N4BP2L2 (NEDD4 binding protein 2 like 2)

Gene

• Entrez ID: 10443
• Gene name: NEDD4 binding protein 2 like 2
• Gene symbol: N4BP2L2
• Synonyms (NCBI Gene): 92M18.3, CG005, CG016, PFAAP5
• Chromosome: 13
• Chromosome location: 13q13.1

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1158061584	T>-,TT	Pathogenic	Coding sequence variant, frameshift variant, genic downstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042159	hsa-miR-484	CLASH	23622248
MIRT037873	hsa-miR-455-3p	CLASH	23622248
MIRT681848	hsa-miR-106a-5p	HITS-CLIP	23706177
MIRT681847	hsa-miR-106b-5p	HITS-CLIP	23706177
MIRT681846	hsa-miR-17-5p	HITS-CLIP	23706177
MIRT681845	hsa-miR-20a-5p	HITS-CLIP	23706177
MIRT681844	hsa-miR-20b-5p	HITS-CLIP	23706177
MIRT681843	hsa-miR-519d-3p	HITS-CLIP	23706177
MIRT681842	hsa-miR-526b-3p	HITS-CLIP	23706177
MIRT681841	hsa-miR-93-5p	HITS-CLIP	23706177
MIRT681840	hsa-miR-302a-3p	HITS-CLIP	23706177
MIRT681839	hsa-miR-302b-3p	HITS-CLIP	23706177
MIRT681838	hsa-miR-302c-3p	HITS-CLIP	23706177
MIRT681837	hsa-miR-302d-3p	HITS-CLIP	23706177
MIRT681836	hsa-miR-302e	HITS-CLIP	23706177
MIRT681835	hsa-miR-372-3p	HITS-CLIP	23706177
MIRT681834	hsa-miR-373-3p	HITS-CLIP	23706177
MIRT681833	hsa-miR-520a-3p	HITS-CLIP	23706177
MIRT681832	hsa-miR-520b	HITS-CLIP	23706177
MIRT681831	hsa-miR-520c-3p	HITS-CLIP	23706177
MIRT681830	hsa-miR-520d-3p	HITS-CLIP	23706177
MIRT681829	hsa-miR-520e	HITS-CLIP	23706177
MIRT681828	hsa-miR-552-3p	HITS-CLIP	23706177
MIRT681827	hsa-miR-449b-3p	HITS-CLIP	23706177
MIRT681826	hsa-miR-512-3p	HITS-CLIP	23706177
MIRT681825	hsa-miR-6504-3p	HITS-CLIP	23706177
MIRT681824	hsa-miR-520g-3p	HITS-CLIP	23706177
MIRT681823	hsa-miR-520h	HITS-CLIP	23706177
MIRT681822	hsa-miR-3934-5p	HITS-CLIP	23706177
MIRT681821	hsa-miR-186-3p	HITS-CLIP	23706177
MIRT681820	hsa-miR-150-5p	HITS-CLIP	23706177
MIRT681819	hsa-miR-619-5p	HITS-CLIP	23706177
MIRT681818	hsa-miR-6506-5p	HITS-CLIP	23706177
MIRT681817	hsa-miR-4731-5p	HITS-CLIP	23706177
MIRT681816	hsa-miR-5589-5p	HITS-CLIP	23706177
MIRT681815	hsa-miR-4694-5p	HITS-CLIP	23706177
MIRT681814	hsa-miR-3152-3p	HITS-CLIP	23706177
MIRT681813	hsa-miR-5095	HITS-CLIP	23706177
MIRT681812	hsa-miR-7151-3p	HITS-CLIP	23706177
MIRT681811	hsa-miR-5089-5p	HITS-CLIP	23706177
MIRT518887	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT518886	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT518885	hsa-miR-3149	PAR-CLIP	23446348
MIRT681848	hsa-miR-106a-5p	HITS-CLIP	23706177
MIRT681847	hsa-miR-106b-5p	HITS-CLIP	23706177
MIRT681846	hsa-miR-17-5p	HITS-CLIP	23706177
MIRT681845	hsa-miR-20a-5p	HITS-CLIP	23706177
MIRT681844	hsa-miR-20b-5p	HITS-CLIP	23706177
MIRT681843	hsa-miR-519d-3p	HITS-CLIP	23706177
MIRT681842	hsa-miR-526b-3p	HITS-CLIP	23706177
MIRT681841	hsa-miR-93-5p	HITS-CLIP	23706177
MIRT681840	hsa-miR-302a-3p	HITS-CLIP	23706177
MIRT681839	hsa-miR-302b-3p	HITS-CLIP	23706177
MIRT681838	hsa-miR-302c-3p	HITS-CLIP	23706177
MIRT681837	hsa-miR-302d-3p	HITS-CLIP	23706177
MIRT681836	hsa-miR-302e	HITS-CLIP	23706177
MIRT681835	hsa-miR-372-3p	HITS-CLIP	23706177
MIRT681834	hsa-miR-373-3p	HITS-CLIP	23706177
MIRT681833	hsa-miR-520a-3p	HITS-CLIP	23706177
MIRT681832	hsa-miR-520b	HITS-CLIP	23706177
MIRT681831	hsa-miR-520c-3p	HITS-CLIP	23706177
MIRT681830	hsa-miR-520d-3p	HITS-CLIP	23706177
MIRT681829	hsa-miR-520e	HITS-CLIP	23706177
MIRT681828	hsa-miR-552-3p	HITS-CLIP	23706177
MIRT681827	hsa-miR-449b-3p	HITS-CLIP	23706177
MIRT681826	hsa-miR-512-3p	HITS-CLIP	23706177
MIRT681825	hsa-miR-6504-3p	HITS-CLIP	23706177
MIRT681824	hsa-miR-520g-3p	HITS-CLIP	23706177
MIRT681823	hsa-miR-520h	HITS-CLIP	23706177
MIRT681822	hsa-miR-3934-5p	HITS-CLIP	23706177
MIRT681821	hsa-miR-186-3p	HITS-CLIP	23706177
MIRT681820	hsa-miR-150-5p	HITS-CLIP	23706177
MIRT681819	hsa-miR-619-5p	HITS-CLIP	23706177
