Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10279
Gene name Gene Name - the full gene name approved by the HGNC.
Serine protease 16
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRSS16
Synonyms (NCBI Gene) Gene synonyms aliases
TSSP
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030266 hsa-miR-26b-5p Microarray 19088304
MIRT570263 hsa-miR-28-5p PAR-CLIP 20371350
MIRT570262 hsa-miR-3139 PAR-CLIP 20371350
MIRT570261 hsa-miR-708-5p PAR-CLIP 20371350
MIRT570260 hsa-miR-4487 PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005764 Component Lysosome IBA 21873635
GO:0005764 Component Lysosome IDA 10527559
GO:0005768 Component Endosome IBA 21873635
GO:0005768 Component Endosome IDA 10527559
GO:0006508 Process Proteolysis IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607169 9480 ENSG00000112812
Protein
UniProt ID Q9NQE7
Protein name Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16)
Protein function Protease that may play a role in T-cell development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05577 Peptidase_S28 64 494 Serine carboxypeptidase S28 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in cortical thymic epithelial cells.
Sequence
Sequence length 514
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
22384243, 22488895
Unknown
Disease term Disease name Evidence References Source
Gout Gout GWAS
Insomnia Insomnia GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 36204642
Neoplasm Metastasis Associate 28639897
Schizophrenia Associate 32626976
Tay Sachs Disease AB Variant Stimulate 36797681
Thymoma Associate 36797681
Uterine Cervical Neoplasms Associate 28639897