Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10371
Gene name	Semaphorin 3A
Gene symbol	SEMA3A
Synonyms (NCBI Gene)	COLL1HH16Hsema-IHsema-IIISEMA1SEMADSEMAIIISEMALSemDcoll-1
Chromosome	7
Chromosome location	7q21.11
Summary	This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or

Show/Hide all (3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs138952094	G>A	Benign, likely-pathogenic	Missense variant, coding sequence variant
rs147436181	C>T	Not-provided, risk-factor, benign	Coding sequence variant, missense variant
rs1064793265	G>A	Likely-pathogenic	Stop gained, coding sequence variant

225

Show/Hide all (225)

miRTarBase ID	miRNA	Experiments
MIRT1334604	hsa-miR-141	CLIP-seq
MIRT1334605	hsa-miR-15a	CLIP-seq
MIRT1334606	hsa-miR-15b	CLIP-seq
MIRT1334607	hsa-miR-16	CLIP-seq
MIRT1334608	hsa-miR-186	CLIP-seq
MIRT1334609	hsa-miR-195	CLIP-seq
MIRT1334610	hsa-miR-200a	CLIP-seq
MIRT1334611	hsa-miR-3120-3p	CLIP-seq
MIRT1334612	hsa-miR-3133	CLIP-seq
MIRT1334613	hsa-miR-3154	CLIP-seq
MIRT1334614	hsa-miR-3179	CLIP-seq
MIRT1334615	hsa-miR-3682-3p	CLIP-seq
MIRT1334616	hsa-miR-3689d	CLIP-seq
MIRT1334617	hsa-miR-3921	CLIP-seq
MIRT1334618	hsa-miR-424	CLIP-seq
MIRT1334619	hsa-miR-4502	CLIP-seq
MIRT1334620	hsa-miR-4653-5p	CLIP-seq
MIRT1334621	hsa-miR-494	CLIP-seq
MIRT1334622	hsa-miR-497	CLIP-seq
MIRT2098977	hsa-miR-1266	CLIP-seq
MIRT2098978	hsa-miR-145	CLIP-seq
MIRT1334605	hsa-miR-15a	CLIP-seq
MIRT1334606	hsa-miR-15b	CLIP-seq
MIRT1334607	hsa-miR-16	CLIP-seq
MIRT1334609	hsa-miR-195	CLIP-seq
MIRT2098979	hsa-miR-3664-3p	CLIP-seq
MIRT1334618	hsa-miR-424	CLIP-seq
MIRT2098980	hsa-miR-4269	CLIP-seq
MIRT2098981	hsa-miR-4514	CLIP-seq
MIRT2098982	hsa-miR-4518	CLIP-seq
MIRT2098983	hsa-miR-4692	CLIP-seq
MIRT2098984	hsa-miR-4742-5p	CLIP-seq
MIRT1334622	hsa-miR-497	CLIP-seq
MIRT2323814	hsa-miR-203	CLIP-seq
MIRT2394200	hsa-miR-3171	CLIP-seq
MIRT2442610	hsa-miR-3658	CLIP-seq
MIRT2442611	hsa-miR-485-3p	CLIP-seq
MIRT2619604	hsa-miR-106a	CLIP-seq
MIRT2619605	hsa-miR-106b	CLIP-seq
MIRT2619606	hsa-miR-1183	CLIP-seq
MIRT2619607	hsa-miR-1207-3p	CLIP-seq
MIRT2619608	hsa-miR-1208	CLIP-seq
MIRT2619609	hsa-miR-1258	CLIP-seq
MIRT2619610	hsa-miR-1264	CLIP-seq
MIRT2098977	hsa-miR-1266	CLIP-seq
MIRT2619611	hsa-miR-129-5p	CLIP-seq
MIRT2619612	hsa-miR-132	CLIP-seq
MIRT1334604	hsa-miR-141	CLIP-seq
MIRT2619613	hsa-miR-144	CLIP-seq
MIRT2619614	hsa-miR-17	CLIP-seq
MIRT1334608	hsa-miR-186	CLIP-seq
MIRT2619615	hsa-miR-1909	CLIP-seq
MIRT2619616	hsa-miR-192	CLIP-seq
MIRT1334610	hsa-miR-200a	CLIP-seq
MIRT2619617	hsa-miR-208a	CLIP-seq
MIRT2619618	hsa-miR-208b	CLIP-seq
MIRT2619619	hsa-miR-20a	CLIP-seq
MIRT2619620	hsa-miR-20b	CLIP-seq
MIRT2619621	hsa-miR-2115	CLIP-seq
MIRT2619622	hsa-miR-2116	CLIP-seq
MIRT2619623	hsa-miR-2117	CLIP-seq
MIRT2619624	hsa-miR-212	CLIP-seq
MIRT2619625	hsa-miR-215	CLIP-seq
