Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10401
Gene name Gene Name - the full gene name approved by the HGNC.	Protein inhibitor of activated STAT 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIAS3
Synonyms (NCBI Gene) Gene synonyms aliases	ZMIZ5
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q21.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes

Show/Hide all(227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006288	hsa-miR-21-5p	Luciferase reporter assay	22316494
MIRT006288	hsa-miR-21-5p	Luciferase reporter assay	22316494
MIRT006288	hsa-miR-21-5p	Luciferase reporter assay	22316494
MIRT006288	hsa-miR-21-5p	Luciferase reporter assay	22316494
MIRT006288	hsa-miR-21-5p	Luciferase reporter assay	22316494
MIRT006288	hsa-miR-21-5p	Luciferase reporter assay	22316494
MIRT047704	hsa-miR-10a-5p	CLASH	23622248
MIRT053024	hsa-miR-18a-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR	23322197
MIRT053294	hsa-miR-125b-5p	Luciferase reporter assay, Western blot	23857508
MIRT053024	hsa-miR-18a-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR	23322197
MIRT006288	hsa-miR-21-5p	ELISA, qRT-PCR, Western blot	23998932
MIRT006288	hsa-miR-21-5p	ELISA, qRT-PCR, Western blot	23998932
MIRT1232893	hsa-miR-1225-3p	CLIP-seq
MIRT1232894	hsa-miR-1231	CLIP-seq
MIRT1232895	hsa-miR-1262	CLIP-seq
MIRT1232896	hsa-miR-1291	CLIP-seq
MIRT1232897	hsa-miR-181a	CLIP-seq
MIRT1232898	hsa-miR-181b	CLIP-seq
MIRT1232899	hsa-miR-181c	CLIP-seq
MIRT1232900	hsa-miR-181d	CLIP-seq
MIRT1232901	hsa-miR-185	CLIP-seq
MIRT1232902	hsa-miR-18a	CLIP-seq
MIRT1232903	hsa-miR-18b	CLIP-seq
MIRT1232904	hsa-miR-298	CLIP-seq
MIRT1232905	hsa-miR-3115	CLIP-seq
MIRT1232906	hsa-miR-3120-5p	CLIP-seq
MIRT1232907	hsa-miR-3170	CLIP-seq
MIRT1232908	hsa-miR-3176	CLIP-seq
MIRT1232909	hsa-miR-3187-3p	CLIP-seq
MIRT1232910	hsa-miR-328	CLIP-seq
MIRT1232911	hsa-miR-335	CLIP-seq
MIRT1232912	hsa-miR-3918	CLIP-seq
MIRT1232913	hsa-miR-3922-3p	CLIP-seq
MIRT1232914	hsa-miR-3943	CLIP-seq
MIRT1232915	hsa-miR-410	CLIP-seq
MIRT1232916	hsa-miR-4260	CLIP-seq
MIRT1232917	hsa-miR-4262	CLIP-seq
MIRT1232918	hsa-miR-4278	CLIP-seq
MIRT1232919	hsa-miR-4282	CLIP-seq
MIRT1232920	hsa-miR-4306	CLIP-seq
MIRT1232921	hsa-miR-4435	CLIP-seq
MIRT1232922	hsa-miR-4644	CLIP-seq
MIRT1232923	hsa-miR-4650-5p	CLIP-seq
MIRT1232924	hsa-miR-4694-3p	CLIP-seq
MIRT1232925	hsa-miR-4701-3p	CLIP-seq
MIRT1232926	hsa-miR-4701-5p	CLIP-seq
MIRT1232927	hsa-miR-4716-3p	CLIP-seq
MIRT1232928	hsa-miR-4735-3p	CLIP-seq
MIRT1232929	hsa-miR-4749-3p	CLIP-seq
MIRT1232930	hsa-miR-4755-3p	CLIP-seq
MIRT1232931	hsa-miR-4761-5p	CLIP-seq
MIRT1232932	hsa-miR-4795-3p	CLIP-seq
MIRT1232933	hsa-miR-513b	CLIP-seq
MIRT1232934	hsa-miR-522	CLIP-seq
MIRT1232935	hsa-miR-543	CLIP-seq
MIRT1232936	hsa-miR-548a-5p	CLIP-seq
MIRT1232937	hsa-miR-548ab	CLIP-seq
MIRT1232938	hsa-miR-548ak	CLIP-seq
MIRT1232939	hsa-miR-548b-5p	CLIP-seq
MIRT1232940	hsa-miR-548c-5p	CLIP-seq
MIRT1232941	hsa-miR-548d-5p	CLIP-seq
