TUBA1B (tubulin alpha 1b)

Gene

• Entrez ID: 10376
• Gene name: Tubulin alpha 1b
• Gene symbol: TUBA1B
• Synonyms (NCBI Gene): K-ALPHA-1
• Chromosome: 12
• Chromosome location: 12q13.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016595	hsa-miR-193b-3p	Proteomics	21512034
MIRT052015	hsa-let-7b-5p	CLASH	23622248
MIRT052015	hsa-let-7b-5p	CLASH	23622248
MIRT051439	hsa-let-7e-5p	CLASH	23622248
MIRT049937	hsa-miR-30a-5p	CLASH	23622248
MIRT048292	hsa-miR-107	CLASH	23622248
MIRT048190	hsa-miR-196a-5p	CLASH	23622248
MIRT048190	hsa-miR-196a-5p	CLASH	23622248
MIRT047458	hsa-miR-10b-5p	CLASH	23622248
MIRT047209	hsa-miR-182-5p	CLASH	23622248
MIRT044555	hsa-miR-320a	CLASH	23622248
MIRT044555	hsa-miR-320a	CLASH	23622248
MIRT043044	hsa-miR-324-5p	CLASH	23622248
MIRT042042	hsa-miR-484	CLASH	23622248
MIRT042042	hsa-miR-484	CLASH	23622248
MIRT040370	hsa-miR-615-3p	CLASH	23622248
MIRT039463	hsa-miR-652-3p	CLASH	23622248
MIRT039463	hsa-miR-652-3p	CLASH	23622248
MIRT039413	hsa-miR-421	CLASH	23622248
MIRT038647	hsa-miR-140-3p	CLASH	23622248
MIRT038384	hsa-miR-296-3p	CLASH	23622248
MIRT037972	hsa-miR-505-5p	CLASH	23622248
MIRT037513	hsa-miR-744-5p	CLASH	23622248
MIRT037513	hsa-miR-744-5p	CLASH	23622248
MIRT037246	hsa-miR-877-5p	CLASH	23622248
MIRT037246	hsa-miR-877-5p	CLASH	23622248
MIRT036931	hsa-miR-877-3p	CLASH	23622248
MIRT036931	hsa-miR-877-3p	CLASH	23622248
MIRT036718	hsa-miR-760	CLASH	23622248
MIRT036718	hsa-miR-760	CLASH	23622248
MIRT036296	hsa-miR-1229-3p	CLASH	23622248
MIRT052893	hsa-miR-3934-5p	CLASH	23622248
MIRT504420	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT504419	hsa-miR-4643	PAR-CLIP	20371350
MIRT504418	hsa-miR-552-3p	PAR-CLIP	20371350
MIRT504417	hsa-miR-1272	PAR-CLIP	20371350
MIRT504416	hsa-miR-1322	PAR-CLIP	20371350
MIRT504414	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT504413	hsa-miR-4534	PAR-CLIP	20371350
MIRT504412	hsa-miR-8082	PAR-CLIP	20371350
MIRT504411	hsa-miR-3134	PAR-CLIP	20371350
MIRT504410	hsa-miR-3148	PAR-CLIP	20371350
MIRT504409	hsa-miR-6124	PAR-CLIP	20371350
MIRT563810	hsa-miR-569	PAR-CLIP	20371350
MIRT504408	hsa-miR-466	PAR-CLIP	20371350
MIRT504407	hsa-miR-5095	PAR-CLIP	20371350
MIRT504406	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT563809	hsa-miR-2053	PAR-CLIP	20371350
MIRT504420	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504419	hsa-miR-4643	PAR-CLIP	23446348
MIRT504418	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT504417	hsa-miR-1272	PAR-CLIP	23446348
MIRT504416	hsa-miR-1322	PAR-CLIP	23446348
MIRT504415	hsa-miR-3688-3p	PAR-CLIP	23446348
MIRT504414	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT504413	hsa-miR-4534	PAR-CLIP	23446348
MIRT504412	hsa-miR-8082	PAR-CLIP	23446348
MIRT504411	hsa-miR-3134	PAR-CLIP	23446348
MIRT504410	hsa-miR-3148	PAR-CLIP	23446348
MIRT504409	hsa-miR-6124	PAR-CLIP	23446348
MIRT504408	hsa-miR-466	PAR-CLIP	23446348
MIRT504407	hsa-miR-5095	PAR-CLIP	23446348
MIRT504406	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT504420	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT504419	hsa-miR-4643	PAR-CLIP	20371350
MIRT504418	hsa-miR-552-3p	PAR-CLIP	20371350
MIRT504417	hsa-miR-1272	PAR-CLIP	20371350
MIRT504416	hsa-miR-1322	PAR-CLIP	20371350
MIRT504414	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT504413	hsa-miR-4534	PAR-CLIP	20371350
MIRT504412	hsa-miR-8082	PAR-CLIP	20371350
MIRT504411	hsa-miR-3134	PAR-CLIP	20371350
MIRT504410	hsa-miR-3148	PAR-CLIP	20371350
MIRT504409	hsa-miR-6124	PAR-CLIP	20371350
MIRT563810	hsa-miR-569	PAR-CLIP	20371350
MIRT504408	hsa-miR-466	PAR-CLIP	20371350