MIRT2619626	hsa-miR-216a	CLIP-seq
MIRT2619627	hsa-miR-2681	CLIP-seq
MIRT2619628	hsa-miR-3143	CLIP-seq
MIRT2619629	hsa-miR-3148	CLIP-seq
MIRT2619630	hsa-miR-3152-5p	CLIP-seq
MIRT2619631	hsa-miR-3194-3p	CLIP-seq
MIRT2619632	hsa-miR-323-5p	CLIP-seq
MIRT2619633	hsa-miR-3529	CLIP-seq
MIRT2619634	hsa-miR-3609	CLIP-seq
MIRT2619635	hsa-miR-3617	CLIP-seq
MIRT2619636	hsa-miR-3622a-3p	CLIP-seq
MIRT2619637	hsa-miR-3622b-3p	CLIP-seq
MIRT2619638	hsa-miR-3646	CLIP-seq
MIRT2619639	hsa-miR-3647-3p	CLIP-seq
MIRT2098979	hsa-miR-3664-3p	CLIP-seq
MIRT2619640	hsa-miR-3671	CLIP-seq
MIRT2619641	hsa-miR-371-5p	CLIP-seq
MIRT2619642	hsa-miR-371b-5p	CLIP-seq
MIRT2619643	hsa-miR-375	CLIP-seq
MIRT2619644	hsa-miR-379	CLIP-seq
MIRT2619645	hsa-miR-3977	CLIP-seq
MIRT2619646	hsa-miR-3978	CLIP-seq
MIRT2619647	hsa-miR-409-3p	CLIP-seq
MIRT2619648	hsa-miR-4261	CLIP-seq
MIRT2098980	hsa-miR-4269	CLIP-seq
MIRT2619649	hsa-miR-4273	CLIP-seq
MIRT2619650	hsa-miR-4420	CLIP-seq
MIRT2619651	hsa-miR-4424	CLIP-seq
MIRT2619652	hsa-miR-4427	CLIP-seq
MIRT2619653	hsa-miR-4451	CLIP-seq
MIRT2619654	hsa-miR-4474-5p	CLIP-seq
MIRT2619655	hsa-miR-4477a	CLIP-seq
MIRT2619656	hsa-miR-4495	CLIP-seq
MIRT2619657	hsa-miR-4496	CLIP-seq
MIRT2098981	hsa-miR-4514	CLIP-seq
MIRT2098982	hsa-miR-4518	CLIP-seq
MIRT2619658	hsa-miR-4649-3p	CLIP-seq
MIRT2619659	hsa-miR-4650-3p	CLIP-seq
MIRT2619660	hsa-miR-4663	CLIP-seq
MIRT2619661	hsa-miR-4677-3p	CLIP-seq
MIRT2619662	hsa-miR-4677-5p	CLIP-seq
MIRT2619663	hsa-miR-4679	CLIP-seq
MIRT2619664	hsa-miR-4680-3p	CLIP-seq
MIRT2619665	hsa-miR-4682	CLIP-seq
MIRT2098983	hsa-miR-4692	CLIP-seq
MIRT2619666	hsa-miR-4695-3p	CLIP-seq
MIRT2619667	hsa-miR-4728-3p	CLIP-seq
MIRT2098984	hsa-miR-4742-5p	CLIP-seq
MIRT2619668	hsa-miR-4760-5p	CLIP-seq
MIRT2619669	hsa-miR-4774-3p	CLIP-seq
MIRT2619670	hsa-miR-4796-3p	CLIP-seq
MIRT2619671	hsa-miR-486-5p	CLIP-seq
MIRT1334621	hsa-miR-494	CLIP-seq
MIRT2619672	hsa-miR-498	CLIP-seq
MIRT2619673	hsa-miR-499-5p	CLIP-seq
MIRT2619674	hsa-miR-509-3p	CLIP-seq
MIRT2619675	hsa-miR-519d	CLIP-seq
MIRT2619676	hsa-miR-539	CLIP-seq
MIRT2619677	hsa-miR-548ah	CLIP-seq
MIRT2619678	hsa-miR-548c-3p	CLIP-seq
MIRT2619679	hsa-miR-556-5p	CLIP-seq
MIRT2619680	hsa-miR-582-5p	CLIP-seq
MIRT2619681	hsa-miR-641	CLIP-seq
MIRT2619682	hsa-miR-642b	CLIP-seq
MIRT2619683	hsa-miR-649	CLIP-seq
MIRT2619684	hsa-miR-656	CLIP-seq
MIRT2619685	hsa-miR-876-3p	CLIP-seq
MIRT2619686	hsa-miR-93	CLIP-seq
MIRT2619604	hsa-miR-106a	CLIP-seq
MIRT2619605	hsa-miR-106b	CLIP-seq
MIRT2619606	hsa-miR-1183	CLIP-seq
MIRT2619607	hsa-miR-1207-3p	CLIP-seq
MIRT2619608	hsa-miR-1208	CLIP-seq
MIRT2619609	hsa-miR-1258	CLIP-seq
MIRT2619610	hsa-miR-1264	CLIP-seq
MIRT2098977	hsa-miR-1266	CLIP-seq
MIRT2619611	hsa-miR-129-5p	CLIP-seq
MIRT1334604	hsa-miR-141	CLIP-seq
MIRT2619614	hsa-miR-17	CLIP-seq
MIRT1334608	hsa-miR-186	CLIP-seq
MIRT2619615	hsa-miR-1909	CLIP-seq
