EMC8 (ER membrane protein complex subunit 8)

Gene

• Entrez ID: 10328
• Gene name: ER membrane protein complex subunit 8
• Gene symbol: EMC8
• Synonyms (NCBI Gene): C16orf2, C16orf4, COX4NB, FAM158B, NOC4
• Chromosome: 16
• Chromosome location: 16q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041833	hsa-miR-484	CLASH	23622248
MIRT688409	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT688408	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT688407	hsa-miR-7845-5p	HITS-CLIP	23313552
MIRT688406	hsa-miR-654-3p	HITS-CLIP	23313552
MIRT688405	hsa-miR-211-3p	HITS-CLIP	23313552
MIRT688404	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT688403	hsa-miR-6761-5p	HITS-CLIP	23313552
MIRT688402	hsa-miR-3130-3p	HITS-CLIP	23313552
MIRT688401	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT688400	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT688399	hsa-miR-346	HITS-CLIP	23313552
MIRT688398	hsa-miR-500a-3p	HITS-CLIP	23313552
MIRT688397	hsa-miR-4288	HITS-CLIP	23313552
MIRT688396	hsa-miR-632	HITS-CLIP	23313552
MIRT563071	hsa-miR-4662a-3p	PAR-CLIP	20371350
MIRT563069	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT563070	hsa-miR-3119	PAR-CLIP	20371350
MIRT688409	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT688408	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT688407	hsa-miR-7845-5p	HITS-CLIP	23313552
MIRT688406	hsa-miR-654-3p	HITS-CLIP	23313552
MIRT688405	hsa-miR-211-3p	HITS-CLIP	23313552
MIRT688404	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT688403	hsa-miR-6761-5p	HITS-CLIP	23313552
MIRT688402	hsa-miR-3130-3p	HITS-CLIP	23313552
MIRT688401	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT688400	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT688399	hsa-miR-346	HITS-CLIP	23313552
MIRT688398	hsa-miR-500a-3p	HITS-CLIP	23313552
MIRT688397	hsa-miR-4288	HITS-CLIP	23313552
MIRT688396	hsa-miR-632	HITS-CLIP	23313552
MIRT563071	hsa-miR-4662a-3p	PAR-CLIP	20371350
MIRT563069	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT563070	hsa-miR-3119	PAR-CLIP	20371350

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 22119785, 26496610, 28514442, 30021884, 32296183, 32439656, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IDA	22119785
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	29242231
GO:0005794	Component	Golgi apparatus	IDA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0032977	Function	Membrane insertase activity	IMP	29809151, 30415835
GO:0045050	Process	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA	29242231
GO:0045050	Process	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP	29809151, 30415835
GO:0071816	Process	Tail-anchored membrane protein insertion into ER membrane	IDA	29242231
GO:0072546	Component	EMC complex	IBA
GO:0072546	Component	EMC complex	IDA	22119785
GO:0072546	Component	EMC complex	IEA
GO:0072546	Component	EMC complex	IPI	32439656

Other IDs

• MIM: 604886
• HGNC: 7864
• e!Ensembl: ENSG00000131148

Protein

• UniProt ID: O43402
• Protein name: ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)
• Protein function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed
• PDB: 6WW7, 7ADO, 7ADP, 8EOI, 8J0N, 8J0O, 8S9S, 9C7V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03665	UPF0172	3 → 202	Uncharacterised protein family (UPF0172)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.
• Sequence:

  MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPL
  FHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFS
  DTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSY
  ETLVDFDNHLDDIRNDWTNPEINKAVLHLC

• Sequence length: 210