MIRT504407	hsa-miR-5095	PAR-CLIP	20371350
MIRT504406	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT563809	hsa-miR-2053	PAR-CLIP	20371350
MIRT504420	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504419	hsa-miR-4643	PAR-CLIP	23446348
MIRT504418	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT504417	hsa-miR-1272	PAR-CLIP	23446348
MIRT504416	hsa-miR-1322	PAR-CLIP	23446348
MIRT504415	hsa-miR-3688-3p	PAR-CLIP	23446348
MIRT504414	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT504413	hsa-miR-4534	PAR-CLIP	23446348
MIRT504412	hsa-miR-8082	PAR-CLIP	23446348
MIRT504411	hsa-miR-3134	PAR-CLIP	23446348
MIRT504410	hsa-miR-3148	PAR-CLIP	23446348
MIRT504409	hsa-miR-6124	PAR-CLIP	23446348
MIRT504408	hsa-miR-466	PAR-CLIP	23446348
MIRT504407	hsa-miR-5095	PAR-CLIP	23446348
MIRT504406	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT1462977	hsa-miR-1205	CLIP-seq
MIRT1462978	hsa-miR-127-5p	CLIP-seq
MIRT1462979	hsa-miR-1909	CLIP-seq
MIRT1462980	hsa-miR-223	CLIP-seq
MIRT1462981	hsa-miR-3192	CLIP-seq
MIRT1462982	hsa-miR-320e	CLIP-seq
MIRT1462983	hsa-miR-3617	CLIP-seq
MIRT1462984	hsa-miR-3918	CLIP-seq
MIRT1462985	hsa-miR-3926	CLIP-seq
MIRT1462986	hsa-miR-4300	CLIP-seq
MIRT1462987	hsa-miR-4314	CLIP-seq
MIRT1462988	hsa-miR-4646-5p	CLIP-seq
MIRT1462989	hsa-miR-4697-3p	CLIP-seq
MIRT1462990	hsa-miR-4717-3p	CLIP-seq
MIRT1462991	hsa-miR-4802-3p	CLIP-seq
MIRT1462992	hsa-miR-552	CLIP-seq
MIRT1462993	hsa-miR-570	CLIP-seq
MIRT1462994	hsa-miR-641	CLIP-seq
MIRT1462995	hsa-miR-920	CLIP-seq
MIRT1462996	hsa-miR-935	CLIP-seq
MIRT1462977	hsa-miR-1205	CLIP-seq
MIRT1557232	hsa-miR-1261	CLIP-seq
MIRT1462979	hsa-miR-1909	CLIP-seq
MIRT1462984	hsa-miR-3918	CLIP-seq
MIRT1462985	hsa-miR-3926	CLIP-seq
MIRT1462977	hsa-miR-1205	CLIP-seq
MIRT1557232	hsa-miR-1261	CLIP-seq
MIRT1462978	hsa-miR-127-5p	CLIP-seq
MIRT1462979	hsa-miR-1909	CLIP-seq
MIRT1462980	hsa-miR-223	CLIP-seq
MIRT1462981	hsa-miR-3192	CLIP-seq
MIRT1462982	hsa-miR-320e	CLIP-seq
MIRT1462983	hsa-miR-3617	CLIP-seq
MIRT1462984	hsa-miR-3918	CLIP-seq
MIRT1462985	hsa-miR-3926	CLIP-seq
MIRT1462986	hsa-miR-4300	CLIP-seq
MIRT1462987	hsa-miR-4314	CLIP-seq
MIRT1462988	hsa-miR-4646-5p	CLIP-seq
MIRT1462989	hsa-miR-4697-3p	CLIP-seq
MIRT1462990	hsa-miR-4717-3p	CLIP-seq
MIRT1462991	hsa-miR-4802-3p	CLIP-seq
MIRT1462992	hsa-miR-552	CLIP-seq
MIRT1462993	hsa-miR-570	CLIP-seq
MIRT1462994	hsa-miR-641	CLIP-seq
MIRT1462995	hsa-miR-920	CLIP-seq
MIRT1462996	hsa-miR-935	CLIP-seq
MIRT1462977	hsa-miR-1205	CLIP-seq
MIRT1557232	hsa-miR-1261	CLIP-seq
MIRT1462978	hsa-miR-127-5p	CLIP-seq
MIRT1462979	hsa-miR-1909	CLIP-seq
MIRT1462980	hsa-miR-223	CLIP-seq
MIRT1462981	hsa-miR-3192	CLIP-seq
MIRT1462982	hsa-miR-320e	CLIP-seq
MIRT1462983	hsa-miR-3617	CLIP-seq
MIRT1462984	hsa-miR-3918	CLIP-seq
MIRT1462985	hsa-miR-3926	CLIP-seq
MIRT1462986	hsa-miR-4300	CLIP-seq
MIRT1462987	hsa-miR-4314	CLIP-seq
MIRT1462988	hsa-miR-4646-5p	CLIP-seq
MIRT1462989	hsa-miR-4697-3p	CLIP-seq
MIRT1462990	hsa-miR-4717-3p	CLIP-seq
MIRT1462991	hsa-miR-4802-3p	CLIP-seq
MIRT1462992	hsa-miR-552	CLIP-seq
MIRT1462993	hsa-miR-570	CLIP-seq
MIRT1462994	hsa-miR-641	CLIP-seq
MIRT1462995	hsa-miR-920	CLIP-seq
MIRT1462996	hsa-miR-935	CLIP-seq
MIRT1462978	hsa-miR-127-5p	CLIP-seq
MIRT1462980	hsa-miR-223	CLIP-seq
MIRT1462982	hsa-miR-320e	CLIP-seq
MIRT1462989	hsa-miR-4697-3p	CLIP-seq
MIRT1462990	hsa-miR-4717-3p	CLIP-seq
MIRT1462991	hsa-miR-4802-3p	CLIP-seq
MIRT1462992	hsa-miR-552	CLIP-seq
MIRT1462993	hsa-miR-570	CLIP-seq
MIRT1462996	hsa-miR-935	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PPARA	Unknown	23029400
RORA	Unknown	23029400