MIRT2619616	hsa-miR-192	CLIP-seq
MIRT1334610	hsa-miR-200a	CLIP-seq
MIRT2619617	hsa-miR-208a	CLIP-seq
MIRT2619618	hsa-miR-208b	CLIP-seq
MIRT2619619	hsa-miR-20a	CLIP-seq
MIRT2619620	hsa-miR-20b	CLIP-seq
MIRT2619621	hsa-miR-2115	CLIP-seq
MIRT2619623	hsa-miR-2117	CLIP-seq
MIRT2619625	hsa-miR-215	CLIP-seq
MIRT2619626	hsa-miR-216a	CLIP-seq
MIRT2619627	hsa-miR-2681	CLIP-seq
MIRT2619628	hsa-miR-3143	CLIP-seq
MIRT2619629	hsa-miR-3148	CLIP-seq
MIRT2619630	hsa-miR-3152-5p	CLIP-seq
MIRT2619631	hsa-miR-3194-3p	CLIP-seq
MIRT2690354	hsa-miR-320a	CLIP-seq
MIRT2690355	hsa-miR-320b	CLIP-seq
MIRT2690356	hsa-miR-320c	CLIP-seq
MIRT2690357	hsa-miR-320d	CLIP-seq
MIRT2619632	hsa-miR-323-5p	CLIP-seq
MIRT2619633	hsa-miR-3529	CLIP-seq
MIRT2619634	hsa-miR-3609	CLIP-seq
MIRT2619635	hsa-miR-3617	CLIP-seq
MIRT2619636	hsa-miR-3622a-3p	CLIP-seq
MIRT2619637	hsa-miR-3622b-3p	CLIP-seq
MIRT2619638	hsa-miR-3646	CLIP-seq
MIRT2619639	hsa-miR-3647-3p	CLIP-seq
MIRT2098979	hsa-miR-3664-3p	CLIP-seq
MIRT2619640	hsa-miR-3671	CLIP-seq
MIRT2619641	hsa-miR-371-5p	CLIP-seq
MIRT2619642	hsa-miR-371b-5p	CLIP-seq
MIRT2619644	hsa-miR-379	CLIP-seq
MIRT2619646	hsa-miR-3978	CLIP-seq
MIRT2619648	hsa-miR-4261	CLIP-seq
MIRT2098980	hsa-miR-4269	CLIP-seq
MIRT2619649	hsa-miR-4273	CLIP-seq
MIRT2619650	hsa-miR-4420	CLIP-seq
MIRT2619651	hsa-miR-4424	CLIP-seq
MIRT2619652	hsa-miR-4427	CLIP-seq
MIRT2690358	hsa-miR-4429	CLIP-seq
MIRT2619653	hsa-miR-4451	CLIP-seq
MIRT2619654	hsa-miR-4474-5p	CLIP-seq
MIRT2619655	hsa-miR-4477a	CLIP-seq
MIRT2619656	hsa-miR-4495	CLIP-seq
MIRT2619657	hsa-miR-4496	CLIP-seq
MIRT2098981	hsa-miR-4514	CLIP-seq
MIRT2098982	hsa-miR-4518	CLIP-seq
MIRT2619658	hsa-miR-4649-3p	CLIP-seq
MIRT2619659	hsa-miR-4650-3p	CLIP-seq
MIRT2619660	hsa-miR-4663	CLIP-seq
MIRT2619661	hsa-miR-4677-3p	CLIP-seq
MIRT2619663	hsa-miR-4679	CLIP-seq
MIRT2619664	hsa-miR-4680-3p	CLIP-seq
MIRT2619665	hsa-miR-4682	CLIP-seq
MIRT2098983	hsa-miR-4692	CLIP-seq
MIRT2690359	hsa-miR-4694-3p	CLIP-seq
MIRT2619666	hsa-miR-4695-3p	CLIP-seq
MIRT2619667	hsa-miR-4728-3p	CLIP-seq
MIRT2098984	hsa-miR-4742-5p	CLIP-seq
MIRT2690360	hsa-miR-4753-3p	CLIP-seq
MIRT2619668	hsa-miR-4760-5p	CLIP-seq
MIRT2619669	hsa-miR-4774-3p	CLIP-seq
MIRT2619670	hsa-miR-4796-3p	CLIP-seq
MIRT2619671	hsa-miR-486-5p	CLIP-seq
MIRT1334621	hsa-miR-494	CLIP-seq
MIRT2619672	hsa-miR-498	CLIP-seq
MIRT2619673	hsa-miR-499-5p	CLIP-seq
MIRT2619674	hsa-miR-509-3p	CLIP-seq
MIRT2619675	hsa-miR-519d	CLIP-seq
MIRT2690361	hsa-miR-522	CLIP-seq
MIRT2619676	hsa-miR-539	CLIP-seq
MIRT2619677	hsa-miR-548ah	CLIP-seq
MIRT2619678	hsa-miR-548c-3p	CLIP-seq
MIRT2619679	hsa-miR-556-5p	CLIP-seq
MIRT2619680	hsa-miR-582-5p	CLIP-seq
MIRT2619681	hsa-miR-641	CLIP-seq
MIRT2619682	hsa-miR-642b	CLIP-seq
MIRT2619683	hsa-miR-649	CLIP-seq
MIRT2619685	hsa-miR-876-3p	CLIP-seq
MIRT2619686	hsa-miR-93	CLIP-seq
MIRT2690362	hsa-miR-944	CLIP-seq

