Gene Gene information from NCBI Gene database.
Entrez ID 10314
Gene name LanC like glutathione S-transferase 1
Gene symbol LANCL1
Synonyms (NCBI Gene)
GPR69Ap40
Chromosome 2
Chromosome location 2q34
Summary This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme comp
miRNA miRNA information provided by mirtarbase database.
580
miRTarBase ID miRNA Experiments Reference
MIRT025923 hsa-miR-7-5p Microarray 19073608
MIRT562031 hsa-miR-15a-5p PAR-CLIP 20371350
MIRT562030 hsa-miR-15b-5p PAR-CLIP 20371350
MIRT562029 hsa-miR-16-5p PAR-CLIP 20371350
MIRT562028 hsa-miR-195-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IEA
GO:0004364 Function Glutathione transferase activity ISS
GO:0004930 Function G protein-coupled receptor activity TAS 9512664
GO:0005515 Function Protein binding IPI 17500595, 19528316, 32296183, 32814053
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604155 6508 ENSG00000115365
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43813
Protein name Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1)
Protein function Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development
PDB 3E6U , 3E73 , 8CZK , 8CZL , 8D0V , 8D19
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05147 LANC_like 55 399 Lanthionine synthetase C-like protein Family
Tissue specificity TISSUE SPECIFICITY: Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and tes
Sequence
Sequence length 399
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Glutathione metabolism
Metabolic pathways
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CONTRACTURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 31322548, 36016939
★☆☆☆☆
Found in Text Mining only
Asthma Associate 30669148
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 37540188
★☆☆☆☆
Found in Text Mining only
Liver Neoplasms Associate 37540188
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 37540188
★☆☆☆☆
Found in Text Mining only
Neuralgia Associate 35510269
★☆☆☆☆
Found in Text Mining only