MIRT1232942	hsa-miR-548h	CLIP-seq
MIRT1232943	hsa-miR-548i	CLIP-seq
MIRT1232944	hsa-miR-548j	CLIP-seq
MIRT1232945	hsa-miR-548n	CLIP-seq
MIRT1232946	hsa-miR-548s	CLIP-seq
MIRT1232947	hsa-miR-548w	CLIP-seq
MIRT1232948	hsa-miR-548y	CLIP-seq
MIRT1232949	hsa-miR-559	CLIP-seq
MIRT1232950	hsa-miR-588	CLIP-seq
MIRT1232951	hsa-miR-606	CLIP-seq
MIRT1232952	hsa-miR-625	CLIP-seq
MIRT1552304	hsa-miR-1275	CLIP-seq
MIRT1552305	hsa-miR-2277-3p	CLIP-seq
MIRT1552306	hsa-miR-3147	CLIP-seq
MIRT1552307	hsa-miR-4302	CLIP-seq
MIRT1552308	hsa-miR-4425	CLIP-seq
MIRT1552309	hsa-miR-4525	CLIP-seq
MIRT1552310	hsa-miR-4665-5p	CLIP-seq
MIRT1552311	hsa-miR-4723-5p	CLIP-seq
MIRT1232952	hsa-miR-625	CLIP-seq
MIRT2068506	hsa-miR-1	CLIP-seq
MIRT2068507	hsa-miR-1178	CLIP-seq
MIRT2068508	hsa-miR-1207-5p	CLIP-seq
MIRT2068509	hsa-miR-1227	CLIP-seq
MIRT2068510	hsa-miR-1243	CLIP-seq
MIRT2068511	hsa-miR-1245b-5p	CLIP-seq
MIRT1552304	hsa-miR-1275	CLIP-seq
MIRT2068512	hsa-miR-129-3p	CLIP-seq
MIRT2068513	hsa-miR-1302	CLIP-seq
MIRT2068514	hsa-miR-1827	CLIP-seq
MIRT2068515	hsa-miR-1909	CLIP-seq
MIRT2068516	hsa-miR-206	CLIP-seq
MIRT1552305	hsa-miR-2277-3p	CLIP-seq
MIRT1232906	hsa-miR-3120-5p	CLIP-seq
MIRT2068517	hsa-miR-3122	CLIP-seq
MIRT2068518	hsa-miR-3142	CLIP-seq
MIRT2068519	hsa-miR-3143	CLIP-seq
MIRT1552306	hsa-miR-3147	CLIP-seq
MIRT2068520	hsa-miR-3157-5p	CLIP-seq
MIRT1232908	hsa-miR-3176	CLIP-seq
MIRT2068521	hsa-miR-3199	CLIP-seq
MIRT2068522	hsa-miR-3612	CLIP-seq
MIRT2068523	hsa-miR-3654	CLIP-seq
MIRT2068524	hsa-miR-3692	CLIP-seq
MIRT2068525	hsa-miR-3913-5p	CLIP-seq
MIRT1232913	hsa-miR-3922-3p	CLIP-seq
MIRT2068526	hsa-miR-4264	CLIP-seq
MIRT2068527	hsa-miR-4266	CLIP-seq
MIRT2068528	hsa-miR-4271	CLIP-seq
MIRT2068529	hsa-miR-4279	CLIP-seq
MIRT2068530	hsa-miR-4293	CLIP-seq
MIRT2068531	hsa-miR-4298	CLIP-seq
MIRT1552307	hsa-miR-4302	CLIP-seq
MIRT2068532	hsa-miR-4312	CLIP-seq
MIRT2068533	hsa-miR-4328	CLIP-seq
MIRT2068534	hsa-miR-4421	CLIP-seq
MIRT1552308	hsa-miR-4425	CLIP-seq
MIRT1552309	hsa-miR-4525	CLIP-seq
MIRT2068535	hsa-miR-455-5p	CLIP-seq
MIRT1552310	hsa-miR-4665-5p	CLIP-seq
MIRT2068536	hsa-miR-4690-3p	CLIP-seq
MIRT2068537	hsa-miR-4695-5p	CLIP-seq
MIRT1552311	hsa-miR-4723-5p	CLIP-seq
MIRT2068538	hsa-miR-4725-3p	CLIP-seq
MIRT2068539	hsa-miR-4763-3p	CLIP-seq
MIRT2068540	hsa-miR-4779	CLIP-seq
MIRT2068541	hsa-miR-4797-3p	CLIP-seq
MIRT2068542	hsa-miR-4803	CLIP-seq
MIRT2068543	hsa-miR-587	CLIP-seq
MIRT2068544	hsa-miR-613	CLIP-seq
MIRT1232952	hsa-miR-625	CLIP-seq
MIRT2068545	hsa-miR-650	CLIP-seq
MIRT2068546	hsa-miR-940	CLIP-seq
MIRT2068507	hsa-miR-1178	CLIP-seq
MIRT1232893	hsa-miR-1225-3p	CLIP-seq
MIRT1232895	hsa-miR-1262	CLIP-seq
MIRT2068513	hsa-miR-1302	CLIP-seq
MIRT1232897	hsa-miR-181a	CLIP-seq
MIRT1232898	hsa-miR-181b	CLIP-seq
MIRT1232899	hsa-miR-181c	CLIP-seq
MIRT1232900	hsa-miR-181d	CLIP-seq
MIRT1552305	hsa-miR-2277-3p	CLIP-seq
MIRT1232905	hsa-miR-3115	CLIP-seq
MIRT2068517	hsa-miR-3122	CLIP-seq