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0001764	Process	Neuron migration	ISS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	8269517
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	TAS	19909241
GO:0008045	Process	Motor neuron axon guidance	IBA
GO:0008045	Process	Motor neuron axon guidance	ISS
GO:0010977	Process	Negative regulation of neuron projection development	IMP	21593320
GO:0021612	Process	Facial nerve structural organization	ISS
GO:0021637	Process	Trigeminal nerve structural organization	ISS
GO:0021675	Process	Nerve development	ISS
GO:0021772	Process	Olfactory bulb development	IMP	22416012
GO:0021785	Process	Branchiomotor neuron axon guidance	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030424	Component	Axon	IBA
GO:0030900	Process	Forebrain development	IEA
GO:0038191	Function	Neuropilin binding	IBA
GO:0038191	Function	Neuropilin binding	ISS
GO:0045499	Function	Chemorepellent activity	IBA
GO:0045499	Function	Chemorepellent activity	TAS	19909241
GO:0046330	Process	Positive regulation of JNK cascade	TAS	22683681
GO:0048485	Process	Sympathetic nervous system development	TAS	19909241
GO:0048841	Process	Regulation of axon extension involved in axon guidance	IDA	18053124
GO:0048846	Process	Axon extension involved in axon guidance	ISS
GO:0048880	Process	Sensory system development	TAS	19909241
GO:0050919	Process	Negative chemotaxis	IBA
GO:0060385	Process	Axonogenesis involved in innervation	ISS
GO:0061549	Process	Sympathetic ganglion development	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	TAS	19909241
GO:0097490	Process	Sympathetic neuron projection extension	ISS
GO:0097491	Process	Sympathetic neuron projection guidance	ISS
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0150020	Process	Basal dendrite arborization	ISS	22683681
GO:0150020	Process	Basal dendrite arborization	TAS	22683681
GO:1901166	Process	Neural crest cell migration involved in autonomic nervous system development	ISS