MIRT681818	hsa-miR-6506-5p	HITS-CLIP	23706177
MIRT681817	hsa-miR-4731-5p	HITS-CLIP	23706177
MIRT681816	hsa-miR-5589-5p	HITS-CLIP	23706177
MIRT681815	hsa-miR-4694-5p	HITS-CLIP	23706177
MIRT681814	hsa-miR-3152-3p	HITS-CLIP	23706177
MIRT681813	hsa-miR-5095	HITS-CLIP	23706177
MIRT681812	hsa-miR-7151-3p	HITS-CLIP	23706177
MIRT681811	hsa-miR-5089-5p	HITS-CLIP	23706177
MIRT518887	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT518886	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT518885	hsa-miR-3149	PAR-CLIP	23446348
MIRT1171104	hsa-miR-1252	CLIP-seq
MIRT1171105	hsa-miR-1273f	CLIP-seq
MIRT1171106	hsa-miR-1321	CLIP-seq
MIRT1171107	hsa-miR-1537	CLIP-seq
MIRT1171108	hsa-miR-188-5p	CLIP-seq
MIRT1171109	hsa-miR-196a	CLIP-seq
MIRT1171110	hsa-miR-196b	CLIP-seq
MIRT1171111	hsa-miR-299-3p	CLIP-seq
MIRT1171112	hsa-miR-31	CLIP-seq
MIRT1171113	hsa-miR-3128	CLIP-seq
MIRT1171114	hsa-miR-3148	CLIP-seq
MIRT1171115	hsa-miR-3151	CLIP-seq
MIRT1171116	hsa-miR-3162-5p	CLIP-seq
MIRT1171117	hsa-miR-3170	CLIP-seq
MIRT1171118	hsa-miR-34b	CLIP-seq
MIRT1171119	hsa-miR-3606	CLIP-seq
MIRT1171120	hsa-miR-4447	CLIP-seq
MIRT1171121	hsa-miR-4472	CLIP-seq
MIRT1171122	hsa-miR-4477b	CLIP-seq
MIRT1171123	hsa-miR-4511	CLIP-seq
MIRT1171124	hsa-miR-4739	CLIP-seq
MIRT1171125	hsa-miR-4756-5p	CLIP-seq
MIRT1171126	hsa-miR-491-5p	CLIP-seq
MIRT1171127	hsa-miR-548ac	CLIP-seq
MIRT1171128	hsa-miR-548ag	CLIP-seq
MIRT1171129	hsa-miR-548ai	CLIP-seq
MIRT1171130	hsa-miR-548d-3p	CLIP-seq
MIRT1171131	hsa-miR-548z	CLIP-seq
MIRT2049348	hsa-miR-377	CLIP-seq
MIRT2049349	hsa-miR-4646-5p	CLIP-seq
MIRT2049350	hsa-miR-4775	CLIP-seq
MIRT2049351	hsa-miR-590-3p	CLIP-seq
MIRT2454764	hsa-miR-1297	CLIP-seq
MIRT2454765	hsa-miR-1305	CLIP-seq
MIRT2454766	hsa-miR-130a	CLIP-seq
MIRT2454767	hsa-miR-130b	CLIP-seq
MIRT2454768	hsa-miR-26a	CLIP-seq
MIRT2454769	hsa-miR-26b	CLIP-seq
MIRT2454770	hsa-miR-301a	CLIP-seq
MIRT2454771	hsa-miR-301b	CLIP-seq
MIRT2454772	hsa-miR-3065-5p	CLIP-seq
MIRT2454773	hsa-miR-3666	CLIP-seq
MIRT2454774	hsa-miR-4295	CLIP-seq
MIRT2454775	hsa-miR-4465	CLIP-seq
MIRT2454776	hsa-miR-454	CLIP-seq
MIRT2454777	hsa-miR-498	CLIP-seq
MIRT2454778	hsa-miR-519a	CLIP-seq
MIRT2454779	hsa-miR-519b-3p	CLIP-seq
MIRT2454780	hsa-miR-519c-3p	CLIP-seq
MIRT2454781	hsa-miR-618	CLIP-seq
MIRT2465685	hsa-miR-153	CLIP-seq
MIRT2465686	hsa-miR-3691-3p	CLIP-seq
MIRT2465687	hsa-miR-448	CLIP-seq
MIRT2465688	hsa-miR-578	CLIP-seq
MIRT2049350	hsa-miR-4775	CLIP-seq
MIRT2049351	hsa-miR-590-3p	CLIP-seq
MIRT2576680	hsa-miR-214	CLIP-seq
MIRT2576681	hsa-miR-345	CLIP-seq
MIRT2576682	hsa-miR-3605-3p	CLIP-seq
MIRT2576683	hsa-miR-3619-5p	CLIP-seq
MIRT2576684	hsa-miR-3663-3p	CLIP-seq
MIRT2576685	hsa-miR-3973	CLIP-seq
MIRT2576686	hsa-miR-4291	CLIP-seq
MIRT2576687	hsa-miR-433	CLIP-seq
MIRT2576688	hsa-miR-4714-5p	CLIP-seq
MIRT2576689	hsa-miR-520g	CLIP-seq
MIRT2576690	hsa-miR-761	CLIP-seq
MIRT2576691	hsa-miR-888	CLIP-seq
MIRT2576692	hsa-miR-922	CLIP-seq
MIRT2576685	hsa-miR-3973	CLIP-seq
MIRT2576689	hsa-miR-520g	CLIP-seq
MIRT2576691	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0001701	Process	In utero embryonic development	IEA
GO:0001824	Process	Blastocyst development	IEA
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003714	Function	Transcription corepressor activity	ISS
GO:0005515	Function	Protein binding	IPI	19506020, 23088713, 25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19506020
GO:0005634	Component	Nucleus	IEA
GO:0017053	Component	Transcription repressor complex	IDA	19506020
GO:0019899	Function	Enzyme binding	IPI	19506020
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1902035	Process	Positive regulation of hematopoietic stem cell proliferation	IMP	19506020
GO:1902037	Process	Negative regulation of hematopoietic stem cell differentiation	IMP	19506020

