Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein
Entrez ID	1033
Gene name	Cyclin dependent kinase inhibitor 3
Gene symbol	CDKN3
Synonyms (NCBI Gene)	CDI1CIP2KAPKAP1
Chromosome	14
Chromosome location	14q22.2
Summary	The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005705	hsa-miR-146a-5p	Western blot	19944095
MIRT024518	hsa-miR-215-5p	Microarray	19074876
MIRT026751	hsa-miR-192-5p	Microarray	19074876
MIRT049159	hsa-miR-92a-3p	CLASH	23622248
MIRT642630	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642629	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT642628	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT642627	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT642626	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642625	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642624	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT642623	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642622	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642621	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT642620	hsa-miR-4284	HITS-CLIP	23824327
MIRT642619	hsa-miR-7641	HITS-CLIP	23824327
MIRT642618	hsa-miR-3689d	HITS-CLIP	23824327
MIRT642617	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT642630	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642629	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT642628	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT642627	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT642626	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642625	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642624	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT642623	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642622	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642621	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT642620	hsa-miR-4284	HITS-CLIP	23824327
MIRT642619	hsa-miR-7641	HITS-CLIP	23824327
MIRT642618	hsa-miR-3689d	HITS-CLIP	23824327
MIRT642617	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT881888	hsa-miR-1297	CLIP-seq
MIRT881889	hsa-miR-141	CLIP-seq
MIRT881890	hsa-miR-181a	CLIP-seq
MIRT881891	hsa-miR-181b	CLIP-seq
MIRT881892	hsa-miR-181c	CLIP-seq
MIRT881893	hsa-miR-181d	CLIP-seq
MIRT881894	hsa-miR-200a	CLIP-seq
MIRT881895	hsa-miR-26a	CLIP-seq
MIRT881896	hsa-miR-26b	CLIP-seq
MIRT881897	hsa-miR-3161	CLIP-seq
MIRT881898	hsa-miR-323-5p	CLIP-seq
MIRT881899	hsa-miR-4262	CLIP-seq
MIRT881900	hsa-miR-4456	CLIP-seq
MIRT881901	hsa-miR-4465	CLIP-seq
MIRT881902	hsa-miR-579	CLIP-seq
MIRT881903	hsa-miR-876-3p	CLIP-seq
MIRT881888	hsa-miR-1297	CLIP-seq
MIRT881904	hsa-miR-1324	CLIP-seq
MIRT881889	hsa-miR-141	CLIP-seq
MIRT881890	hsa-miR-181a	CLIP-seq
MIRT881891	hsa-miR-181b	CLIP-seq
MIRT881892	hsa-miR-181c	CLIP-seq
MIRT881893	hsa-miR-181d	CLIP-seq
MIRT881894	hsa-miR-200a	CLIP-seq
MIRT881895	hsa-miR-26a	CLIP-seq
MIRT881896	hsa-miR-26b	CLIP-seq
MIRT881905	hsa-miR-3130-3p	CLIP-seq
MIRT881906	hsa-miR-3146	CLIP-seq
MIRT881897	hsa-miR-3161	CLIP-seq
MIRT881898	hsa-miR-323-5p	CLIP-seq
MIRT881907	hsa-miR-3942-3p	CLIP-seq
MIRT881899	hsa-miR-4262	CLIP-seq
MIRT881900	hsa-miR-4456	CLIP-seq
MIRT881901	hsa-miR-4465	CLIP-seq
MIRT881908	hsa-miR-4686	CLIP-seq
MIRT881909	hsa-miR-4793-3p	CLIP-seq
MIRT881910	hsa-miR-548a-3p	CLIP-seq
MIRT881911	hsa-miR-548e	CLIP-seq
MIRT881912	hsa-miR-548f	CLIP-seq
MIRT881902	hsa-miR-579	CLIP-seq
MIRT881913	hsa-miR-651	CLIP-seq
