NET1 (neuroepithelial cell transforming 1)

Gene

• Entrez ID: 10276
• Gene name: Neuroepithelial cell transforming 1
• Gene symbol: NET1
• Synonyms (NCBI Gene): ARHGEF8, NET1A
• Chromosome: 10
• Chromosome location: 10p15.1
• Summary: This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019642	hsa-miR-340-5p	Sequencing	20371350
MIRT029990	hsa-miR-26b-5p	Microarray	19088304
MIRT030610	hsa-miR-24-3p	Microarray	19748357
MIRT044778	hsa-miR-320a	CLASH	23622248
MIRT438530	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	25041463
MIRT438530	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	25041463
MIRT438530	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	25041463
MIRT438530	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	25041463
MIRT019642	hsa-miR-340-5p	Luciferase reporter assay, qRT-PCR, Western blotting	33955315
MIRT735554	hsa-miR-505-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR, ELISA	33061457
MIRT1180684	hsa-miR-1	CLIP-seq
MIRT1180685	hsa-miR-105	CLIP-seq
MIRT1180686	hsa-miR-1193	CLIP-seq
MIRT1180687	hsa-miR-1305	CLIP-seq
MIRT1180688	hsa-miR-1323	CLIP-seq
MIRT1180689	hsa-miR-1324	CLIP-seq
MIRT1180690	hsa-miR-135a	CLIP-seq
MIRT1180691	hsa-miR-135b	CLIP-seq
MIRT1180692	hsa-miR-141	CLIP-seq
MIRT1180693	hsa-miR-144	CLIP-seq
MIRT1180694	hsa-miR-193a-3p	CLIP-seq
MIRT1180695	hsa-miR-193b	CLIP-seq
MIRT1180696	hsa-miR-200a	CLIP-seq
MIRT1180697	hsa-miR-206	CLIP-seq
MIRT1180698	hsa-miR-219-2-3p	CLIP-seq
MIRT1180699	hsa-miR-24	CLIP-seq
MIRT1180700	hsa-miR-27a	CLIP-seq
MIRT1180701	hsa-miR-27b	CLIP-seq
MIRT1180702	hsa-miR-2964a-3p	CLIP-seq
MIRT1180703	hsa-miR-3065-5p	CLIP-seq
MIRT1180704	hsa-miR-3119	CLIP-seq
MIRT1180705	hsa-miR-3129-3p	CLIP-seq
MIRT1180706	hsa-miR-3134	CLIP-seq
MIRT1180707	hsa-miR-329	CLIP-seq
MIRT1180708	hsa-miR-338-5p	CLIP-seq
MIRT1180709	hsa-miR-33a	CLIP-seq
MIRT1180710	hsa-miR-33b	CLIP-seq
MIRT1180711	hsa-miR-3610	CLIP-seq
MIRT1180712	hsa-miR-3613-3p	CLIP-seq
MIRT1180713	hsa-miR-3614-5p	CLIP-seq
MIRT1180714	hsa-miR-362-3p	CLIP-seq
MIRT1180715	hsa-miR-3646	CLIP-seq
MIRT1180716	hsa-miR-3662	CLIP-seq
MIRT1180717	hsa-miR-3680	CLIP-seq
MIRT1180718	hsa-miR-3692	CLIP-seq
MIRT1180719	hsa-miR-371b-5p	CLIP-seq
