SPON1 (spondin 1)

Gene

• Entrez ID: 10418
• Gene name: Spondin 1
• Gene symbol: SPON1
• Synonyms (NCBI Gene): VSGP/F-spondin, f-spondin
• Chromosome: 11
• Chromosome location: 11p15.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1385144	hsa-miR-1207-3p	CLIP-seq
MIRT1385145	hsa-miR-1256	CLIP-seq
MIRT1385146	hsa-miR-1271	CLIP-seq
MIRT1385147	hsa-miR-182	CLIP-seq
MIRT1385148	hsa-miR-21	CLIP-seq
MIRT1385149	hsa-miR-3064-5p	CLIP-seq
MIRT1385150	hsa-miR-3135b	CLIP-seq
MIRT1385151	hsa-miR-3605-3p	CLIP-seq
MIRT1385152	hsa-miR-3616-3p	CLIP-seq
MIRT1385153	hsa-miR-3617	CLIP-seq
MIRT1385154	hsa-miR-3652	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT1385156	hsa-miR-3689d	CLIP-seq
MIRT1385157	hsa-miR-4292	CLIP-seq
MIRT1385158	hsa-miR-4308	CLIP-seq
MIRT1385159	hsa-miR-4430	CLIP-seq
MIRT1385160	hsa-miR-4435	CLIP-seq
MIRT1385161	hsa-miR-4505	CLIP-seq
MIRT1385162	hsa-miR-4539	CLIP-seq
MIRT1385163	hsa-miR-4642	CLIP-seq
MIRT1385164	hsa-miR-4698	CLIP-seq
MIRT1385165	hsa-miR-4710	CLIP-seq
MIRT1385166	hsa-miR-4721	CLIP-seq
MIRT1385167	hsa-miR-485-5p	CLIP-seq
MIRT1385168	hsa-miR-548c-3p	CLIP-seq
MIRT1385169	hsa-miR-548u	CLIP-seq
MIRT1385170	hsa-miR-590-5p	CLIP-seq
MIRT1385171	hsa-miR-641	CLIP-seq
MIRT1385172	hsa-miR-96	CLIP-seq
MIRT2115271	hsa-miR-3134	CLIP-seq
MIRT2115272	hsa-miR-3163	CLIP-seq
MIRT2115273	hsa-miR-3647-3p	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT2115274	hsa-miR-4534	CLIP-seq
MIRT2115275	hsa-miR-4802-5p	CLIP-seq
MIRT2337996	hsa-miR-136	CLIP-seq
MIRT2337997	hsa-miR-2054	CLIP-seq
MIRT2337998	hsa-miR-3152-5p	CLIP-seq
MIRT2337999	hsa-miR-380	CLIP-seq
MIRT2338000	hsa-miR-4423-5p	CLIP-seq
MIRT2338001	hsa-miR-4491	CLIP-seq
MIRT2338002	hsa-miR-4657	CLIP-seq
MIRT2338003	hsa-miR-4716-5p	CLIP-seq
MIRT2631530	hsa-miR-1178	CLIP-seq
MIRT2631531	hsa-miR-1184	CLIP-seq
MIRT2631532	hsa-miR-1205	CLIP-seq
MIRT1385144	hsa-miR-1207-3p	CLIP-seq
MIRT2631533	hsa-miR-1231	CLIP-seq
MIRT1385145	hsa-miR-1256	CLIP-seq
MIRT2631534	hsa-miR-1265	CLIP-seq
MIRT1385146	hsa-miR-1271	CLIP-seq
MIRT2631535	hsa-miR-1273e	CLIP-seq
MIRT2631536	hsa-miR-1286	CLIP-seq
MIRT2631537	hsa-miR-1297	CLIP-seq
MIRT1385147	hsa-miR-182	CLIP-seq
MIRT2631538	hsa-miR-204	CLIP-seq
MIRT2631539	hsa-miR-211	CLIP-seq
MIRT2631540	hsa-miR-216b	CLIP-seq
MIRT2631541	hsa-miR-2355-5p	CLIP-seq
MIRT2631542	hsa-miR-26a	CLIP-seq
MIRT2631543	hsa-miR-26b	CLIP-seq
MIRT2631544	hsa-miR-2964a-3p	CLIP-seq
MIRT2631545	hsa-miR-302f	CLIP-seq
MIRT1385149	hsa-miR-3064-5p	CLIP-seq
MIRT2631546	hsa-miR-3117-5p	CLIP-seq
MIRT2631547	hsa-miR-3120-5p	CLIP-seq
MIRT2631548	hsa-miR-3128	CLIP-seq
MIRT2631549	hsa-miR-3133	CLIP-seq
MIRT1385150	hsa-miR-3135b	CLIP-seq
MIRT2631550	hsa-miR-3153	CLIP-seq
MIRT2631551	hsa-miR-3158-5p	CLIP-seq
MIRT2115272	hsa-miR-3163	CLIP-seq
MIRT2631552	hsa-miR-326	CLIP-seq
MIRT2631553	hsa-miR-330-5p	CLIP-seq
MIRT1385152	hsa-miR-3616-3p	CLIP-seq
MIRT2631554	hsa-miR-3646	CLIP-seq
MIRT1385154	hsa-miR-3652	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT2631555	hsa-miR-3679-3p	CLIP-seq
MIRT1385156	hsa-miR-3689d	CLIP-seq
MIRT2631556	hsa-miR-3691-5p	CLIP-seq
