Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	10452
Gene name	Translocase of outer mitochondrial membrane 40
Gene symbol	TOMM40
Synonyms (NCBI Gene)	C19orf1D19S1177EPER-EC1PEREC1TOM40
Chromosome	19
Chromosome location	19q13.32
Summary	The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitocho

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025243	hsa-miR-34a-5p	Proteomics	21566225
MIRT025243	hsa-miR-34a-5p	Proteomics	21566225
MIRT025243	hsa-miR-34a-5p	Proteomics	21566225
MIRT025243	hsa-miR-34a-5p	Proteomics	21566225
MIRT042816	hsa-miR-324-3p	CLASH	23622248
MIRT042204	hsa-miR-484	CLASH	23622248
MIRT040094	hsa-miR-615-3p	CLASH	23622248
MIRT640238	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT640237	hsa-miR-8073	HITS-CLIP	23824327
MIRT640236	hsa-miR-1306-3p	HITS-CLIP	23824327
MIRT640235	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT640234	hsa-miR-5695	HITS-CLIP	23824327
MIRT640233	hsa-miR-3176	HITS-CLIP	23824327
MIRT640232	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT640231	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT640230	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT640229	hsa-miR-6131	HITS-CLIP	23824327
MIRT640228	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT640227	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT640226	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT640225	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT640224	hsa-miR-548s	HITS-CLIP	23824327
MIRT640223	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT640222	hsa-miR-588	HITS-CLIP	23824327
MIRT640221	hsa-miR-4435	HITS-CLIP	23824327
MIRT640220	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT640219	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT640218	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT640217	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT568688	hsa-miR-4453	PAR-CLIP	20371350
MIRT568687	hsa-miR-4538	PAR-CLIP	20371350
MIRT568686	hsa-miR-1245b-3p	PAR-CLIP	20371350
MIRT568685	hsa-miR-3136-3p	PAR-CLIP	20371350
MIRT568684	hsa-miR-7155-3p	PAR-CLIP	20371350
MIRT568683	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT568688	hsa-miR-4453	PAR-CLIP	20371350
MIRT568687	hsa-miR-4538	PAR-CLIP	20371350
MIRT568686	hsa-miR-1245b-3p	PAR-CLIP	20371350
MIRT568685	hsa-miR-3136-3p	PAR-CLIP	20371350
MIRT568684	hsa-miR-7155-3p	PAR-CLIP	20371350
MIRT568683	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT640238	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT640237	hsa-miR-8073	HITS-CLIP	23824327
MIRT640236	hsa-miR-1306-3p	HITS-CLIP	23824327
MIRT640235	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT640234	hsa-miR-5695	HITS-CLIP	23824327
MIRT640233	hsa-miR-3176	HITS-CLIP	23824327
MIRT640232	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT640231	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT640230	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT640229	hsa-miR-6131	HITS-CLIP	23824327
MIRT640228	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT640227	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT640226	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT640225	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT640224	hsa-miR-548s	HITS-CLIP	23824327
MIRT640223	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT640222	hsa-miR-588	HITS-CLIP	23824327
MIRT640221	hsa-miR-4435	HITS-CLIP	23824327
MIRT640220	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT640219	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT640218	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT640217	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT568688	hsa-miR-4453	PAR-CLIP	20371350
MIRT568687	hsa-miR-4538	PAR-CLIP	20371350
MIRT568686	hsa-miR-1245b-3p	PAR-CLIP	20371350
MIRT568685	hsa-miR-3136-3p	PAR-CLIP	20371350
MIRT568684	hsa-miR-7155-3p	PAR-CLIP	20371350
MIRT568683	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT568688	hsa-miR-4453	PAR-CLIP	20371350
MIRT568687	hsa-miR-4538	PAR-CLIP	20371350
MIRT568686	hsa-miR-1245b-3p	PAR-CLIP	20371350
MIRT568685	hsa-miR-3136-3p	PAR-CLIP	20371350
MIRT568684	hsa-miR-7155-3p	PAR-CLIP	20371350
MIRT568683	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT1446688	hsa-miR-1207-5p	CLIP-seq
MIRT1446689	hsa-miR-1909	CLIP-seq
MIRT1446690	hsa-miR-3688-5p	CLIP-seq
MIRT1446691	hsa-miR-3689d	CLIP-seq
MIRT1446692	hsa-miR-4716-3p	CLIP-seq
MIRT1446693	hsa-miR-4723-5p	CLIP-seq