MIRT1232907	hsa-miR-3170	CLIP-seq
MIRT1232909	hsa-miR-3187-3p	CLIP-seq
MIRT2068521	hsa-miR-3199	CLIP-seq
MIRT2295676	hsa-miR-345	CLIP-seq
MIRT2295677	hsa-miR-361-3p	CLIP-seq
MIRT2295678	hsa-miR-383	CLIP-seq
MIRT2068525	hsa-miR-3913-5p	CLIP-seq
MIRT1232914	hsa-miR-3943	CLIP-seq
MIRT1232917	hsa-miR-4262	CLIP-seq
MIRT2068531	hsa-miR-4298	CLIP-seq
MIRT1552307	hsa-miR-4302	CLIP-seq
MIRT1552308	hsa-miR-4425	CLIP-seq
MIRT1232921	hsa-miR-4435	CLIP-seq
MIRT1232925	hsa-miR-4701-3p	CLIP-seq
MIRT1232926	hsa-miR-4701-5p	CLIP-seq
MIRT2295679	hsa-miR-4731-5p	CLIP-seq
MIRT1232932	hsa-miR-4795-3p	CLIP-seq
MIRT1232933	hsa-miR-513b	CLIP-seq
MIRT1232935	hsa-miR-543	CLIP-seq
MIRT1232946	hsa-miR-548s	CLIP-seq
MIRT2068543	hsa-miR-587	CLIP-seq
MIRT1232950	hsa-miR-588	CLIP-seq
MIRT1232952	hsa-miR-625	CLIP-seq
MIRT2295680	hsa-miR-759	CLIP-seq
MIRT2068508	hsa-miR-1207-5p	CLIP-seq
MIRT2068510	hsa-miR-1243	CLIP-seq
MIRT2068511	hsa-miR-1245b-5p	CLIP-seq
MIRT2068514	hsa-miR-1827	CLIP-seq
MIRT2068515	hsa-miR-1909	CLIP-seq
MIRT2593484	hsa-miR-2681	CLIP-seq
MIRT2068518	hsa-miR-3142	CLIP-seq
MIRT2593485	hsa-miR-3158-5p	CLIP-seq
MIRT2593486	hsa-miR-3198	CLIP-seq
MIRT2068522	hsa-miR-3612	CLIP-seq
MIRT2068523	hsa-miR-3654	CLIP-seq
MIRT2593487	hsa-miR-3924	CLIP-seq
MIRT2068527	hsa-miR-4266	CLIP-seq
MIRT2068528	hsa-miR-4271	CLIP-seq
MIRT2593488	hsa-miR-4309	CLIP-seq
MIRT2068537	hsa-miR-4695-5p	CLIP-seq
MIRT2068538	hsa-miR-4725-3p	CLIP-seq
MIRT2593489	hsa-miR-4753-5p	CLIP-seq
MIRT2068539	hsa-miR-4763-3p	CLIP-seq
MIRT2068540	hsa-miR-4779	CLIP-seq
MIRT2593490	hsa-miR-496	CLIP-seq
MIRT2068545	hsa-miR-650	CLIP-seq
MIRT2593491	hsa-miR-659	CLIP-seq
MIRT2593492	hsa-miR-9	CLIP-seq
MIRT2068546	hsa-miR-940	CLIP-seq
MIRT2068508	hsa-miR-1207-5p	CLIP-seq
MIRT2068510	hsa-miR-1243	CLIP-seq
MIRT2068511	hsa-miR-1245b-5p	CLIP-seq
MIRT2068514	hsa-miR-1827	CLIP-seq
MIRT2687860	hsa-miR-186	CLIP-seq
MIRT2068515	hsa-miR-1909	CLIP-seq
MIRT2593484	hsa-miR-2681	CLIP-seq
MIRT2687861	hsa-miR-3133	CLIP-seq
MIRT2068518	hsa-miR-3142	CLIP-seq
MIRT2593485	hsa-miR-3158-5p	CLIP-seq
MIRT2687862	hsa-miR-3180-5p	CLIP-seq
MIRT2593486	hsa-miR-3198	CLIP-seq
MIRT2068522	hsa-miR-3612	CLIP-seq
MIRT2068523	hsa-miR-3654	CLIP-seq
MIRT2593487	hsa-miR-3924	CLIP-seq
MIRT2068527	hsa-miR-4266	CLIP-seq
MIRT2068528	hsa-miR-4271	CLIP-seq
MIRT2593488	hsa-miR-4309	CLIP-seq
MIRT2687863	hsa-miR-4509	CLIP-seq
MIRT2068537	hsa-miR-4695-5p	CLIP-seq
MIRT2687864	hsa-miR-4715-3p	CLIP-seq
MIRT2068538	hsa-miR-4725-3p	CLIP-seq
MIRT2687865	hsa-miR-4744	CLIP-seq
MIRT2593489	hsa-miR-4753-5p	CLIP-seq
MIRT2068539	hsa-miR-4763-3p	CLIP-seq
MIRT2068540	hsa-miR-4779	CLIP-seq
MIRT2593490	hsa-miR-496	CLIP-seq
MIRT2687866	hsa-miR-520a-5p	CLIP-seq
MIRT2687867	hsa-miR-525-5p	CLIP-seq
MIRT2068545	hsa-miR-650	CLIP-seq
MIRT2593491	hsa-miR-659	CLIP-seq
MIRT2593492	hsa-miR-9	CLIP-seq
MIRT2068546	hsa-miR-940	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
STAT3	Activation	14630083
TP53	Repression	11877452