MIM	HGNC	e!Ensembl
603961	10723	ENSG00000075213

Q14563

Protein name

Semaphorin-3A (Semaphorin III) (Sema III)

Protein function

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Bi

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	59 → 496	Sema domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the dorsal root ganglia. {ECO:0000269|PubMed:28270793}.

Sequence

MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTF
LLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV
LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASL
LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED
DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG
IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD
GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP
IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM
TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS
ACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPK
SQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTL
LKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE
FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV

Sequence length

771

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling

104

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Amenorrhea	Conflicting classifications of pathogenicity	rs139295139	RCV001849309
Delayed puberty	Benign; Likely benign	rs138952094	RCV000156947
Familial cancer of breast	Benign	rs150288942	RCV005903538
Gastric cancer	Benign	rs150288942	RCV005903540
Hepatocellular carcinoma	Benign	rs150288942	RCV005903539
Hypogonadotropic hypogonadism 16 with or without anosmia	risk factor; Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs1404070020, rs553661856, rs919402688, rs137871935, rs147436181, rs2484774376, rs138694505, rs36026860, rs318240751, rs318240753, rs139295139	RCV001785416 RCV001785417 RCV001785418 RCV003992769 RCV000032921 RCV000032922 RCV002489291 RCV000987902 RCV000987901 RCV001262880 RCV000987903
Male infertility with azoospermia or oligozoospermia due to single gene mutation	Conflicting classifications of pathogenicity	rs137871935	RCV003991595
Martsolf syndrome 1	Uncertain significance	rs318240752	RCV002305443
Ovarian serous cystadenocarcinoma	Benign	rs150288942	RCV005903541
See cases	Conflicting classifications of pathogenicity	rs747485179	RCV003128436
SEMA3A-related disorder	Benign; Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	rs74349534, rs553661856, rs766918295, rs138952094, rs776695769, rs756376042, rs746952334, rs762141269, rs200588059, rs749954349, rs142028375, rs148900275, rs557001005, rs749759577, rs549486833 View all (63 more)	RCV003976077 RCV004749740 RCV004749764 RCV003965171 RCV003418717 RCV004749925 RCV004749928 RCV004750310 RCV003395642 RCV003900901 RCV003396851 RCV003396866 RCV003417902 RCV003410333 RCV003966325 RCV003399752 RCV003412033 RCV003414102 RCV003417035 RCV003408679 RCV003417133 RCV003410719 RCV003419260 RCV003391399 RCV003427952 RCV003399618 RCV003410397 RCV003410406 RCV003392842 RCV003422482 RCV003956506 RCV004750423 RCV003981152 RCV003896629 RCV003894586 RCV003893794 RCV003896435 RCV003896437 RCV003902225 RCV003894446 RCV003901656 RCV003913892 RCV003959796 RCV003944746 RCV003924659 RCV003979221 RCV003976908 RCV003983726 RCV003947319 RCV003969849 RCV003967033 RCV003967150 RCV003969464 RCV003969011 RCV003962208 RCV003966848 RCV003976421 RCV004750466 RCV004750467 RCV003903167 RCV003957985 RCV003910452 RCV003940554 RCV003968299 RCV003912978 RCV003958132 RCV003910719 RCV003950587 RCV004749546 RCV003942836 RCV003970499 RCV003895677 RCV004749553 RCV003983288 RCV003964917 RCV003407448 RCV003407449 RCV003415832 RCV003952488

Show/Hide Text Mining Associations (70)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Kidney Injury	Associate	24756974
Alcoholism	Associate	29071344
Alzheimer Disease	Associate	33663605
Arrhythmias Cardiac	Associate	24963029
Arthritis	Associate	22697500
Arthritis Rheumatoid	Inhibit	23343469
Arthritis Rheumatoid	Associate	28775366
Arthritis Rheumatoid	Stimulate	30538782
Bone Diseases	Associate	25336945
Breast Neoplasms	Associate	18787945, 20655307, 29971782, 31929841, 38263416
Breast Neoplasms	Stimulate	25973043
Brugada Syndrome	Associate	24963029
Cartilage Diseases	Associate	36430655
Choroidal Neovascularization	Associate	33876574
Colorectal Neoplasms	Associate	36510452
Combined Pituitary Hormone Deficiency	Associate	32612575
Congenital anosmia	Associate	29255181
Crohn Disease	Inhibit	25978359
Death Sudden Cardiac	Associate	24963029
Dermatitis	Stimulate	33905439
Dermatitis Atopic	Associate	33905439, 36075451
Dermatomyositis	Inhibit	36012289
Diabetic Nephropathies	Associate	24756974
Diabetic Nephropathies	Stimulate	36583231
Endometriosis	Associate	26720585
Erectile Dysfunction	Associate	38111702
Exanthema	Associate	31394943
Glioma	Associate	35148403
Growth Disorders	Associate	32612575, 33369061
Heart Arrest	Associate	23593010
Heart Defects Congenital	Associate	33369061
HEM dysplasia	Associate	33369061
Hepatitis C Chronic	Stimulate	30592759
Hirschsprung Disease	Associate	21898659, 23372769
Hypertension	Associate	24756974
Hypogonadism	Associate	26199944, 32612575, 33369061, 35295983
Inflammation	Associate	25978359, 31394943, 39375631
Inflammatory Bowel Diseases	Associate	25978359
Kallmann Syndrome	Associate	29255181, 33369061
Kidney Diseases	Associate	22697500, 24756974, 31394943
Leukemia	Associate	18056484, 30378769
Leukemia Myeloid Acute	Stimulate	26043758
Leukemia Myeloid Acute	Associate	30378769
Lupus Erythematosus Systemic	Associate	22697500, 31394943
Lymphatic Metastasis	Inhibit	25197349
Macular Degeneration	Associate	33876574
Malformations of Cortical Development Group I	Stimulate	11331362
Mobius Syndrome	Associate	31033088
Monoclonal Gammopathy of Undetermined Significance	Associate	16684957
Multiple Myeloma	Associate	16684957
Musculoskeletal Abnormalities	Associate	33369061
Neoplasm Metastasis	Associate	22926477, 25197349, 25973043
Neoplasms	Associate	14656993, 24264315, 29740048, 36296971
Neoplasms	Inhibit	18787945, 25197349, 30378769
Neoplasms Mesothelial	Inhibit	14656993
Olfaction Disorders	Associate	29255181, 33369061
Oral Ulcer	Associate	31394943
Osteoarthritis	Associate	36430655
Prostatic Neoplasms	Associate	24264315, 29740048
Proteinuria	Stimulate	24756974
Prurigo	Associate	36075451
Pruritus	Associate	33905439, 36075451
Renal Insufficiency Chronic	Associate	24756974
Sick Sinus Syndrome	Associate	23593010
Small Fiber Neuropathy	Associate	36012289
Stomach Neoplasms	Inhibit	25197349
Tongue Neoplasms	Inhibit	22926477
Ventricular Dysfunction Left	Associate	39375631
Ventricular Fibrillation	Associate	23593010
Wounds and Injuries	Associate	36583231

SEMA3A (semaphorin 3A)