TLR6 (toll like receptor 6)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10333 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Toll like receptor 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TLR6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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CD286 |
Chromosome
Chromosome number
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4 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4p14 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func |
miRNA
miRNA information provided by mirtarbase database.
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Transcription factors | |||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||||||||||||
UniProt ID | Q9Y2C9 | |||||||||||||||||||||||||
Protein name | Toll-like receptor 6 (CD antigen CD286) | |||||||||||||||||||||||||
Protein function | Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation | |||||||||||||||||||||||||
PDB | 4OM7 | |||||||||||||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells. | |||||||||||||||||||||||||
Sequence |
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Sequence length | 796 | |||||||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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