MIRT1180720	hsa-miR-374a	CLIP-seq
MIRT1180721	hsa-miR-374b	CLIP-seq
MIRT1180722	hsa-miR-3915	CLIP-seq
MIRT1180723	hsa-miR-3919	CLIP-seq
MIRT1180724	hsa-miR-3920	CLIP-seq
MIRT1180725	hsa-miR-3926	CLIP-seq
MIRT1180726	hsa-miR-3928	CLIP-seq
MIRT1180727	hsa-miR-3941	CLIP-seq
MIRT1180728	hsa-miR-3942-3p	CLIP-seq
MIRT1180729	hsa-miR-3944-3p	CLIP-seq
MIRT1180730	hsa-miR-421	CLIP-seq
MIRT1180731	hsa-miR-4282	CLIP-seq
MIRT1180732	hsa-miR-4284	CLIP-seq
MIRT1180733	hsa-miR-4289	CLIP-seq
MIRT1180734	hsa-miR-4436b-5p	CLIP-seq
MIRT1180735	hsa-miR-4452	CLIP-seq
MIRT1180736	hsa-miR-4495	CLIP-seq
MIRT1180737	hsa-miR-4528	CLIP-seq
MIRT1180738	hsa-miR-4635	CLIP-seq
MIRT1180739	hsa-miR-4699-3p	CLIP-seq
MIRT1180740	hsa-miR-4705	CLIP-seq
MIRT1180741	hsa-miR-4709-3p	CLIP-seq
MIRT1180742	hsa-miR-4736	CLIP-seq
MIRT1180743	hsa-miR-4762-3p	CLIP-seq
MIRT1180744	hsa-miR-4764-3p	CLIP-seq
MIRT1180745	hsa-miR-4789-5p	CLIP-seq
MIRT1180746	hsa-miR-4797-5p	CLIP-seq
MIRT1180747	hsa-miR-495	CLIP-seq
MIRT1180748	hsa-miR-505	CLIP-seq
MIRT1180749	hsa-miR-513a-5p	CLIP-seq
MIRT1180750	hsa-miR-539	CLIP-seq
MIRT1180751	hsa-miR-548a-3p	CLIP-seq
MIRT1180752	hsa-miR-548ac	CLIP-seq
MIRT1180753	hsa-miR-548ae	CLIP-seq
MIRT1180754	hsa-miR-548aj	CLIP-seq
MIRT1180755	hsa-miR-548am	CLIP-seq
MIRT1180756	hsa-miR-548c-3p	CLIP-seq
MIRT1180757	hsa-miR-548d-3p	CLIP-seq
MIRT1180758	hsa-miR-548e	CLIP-seq
MIRT1180759	hsa-miR-548f	CLIP-seq
MIRT1180760	hsa-miR-548o	CLIP-seq
MIRT1180761	hsa-miR-548s	CLIP-seq
MIRT1180762	hsa-miR-548x	CLIP-seq
MIRT1180763	hsa-miR-548z	CLIP-seq
MIRT1180764	hsa-miR-579	CLIP-seq
MIRT1180765	hsa-miR-582-5p	CLIP-seq
MIRT1180766	hsa-miR-603	CLIP-seq
MIRT1180767	hsa-miR-606	CLIP-seq
MIRT1180768	hsa-miR-607	CLIP-seq
MIRT1180769	hsa-miR-613	CLIP-seq
MIRT1180770	hsa-miR-633	CLIP-seq
MIRT1180771	hsa-miR-642a	CLIP-seq
MIRT1180772	hsa-miR-657	CLIP-seq
MIRT1180773	hsa-miR-664	CLIP-seq
MIRT1180774	hsa-miR-1262	CLIP-seq
MIRT1180775	hsa-miR-1272	CLIP-seq
MIRT1180776	hsa-miR-1322	CLIP-seq
MIRT1180690	hsa-miR-135a	CLIP-seq
MIRT1180691	hsa-miR-135b	CLIP-seq
MIRT1180777	hsa-miR-140-5p	CLIP-seq
MIRT1180692	hsa-miR-141	CLIP-seq
MIRT1180778	hsa-miR-142-5p	CLIP-seq
