Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
104
Gene name Gene Name - the full gene name approved by the HGNC.
Adenosine deaminase RNA specific B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADARB1
Synonyms (NCBI Gene) Gene synonyms aliases
ADAR2, DRABA2, DRADA2, NEDHYMS, RED1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDHYMS
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020174 hsa-miR-130b-3p Sequencing 20371350
MIRT022259 hsa-miR-124-3p Microarray 18668037
MIRT025443 hsa-miR-34a-5p Proteomics 21566225
MIRT025977 hsa-miR-148a-3p Sequencing 20371350
MIRT027945 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0003725 Function Double-stranded RNA binding IBA 21873635
GO:0003726 Function Double-stranded RNA adenosine deaminase activity IBA 21873635
GO:0003726 Function Double-stranded RNA adenosine deaminase activity IDA 32220291
GO:0003729 Function MRNA binding TAS 9149227
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601218 226 ENSG00000197381
Protein
UniProt ID P78563
Protein name Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)
Protein function Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and
PDB 1ZY7 , 5ED1 , 5ED2 , 5HP2 , 5HP3 , 6D06 , 6VFF , 7KFN , 8E0F , 8E4X , 9D5J , 9D5K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00035 dsrm 79 141 Double-stranded RNA binding motif Domain
PF00035 dsrm 239 296 Double-stranded RNA binding motif Domain
PF02137 A_deamin 370 731 Adenosine-deaminase (editase) domain Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:91492
Sequence
Sequence length 741
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    C6 deamination of adenosine
Formation of editosomes by ADAR proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
30130595
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21984433, 24443933
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Mental Depression Mental Depression GWAS
Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 31491024
Astrocytoma Inhibit 23697632
Ataxia Associate 32719099
Cap Myopathy Associate 18708348
Carcinogenesis Associate 28821813
Carcinoma Hepatocellular Associate 24386085
Carcinoma in Situ Associate 40010639
Carcinoma Squamous Cell Associate 32016472
Chordoma Associate 25673044
Death Associate 32220291, 32719099