Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1040
Gene name Gene Name - the full gene name approved by the HGNC.
CDP-diacylglycerol synthase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDS1
Synonyms (NCBI Gene) Gene synonyms aliases
CDS 1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.23
Summary Summary of gene provided in NCBI Entrez Gene.
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzy
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019089 hsa-miR-335-5p Microarray 18185580
MIRT043107 hsa-miR-324-5p CLASH 23622248
MIRT437688 hsa-miR-223-3p Microarray, qRT-PCR 22815788
MIRT882270 hsa-miR-1237 CLIP-seq
MIRT882271 hsa-miR-124 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004142 Function Diacylglycerol cholinephosphotransferase activity NAS 9115637
GO:0004605 Function Phosphatidate cytidylyltransferase activity IDA 8863531, 9407135, 25375833
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IDA 25375833, 26946540, 31548309
GO:0005783 Component Endoplasmic reticulum ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603548 1800 ENSG00000163624
Protein
UniProt ID Q92903
Protein name Phosphatidate cytidylyltransferase 1 (EC 2.7.7.41) (CDP-DAG synthase 1) (CDP-DG synthase 1) (CDP-diacylglycerol synthase 1) (CDS 1) (CDP-diglyceride pyrophosphorylase 1) (CDP-diglyceride synthase 1) (CTP:phosphatidate cytidylyltransferase 1)
Protein function Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833, PubMed:9407135). Exhibits almost no ac
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01148 CTP_transf_1 87 417 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver. {ECO:0000269|PubMed:9407135}.
Sequence
Sequence length 461
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerophospholipid metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of PI
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 16316942
Associations from Text Mining
Disease Name Relationship Type References
Ataxia Telangiectasia Associate 9889122
Carcinoma Non Small Cell Lung Associate 20980099
Colorectal Neoplasms Associate 33378017
Neoplasm Metastasis Associate 33378017