Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10342
Gene name Gene Name - the full gene name approved by the HGNC.	Trafficking from ER to golgi regulator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TFG
Synonyms (NCBI Gene) Gene synonyms aliases	HMSNP, SPG57, TF6, TRKT3
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q12.2
Summary Summary of gene provided in NCBI Entrez Gene.	There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Mult

Show/Hide all(6)

SNP ID	Visualize variation	Clinical significance	Consequence
rs111356679	C>G	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs207482230	C>T	Pathogenic	Coding sequence variant, missense variant
rs587777175	C>T	Pathogenic	Missense variant, coding sequence variant
rs587777789	G>A,T	Pathogenic	Missense variant, coding sequence variant
rs764959531	C>A,T	Likely-pathogenic	Coding sequence variant, synonymous variant, stop gained
rs1559726842	T>C	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant

Show/Hide all(106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004131	hsa-miR-192-5p	Microarray	16822819
MIRT049807	hsa-miR-92a-3p	CLASH	23622248
MIRT048315	hsa-miR-106a-5p	CLASH	23622248
MIRT041287	hsa-miR-193b-3p	CLASH	23622248
MIRT036854	hsa-miR-877-3p	CLASH	23622248
MIRT160565	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT160565	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT1420604	hsa-miR-2053	CLIP-seq
MIRT1420605	hsa-miR-338-3p	CLIP-seq
MIRT1420606	hsa-miR-3591-3p	CLIP-seq
MIRT1420607	hsa-miR-371-5p	CLIP-seq
MIRT1420608	hsa-miR-371b-5p	CLIP-seq
MIRT1420609	hsa-miR-4275	CLIP-seq
MIRT1420610	hsa-miR-4530	CLIP-seq
MIRT1420611	hsa-miR-487a	CLIP-seq
MIRT1420612	hsa-miR-499-3p	CLIP-seq
MIRT1420613	hsa-miR-499a-3p	CLIP-seq
MIRT1420614	hsa-miR-513c	CLIP-seq
MIRT1420615	hsa-miR-514b-5p	CLIP-seq
MIRT1420616	hsa-miR-545	CLIP-seq
MIRT1420617	hsa-miR-569	CLIP-seq
MIRT1420618	hsa-miR-630	CLIP-seq
MIRT1420619	hsa-miR-643	CLIP-seq
MIRT1420620	hsa-miR-889	CLIP-seq
MIRT1420621	hsa-miR-15a	CLIP-seq
MIRT1420622	hsa-miR-15b	CLIP-seq
MIRT1420623	hsa-miR-16	CLIP-seq
MIRT1420624	hsa-miR-195	CLIP-seq
MIRT1420604	hsa-miR-2053	CLIP-seq
MIRT1420625	hsa-miR-221	CLIP-seq
MIRT1420626	hsa-miR-222	CLIP-seq
MIRT1420627	hsa-miR-3122	CLIP-seq
MIRT1420628	hsa-miR-323-3p	CLIP-seq
MIRT1420629	hsa-miR-3689a-3p	CLIP-seq
MIRT1420630	hsa-miR-3689c	CLIP-seq
MIRT1420607	hsa-miR-371-5p	CLIP-seq
MIRT1420608	hsa-miR-371b-5p	CLIP-seq
MIRT1420631	hsa-miR-3913-5p	CLIP-seq
MIRT1420632	hsa-miR-424	CLIP-seq
MIRT1420633	hsa-miR-4302	CLIP-seq
MIRT1420634	hsa-miR-4426	CLIP-seq
MIRT1420635	hsa-miR-4477a	CLIP-seq
MIRT1420636	hsa-miR-4480	CLIP-seq
MIRT1420637	hsa-miR-4524	CLIP-seq
MIRT1420638	hsa-miR-4647	CLIP-seq
MIRT1420639	hsa-miR-4662b	CLIP-seq
MIRT1420640	hsa-miR-4728-5p	CLIP-seq
MIRT1420641	hsa-miR-4789-5p	CLIP-seq
MIRT1420642	hsa-miR-497	CLIP-seq
MIRT1420612	hsa-miR-499-3p	CLIP-seq
MIRT1420613	hsa-miR-499a-3p	CLIP-seq
MIRT1420643	hsa-miR-503	CLIP-seq
MIRT1420614	hsa-miR-513c	CLIP-seq
MIRT1420615	hsa-miR-514b-5p	CLIP-seq
MIRT1420617	hsa-miR-569	CLIP-seq
MIRT1420644	hsa-miR-621	CLIP-seq
MIRT1420618	hsa-miR-630	CLIP-seq
MIRT1420645	hsa-miR-633	CLIP-seq
MIRT1420619	hsa-miR-643	CLIP-seq
MIRT1420646	hsa-miR-646	CLIP-seq
MIRT1420620	hsa-miR-889	CLIP-seq
MIRT1420633	hsa-miR-4302	CLIP-seq
MIRT1420635	hsa-miR-4477a	CLIP-seq
MIRT1420641	hsa-miR-4789-5p	CLIP-seq
MIRT1420618	hsa-miR-630	CLIP-seq
MIRT1420619	hsa-miR-643	CLIP-seq
MIRT1420620	hsa-miR-889	CLIP-seq
MIRT2126327	hsa-miR-4705	CLIP-seq
MIRT1420620	hsa-miR-889	CLIP-seq
MIRT2126328	hsa-miR-34b	CLIP-seq
MIRT1420607	hsa-miR-371-5p	CLIP-seq
MIRT1420608	hsa-miR-371b-5p	CLIP-seq
MIRT1420633	hsa-miR-4302	CLIP-seq
MIRT2126329	hsa-miR-4666-5p	CLIP-seq
MIRT2126327	hsa-miR-4705	CLIP-seq
MIRT1420641	hsa-miR-4789-5p	CLIP-seq
MIRT1420614	hsa-miR-513c	CLIP-seq
MIRT1420615	hsa-miR-514b-5p	CLIP-seq
MIRT1420618	hsa-miR-630	CLIP-seq
MIRT1420619	hsa-miR-643	CLIP-seq
MIRT1420620	hsa-miR-889	CLIP-seq
MIRT2348317	hsa-miR-1243	CLIP-seq
MIRT2348318	hsa-miR-1278	CLIP-seq
MIRT2348319	hsa-miR-1289	CLIP-seq
MIRT1420627	hsa-miR-3122	CLIP-seq
MIRT2348320	hsa-miR-3198	CLIP-seq
MIRT1420605	hsa-miR-338-3p	CLIP-seq
MIRT2126328	hsa-miR-34b	CLIP-seq
MIRT1420606	hsa-miR-3591-3p	CLIP-seq
MIRT2348321	hsa-miR-3654	CLIP-seq
MIRT1420629	hsa-miR-3689a-3p	CLIP-seq
MIRT1420630	hsa-miR-3689c	CLIP-seq
MIRT1420631	hsa-miR-3913-5p	CLIP-seq
MIRT2348322	hsa-miR-4255	CLIP-seq
MIRT2348323	hsa-miR-4294	CLIP-seq
MIRT1420633	hsa-miR-4302	CLIP-seq
MIRT2348324	hsa-miR-4309	CLIP-seq
MIRT1420635	hsa-miR-4477a	CLIP-seq
MIRT1420610	hsa-miR-4530	CLIP-seq
MIRT2126329	hsa-miR-4666-5p	CLIP-seq
MIRT2126327	hsa-miR-4705	CLIP-seq
MIRT1420640	hsa-miR-4728-5p	CLIP-seq
MIRT1420641	hsa-miR-4789-5p	CLIP-seq
MIRT1420616	hsa-miR-545	CLIP-seq
MIRT1420620	hsa-miR-889	CLIP-seq
MIRT2348325	hsa-miR-924	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 17110338, 21478858, 25416956, 25910212, 26871637, 27813252, 31515488, 32296183, 32814053, 35156780, 36012204
GO:0005737	Component	Cytoplasm	NAS	7565764
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	21478858, 27813252
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	16169070, 25416956, 27107012, 32296183
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0048208	Process	COPII vesicle coating	IEA
GO:0070971	Component	Endoplasmic reticulum exit site	IBA
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	21478858, 27813252

