PRSS16 (serine protease 16)

Gene

• Entrez ID: 10279
• Gene name: Serine protease 16
• Gene symbol: PRSS16
• Synonyms (NCBI Gene): TSSP
• Chromosome: 6
• Chromosome location: 6p22.1
• Summary: This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030266	hsa-miR-26b-5p	Microarray	19088304
MIRT570263	hsa-miR-28-5p	PAR-CLIP	20371350
MIRT570262	hsa-miR-3139	PAR-CLIP	20371350
MIRT570261	hsa-miR-708-5p	PAR-CLIP	20371350
MIRT570260	hsa-miR-4487	PAR-CLIP	20371350
MIRT570259	hsa-miR-3135b	PAR-CLIP	20371350
MIRT570258	hsa-miR-504-3p	PAR-CLIP	20371350
MIRT570257	hsa-miR-122-5p	PAR-CLIP	20371350
MIRT462249	hsa-miR-4311	PAR-CLIP	23592263
MIRT462250	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT462248	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT462247	hsa-miR-3125	PAR-CLIP	23592263
MIRT462246	hsa-miR-3916	PAR-CLIP	23592263
MIRT462245	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT462244	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT462243	hsa-miR-6077	PAR-CLIP	23592263
MIRT462242	hsa-miR-3153	PAR-CLIP	23592263
MIRT462241	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT462240	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT462239	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT462238	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT462237	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT570263	hsa-miR-28-5p	PAR-CLIP	20371350
MIRT570262	hsa-miR-3139	PAR-CLIP	20371350
MIRT570261	hsa-miR-708-5p	PAR-CLIP	20371350
MIRT570260	hsa-miR-4487	PAR-CLIP	20371350
MIRT570259	hsa-miR-3135b	PAR-CLIP	20371350
MIRT570258	hsa-miR-504-3p	PAR-CLIP	20371350
MIRT570257	hsa-miR-122-5p	PAR-CLIP	20371350
MIRT462249	hsa-miR-4311	PAR-CLIP	23592263
MIRT462250	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT462248	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT462247	hsa-miR-3125	PAR-CLIP	23592263
MIRT462246	hsa-miR-3916	PAR-CLIP	23592263
MIRT462245	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT462244	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT462243	hsa-miR-6077	PAR-CLIP	23592263
MIRT462242	hsa-miR-3153	PAR-CLIP	23592263
MIRT462241	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT462240	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT462239	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT462238	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT462237	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT1268383	hsa-miR-1197	CLIP-seq
MIRT1268384	hsa-miR-122	CLIP-seq
MIRT1268385	hsa-miR-1224-5p	CLIP-seq
MIRT1268386	hsa-miR-1253	CLIP-seq
MIRT1268387	hsa-miR-1266	CLIP-seq
MIRT1268388	hsa-miR-1273d	CLIP-seq
MIRT1268389	hsa-miR-185	CLIP-seq
MIRT1268390	hsa-miR-1909	CLIP-seq
MIRT1268391	hsa-miR-198	CLIP-seq
MIRT1268392	hsa-miR-214	CLIP-seq
MIRT1268393	hsa-miR-2278	CLIP-seq
MIRT1268394	hsa-miR-2467-3p	CLIP-seq
MIRT1268395	hsa-miR-3121-3p	CLIP-seq
MIRT1268396	hsa-miR-3126-5p	CLIP-seq
MIRT1268397	hsa-miR-3150b-3p	CLIP-seq
MIRT1268398	hsa-miR-3160-5p	CLIP-seq
MIRT1268399	hsa-miR-3169	CLIP-seq
MIRT1268400	hsa-miR-320e	CLIP-seq
MIRT1268401	hsa-miR-3619-5p	CLIP-seq
MIRT1268402	hsa-miR-3646	CLIP-seq
MIRT1268403	hsa-miR-375	CLIP-seq
MIRT1268404	hsa-miR-383	CLIP-seq
MIRT1268405	hsa-miR-3915	CLIP-seq
MIRT1268406	hsa-miR-3919	CLIP-seq
MIRT1268407	hsa-miR-3936	CLIP-seq
MIRT1268408	hsa-miR-3976	CLIP-seq
MIRT1268409	hsa-miR-3978	CLIP-seq
MIRT1268410	hsa-miR-4251	CLIP-seq
MIRT1268411	hsa-miR-4270	CLIP-seq
MIRT1268412	hsa-miR-4276	CLIP-seq
