PCGF3 (polycomb group ring finger 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 10336
Gene name Polycomb group ring finger 3
Gene symbol PCGF3
Synonyms (NCBI Gene)
DONG1RNF3RNF3A
Chromosome 4
Chromosome location 4p16.3
Summary The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
1117
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1117)
miRTarBase ID miRNA Experiments Reference
MIRT026048 hsa-miR-196a-5p Sequencing 20371350
MIRT032156 hsa-let-7d-5p Sequencing 20371350
MIRT052339 hsa-let-7b-5p CLASH 23622248
MIRT051823 hsa-let-7c-5p CLASH 23622248
MIRT569438 hsa-miR-3929 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000805 Component X chromosome IEA
GO:0000805 Component X chromosome ISS
GO:0005515 Function Protein binding IPI 21282530, 22493164, 24981860, 25416956, 27705803, 32296183, 33961781
GO:0005634 Component Nucleus IDA 21282530
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
617543 10066 ENSG00000185619
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q3KNV8
Protein name Polycomb group RING finger protein 3 (RING finger protein 3A)
Protein function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 16 → 55 Domain
PF16207 RAWUL 172 → 236 RAWUL domain RING finger- and WD40-associated ubiquitin-like Domain
Sequence 
MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIH
QSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLD
SHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQA
TVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMD
LL
Sequence length 242
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Polycomb repressive complex
Signaling pathways regulating pluripotency of stem cells 		 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (6)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (3)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 39529637
★★★★★
★☆☆☆☆
Found in Text Mining only
Pancreatic Intraductal Neoplasms Associate 27282351
★★★★★
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Associate 21248740, 33523105
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations