Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10301
Gene name Gene Name - the full gene name approved by the HGNC.	Deleted in lymphocytic leukemia 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DLEU1
Synonyms (NCBI Gene) Gene synonyms aliases	BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q14.2-q14.3

Show/Hide all(162)

miRTarBase ID	miRNA	Experiments	Reference
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717150	hsa-miR-3714	HITS-CLIP	19536157
MIRT717149	hsa-miR-3910	HITS-CLIP	19536157
MIRT717148	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT717147	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT717146	hsa-miR-940	HITS-CLIP	19536157
MIRT717145	hsa-miR-488-5p	HITS-CLIP	19536157
MIRT717144	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT717143	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT717141	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT717142	hsa-miR-4736	HITS-CLIP	19536157
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717139	hsa-miR-506-3p	HITS-CLIP	19536157
MIRT717138	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717150	hsa-miR-3714	HITS-CLIP	19536157
MIRT717149	hsa-miR-3910	HITS-CLIP	19536157
MIRT717148	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT717147	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT717146	hsa-miR-940	HITS-CLIP	19536157
MIRT717145	hsa-miR-488-5p	HITS-CLIP	19536157
MIRT717144	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT717143	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT717141	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT717142	hsa-miR-4736	HITS-CLIP	19536157
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717139	hsa-miR-506-3p	HITS-CLIP	19536157
MIRT717138	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631454	hsa-miR-4421	HITS-CLIP	23824327
MIRT631453	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT633561	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT633560	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT633559	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT633558	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT633557	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT633556	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633555	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT633554	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT633553	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT633556	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633555	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT633554	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT633553	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631454	hsa-miR-4421	HITS-CLIP	23824327
MIRT631453	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT633561	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT633560	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT633559	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT633558	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT633557	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT633556	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633555	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT633554	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT633553	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631455	hsa-miR-622	HITS-CLIP	23824327
MIRT631454	hsa-miR-4421	HITS-CLIP	23824327
MIRT631453	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717150	hsa-miR-3714	HITS-CLIP	19536157
MIRT717149	hsa-miR-3910	HITS-CLIP	19536157
MIRT717148	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT717147	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT717146	hsa-miR-940	HITS-CLIP	19536157
MIRT717145	hsa-miR-488-5p	HITS-CLIP	19536157
MIRT717144	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT717143	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT717141	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT717142	hsa-miR-4736	HITS-CLIP	19536157
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717139	hsa-miR-506-3p	HITS-CLIP	19536157
MIRT717138	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717150	hsa-miR-3714	HITS-CLIP	19536157
MIRT717149	hsa-miR-3910	HITS-CLIP	19536157
MIRT717148	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT717147	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT717146	hsa-miR-940	HITS-CLIP	19536157
MIRT717145	hsa-miR-488-5p	HITS-CLIP	19536157
MIRT717144	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT717143	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT717141	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT717142	hsa-miR-4736	HITS-CLIP	19536157
MIRT717140	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT717139	hsa-miR-506-3p	HITS-CLIP	19536157
MIRT717138	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631454	hsa-miR-4421	HITS-CLIP	23824327
MIRT631453	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT633561	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT633560	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT633559	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT633558	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT633557	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT633556	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633555	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT633554	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT633553	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT633556	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633555	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT633554	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT633553	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631454	hsa-miR-4421	HITS-CLIP	23824327
MIRT631453	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT633561	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT633560	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT633559	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT633558	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT633557	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT633556	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633555	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT633554	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT633553	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327
MIRT631458	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631457	hsa-miR-764	HITS-CLIP	23824327
MIRT631456	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631455	hsa-miR-622	HITS-CLIP	23824327
MIRT631454	hsa-miR-4421	HITS-CLIP	23824327
MIRT631453	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT631452	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT631451	hsa-miR-4264	HITS-CLIP	23824327
MIRT631450	hsa-miR-640	HITS-CLIP	23824327

MIM	HGNC	e!Ensembl
605765	13747	ENSG00000176124

Protein

UniProt ID

O43261

Protein name

Leukemia-associated protein 1 (Deleted in lymphocytic leukemia 1) (HBV X-transactivated gene 6 protein) (HBV XAg-transactivated protein 6)

Protein function

May act as a tumor suppressor.

Family and domains

Sequence

MRPCIWIHVHLKPPCRLVELLPFSSALQGLSHLSLGTTLPVILPERNEEQNLQELSHNAD
KYQMGDCCKEEIDDSIFY

Sequence length

Interactions

View interactions

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	30595370
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	30718926, 31264924, 30054458
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	31407831
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912 View all (22 more)	30595370
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	22190364, 27386562, 21833088, 24076602, 31407831

Show/Hide Unknown Diseases (15)

Disease term	Disease name	Evidence	References	Source
Unknown
Celiac disease	Celiac Disease, Celiac disease		20190752	ClinVar, GWAS
Eczema	Eczema			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Biliary Cholangitis	Biliary Cholangitis			GWAS
Osteosarcoma	Osteosarcoma	Collectively, our study identifies Rad18 as a driver of OS doxorubicin resistance that promotes the HR pathway and indicates that targeting Rad18 is an effective approach to overcome chemotherapy resistance in OS.		GWAS, CBGDA
Diabetes	Diabetes			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Hypertension	Hypertension			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Uterine Fibroids	Uterine Fibroids			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Otosclerosis	Otosclerosis			GWAS
Endometriosis	Endometriosis			GWAS
Atrial Fibrillation	Atrial Fibrillation			GWAS

Show/Hide Text Mining Associations (46)

Disease Name	Relationship Type	References
Associations from Text Mining
Aortic Valve Disease	Associate	33125279
Breast Neoplasms	Associate	31841195, 35853854, 38012271
Carcinogenesis	Associate	31379208
Carcinoma Hepatocellular	Associate	31207081
Carcinoma Renal Cell	Associate	31702026, 31858537, 33932757
Celiac Disease	Associate	24911414
Cholangiocarcinoma	Associate	35864972
Congenital contractural arachnodactyly	Stimulate	35864972
Disease	Associate	33125279
Endometrial Neoplasms	Stimulate	33327893
Esophageal Squamous Cell Carcinoma	Associate	35619131
Glioblastoma	Stimulate	31713587
Glioblastoma	Associate	36878845, 37432454
Hematologic Neoplasms	Inhibit	23593011
Inflammation	Associate	35647200
Leukemia	Associate	6611181
Leukemia B Cell	Associate	3490495, 7034809
Leukemia Lymphocytic Chronic B Cell	Inhibit	23593011
Leukemia Lymphocytic Chronic B Cell	Associate	3490495
Leukemia Lymphoma Adult T Cell	Associate	6611181
Leukemia Prolymphocytic	Associate	7034809
Leukemia T Cell	Associate	17539775
Liposarcoma Myxoid	Associate	34168281
Lupus Erythematosus Systemic	Associate	2646322
Lymphatic Metastasis	Associate	31858537
Lymphoma Non Hodgkin	Associate	7034809
Mycosis Fungoides	Associate	18832135
Neoplasm Metastasis	Stimulate	31207081, 31858537
Neoplasm Metastasis	Associate	33932757, 35853854
Neoplasms	Inhibit	17539775, 18832135, 23593011
Neoplasms	Associate	31207081, 31702026, 31713587, 34997014, 35853854, 35864972, 7034809
Neoplasms	Stimulate	35619131, 36878845
Osteoarthritis	Stimulate	35647200
Osteosarcoma	Associate	31379208
Ovarian Neoplasms	Associate	34740384
Papillomavirus Infections	Stimulate	35014679
Pleural Effusion	Associate	6982389
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	7034809
Primary Ovarian Insufficiency	Stimulate	34740384
Shwachman Diamond Syndrome	Inhibit	17539775
Squamous Cell Carcinoma of Head and Neck	Stimulate	33880596
Squamous Cell Carcinoma of Head and Neck	Associate	34650128, 36039933
Stroke	Associate	32233580
Tuberculosis Pleural	Associate	6982389
Uterine Cervical Neoplasms	Stimulate	35014679
Uterine Diseases	Associate	33327893

DLEU1 (deleted in lymphocytic leukemia 1)