Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10328
Gene name Gene Name - the full gene name approved by the HGNC.	ER membrane protein complex subunit 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EMC8
Synonyms (NCBI Gene) Gene synonyms aliases	C16orf2, C16orf4, COX4NB, FAM158B, NOC4
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q24.1

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miRTarBase ID	miRNA	Experiments	Reference
MIRT041833	hsa-miR-484	CLASH	23622248
MIRT688409	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT688408	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT688407	hsa-miR-7845-5p	HITS-CLIP	23313552
MIRT688406	hsa-miR-654-3p	HITS-CLIP	23313552
MIRT688405	hsa-miR-211-3p	HITS-CLIP	23313552
MIRT688404	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT688403	hsa-miR-6761-5p	HITS-CLIP	23313552
MIRT688402	hsa-miR-3130-3p	HITS-CLIP	23313552
MIRT688401	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT688400	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT688399	hsa-miR-346	HITS-CLIP	23313552
MIRT688398	hsa-miR-500a-3p	HITS-CLIP	23313552
MIRT688397	hsa-miR-4288	HITS-CLIP	23313552
MIRT688396	hsa-miR-632	HITS-CLIP	23313552
MIRT563071	hsa-miR-4662a-3p	PAR-CLIP	20371350
MIRT563069	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT563070	hsa-miR-3119	PAR-CLIP	20371350
MIRT688409	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT688408	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT688407	hsa-miR-7845-5p	HITS-CLIP	23313552
MIRT688406	hsa-miR-654-3p	HITS-CLIP	23313552
MIRT688405	hsa-miR-211-3p	HITS-CLIP	23313552
MIRT688404	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT688403	hsa-miR-6761-5p	HITS-CLIP	23313552
MIRT688402	hsa-miR-3130-3p	HITS-CLIP	23313552
MIRT688401	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT688400	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT688399	hsa-miR-346	HITS-CLIP	23313552
MIRT688398	hsa-miR-500a-3p	HITS-CLIP	23313552
MIRT688397	hsa-miR-4288	HITS-CLIP	23313552
MIRT688396	hsa-miR-632	HITS-CLIP	23313552
MIRT563071	hsa-miR-4662a-3p	PAR-CLIP	20371350
MIRT563069	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT563070	hsa-miR-3119	PAR-CLIP	20371350

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 22119785, 26496610, 28514442, 30021884, 32296183, 32439656
GO:0005737	Component	Cytoplasm	IDA	22119785
GO:0005829	Component	Cytosol	IDA
GO:0016020	Component	Membrane	HDA	19946888
GO:0032977	Function	Membrane insertase activity	IMP	29809151, 30415835
GO:0045050	Process	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP	29809151, 30415835
GO:0071816	Process	Tail-anchored membrane protein insertion into ER membrane	IDA	29242231
GO:0072546	Component	EMC complex	IBA	21873635
GO:0072546	Component	EMC complex	IDA	22119785

MIM	HGNC	e!Ensembl
604886	7864	ENSG00000131148

Protein

UniProt ID

O43402

Protein name

ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)

Protein function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed

PDB

6WW7 , 7ADO , 7ADP , 8EOI , 8J0N , 8J0O , 8S9S , 9C7V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03665	UPF0172	3 → 202	Uncharacterised protein family (UPF0172)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.

Sequence

MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPL
FHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFS
DTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSY
ETLVDFDNHLDDIRNDWTNPEINKAVLHLC

Sequence length

210

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Myocardial infarction	Myocardial Infarction	21211798	ClinVar
Diabetes	Diabetes		GWAS

EMC8 (ER membrane protein complex subunit 8)