Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	103910
Gene name	Myosin light chain 12B
Gene symbol	MYL12B
Synonyms (NCBI Gene)	MLC-BMRLC2
Chromosome	18
Chromosome location	18p11.31
Summary	The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [

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miRTarBase ID	miRNA	Experiments	Reference
MIRT041406	hsa-miR-193b-3p	CLASH	23622248
MIRT080003	hsa-miR-4311	PAR-CLIP	20371350
MIRT561170	hsa-miR-582-3p	PAR-CLIP	20371350
MIRT561171	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT561169	hsa-miR-641	PAR-CLIP	20371350
MIRT080000	hsa-miR-379-3p	PAR-CLIP	20371350
MIRT080001	hsa-miR-411-3p	PAR-CLIP	20371350
MIRT080004	hsa-miR-4251	PAR-CLIP	20371350
MIRT561168	hsa-miR-4329	PAR-CLIP	20371350
MIRT561167	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT080005	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT080006	hsa-miR-548ax	PAR-CLIP	20371350
MIRT080002	hsa-miR-1253	PAR-CLIP	20371350
MIRT080009	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT080003	hsa-miR-4311	PAR-CLIP	20371350
MIRT561170	hsa-miR-582-3p	PAR-CLIP	20371350
MIRT561171	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT561169	hsa-miR-641	PAR-CLIP	20371350
MIRT080000	hsa-miR-379-3p	PAR-CLIP	20371350
MIRT080001	hsa-miR-411-3p	PAR-CLIP	20371350
MIRT080004	hsa-miR-4251	PAR-CLIP	20371350
MIRT561168	hsa-miR-4329	PAR-CLIP	20371350
MIRT561167	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT080005	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT080006	hsa-miR-548ax	PAR-CLIP	20371350
MIRT080002	hsa-miR-1253	PAR-CLIP	20371350
MIRT080009	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168572	hsa-miR-1285	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168575	hsa-miR-23a	CLIP-seq
MIRT1168576	hsa-miR-23b	CLIP-seq
MIRT1168577	hsa-miR-23c	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168579	hsa-miR-3187-5p	CLIP-seq
MIRT1168580	hsa-miR-320a	CLIP-seq
MIRT1168581	hsa-miR-320b	CLIP-seq
MIRT1168582	hsa-miR-320c	CLIP-seq
MIRT1168583	hsa-miR-320d	CLIP-seq
MIRT1168584	hsa-miR-3613-3p	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168585	hsa-miR-378g	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168588	hsa-miR-4310	CLIP-seq
MIRT1168589	hsa-miR-4314	CLIP-seq
MIRT1168590	hsa-miR-4429	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168591	hsa-miR-4486	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168593	hsa-miR-499-3p	CLIP-seq
MIRT1168594	hsa-miR-499a-3p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168595	hsa-miR-607	CLIP-seq
MIRT1168596	hsa-miR-612	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168598	hsa-miR-627	CLIP-seq
MIRT1168599	hsa-miR-653	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168572	hsa-miR-1285	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168575	hsa-miR-23a	CLIP-seq
MIRT1168576	hsa-miR-23b	CLIP-seq
MIRT1168577	hsa-miR-23c	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168579	hsa-miR-3187-5p	CLIP-seq
MIRT1168580	hsa-miR-320a	CLIP-seq
MIRT1168581	hsa-miR-320b	CLIP-seq
MIRT1168582	hsa-miR-320c	CLIP-seq
MIRT1168583	hsa-miR-320d	CLIP-seq
MIRT2277392	hsa-miR-338-3p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168585	hsa-miR-378g	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168589	hsa-miR-4314	CLIP-seq
MIRT1168590	hsa-miR-4429	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168591	hsa-miR-4486	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT2277393	hsa-miR-4530	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT2277394	hsa-miR-4668-3p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168593	hsa-miR-499-3p	CLIP-seq
MIRT1168594	hsa-miR-499a-3p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT2277395	hsa-miR-545	CLIP-seq
MIRT2277396	hsa-miR-548aa	CLIP-seq
MIRT2277397	hsa-miR-548c-3p	CLIP-seq
MIRT2277398	hsa-miR-548p	CLIP-seq
MIRT1168596	hsa-miR-612	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168599	hsa-miR-653	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168599	hsa-miR-653	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168584	hsa-miR-3613-3p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168593	hsa-miR-499-3p	CLIP-seq
MIRT1168594	hsa-miR-499a-3p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IBA
GO:0001725	Component	Stress fiber	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	19328794, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005903	Component	Brush border	IEA
GO:0005938	Component	Cell cortex	IDA	23870127
GO:0008360	Process	Regulation of cell shape	IEA
GO:0016459	Component	Myosin complex	IEA
GO:0016460	Component	Myosin II complex	IBA
GO:0016460	Component	Myosin II complex	IEA
GO:0030016	Component	Myofibril	IBA
GO:0030018	Component	Z disc	IEA
GO:0032036	Function	Myosin heavy chain binding	IBA
GO:0032036	Function	Myosin heavy chain binding	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0045177	Component	Apical part of cell	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
609211	29827	ENSG00000118680

O14950

Protein name

Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)

Protein function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cy

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13405	EF-hand_6	33 → 62	EF-hand domain	Domain
PF08976	EF-hand_11	92 → 168	EF-hand domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed in various hematopoietic cells. {ECO:0000269|PubMed:11436981, ECO:0000269|PubMed:18480596}.

Sequence

MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE
DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD

Sequence length

172

Interactions

View interactions

	KEGG		Reactome
	Axon guidance Focal adhesion Adherens junction Tight junction Platelet activation Leukocyte transendothelial migration Regulation of actin cytoskeleton Motor proteins Shigellosis Salmonella infection		Smooth Muscle Contraction RHO GTPases activate PAKs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANTI-NEUTROPHIL ANTIBODY ASSOCIATED VASCULITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN INJURY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Cardiomyopathies	Associate	33731536	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Associate	19046427	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disease	Associate	33731536	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Stimulate	23963366	★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Diseases	Associate	33731536	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	17131471	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	23374291	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	37588985	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	23538510	★★★★★ ★☆☆☆☆ Found in Text Mining only

MYL12B (myosin light chain 12B)