Gene Gene information from NCBI Gene database.
Entrez ID 10424
Gene name Progesterone receptor membrane component 2
Gene symbol PGRMC2
Synonyms (NCBI Gene)
DG6PMBP
Chromosome 4
Chromosome location 4q28.2
miRNA miRNA information provided by mirtarbase database.
470
miRTarBase ID miRNA Experiments Reference
MIRT002672 hsa-miR-124-3p Microarray 15685193
MIRT020691 hsa-miR-155-5p Proteomics 18668040
MIRT002672 hsa-miR-124-3p Microarray 18668037
MIRT002672 hsa-miR-124-3p Microarray 15685193
MIRT023684 hsa-miR-1-3p Proteomics;Microarray 18668037
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0003707 Function Nuclear steroid receptor activity TAS 9705155
GO:0005496 Function Steroid binding IEA
GO:0005496 Function Steroid binding TAS 9705155
GO:0005515 Function Protein binding IPI 27599036, 27754849, 29513927, 32296183, 33961781, 35271311
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607735 16089 ENSG00000164040
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15173
Protein name Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)
Protein function Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for d
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00173 Cyt-b5 104 201 Cytochrome b5-like Heme/Steroid binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717). {ECO:0000269|PubMed:23793472, ECO:0000269|PubMed:37453717}.
Sequence
MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVAL
VALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRIL
LAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQM
ESVREWEMQFKEKYDYVGRLL
KPGEEPSEYTDEEDTKDHNKQD
Sequence length 223
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Neuroactive ligand-receptor interaction  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hirschsprung disease, susceptibility to, 1 Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 29563759
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 35845138
★☆☆☆☆
Found in Text Mining only
Glioma Associate 28222026
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hypoxia Stimulate 28222026
★☆☆☆☆
Found in Text Mining only
Hypoxia Brain Associate 28222026
★☆☆☆☆
Found in Text Mining only
Neoplasms Inhibit 29563759
★☆☆☆☆
Found in Text Mining only
Ovarian Diseases Associate 22355044
★☆☆☆☆
Found in Text Mining only
Ovarian Diseases Stimulate 35295989
★☆☆☆☆
Found in Text Mining only