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0000226	Process	Microtubule cytoskeleton organization	IDA	34996871
GO:0000278	Process	Mitotic cell cycle	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0003924	Function	GTPase activity	IDA	34996871
GO:0005198	Function	Structural molecule activity	TAS	12090300
GO:0005200	Function	Structural constituent of cytoskeleton	IBA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	34996871
GO:0005200	Function	Structural constituent of cytoskeleton	IEA
GO:0005515	Function	Protein binding	IPI	11698390, 18457437, 24021646, 25416956, 32814053, 35271311
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IDA	34996871
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IDA	21525035
GO:0005874	Component	Microtubule	IEA
GO:0005874	Component	Microtubule	TAS	12090300
GO:0005881	Component	Cytoplasmic microtubule	IEA
GO:0005929	Component	Cilium	IDA
GO:0007017	Process	Microtubule-based process	IEA
GO:0007017	Process	Microtubule-based process	TAS	12090300
GO:0015630	Component	Microtubule cytoskeleton	IDA	34996871
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030705	Process	Cytoskeleton-dependent intracellular transport	TAS	12090300
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	21753002
GO:0051301	Process	Cell division	TAS	12090300
GO:0071353	Process	Cellular response to interleukin-4	IEA

Other IDs

• MIM: 602530
• HGNC: 18809
• e!Ensembl: ENSG00000123416

Protein

• UniProt ID: P68363
• Protein name: Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]
• Protein function: Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubul
• PDB: 2E4H, 5IJ0, 5IJ9, 5N5N, 6E7B, 6E7C, 6I2I, 6J4V, 6J8O, 6QUS, 6QUY, 6QVE, 6QVJ, 6S8L, 7LXB, 7M18, 7M20, 7PJF, 7SJ7, 7SJ8, 7SJ9, 7SJA, 7Z6S, 7ZCW, 8T42, 8U3Z, 8V2J, 8VA2, 8VRJ, 8VRK, 8VT7, 9BP6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00091	Tubulin	3 → 214	Tubulin/FtsZ family, GTPase domain	Domain
  PF03953	Tubulin_C	263 → 393	Tubulin C-terminal domain	Domain

