Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10333
Gene name Gene Name - the full gene name approved by the HGNC.
Toll like receptor 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TLR6
Synonyms (NCBI Gene) Gene synonyms aliases
CD286
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p14
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT679765 hsa-miR-1245a HITS-CLIP 23824327
MIRT679764 hsa-miR-8079 HITS-CLIP 23824327
MIRT679763 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT679762 hsa-miR-3653-5p HITS-CLIP 23824327
MIRT679761 hsa-miR-3663-5p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
HIF1A Unknown 18159247
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IC 20037584
GO:0001774 Process Microglial cell activation IEA
GO:0001775 Process Cell activation IDA 15294986
GO:0002224 Process Toll-like receptor signaling pathway IBA 21873635
GO:0002224 Process Toll-like receptor signaling pathway TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605403 16711 ENSG00000174130
Protein
UniProt ID Q9Y2C9
Protein name Toll-like receptor 6 (CD antigen CD286)
Protein function Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation
PDB 4OM7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 76 133 Leucine rich repeat Repeat
PF13855 LRR_8 450 507 Leucine rich repeat Repeat
PF01463 LRRCT 558 583 Leucine rich repeat C-terminal domain Family
PF01582 TIR 641 796 TIR domain Family
Tissue specificity TISSUE SPECIFICITY: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Sequence
MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMS
QNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI
VSFRHLDLSFNDF
KALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN
YYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIK
FLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS
KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF
TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRH
KENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNV
AFNSLTDLPGCGSFSSLSVLIIDHNSV
SHPSADFFQSCQKMRSIKAGDNPFQCTCELREF
VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAV
TVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSEL
VPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH
HNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA
FNMKLTLVTENNDVKS
Sequence length 796
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Phagosome
Toll-like receptor signaling pathway
Salmonella infection
Chagas disease
Tuberculosis
Lipid and atherosclerosis
  ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16537705
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 29785011 ClinVar, GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abscess Associate 31786695
Adenocarcinoma Associate 27008696
Adenocarcinoma of Lung Stimulate 37746997
Adenocarcinoma of Lung Associate 38204755
Arthritis Infectious Associate 20740673
Arthritis Rheumatoid Associate 31376255
Asthma Associate 16188043, 20815312, 28262750, 33066754
Astrocytoma Associate 29912993
Autism Spectrum Disorder Associate 22226452
Autoimmune Diseases Associate 29339359