Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10397
Gene name Gene Name - the full gene name approved by the HGNC.
N-myc downstream regulated 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NDRG1
Synonyms (NCBI Gene) Gene synonyms aliases
CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11575976 C>G,T Pathogenic, uncertain-significance Splice acceptor variant
rs119483085 G>A Pathogenic Upstream transcript variant, genic upstream transcript variant, stop gained, coding sequence variant
rs143549909 G>A,T Conflicting-interpretations-of-pathogenicity Synonymous variant, missense variant, coding sequence variant
rs145871479 C>T Uncertain-significance, conflicting-interpretations-of-pathogenicity 5 prime UTR variant, intron variant, coding sequence variant, genic upstream transcript variant, missense variant
rs201959970 G>A Conflicting-interpretations-of-pathogenicity, likely-benign Synonymous variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018414 hsa-miR-335-5p Microarray 18185580
MIRT025409 hsa-miR-34a-5p Proteomics 21566225
MIRT025409 hsa-miR-34a-5p Proteomics 21566225
MIRT025409 hsa-miR-34a-5p Proteomics 21566225
MIRT052351 hsa-let-7b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
AR Unknown 17075604
ETS1 Repression 18381358
FOXD3 Activation 24269992
MYC Repression 11936845
MYC Unknown 21976667
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15607035, 17220478, 17786215, 25416956, 32814053, 35271311
GO:0005634 Component Nucleus IDA 9766676
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 9766676
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605262 7679 ENSG00000104419
Protein
UniProt ID Q92597
Protein name Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)
Protein function Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell tra
PDB 6ZMM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03096 Ndr 34 316 Ndr family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocyte
Sequence
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Charcot-Marie-Tooth Disease charcot-marie-tooth disease type 4, charcot-marie-tooth disease type 4d, Charcot-Marie-Tooth Disease rs1586446057, rs1588216753, rs1855957969, rs1586407193, rs758718584, rs119483085, rs879254290, rs1060503092 N/A
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 24299561
Adenocarcinoma Follicular Stimulate 20835551
Adenoma Pleomorphic Associate 32345665
Astrocytoma Associate 33709284
Brain Neoplasms Associate 40530439
Breast Neoplasms Stimulate 21909787
Breast Neoplasms Associate 23899187, 25732125, 26852918, 30337371, 30497328, 31443698, 35508987, 35859293, 36127332, 36307826, 37338518, 37600707, 37854018, 39770056, 40530439
Breast Neoplasms Inhibit 31253870
Carcinogenesis Stimulate 14966915
Carcinogenesis Associate 18377423, 18653908, 21909787, 22678098, 26245647