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0001085	Function	RNA polymerase II transcription factor binding	IBA	21873635
GO:0003712	Function	Transcription coregulator activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11060035, 21965678, 28842558, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008022	Function	Protein C-terminus binding	IPI	14715251
GO:0008270	Function	Zinc ion binding	IEA
GO:0009725	Process	Response to hormone	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0015459	Function	Potassium channel regulator activity	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0016925	Process	Protein sumoylation	IBA	21873635
GO:0016925	Process	Protein sumoylation	IEA
GO:0016925	Process	Protein sumoylation	ISS
GO:0016925	Process	Protein sumoylation	TAS
GO:0019789	Function	SUMO transferase activity	EXP	15507434
GO:0019899	Function	Enzyme binding	IPI	17087506
GO:0030425	Component	Dendrite	IEA
GO:0033234	Process	Negative regulation of protein sumoylation	IDA	24651376
GO:0033235	Process	Positive regulation of protein sumoylation	IDA	17696781, 21965678
GO:0045202	Component	Synapse	IEA
GO:0045671	Process	Negative regulation of osteoclast differentiation	IEA
GO:0045838	Process	Positive regulation of membrane potential	IEA
GO:0047485	Function	Protein N-terminus binding	IEA
GO:0061665	Function	SUMO ligase activity	IBA	21873635
GO:0071847	Process	TNFSF11-mediated signaling pathway	IEA