MIRT1180693	hsa-miR-144	CLIP-seq
MIRT1180779	hsa-miR-181a	CLIP-seq
MIRT1180780	hsa-miR-181b	CLIP-seq
MIRT1180781	hsa-miR-181c	CLIP-seq
MIRT1180782	hsa-miR-181d	CLIP-seq
MIRT1180694	hsa-miR-193a-3p	CLIP-seq
MIRT1180695	hsa-miR-193b	CLIP-seq
MIRT1180783	hsa-miR-199a-3p	CLIP-seq
MIRT1180784	hsa-miR-199b-3p	CLIP-seq
MIRT1180696	hsa-miR-200a	CLIP-seq
MIRT1180785	hsa-miR-203	CLIP-seq
MIRT1180698	hsa-miR-219-2-3p	CLIP-seq
MIRT1180786	hsa-miR-22	CLIP-seq
MIRT1180699	hsa-miR-24	CLIP-seq
MIRT1180700	hsa-miR-27a	CLIP-seq
MIRT1180701	hsa-miR-27b	CLIP-seq
MIRT1180702	hsa-miR-2964a-3p	CLIP-seq
MIRT1180787	hsa-miR-3127-3p	CLIP-seq
MIRT1180788	hsa-miR-3129-5p	CLIP-seq
MIRT1180789	hsa-miR-3145-5p	CLIP-seq
MIRT1180707	hsa-miR-329	CLIP-seq
MIRT1180790	hsa-miR-340	CLIP-seq
MIRT1180712	hsa-miR-3613-3p	CLIP-seq
MIRT1180713	hsa-miR-3614-5p	CLIP-seq
MIRT1180791	hsa-miR-3616-5p	CLIP-seq
MIRT1180714	hsa-miR-362-3p	CLIP-seq
MIRT1180792	hsa-miR-3647-5p	CLIP-seq
MIRT1180718	hsa-miR-3692	CLIP-seq
MIRT1180719	hsa-miR-371b-5p	CLIP-seq
MIRT1180723	hsa-miR-3919	CLIP-seq
MIRT1180724	hsa-miR-3920	CLIP-seq
MIRT1180725	hsa-miR-3926	CLIP-seq
MIRT1180727	hsa-miR-3941	CLIP-seq
MIRT1180793	hsa-miR-4262	CLIP-seq
MIRT1180732	hsa-miR-4284	CLIP-seq
MIRT1180734	hsa-miR-4436b-5p	CLIP-seq
MIRT1180735	hsa-miR-4452	CLIP-seq
MIRT1180794	hsa-miR-4464	CLIP-seq
MIRT1180736	hsa-miR-4495	CLIP-seq
MIRT1180739	hsa-miR-4699-3p	CLIP-seq
MIRT1180795	hsa-miR-4701-3p	CLIP-seq
MIRT1180796	hsa-miR-4716-5p	CLIP-seq
MIRT1180797	hsa-miR-4748	CLIP-seq
MIRT1180743	hsa-miR-4762-3p	CLIP-seq
MIRT1180798	hsa-miR-4769-3p	CLIP-seq
MIRT1180799	hsa-miR-4774-5p	CLIP-seq
MIRT1180800	hsa-miR-4789-3p	CLIP-seq
MIRT1180801	hsa-miR-4795-5p	CLIP-seq
MIRT1180746	hsa-miR-4797-5p	CLIP-seq
MIRT1180748	hsa-miR-505	CLIP-seq
MIRT1180802	hsa-miR-508-5p	CLIP-seq
MIRT1180749	hsa-miR-513a-5p	CLIP-seq
MIRT1180750	hsa-miR-539	CLIP-seq
MIRT1180803	hsa-miR-548a-5p	CLIP-seq
MIRT1180804	hsa-miR-548ab	CLIP-seq
MIRT1180805	hsa-miR-548ak	CLIP-seq
MIRT1180806	hsa-miR-548b-5p	CLIP-seq
MIRT1180756	hsa-miR-548c-3p	CLIP-seq
MIRT1180807	hsa-miR-548c-5p	CLIP-seq
MIRT1180808	hsa-miR-548d-5p	CLIP-seq
MIRT1180809	hsa-miR-548h	CLIP-seq
MIRT1180810	hsa-miR-548i	CLIP-seq