MIRT2631557	hsa-miR-3692	CLIP-seq
MIRT2631558	hsa-miR-3921	CLIP-seq
MIRT2631559	hsa-miR-4264	CLIP-seq
MIRT2631560	hsa-miR-4267	CLIP-seq
MIRT2631561	hsa-miR-4268	CLIP-seq
MIRT2631562	hsa-miR-4276	CLIP-seq
MIRT2631563	hsa-miR-4282	CLIP-seq
MIRT2631564	hsa-miR-4286	CLIP-seq
MIRT2631565	hsa-miR-4327	CLIP-seq
MIRT2631566	hsa-miR-433	CLIP-seq
MIRT2631567	hsa-miR-4425	CLIP-seq
MIRT1385159	hsa-miR-4430	CLIP-seq
MIRT2631568	hsa-miR-4446-5p	CLIP-seq
MIRT2631569	hsa-miR-4448	CLIP-seq
MIRT2631570	hsa-miR-4464	CLIP-seq
MIRT2631571	hsa-miR-4465	CLIP-seq
MIRT2631572	hsa-miR-448	CLIP-seq
MIRT2631573	hsa-miR-4486	CLIP-seq
MIRT2338001	hsa-miR-4491	CLIP-seq
MIRT2631574	hsa-miR-4495	CLIP-seq
MIRT1385161	hsa-miR-4505	CLIP-seq
MIRT2631575	hsa-miR-4535	CLIP-seq
MIRT1385162	hsa-miR-4539	CLIP-seq
MIRT1385163	hsa-miR-4642	CLIP-seq
MIRT2631576	hsa-miR-4649-5p	CLIP-seq
MIRT2631577	hsa-miR-4652-3p	CLIP-seq
MIRT2631578	hsa-miR-4653-5p	CLIP-seq
MIRT2338002	hsa-miR-4657	CLIP-seq
MIRT2631579	hsa-miR-4668-5p	CLIP-seq
MIRT1385165	hsa-miR-4710	CLIP-seq
MIRT2631580	hsa-miR-4720-5p	CLIP-seq
MIRT1385166	hsa-miR-4721	CLIP-seq
MIRT2631581	hsa-miR-4722-5p	CLIP-seq
MIRT2631582	hsa-miR-4748	CLIP-seq
MIRT2631583	hsa-miR-4752	CLIP-seq
MIRT2631584	hsa-miR-4755-5p	CLIP-seq
MIRT2631585	hsa-miR-4758-3p	CLIP-seq
MIRT2631586	hsa-miR-4760-5p	CLIP-seq
MIRT2631587	hsa-miR-4764-5p	CLIP-seq
MIRT2631588	hsa-miR-4768-5p	CLIP-seq
MIRT2631589	hsa-miR-4776-5p	CLIP-seq
MIRT2631590	hsa-miR-4797-3p	CLIP-seq
MIRT2631591	hsa-miR-4799-3p	CLIP-seq
MIRT1385167	hsa-miR-485-5p	CLIP-seq
MIRT2631592	hsa-miR-486-5p	CLIP-seq
MIRT2631593	hsa-miR-492	CLIP-seq
MIRT2631594	hsa-miR-512-5p	CLIP-seq
MIRT2631595	hsa-miR-513a-3p	CLIP-seq
MIRT2631596	hsa-miR-570	CLIP-seq
MIRT2631597	hsa-miR-593	CLIP-seq
MIRT2631598	hsa-miR-623	CLIP-seq
MIRT2631599	hsa-miR-630	CLIP-seq
MIRT2631600	hsa-miR-634	CLIP-seq
MIRT2631601	hsa-miR-654-3p	CLIP-seq
MIRT2631602	hsa-miR-660	CLIP-seq
MIRT2631603	hsa-miR-873	CLIP-seq
MIRT1385172	hsa-miR-96	CLIP-seq
MIRT2631530	hsa-miR-1178	CLIP-seq
MIRT2631531	hsa-miR-1184	CLIP-seq
MIRT2631532	hsa-miR-1205	CLIP-seq
MIRT1385144	hsa-miR-1207-3p	CLIP-seq
MIRT2631533	hsa-miR-1231	CLIP-seq
MIRT1385145	hsa-miR-1256	CLIP-seq
MIRT2631534	hsa-miR-1265	CLIP-seq
MIRT1385146	hsa-miR-1271	CLIP-seq
MIRT2631535	hsa-miR-1273e	CLIP-seq
MIRT2631536	hsa-miR-1286	CLIP-seq
MIRT2631537	hsa-miR-1297	CLIP-seq
MIRT1385147	hsa-miR-182	CLIP-seq
MIRT2631538	hsa-miR-204	CLIP-seq
MIRT2631539	hsa-miR-211	CLIP-seq
MIRT2631540	hsa-miR-216b	CLIP-seq
MIRT2631541	hsa-miR-2355-5p	CLIP-seq
MIRT2631542	hsa-miR-26a	CLIP-seq
MIRT2631543	hsa-miR-26b	CLIP-seq
MIRT2631544	hsa-miR-2964a-3p	CLIP-seq
MIRT2631545	hsa-miR-302f	CLIP-seq
MIRT1385149	hsa-miR-3064-5p	CLIP-seq
MIRT2691906	hsa-miR-3065-5p	CLIP-seq
MIRT2631546	hsa-miR-3117-5p	CLIP-seq
MIRT2631547	hsa-miR-3120-5p	CLIP-seq
MIRT2631548	hsa-miR-3128	CLIP-seq
MIRT2631549	hsa-miR-3133	CLIP-seq
MIRT1385150	hsa-miR-3135b	CLIP-seq
MIRT2631550	hsa-miR-3153	CLIP-seq
MIRT2631551	hsa-miR-3158-5p	CLIP-seq
MIRT2115272	hsa-miR-3163	CLIP-seq
MIRT2631552	hsa-miR-326	CLIP-seq
MIRT2631553	hsa-miR-330-5p	CLIP-seq
