Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10278
Gene name Gene Name - the full gene name approved by the HGNC.	Embryonal Fyn-associated substrate
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EFS
Synonyms (NCBI Gene) Gene synonyms aliases	CAS3, CASS3, EFS1, EFS2, HEFS, SIN
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin bindin

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016538	hsa-miR-193b-3p	Microarray	20304954
MIRT954629	hsa-miR-1293	CLIP-seq
MIRT954630	hsa-miR-299-3p	CLIP-seq
MIRT954631	hsa-miR-3180-5p	CLIP-seq
MIRT954632	hsa-miR-4257	CLIP-seq
MIRT954633	hsa-miR-4483	CLIP-seq
MIRT954634	hsa-miR-4491	CLIP-seq
MIRT954635	hsa-miR-4536	CLIP-seq
MIRT954636	hsa-miR-4657	CLIP-seq
MIRT954637	hsa-miR-4726-3p	CLIP-seq
MIRT954638	hsa-miR-520a-5p	CLIP-seq
MIRT954639	hsa-miR-525-5p	CLIP-seq
MIRT954640	hsa-miR-544	CLIP-seq
MIRT954641	hsa-miR-663b	CLIP-seq
MIRT1982737	hsa-miR-1207-5p	CLIP-seq
MIRT1982738	hsa-miR-183	CLIP-seq
MIRT1982739	hsa-miR-330-3p	CLIP-seq
MIRT1982740	hsa-miR-4307	CLIP-seq
MIRT1982741	hsa-miR-4736	CLIP-seq
MIRT1982742	hsa-miR-4763-3p	CLIP-seq
MIRT1982743	hsa-miR-657	CLIP-seq
MIRT1982739	hsa-miR-330-3p	CLIP-seq
MIRT2217602	hsa-miR-4677-3p	CLIP-seq
MIRT2217603	hsa-miR-4679	CLIP-seq
MIRT2387245	hsa-miR-4326	CLIP-seq
MIRT2521633	hsa-miR-1178	CLIP-seq
MIRT2521634	hsa-miR-29a	CLIP-seq
MIRT2521635	hsa-miR-29b	CLIP-seq
MIRT2521636	hsa-miR-29c	CLIP-seq
MIRT2521637	hsa-miR-3663-3p	CLIP-seq
MIRT2521638	hsa-miR-4446-3p	CLIP-seq
MIRT2521639	hsa-miR-4663	CLIP-seq
MIRT2521640	hsa-miR-4685-5p	CLIP-seq
MIRT2521641	hsa-miR-4733-3p	CLIP-seq
MIRT2521642	hsa-miR-604	CLIP-seq
MIRT2521643	hsa-miR-647	CLIP-seq
MIRT2521644	hsa-miR-767-3p	CLIP-seq
MIRT2521633	hsa-miR-1178	CLIP-seq
MIRT2521634	hsa-miR-29a	CLIP-seq
MIRT2521635	hsa-miR-29b	CLIP-seq
MIRT2521636	hsa-miR-29c	CLIP-seq
MIRT2521637	hsa-miR-3663-3p	CLIP-seq
MIRT2521638	hsa-miR-4446-3p	CLIP-seq
MIRT2521639	hsa-miR-4663	CLIP-seq
MIRT2521640	hsa-miR-4685-5p	CLIP-seq
MIRT2521641	hsa-miR-4733-3p	CLIP-seq
MIRT2521642	hsa-miR-604	CLIP-seq
MIRT2521643	hsa-miR-647	CLIP-seq
MIRT2521644	hsa-miR-767-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 29892012, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	TAS	9349509
GO:0005886	Component	Plasma membrane	IBA
GO:0005925	Component	Focal adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0016477	Process	Cell migration	IBA
GO:0017124	Function	SH3 domain binding	IEA
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0035556	Process	Intracellular signal transduction	TAS	9349509

MIM	HGNC	e!Ensembl
609906	16898	ENSG00000100842

Protein

UniProt ID

O43281

Protein name

Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)

Protein function

Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14604	SH3_9	12 → 64	Variant SH3 domain	Domain
PF12026	CAS_C	371 → 556	Crk-Associated Substrate C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: The protein has been detected in lung and placenta.

Sequence

MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA
NRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPC
PPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQP
PGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELL
ADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAE
SLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE
MEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEAL
SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVA
AHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ
CVTELAGQALQFTTLLTSLAP

Sequence length

561

Interactions

View interactions

EFS (embryonal Fyn-associated substrate)