Other IDs

• MIM: 615788
• HGNC: 26916
• e!Ensembl: ENSG00000244754

Protein

• UniProt ID: Q92802
• Protein name: NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13671	AAA_33	404 → 537		Domain

• Sequence:

  MSYGEIEGKFLGPREEVTSEPRCKKLKSTTESYVFHNHSNADFHRIQEKTGNDWVPVTII
  DVRGHSYLQENKIKTTDLHRPLHDEMPGNRPDVIESIDSQVLQEARPPLVSADDEIYSTS
  KAFIGPIYKPPEKKKRNEGRNEAHVLNGINDRGGQKEKQKFNSEKSEIDNELFQFYKEIE
  ELEKEKDGFENSCKESEPSQEQFVPFYEGHNNGLLKPDEEKKDLSNKAMPSHCDYQQNLG
  NEPDKYPCNGQVIPTFCDTSFTSFRPEWQSVYPFIVPYGPPLPSLNYHLNIQRFSGPPNP
  PSNIFQAQDDSQIQNGYYVNNCHVNWNCMTFDQNNEYTDCSENRSSVHPSGNGCSMQDRY
  VSNGFCEVRERCWKDHCMDKHNGTDRFVNQQFQEEKLNKLQKLLILLRGLPGSGKTTLSR
  ILLGQNRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRSPVIIDNTNI
  QAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEELEKRNKHGVSRKKIAQMLDRYEYQMS
  ISIVMNSVEPSHKSTQRPPPPQGRQRWGGSLGSHNRVCVTNNH

• Sequence length: 583

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Short stature	Pathogenic	rs1158061584	RCV000736213

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Associate	11768609
Colorectal Neoplasms	Associate	11768609
Glomerulonephritis Membranous	Associate	37974210
Heart Failure	Associate	32852391
Systemic Inflammatory Response Syndrome	Associate	32852391