MIRT1385152	hsa-miR-3616-3p	CLIP-seq
MIRT2631554	hsa-miR-3646	CLIP-seq
MIRT1385154	hsa-miR-3652	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT2631555	hsa-miR-3679-3p	CLIP-seq
MIRT1385156	hsa-miR-3689d	CLIP-seq
MIRT2631556	hsa-miR-3691-5p	CLIP-seq
MIRT2631557	hsa-miR-3692	CLIP-seq
MIRT2631558	hsa-miR-3921	CLIP-seq
MIRT2631559	hsa-miR-4264	CLIP-seq
MIRT2631560	hsa-miR-4267	CLIP-seq
MIRT2631561	hsa-miR-4268	CLIP-seq
MIRT2631562	hsa-miR-4276	CLIP-seq
MIRT2631563	hsa-miR-4282	CLIP-seq
MIRT2631564	hsa-miR-4286	CLIP-seq
MIRT2631565	hsa-miR-4327	CLIP-seq
MIRT2631566	hsa-miR-433	CLIP-seq
MIRT2631567	hsa-miR-4425	CLIP-seq
MIRT1385159	hsa-miR-4430	CLIP-seq
MIRT2631568	hsa-miR-4446-5p	CLIP-seq
MIRT2631569	hsa-miR-4448	CLIP-seq
MIRT2631570	hsa-miR-4464	CLIP-seq
MIRT2631571	hsa-miR-4465	CLIP-seq
MIRT2631572	hsa-miR-448	CLIP-seq
MIRT2631573	hsa-miR-4486	CLIP-seq
MIRT2338001	hsa-miR-4491	CLIP-seq
MIRT2631574	hsa-miR-4495	CLIP-seq
MIRT1385161	hsa-miR-4505	CLIP-seq
MIRT2631575	hsa-miR-4535	CLIP-seq
MIRT1385162	hsa-miR-4539	CLIP-seq
MIRT1385163	hsa-miR-4642	CLIP-seq
MIRT2631576	hsa-miR-4649-5p	CLIP-seq
MIRT2631577	hsa-miR-4652-3p	CLIP-seq
MIRT2631578	hsa-miR-4653-5p	CLIP-seq
MIRT2338002	hsa-miR-4657	CLIP-seq
MIRT2631579	hsa-miR-4668-5p	CLIP-seq
MIRT1385165	hsa-miR-4710	CLIP-seq
MIRT2631580	hsa-miR-4720-5p	CLIP-seq
MIRT1385166	hsa-miR-4721	CLIP-seq
MIRT2631581	hsa-miR-4722-5p	CLIP-seq
MIRT2691907	hsa-miR-4731-3p	CLIP-seq
MIRT2631582	hsa-miR-4748	CLIP-seq
MIRT2631583	hsa-miR-4752	CLIP-seq
MIRT2631584	hsa-miR-4755-5p	CLIP-seq
MIRT2631585	hsa-miR-4758-3p	CLIP-seq
MIRT2631586	hsa-miR-4760-5p	CLIP-seq
MIRT2631587	hsa-miR-4764-5p	CLIP-seq
MIRT2631588	hsa-miR-4768-5p	CLIP-seq
MIRT2631589	hsa-miR-4776-5p	CLIP-seq
MIRT2631590	hsa-miR-4797-3p	CLIP-seq
MIRT2631591	hsa-miR-4799-3p	CLIP-seq
MIRT2691908	hsa-miR-4801	CLIP-seq
MIRT1385167	hsa-miR-485-5p	CLIP-seq
MIRT2631592	hsa-miR-486-5p	CLIP-seq
MIRT2631593	hsa-miR-492	CLIP-seq
MIRT2691909	hsa-miR-495	CLIP-seq
MIRT2631594	hsa-miR-512-5p	CLIP-seq
MIRT2631595	hsa-miR-513a-3p	CLIP-seq
MIRT2631596	hsa-miR-570	CLIP-seq
MIRT2631597	hsa-miR-593	CLIP-seq
MIRT2631598	hsa-miR-623	CLIP-seq
MIRT2631599	hsa-miR-630	CLIP-seq
MIRT2631600	hsa-miR-634	CLIP-seq
MIRT2631601	hsa-miR-654-3p	CLIP-seq
MIRT2631602	hsa-miR-660	CLIP-seq
MIRT2631603	hsa-miR-873	CLIP-seq
MIRT1385172	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	ISS
GO:0005201	Function	Extracellular matrix structural constituent	RCA	20551380
GO:0005515	Function	Protein binding	IPI	14983046, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	HDA	20551380
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0010954	Process	Positive regulation of protein processing	IEA
GO:0016485	Process	Protein processing	IEA
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0031012	Component	Extracellular matrix	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0050693	Function	LBD domain binding	IEA
GO:1902430	Process	Negative regulation of amyloid-beta formation	IEA
GO:1902993	Process	Positive regulation of amyloid precursor protein catabolic process	IEA