MIRT881903	hsa-miR-876-3p	CLIP-seq
MIRT881888	hsa-miR-1297	CLIP-seq
MIRT881904	hsa-miR-1324	CLIP-seq
MIRT881889	hsa-miR-141	CLIP-seq
MIRT881890	hsa-miR-181a	CLIP-seq
MIRT881891	hsa-miR-181b	CLIP-seq
MIRT881892	hsa-miR-181c	CLIP-seq
MIRT881893	hsa-miR-181d	CLIP-seq
MIRT881894	hsa-miR-200a	CLIP-seq
MIRT881895	hsa-miR-26a	CLIP-seq
MIRT881896	hsa-miR-26b	CLIP-seq
MIRT881905	hsa-miR-3130-3p	CLIP-seq
MIRT881906	hsa-miR-3146	CLIP-seq
MIRT881897	hsa-miR-3161	CLIP-seq
MIRT881898	hsa-miR-323-5p	CLIP-seq
MIRT881907	hsa-miR-3942-3p	CLIP-seq
MIRT881899	hsa-miR-4262	CLIP-seq
MIRT881900	hsa-miR-4456	CLIP-seq
MIRT881901	hsa-miR-4465	CLIP-seq
MIRT881908	hsa-miR-4686	CLIP-seq
MIRT881909	hsa-miR-4793-3p	CLIP-seq
MIRT881910	hsa-miR-548a-3p	CLIP-seq
MIRT881911	hsa-miR-548e	CLIP-seq
MIRT881912	hsa-miR-548f	CLIP-seq
MIRT881902	hsa-miR-579	CLIP-seq
MIRT881913	hsa-miR-651	CLIP-seq
MIRT881903	hsa-miR-876-3p	CLIP-seq
MIRT881888	hsa-miR-1297	CLIP-seq
MIRT881889	hsa-miR-141	CLIP-seq
MIRT2198004	hsa-miR-146a	CLIP-seq
MIRT2198005	hsa-miR-146b-5p	CLIP-seq
MIRT881890	hsa-miR-181a	CLIP-seq
MIRT881891	hsa-miR-181b	CLIP-seq
MIRT881892	hsa-miR-181c	CLIP-seq
MIRT881893	hsa-miR-181d	CLIP-seq
MIRT881894	hsa-miR-200a	CLIP-seq
MIRT881895	hsa-miR-26a	CLIP-seq
MIRT881896	hsa-miR-26b	CLIP-seq
MIRT2198006	hsa-miR-3123	CLIP-seq
MIRT881905	hsa-miR-3130-3p	CLIP-seq
MIRT881906	hsa-miR-3146	CLIP-seq
MIRT881897	hsa-miR-3161	CLIP-seq
MIRT881898	hsa-miR-323-5p	CLIP-seq
MIRT2198007	hsa-miR-3925-5p	CLIP-seq
MIRT881899	hsa-miR-4262	CLIP-seq
MIRT881900	hsa-miR-4456	CLIP-seq
MIRT881901	hsa-miR-4465	CLIP-seq
MIRT881908	hsa-miR-4686	CLIP-seq
MIRT881909	hsa-miR-4793-3p	CLIP-seq
MIRT881902	hsa-miR-579	CLIP-seq
MIRT881913	hsa-miR-651	CLIP-seq
MIRT881903	hsa-miR-876-3p	CLIP-seq

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Transcription factor	Regulation	Reference
YBX1	Activation	20596676

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000079	Process	Regulation of cyclin-dependent protein serine/threonine kinase activity	TAS	8242750
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS	8127873
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	12745075
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	8242750
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	8242750, 9840943, 11463386, 15530371, 15671017, 24218572, 25852190, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	TAS	8242750
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	8242750
GO:0016787	Function	Hydrolase activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	10669749
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051726	Process	Regulation of cell cycle	IDA	8242750
GO:0051726	Process	Regulation of cell cycle	TAS	8242750

MIM	HGNC	e!Ensembl
123832	1791	ENSG00000100526

Q16667

Protein name

Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase)

Protein function

May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-depen

PDB

1FPZ , 1FQ1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05706	CDKN3	1 → 168	Cyclin-dependent kinase inhibitor 3 (CDKN3)	Domain

Sequence

MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNV
QKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCC
EIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAI
QTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR

Sequence length

212

Interactions

View interactions

CDKN3 (cyclin dependent kinase inhibitor 3)