MIRT1180811	hsa-miR-548j	CLIP-seq
MIRT1180812	hsa-miR-548k	CLIP-seq
MIRT1180813	hsa-miR-548l	CLIP-seq
MIRT1180761	hsa-miR-548s	CLIP-seq
MIRT1180814	hsa-miR-548w	CLIP-seq
MIRT1180815	hsa-miR-548y	CLIP-seq
MIRT1180816	hsa-miR-559	CLIP-seq
MIRT1180817	hsa-miR-561	CLIP-seq
MIRT1180818	hsa-miR-573	CLIP-seq
MIRT1180764	hsa-miR-579	CLIP-seq
MIRT1180819	hsa-miR-582-3p	CLIP-seq
MIRT1180765	hsa-miR-582-5p	CLIP-seq
MIRT1180766	hsa-miR-603	CLIP-seq
MIRT1180770	hsa-miR-633	CLIP-seq
MIRT1180773	hsa-miR-664	CLIP-seq
MIRT1180820	hsa-miR-873	CLIP-seq
MIRT1180821	hsa-miR-936	CLIP-seq
MIRT1551733	hsa-miR-3133	CLIP-seq
MIRT1180775	hsa-miR-1272	CLIP-seq
MIRT2052289	hsa-miR-132	CLIP-seq
MIRT2052290	hsa-miR-212	CLIP-seq
MIRT1180790	hsa-miR-340	CLIP-seq
MIRT2052291	hsa-miR-3682-3p	CLIP-seq
MIRT1180733	hsa-miR-4289	CLIP-seq
MIRT1180800	hsa-miR-4789-3p	CLIP-seq
MIRT1180774	hsa-miR-1262	CLIP-seq
MIRT1180779	hsa-miR-181a	CLIP-seq
MIRT1180780	hsa-miR-181b	CLIP-seq
MIRT1180781	hsa-miR-181c	CLIP-seq
MIRT1180782	hsa-miR-181d	CLIP-seq
MIRT1180694	hsa-miR-193a-3p	CLIP-seq
MIRT1180695	hsa-miR-193b	CLIP-seq
MIRT1180786	hsa-miR-22	CLIP-seq
MIRT1180700	hsa-miR-27a	CLIP-seq
MIRT1180701	hsa-miR-27b	CLIP-seq
MIRT1180789	hsa-miR-3145-5p	CLIP-seq
MIRT1180718	hsa-miR-3692	CLIP-seq
MIRT1180724	hsa-miR-3920	CLIP-seq
MIRT1180725	hsa-miR-3926	CLIP-seq
MIRT1180793	hsa-miR-4262	CLIP-seq
MIRT1180734	hsa-miR-4436b-5p	CLIP-seq
MIRT1180794	hsa-miR-4464	CLIP-seq
MIRT1180739	hsa-miR-4699-3p	CLIP-seq
MIRT1180795	hsa-miR-4701-3p	CLIP-seq
MIRT1180796	hsa-miR-4716-5p	CLIP-seq
MIRT2052292	hsa-miR-4742-3p	CLIP-seq
MIRT1180797	hsa-miR-4748	CLIP-seq
MIRT1180743	hsa-miR-4762-3p	CLIP-seq
MIRT1180798	hsa-miR-4769-3p	CLIP-seq
MIRT1180802	hsa-miR-508-5p	CLIP-seq
MIRT1180749	hsa-miR-513a-5p	CLIP-seq
MIRT1180761	hsa-miR-548s	CLIP-seq
MIRT1180765	hsa-miR-582-5p	CLIP-seq
MIRT1180768	hsa-miR-607	CLIP-seq
MIRT1180684	hsa-miR-1	CLIP-seq
MIRT1180686	hsa-miR-1193	CLIP-seq
MIRT2281690	hsa-miR-1226	CLIP-seq
MIRT1180774	hsa-miR-1262	CLIP-seq
MIRT1180775	hsa-miR-1272	CLIP-seq
MIRT2281691	hsa-miR-1283	CLIP-seq
MIRT1180690	hsa-miR-135a	CLIP-seq
MIRT1180691	hsa-miR-135b	CLIP-seq
MIRT1180777	hsa-miR-140-5p	CLIP-seq