MIM	HGNC	e!Ensembl
605987	16861	ENSG00000131788

Protein

UniProt ID

Q9Y6X2

Protein name

E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)

Protein function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways

PDB

4MVT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14324	PINIT	126 → 278	PINIT domain	Domain
PF02891	zf-MIZ	323 → 372	MIZ/SP-RING zinc finger	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9388184}.

Sequence

MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKEL
YRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLP
QPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLP
GAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSR
PINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHS
RALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEK
KPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPP
PGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPG
SKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQ
HYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHCSATPAPPPGRVSSIVAPG
GALREGHGGPLPSGPSLTGCRSDIISLD

Sequence length

628

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis JAK-STAT signaling pathway		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Cervical cancer	cervical cancer	rs28934571, rs121913482, rs121913483	25061499

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoviridae Infections	Associate	26223632
Alzheimer Disease	Inhibit	34837964
Arthritis Rheumatoid	Associate	34030529
Breast Neoplasms	Stimulate	18246042
Breast Neoplasms	Associate	20854925, 22174013, 26768588, 28423498
Burkitt Lymphoma	Associate	19759907
Carcinoma Hepatocellular	Associate	36748193
Carcinoma Non Small Cell Lung	Associate	19569236, 21497567, 23959540, 25137041, 28972958
Carcinoma Squamous Cell	Associate	23959540, 25573684
Carcinoma Squamous Cell	Inhibit	28972958
Colorectal Neoplasms	Associate	24621823, 29123263, 32964969, 33155205
Death	Associate	25573684
Drug Related Side Effects and Adverse Reactions	Stimulate	26768588
Fibrosis	Associate	17318196
Glioblastoma	Inhibit	21317457
Glioma	Inhibit	21317457
IgA Vasculitis	Associate	34030529
Leukemia Lymphocytic Chronic B Cell	Associate	28947822
Liver Failure	Associate	33155205
Lung Neoplasms	Associate	17032498, 23959540
Lung Neoplasms	Inhibit	21497567
Medulloblastoma	Inhibit	28035977
Mesothelioma Malignant	Associate	30259640
Mitochondrial Diseases	Stimulate	23959540
Multiple Myeloma	Associate	11429412, 22316494
Neoplasm Metastasis	Associate	32964969
Neoplasms	Associate	17032498, 19903771, 25137041, 26768588, 28120918, 30259640
Neoplasms	Stimulate	18246042, 40003884
Neoplasms	Inhibit	28947822
Neoplasms Squamous Cell	Inhibit	25573684
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Associate	34054823
Prostatic Neoplasms	Associate	20854925, 32415173
Sleep Initiation and Maintenance Disorders	Associate	32648482
Small Cell Lung Carcinoma	Inhibit	25573684
Stomach Diseases	Associate	23322197
Stomach Neoplasms	Associate	23322197
Thrombocythemia Essential	Inhibit	24301930

PIAS3 (protein inhibitor of activated STAT 3)