LRRN2 (leucine rich repeat neuronal 2)

Gene

• Entrez ID: 10446
• Gene name: Leucine rich repeat neuronal 2
• Gene symbol: LRRN2
• Synonyms (NCBI Gene): FIGLER7, GAC1, LRANK1, LRRN5
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039294	hsa-miR-671-5p	CLASH	23622248
MIRT1120942	hsa-miR-1273f	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT1120944	hsa-miR-1343	CLIP-seq
MIRT1120945	hsa-miR-143	CLIP-seq
MIRT1120946	hsa-miR-150	CLIP-seq
MIRT1120947	hsa-miR-205	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT1120949	hsa-miR-3197	CLIP-seq
MIRT1120950	hsa-miR-324-5p	CLIP-seq
MIRT1120951	hsa-miR-3942-3p	CLIP-seq
MIRT1120952	hsa-miR-3945	CLIP-seq
MIRT1120953	hsa-miR-4253	CLIP-seq
MIRT1120954	hsa-miR-4663	CLIP-seq
MIRT1120955	hsa-miR-4708-5p	CLIP-seq
MIRT1120956	hsa-miR-4713-5p	CLIP-seq
MIRT1120957	hsa-miR-4770	CLIP-seq
MIRT1120958	hsa-miR-532-3p	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT1120960	hsa-miR-642a	CLIP-seq
MIRT1120961	hsa-miR-3616-3p	CLIP-seq
MIRT1120962	hsa-miR-3669	CLIP-seq
MIRT1120963	hsa-miR-3689d	CLIP-seq
MIRT1120964	hsa-miR-3943	CLIP-seq
MIRT1120965	hsa-miR-4436b-3p	CLIP-seq
MIRT1120966	hsa-miR-4721	CLIP-seq
MIRT1120967	hsa-miR-515-5p	CLIP-seq
MIRT1120968	hsa-miR-548m	CLIP-seq
MIRT1120969	hsa-miR-642b	CLIP-seq
MIRT2034241	hsa-miR-4459	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2264696	hsa-miR-326	CLIP-seq
MIRT2264697	hsa-miR-330-5p	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120954	hsa-miR-4663	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT2453419	hsa-miR-3150a-3p	CLIP-seq
MIRT2453420	hsa-miR-3175	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2453421	hsa-miR-3612	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2453422	hsa-miR-650	CLIP-seq
MIRT2453423	hsa-miR-939	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT2453419	hsa-miR-3150a-3p	CLIP-seq
MIRT2453420	hsa-miR-3175	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2453421	hsa-miR-3612	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2453422	hsa-miR-650	CLIP-seq
MIRT2453423	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0007155	Process	Cell adhesion	TAS	9662332
GO:0007165	Process	Signal transduction	TAS	9662332
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	TAS	9662332

Other IDs

• MIM: 605492
• HGNC: 16914
• e!Ensembl: ENSG00000170382

Protein

• UniProt ID: O75325
• Protein name: Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	69 → 129	Leucine rich repeat	Repeat
  PF13855	LRR_8	93 → 153	Leucine rich repeat	Repeat
  PF13855	LRR_8	117 → 177	Leucine rich repeat	Repeat
  PF13855	LRR_8	213 → 273	Leucine rich repeat	Repeat
  PF13855	LRR_8	310 → 371	Leucine rich repeat	Repeat
  PF07679	I-set	427 → 514	Immunoglobulin I-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Overamplified in malignant gliomas.
• Sequence:

  MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
  TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
  SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
  DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
  SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
  IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
  LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
  LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
  TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
  ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
  FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
  GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS

• Sequence length: 713