MIRT1180692	hsa-miR-141	CLIP-seq
MIRT1180693	hsa-miR-144	CLIP-seq
MIRT1180779	hsa-miR-181a	CLIP-seq
MIRT1180780	hsa-miR-181b	CLIP-seq
MIRT1180781	hsa-miR-181c	CLIP-seq
MIRT1180782	hsa-miR-181d	CLIP-seq
MIRT1180694	hsa-miR-193a-3p	CLIP-seq
MIRT1180695	hsa-miR-193b	CLIP-seq
MIRT2281692	hsa-miR-197	CLIP-seq
MIRT1180783	hsa-miR-199a-3p	CLIP-seq
MIRT1180784	hsa-miR-199b-3p	CLIP-seq
MIRT1180696	hsa-miR-200a	CLIP-seq
MIRT1180785	hsa-miR-203	CLIP-seq
MIRT2281693	hsa-miR-2054	CLIP-seq
MIRT1180697	hsa-miR-206	CLIP-seq
MIRT1180698	hsa-miR-219-2-3p	CLIP-seq
MIRT1180699	hsa-miR-24	CLIP-seq
MIRT1180700	hsa-miR-27a	CLIP-seq
MIRT1180701	hsa-miR-27b	CLIP-seq
MIRT1180702	hsa-miR-2964a-3p	CLIP-seq
MIRT1180704	hsa-miR-3119	CLIP-seq
MIRT1180788	hsa-miR-3129-5p	CLIP-seq
MIRT1180706	hsa-miR-3134	CLIP-seq
MIRT1180789	hsa-miR-3145-5p	CLIP-seq
MIRT2281694	hsa-miR-3155	CLIP-seq
MIRT2281695	hsa-miR-3155b	CLIP-seq
MIRT1180707	hsa-miR-329	CLIP-seq
MIRT1180711	hsa-miR-3610	CLIP-seq
MIRT1180712	hsa-miR-3613-3p	CLIP-seq
MIRT2281696	hsa-miR-3614-3p	CLIP-seq
MIRT1180713	hsa-miR-3614-5p	CLIP-seq
MIRT1180714	hsa-miR-362-3p	CLIP-seq
MIRT1180715	hsa-miR-3646	CLIP-seq
MIRT2281697	hsa-miR-3647-3p	CLIP-seq
MIRT1180716	hsa-miR-3662	CLIP-seq
MIRT1180718	hsa-miR-3692	CLIP-seq
MIRT1180719	hsa-miR-371b-5p	CLIP-seq
MIRT1180720	hsa-miR-374a	CLIP-seq
MIRT1180721	hsa-miR-374b	CLIP-seq
MIRT1180722	hsa-miR-3915	CLIP-seq
MIRT1180723	hsa-miR-3919	CLIP-seq
MIRT1180724	hsa-miR-3920	CLIP-seq
MIRT1180725	hsa-miR-3926	CLIP-seq
MIRT1180726	hsa-miR-3928	CLIP-seq
MIRT1180727	hsa-miR-3941	CLIP-seq
MIRT1180729	hsa-miR-3944-3p	CLIP-seq
MIRT1180793	hsa-miR-4262	CLIP-seq
MIRT1180731	hsa-miR-4282	CLIP-seq
MIRT1180732	hsa-miR-4284	CLIP-seq
MIRT1180734	hsa-miR-4436b-5p	CLIP-seq
MIRT1180735	hsa-miR-4452	CLIP-seq
MIRT1180794	hsa-miR-4464	CLIP-seq
MIRT1180736	hsa-miR-4495	CLIP-seq
MIRT1180737	hsa-miR-4528	CLIP-seq
MIRT1180739	hsa-miR-4699-3p	CLIP-seq
MIRT1180795	hsa-miR-4701-3p	CLIP-seq
MIRT1180796	hsa-miR-4716-5p	CLIP-seq
MIRT2281698	hsa-miR-4733-3p	CLIP-seq
MIRT1180742	hsa-miR-4736	CLIP-seq
MIRT1180797	hsa-miR-4748	CLIP-seq
MIRT1180743	hsa-miR-4762-3p	CLIP-seq
MIRT1180800	hsa-miR-4789-3p	CLIP-seq
