CNPY2 (canopy FGF signaling regulator 2)

Gene

• Entrez ID: 10330
• Gene name: Canopy FGF signaling regulator 2
• Gene symbol: CNPY2
• Synonyms (NCBI Gene): HP10390, MSAP, TMEM4, ZSIG9
• Chromosome: 12
• Chromosome location: 12q13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT901289	hsa-miR-139-5p	CLIP-seq
MIRT901290	hsa-miR-2110	CLIP-seq
MIRT901291	hsa-miR-3120-3p	CLIP-seq
MIRT901292	hsa-miR-3154	CLIP-seq
MIRT901293	hsa-miR-339-5p	CLIP-seq
MIRT901294	hsa-miR-3691-5p	CLIP-seq
MIRT901295	hsa-miR-383	CLIP-seq
MIRT901296	hsa-miR-3973	CLIP-seq
MIRT901297	hsa-miR-4271	CLIP-seq
MIRT901298	hsa-miR-4274	CLIP-seq
MIRT901299	hsa-miR-4303	CLIP-seq
MIRT901300	hsa-miR-4434	CLIP-seq
MIRT901301	hsa-miR-4436a	CLIP-seq
MIRT901302	hsa-miR-4491	CLIP-seq
MIRT901303	hsa-miR-4503	CLIP-seq
MIRT901304	hsa-miR-4516	CLIP-seq
MIRT901305	hsa-miR-4531	CLIP-seq
MIRT901306	hsa-miR-4639-5p	CLIP-seq
MIRT901307	hsa-miR-4657	CLIP-seq
MIRT901308	hsa-miR-4659a-3p	CLIP-seq
MIRT901309	hsa-miR-4659b-3p	CLIP-seq
MIRT901310	hsa-miR-4682	CLIP-seq
MIRT901311	hsa-miR-4725-3p	CLIP-seq
MIRT901312	hsa-miR-4752	CLIP-seq
MIRT901313	hsa-miR-4762-3p	CLIP-seq
MIRT901314	hsa-miR-4762-5p	CLIP-seq
MIRT901315	hsa-miR-4764-5p	CLIP-seq
MIRT901316	hsa-miR-4772-5p	CLIP-seq
MIRT901317	hsa-miR-495	CLIP-seq
MIRT901318	hsa-miR-519a	CLIP-seq
MIRT901319	hsa-miR-519b-3p	CLIP-seq
MIRT901320	hsa-miR-519c-3p	CLIP-seq
MIRT901321	hsa-miR-548l	CLIP-seq
MIRT901322	hsa-miR-596	CLIP-seq
MIRT901323	hsa-miR-627	CLIP-seq
MIRT901324	hsa-miR-922	CLIP-seq
MIRT901325	hsa-miR-924	CLIP-seq
MIRT901290	hsa-miR-2110	CLIP-seq
MIRT901297	hsa-miR-4271	CLIP-seq
MIRT901311	hsa-miR-4725-3p	CLIP-seq
MIRT901318	hsa-miR-519a	CLIP-seq
MIRT901319	hsa-miR-519b-3p	CLIP-seq
MIRT901320	hsa-miR-519c-3p	CLIP-seq
MIRT901322	hsa-miR-596	CLIP-seq
MIRT1967379	hsa-miR-1343	CLIP-seq
MIRT1967380	hsa-miR-3679-3p	CLIP-seq
MIRT1967381	hsa-miR-4446-5p	CLIP-seq
MIRT1967382	hsa-miR-4667-3p	CLIP-seq
MIRT1967383	hsa-miR-637	CLIP-seq
MIRT1967384	hsa-miR-640	CLIP-seq
MIRT901299	hsa-miR-4303	CLIP-seq
MIRT901308	hsa-miR-4659a-3p	CLIP-seq
MIRT901309	hsa-miR-4659b-3p	CLIP-seq
MIRT901310	hsa-miR-4682	CLIP-seq
MIRT901313	hsa-miR-4762-3p	CLIP-seq
MIRT901314	hsa-miR-4762-5p	CLIP-seq
MIRT2447349	hsa-miR-579	CLIP-seq
MIRT901323	hsa-miR-627	CLIP-seq
MIRT901325	hsa-miR-924	CLIP-seq
MIRT901299	hsa-miR-4303	CLIP-seq
MIRT901308	hsa-miR-4659a-3p	CLIP-seq
MIRT901309	hsa-miR-4659b-3p	CLIP-seq
MIRT901310	hsa-miR-4682	CLIP-seq
MIRT901313	hsa-miR-4762-3p	CLIP-seq
MIRT901314	hsa-miR-4762-5p	CLIP-seq
MIRT2447349	hsa-miR-579	CLIP-seq
MIRT901323	hsa-miR-627	CLIP-seq
MIRT901325	hsa-miR-924	CLIP-seq
MIRT901313	hsa-miR-4762-3p	CLIP-seq
MIRT901314	hsa-miR-4762-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12826659, 32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0010629	Process	Negative regulation of gene expression	ISS	22378787
GO:0010988	Process	Regulation of low-density lipoprotein particle clearance	IEA
GO:0010988	Process	Regulation of low-density lipoprotein particle clearance	ISS	22378787

Other IDs

• MIM: 605861
• HGNC: 13529
• e!Ensembl: ENSG00000257727

Protein

• UniProt ID: Q9Y2B0
• Protein name: Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)
• Protein function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11938	DUF3456	27 → 171	TLR4 regulator and MIR-interacting MSAP	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas. {ECO:0000269|PubMed:12826659}.
• Sequence:

  MKGWGWLALLLGALLGTAWARRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINP
  DGSQSVVEVPYARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVVGRNGESSELDL
  QGIRIDSDISGTLKFACESIVEEYEDELIEFFSREADNVKDKLCSKRTDLCDHALHISHD
  EL

• Sequence length: 182

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Abnormality of the face	Likely pathogenic	rs1873865063	RCV002226937
Craniosynostosis syndrome	Likely pathogenic	rs1873865063	RCV002226937

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	29135454, 30070972, 35924107
Neoplasms	Stimulate	29135454
Neoplasms	Associate	35924107