MIRT1268413	hsa-miR-4291	CLIP-seq
MIRT1268414	hsa-miR-4306	CLIP-seq
MIRT1268415	hsa-miR-4419a	CLIP-seq
MIRT1268416	hsa-miR-4441	CLIP-seq
MIRT1268417	hsa-miR-4509	CLIP-seq
MIRT1268418	hsa-miR-4510	CLIP-seq
MIRT1268419	hsa-miR-4518	CLIP-seq
MIRT1268420	hsa-miR-4519	CLIP-seq
MIRT1268421	hsa-miR-4644	CLIP-seq
MIRT1268422	hsa-miR-4689	CLIP-seq
MIRT1268423	hsa-miR-4699-5p	CLIP-seq
MIRT1268424	hsa-miR-4712-3p	CLIP-seq
MIRT1268425	hsa-miR-4738-3p	CLIP-seq
MIRT1268426	hsa-miR-4740-5p	CLIP-seq
MIRT1268427	hsa-miR-4744	CLIP-seq
MIRT1268428	hsa-miR-4751	CLIP-seq
MIRT1268429	hsa-miR-4756-3p	CLIP-seq
MIRT1268430	hsa-miR-4772-5p	CLIP-seq
MIRT1268431	hsa-miR-4784	CLIP-seq
MIRT1268432	hsa-miR-539	CLIP-seq
MIRT1268433	hsa-miR-571	CLIP-seq
MIRT1268434	hsa-miR-577	CLIP-seq
MIRT1268435	hsa-miR-591	CLIP-seq
MIRT1268436	hsa-miR-665	CLIP-seq
MIRT1268437	hsa-miR-671-5p	CLIP-seq
MIRT1268438	hsa-miR-708	CLIP-seq
MIRT1268439	hsa-miR-761	CLIP-seq
MIRT1268440	hsa-miR-922	CLIP-seq
MIRT2078859	hsa-miR-1323	CLIP-seq
MIRT1268391	hsa-miR-198	CLIP-seq
MIRT1268392	hsa-miR-214	CLIP-seq
MIRT1268398	hsa-miR-3160-5p	CLIP-seq
MIRT1268399	hsa-miR-3169	CLIP-seq
MIRT2078860	hsa-miR-3616-3p	CLIP-seq
MIRT1268401	hsa-miR-3619-5p	CLIP-seq
MIRT1268404	hsa-miR-383	CLIP-seq
MIRT1268411	hsa-miR-4270	CLIP-seq
MIRT1268413	hsa-miR-4291	CLIP-seq
MIRT1268416	hsa-miR-4441	CLIP-seq
MIRT2078861	hsa-miR-4452	CLIP-seq
MIRT2078862	hsa-miR-4649-5p	CLIP-seq
MIRT2078863	hsa-miR-4680-3p	CLIP-seq
MIRT1268426	hsa-miR-4740-5p	CLIP-seq
MIRT1268430	hsa-miR-4772-5p	CLIP-seq
MIRT2078864	hsa-miR-4778-3p	CLIP-seq
MIRT2078865	hsa-miR-548o	CLIP-seq
MIRT1268435	hsa-miR-591	CLIP-seq
MIRT2078866	hsa-miR-607	CLIP-seq
MIRT1268436	hsa-miR-665	CLIP-seq
MIRT1268439	hsa-miR-761	CLIP-seq
MIRT1268440	hsa-miR-922	CLIP-seq
MIRT2305130	hsa-miR-382	CLIP-seq
MIRT2305131	hsa-miR-4259	CLIP-seq
MIRT2305132	hsa-miR-4422	CLIP-seq
MIRT2305133	hsa-miR-4425	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005764	Component	Lysosome	IBA
GO:0005764	Component	Lysosome	IDA	10527559
GO:0005764	Component	Lysosome	IEA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA	10527559
GO:0005768	Component	Endosome	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	NAS	10527559
GO:0008239	Function	Dipeptidyl-peptidase activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030163	Process	Protein catabolic process	NAS	10527559
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0070008	Function	Serine-type exopeptidase activity	IEA

Other IDs

• MIM: 607169
• HGNC: 9480
• e!Ensembl: ENSG00000112812

Protein

• UniProt ID: Q9NQE7
• Protein name: Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16)
• Protein function: Protease that may play a role in T-cell development.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05577	Peptidase_S28	64 → 494	Serine carboxypeptidase S28	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in cortical thymic epithelial cells.
• Sequence:

  MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG
  WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP
  AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI
  CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC
  RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG
  QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS
  TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ
  AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER
  PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV

• Sequence length: 514