Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10278
Gene name	Embryonal Fyn-associated substrate
Gene symbol	EFS
Synonyms (NCBI Gene)	CAS3CASS3EFS1EFS2HEFSSIN
Chromosome	14
Chromosome location	14q11.2
Summary	The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin bindin

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016538	hsa-miR-193b-3p	Microarray	20304954
MIRT954629	hsa-miR-1293	CLIP-seq
MIRT954630	hsa-miR-299-3p	CLIP-seq
MIRT954631	hsa-miR-3180-5p	CLIP-seq
MIRT954632	hsa-miR-4257	CLIP-seq
MIRT954633	hsa-miR-4483	CLIP-seq
MIRT954634	hsa-miR-4491	CLIP-seq
MIRT954635	hsa-miR-4536	CLIP-seq
MIRT954636	hsa-miR-4657	CLIP-seq
MIRT954637	hsa-miR-4726-3p	CLIP-seq
MIRT954638	hsa-miR-520a-5p	CLIP-seq
MIRT954639	hsa-miR-525-5p	CLIP-seq
MIRT954640	hsa-miR-544	CLIP-seq
MIRT954641	hsa-miR-663b	CLIP-seq
MIRT1982737	hsa-miR-1207-5p	CLIP-seq
MIRT1982738	hsa-miR-183	CLIP-seq
MIRT1982739	hsa-miR-330-3p	CLIP-seq
MIRT1982740	hsa-miR-4307	CLIP-seq
MIRT1982741	hsa-miR-4736	CLIP-seq
MIRT1982742	hsa-miR-4763-3p	CLIP-seq
MIRT1982743	hsa-miR-657	CLIP-seq
MIRT1982739	hsa-miR-330-3p	CLIP-seq
MIRT2217602	hsa-miR-4677-3p	CLIP-seq
MIRT2217603	hsa-miR-4679	CLIP-seq
MIRT2387245	hsa-miR-4326	CLIP-seq
MIRT2521633	hsa-miR-1178	CLIP-seq
MIRT2521634	hsa-miR-29a	CLIP-seq
MIRT2521635	hsa-miR-29b	CLIP-seq
MIRT2521636	hsa-miR-29c	CLIP-seq
MIRT2521637	hsa-miR-3663-3p	CLIP-seq
MIRT2521638	hsa-miR-4446-3p	CLIP-seq
MIRT2521639	hsa-miR-4663	CLIP-seq
MIRT2521640	hsa-miR-4685-5p	CLIP-seq
MIRT2521641	hsa-miR-4733-3p	CLIP-seq
MIRT2521642	hsa-miR-604	CLIP-seq
MIRT2521643	hsa-miR-647	CLIP-seq
MIRT2521644	hsa-miR-767-3p	CLIP-seq
MIRT2521633	hsa-miR-1178	CLIP-seq
MIRT2521634	hsa-miR-29a	CLIP-seq
MIRT2521635	hsa-miR-29b	CLIP-seq
MIRT2521636	hsa-miR-29c	CLIP-seq
MIRT2521637	hsa-miR-3663-3p	CLIP-seq
MIRT2521638	hsa-miR-4446-3p	CLIP-seq
MIRT2521639	hsa-miR-4663	CLIP-seq
MIRT2521640	hsa-miR-4685-5p	CLIP-seq
MIRT2521641	hsa-miR-4733-3p	CLIP-seq
MIRT2521642	hsa-miR-604	CLIP-seq
MIRT2521643	hsa-miR-647	CLIP-seq
MIRT2521644	hsa-miR-767-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 29892012, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	TAS	9349509
GO:0005886	Component	Plasma membrane	IBA
GO:0005925	Component	Focal adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0016477	Process	Cell migration	IBA
GO:0017124	Function	SH3 domain binding	IEA
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0035556	Process	Intracellular signal transduction	TAS	9349509

MIM	HGNC	e!Ensembl
609906	16898	ENSG00000100842

O43281

Protein name

Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)

Protein function

Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14604	SH3_9	12 → 64	Variant SH3 domain	Domain
PF12026	CAS_C	371 → 556	Crk-Associated Substrate C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: The protein has been detected in lung and placenta.

Sequence

MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA
NRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPC
PPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQP
PGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELL
ADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAE
SLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE
MEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEAL
SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVA
AHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ
CVTELAGQALQFTTLLTSLAP

Sequence length

561

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Sarcoma	Uncertain significance	rs372971469	RCV005932458

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	31558162
Calcinosis Cutis	Associate	21871071
Fetal Growth Retardation	Associate	26830322
Glioma	Associate	28032310, 32012853
Muscular Dystrophy Duchenne	Associate	31811138, 37625413
Neoplasm Metastasis	Associate	21871071
Neoplasms	Associate	21871071
Prostatic Neoplasms	Associate	19229700
Urinary Bladder Neoplasms	Associate	27595989
Uveal melanoma	Associate	21871071

EFS (embryonal Fyn-associated substrate)