MIM	HGNC	e!Ensembl
602498	11758	ENSG00000114354

Protein

UniProt ID

Q92734

Protein name

Protein TFG (TRK-fused gene protein)

Protein function

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:

PDB

8TEQ , 8TER , 9E7C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00564	PB1	10 → 93	PB1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKD
EDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRPLESSQVKYLRRELIELRNKVNRLL
DSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDEINKN
VMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIE
GQMYQQYQQQAGYGAQQPQAPPQQPQQYGIQYSASYSQQTGPQQPQQFQGYGQQPTSQAP
APAFSGQPQQLPAQPPQQYQASNYPAQTYTAQTSQPTNYTVAPASQPGMAPSQPGAYQPR
PGFTSLPGSTMTPPPSGPNPYARNRPPFGQGYTQPGPGYR

Sequence length

400

Interactions

View interactions

	KEGG		Reactome
	Pathways in cancer Thyroid cancer		COPII-mediated vesicle transport

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Hereditary Motor And Sensory Neuropathy	hereditary motor and sensory neuropathy, okinawa type	rs207482230, rs587777789	N/A
Hereditary spastic paraplegia	Hereditary spastic paraplegia 57	rs587777175, rs587777789	N/A

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Amyotrophic Lateral Sclerosis 2 Juvenile	Associate	27601211
Carcinogenesis	Associate	31754244, 32239802
Carcinoma Hepatocellular	Associate	29180379
Carcinoma Pancreatic Ductal	Associate	32239802
Carcinoma Papillary Follicular	Associate	25148236
Charcot Marie Tooth disease X linked recessive 2	Associate	32666699
Cholangiocarcinoma	Associate	31754244
Cushing Syndrome	Associate	36690805
Dysgerminoma	Stimulate	21793190
Fasciculation	Associate	30157421
Glioma	Associate	18093335
Hereditary Sensory and Motor Neuropathy	Associate	35864671
Laryngeal Neoplasms	Associate	20164024
Lymphoma	Associate	19797732
Lymphoma Large Cell Anaplastic	Associate	10556217, 17464320
Meningioma	Associate	28449809
Neoplasm Metastasis	Associate	29883837
Neoplasms	Associate	19797732, 28489605, 30914738, 31690781
Neoplastic Syndromes Hereditary	Associate	33932238
Nervous System Diseases	Associate	30157421
Ovarian Neoplasms	Associate	20969748
Pancreatic Intraductal Neoplasms	Associate	32239802
Pancreatic Neoplasms	Associate	36690805
Sarcoma	Associate	28510278
Sezary Syndrome	Associate	28489605
Soft Tissue Neoplasms	Associate	19797732
Spastic Paraplegia Hereditary	Associate	27601211, 30157421
Thyroid Neoplasms	Associate	19797732, 32737449
Vision Disorders	Associate	27601211

TFG (trafficking from ER to golgi regulator)