MIRT1446694	hsa-miR-4736	CLIP-seq
MIRT1446695	hsa-miR-4763-3p	CLIP-seq
MIRT1446688	hsa-miR-1207-5p	CLIP-seq
MIRT1446689	hsa-miR-1909	CLIP-seq
MIRT1446696	hsa-miR-24	CLIP-seq
MIRT1446690	hsa-miR-3688-5p	CLIP-seq
MIRT1446691	hsa-miR-3689d	CLIP-seq
MIRT1446697	hsa-miR-4283	CLIP-seq
MIRT1446692	hsa-miR-4716-3p	CLIP-seq
MIRT1446693	hsa-miR-4723-5p	CLIP-seq
MIRT1446694	hsa-miR-4736	CLIP-seq
MIRT1446695	hsa-miR-4763-3p	CLIP-seq
MIRT1555124	hsa-miR-4728-5p	CLIP-seq
MIRT2133582	hsa-miR-129-5p	CLIP-seq
MIRT2133583	hsa-miR-3662	CLIP-seq
MIRT2133582	hsa-miR-129-5p	CLIP-seq
MIRT2133584	hsa-miR-340	CLIP-seq
MIRT2133585	hsa-miR-3607-3p	CLIP-seq
MIRT2133583	hsa-miR-3662	CLIP-seq
MIRT2133586	hsa-miR-3686	CLIP-seq
MIRT1446691	hsa-miR-3689d	CLIP-seq
MIRT2133587	hsa-miR-4449	CLIP-seq
MIRT2133588	hsa-miR-4652-3p	CLIP-seq
MIRT2133589	hsa-miR-4783-3p	CLIP-seq
MIRT2133590	hsa-miR-587	CLIP-seq
MIRT2133591	hsa-miR-671-3p	CLIP-seq
MIRT2648547	hsa-miR-1913	CLIP-seq
MIRT2648548	hsa-miR-2110	CLIP-seq
MIRT2648549	hsa-miR-2392	CLIP-seq
MIRT2648550	hsa-miR-3144-5p	CLIP-seq
MIRT2648551	hsa-miR-3180	CLIP-seq
MIRT2648552	hsa-miR-3180-3p	CLIP-seq
MIRT2648553	hsa-miR-3183	CLIP-seq
MIRT2648554	hsa-miR-3191	CLIP-seq
MIRT2648555	hsa-miR-3196	CLIP-seq
MIRT2648556	hsa-miR-3605-5p	CLIP-seq
MIRT2648557	hsa-miR-4268	CLIP-seq
MIRT2648558	hsa-miR-4271	CLIP-seq
MIRT2648559	hsa-miR-4313	CLIP-seq
MIRT2648560	hsa-miR-4443	CLIP-seq
MIRT2648561	hsa-miR-4508	CLIP-seq
MIRT2648562	hsa-miR-4652-5p	CLIP-seq
MIRT2648563	hsa-miR-4655-5p	CLIP-seq
MIRT2648564	hsa-miR-4723-3p	CLIP-seq
MIRT2648565	hsa-miR-4725-3p	CLIP-seq
MIRT2648566	hsa-miR-542-5p	CLIP-seq
MIRT2648567	hsa-miR-639	CLIP-seq
MIRT2648568	hsa-miR-720	CLIP-seq
MIRT2648569	hsa-miR-765	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27554484, 31206022, 31412244
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IMP	11745481
GO:0005741	Component	Mitochondrial outer membrane	ISS	10980201
GO:0005741	Component	Mitochondrial outer membrane	NAS	18331822
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005742	Component	Mitochondrial outer membrane translocase complex	IBA
GO:0005742	Component	Mitochondrial outer membrane translocase complex	IDA	12198123, 15644312
GO:0005743	Component	Mitochondrial inner membrane	IDA	24746669
GO:0005829	Component	Cytosol	IDA
GO:0006626	Process	Protein targeting to mitochondrion	IGI	31206022
GO:0006626	Process	Protein targeting to mitochondrion	ISS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0008320	Function	Protein transmembrane transporter activity	IBA
GO:0008320	Function	Protein transmembrane transporter activity	IEA
GO:0008320	Function	Protein transmembrane transporter activity	ISS
GO:0008320	Function	Protein transmembrane transporter activity	TAS	15644312
GO:0015031	Process	Protein transport	IEA
GO:0015288	Function	Porin activity	IEA
GO:0016020	Component	Membrane	IDA	15644312
GO:0016020	Component	Membrane	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IBA
GO:0030150	Process	Protein import into mitochondrial matrix	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IMP	15644312
GO:0044233	Component	Mitochondria-associated endoplasmic reticulum membrane contact site	IDA	31206022
GO:0045040	Process	Protein insertion into mitochondrial outer membrane	NAS	18331822
GO:0046930	Component	Pore complex	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0140596	Component	TOM complex	NAS	18331822

MIM	HGNC	e!Ensembl
608061	18001	ENSG00000130204

O96008

Protein name

Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)

Protein function

Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a com

PDB

7CK6 , 7CP9 , 7VBY , 7VC4 , 7VD2 , 7VDD , 8XVA , 9EIH , 9EII , 9EIJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01459	Porin_3	79 → 355	Eukaryotic porin	Family

Sequence

MGNVLAASSPPAGPPPPPAPALVGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGA
ATASASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVA
LSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQT
QQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRR
PGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVS
FGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTI
G

Sequence length

361

Interactions

View interactions

	KEGG		Reactome
	Mitophagy - animal Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases		Pink/Parkin Mediated Mitophagy

TOMM40 (translocase of outer mitochondrial membrane 40)