• Sequence:

  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
  HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
  RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
  VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
  SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
  QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
  TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
  AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

• Sequence length: 451

Pathways

KEGG:

Phagosome
Apoptosis
Tight junction
Gap junction
Motor proteins
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Pathogenic Escherichia coli infection
Salmonella infection

Reactome:

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Congenital fibrosis of extraocular muscles	Uncertain significance	rs2498792366	RCV003983791
TUBA1B-associated neurodevelopmental disorder	Uncertain significance	rs2498792203	RCV003322737

Associations from Text Mining
Disease Name	Relationship Type	References
Acute Kidney Injury	Associate	36552715
Adenocarcinoma of Lung	Stimulate	37489256
Alopecia Areata	Associate	29323127
Ameloblastoma	Associate	34508164
Anemia Iron Deficiency	Associate	29499633
Asthenozoospermia	Associate	24268707
Ataxia Telangiectasia	Associate	31819434
Brain Stem Neoplasms	Associate	26130693
Breast Neoplasms	Associate	19215229, 19406749, 22200869, 25503560, 27228351, 37174666, 39232806
Bulbo Spinal Atrophy X Linked	Associate	24925468
Calcinosis Cutis	Associate	25503560
Carcinogenesis	Associate	16101133
Carcinoma Ductal	Associate	19215229
Carcinoma Hepatocellular	Associate	30981109, 32685988, 37056756
Carcinoma Intraductal Noninfiltrating	Associate	19215229
Carcinoma Non Small Cell Lung	Associate	26999101, 30429459, 36408734
Cardiomyopathy Hypertrophic	Associate	31323898
Cardiomyopathy Restrictive	Inhibit	36174041
Cataract	Associate	32985730
Colitis Ulcerative	Associate	29027377
congenital fibrosis of the extraocular muscles	Associate	33649541
Fatty Liver Alcoholic	Associate	32685988
Genetic Diseases Inborn	Associate	34704371
Glioblastoma	Associate	16257120
Glomerulosclerosis Focal Segmental	Associate	33800671
Hereditary Breast and Ovarian Cancer Syndrome	Associate	19215229
Iliotibial Band Syndrome	Associate	34704371
Lissencephaly	Associate	19896110, 26130693, 27431206
Lung Neoplasms	Associate	22904633
Lymphoma Mantle Cell	Associate	18416826
Malformations of Cortical Development	Associate	26130693, 33649541
Mitochondrial Diseases	Associate	37085137
Multicystic Dysplastic Kidney	Associate	33800671
Muscular Dystrophy Duchenne	Associate	31991054
Nasal Polyps	Associate	33982786
Nasopharyngeal Carcinoma	Associate	29747653
Neointima	Associate	32985730
Neoplasm Metastasis	Associate	30504808
Neoplasms	Associate	19339240, 19407367, 20924103, 27447976, 29976237, 33503939, 37174666, 39232806
Neurodegenerative Diseases	Associate	34638726
Neuroinflammatory Diseases	Associate	32210464
Neurologic Manifestations	Associate	22591407
Optic Nerve Hypoplasia	Associate	19896110
Osteogenesis Imperfecta	Inhibit	37566108
Osteosarcoma	Associate	30936265
Ovarian Neoplasms	Associate	19010849, 33475085
Pancreatic Neoplasms	Associate	27447976
Parkinson Disease	Associate	37348876
Pelvic Organ Prolapse	Associate	25923074
Pena Shokeir syndrome type 1	Associate	33168876
Polymicrogyria	Associate	19896110, 22948023, 26130693
Prostatic Neoplasms	Associate	18957327
Prostatic Neoplasms Castration Resistant	Associate	37165308
Pulmonary Disease Chronic Obstructive	Associate	34434188
Rectal Neoplasms	Associate	16101133
Renal Insufficiency Chronic	Associate	33800671
Rett Syndrome	Associate	29730163
Thrombocytosis	Associate	29499633
Uterine Cervical Neoplasms	Associate	29716651
Wilms Tumor	Associate	32908931