Other IDs

• MIM: 604989
• HGNC: 11252
• e!Ensembl: ENSG00000262655

Protein

• UniProt ID: Q9HCB6
• Protein name: Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)
• Protein function: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major fact
• PDB: 2ZOT, 2ZOU, 3COO, 3Q13
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02014	Reeler	44 → 172	Reeler domain	Family
  PF06468	Spond_N	205 → 399	Spondin_N	Domain
  PF00090	TSP_1	446 → 494	Thrombospondin type 1 domain	Domain
  PF00090	TSP_1	505 → 554	Thrombospondin type 1 domain	Domain
  PF00090	TSP_1	562 → 610	Thrombospondin type 1 domain	Domain
  PF00090	TSP_1	618 → 665	Thrombospondin type 1 domain	Domain
  PF19028	TSP1_spondin	669 → 720	Spondin-like TSP1 domain	Domain
  PF00090	TSP_1	758 → 807	Thrombospondin type 1 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen. {ECO:0000269|PubMed:11368520, ECO:0000269|PubMed:9872452}.
• Sequence:

  MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE
  FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEE
  ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK
  LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS
  KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA
  PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG
  VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD
  NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC
  PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL
  PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS
  QAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC
  MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC
  LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMT
  VKKRFKSSQFTSCKDKKEIRACNVHPC

• Sequence length: 807

Pathways

Reactome:

Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins