488458
Colorectal Neoplasms	Associate	29328486
Coronary Artery Disease	Associate	39445733
COVID 19	Associate	34536086
Death	Associate	23934659
Diabetes Mellitus Type 2	Associate	33902539
Disease	Associate	34536086
Esophageal Squamous Cell Carcinoma	Associate	36609391
Hypercholesterolemia	Associate	39445733
Inflammation	Associate	24942571
Inflammation	Stimulate	38072991
Lymphatic Metastasis	Associate	26884850
Neoplasms	Inhibit	23934659
Obesity	Associate	33902539
Ovarian Neoplasms	Inhibit	23934659
Ovarian Neoplasms	Associate	28206956
Subarachnoid Hemorrhage	Associate	36214715

TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1)