MIRT1180745	hsa-miR-4789-5p	CLIP-seq
MIRT1180746	hsa-miR-4797-5p	CLIP-seq
MIRT2281699	hsa-miR-484	CLIP-seq
MIRT2281700	hsa-miR-494	CLIP-seq
MIRT2281701	hsa-miR-499-3p	CLIP-seq
MIRT2281702	hsa-miR-499a-3p	CLIP-seq
MIRT1180748	hsa-miR-505	CLIP-seq
MIRT1180802	hsa-miR-508-5p	CLIP-seq
MIRT1180749	hsa-miR-513a-5p	CLIP-seq
MIRT1180752	hsa-miR-548ac	CLIP-seq
MIRT1180753	hsa-miR-548ae	CLIP-seq
MIRT1180754	hsa-miR-548aj	CLIP-seq
MIRT1180755	hsa-miR-548am	CLIP-seq
MIRT1180757	hsa-miR-548d-3p	CLIP-seq
MIRT1180761	hsa-miR-548s	CLIP-seq
MIRT1180762	hsa-miR-548x	CLIP-seq
MIRT1180763	hsa-miR-548z	CLIP-seq
MIRT1180764	hsa-miR-579	CLIP-seq
MIRT1180819	hsa-miR-582-3p	CLIP-seq
MIRT1180765	hsa-miR-582-5p	CLIP-seq
MIRT2281703	hsa-miR-584	CLIP-seq
MIRT2281704	hsa-miR-587	CLIP-seq
MIRT1180766	hsa-miR-603	CLIP-seq
MIRT2281705	hsa-miR-605	CLIP-seq
MIRT1180768	hsa-miR-607	CLIP-seq
MIRT1180769	hsa-miR-613	CLIP-seq
MIRT1180772	hsa-miR-657	CLIP-seq
MIRT1180773	hsa-miR-664	CLIP-seq
MIRT1180821	hsa-miR-936	CLIP-seq
MIRT1180739	hsa-miR-4699-3p	CLIP-seq
MIRT1180800	hsa-miR-4789-3p	CLIP-seq
MIRT2579889	hsa-miR-1238	CLIP-seq
MIRT1180775	hsa-miR-1272	CLIP-seq
MIRT2579890	hsa-miR-1273d	CLIP-seq
MIRT1180688	hsa-miR-1323	CLIP-seq
MIRT1180689	hsa-miR-1324	CLIP-seq
MIRT2579891	hsa-miR-3183	CLIP-seq
MIRT2579892	hsa-miR-338-3p	CLIP-seq
MIRT1180709	hsa-miR-33a	CLIP-seq
MIRT1180710	hsa-miR-33b	CLIP-seq
MIRT1180717	hsa-miR-3680	CLIP-seq
MIRT1180728	hsa-miR-3942-3p	CLIP-seq
MIRT2579893	hsa-miR-4263	CLIP-seq
MIRT2579894	hsa-miR-4310	CLIP-seq
MIRT2579895	hsa-miR-450b-5p	CLIP-seq
MIRT2579896	hsa-miR-4530	CLIP-seq
MIRT1180738	hsa-miR-4635	CLIP-seq
MIRT1180740	hsa-miR-4705	CLIP-seq
MIRT1180741	hsa-miR-4709-3p	CLIP-seq
MIRT2579897	hsa-miR-4723-3p	CLIP-seq
MIRT2579898	hsa-miR-4753-3p	CLIP-seq
MIRT1180744	hsa-miR-4764-3p	CLIP-seq
MIRT2579899	hsa-miR-518a-5p	CLIP-seq
MIRT2579900	hsa-miR-527	CLIP-seq
MIRT1180760	hsa-miR-548o	CLIP-seq
MIRT1180767	hsa-miR-606	CLIP-seq
MIRT1180771	hsa-miR-642a	CLIP-seq
MIRT2579901	hsa-miR-660	CLIP-seq
MIRT1180775	hsa-miR-1272	CLIP-seq
MIRT1180688	hsa-miR-1323	CLIP-seq
MIRT2579892	hsa-miR-338-3p	CLIP-seq
MIRT2579893	hsa-miR-4263	CLIP-seq
MIRT2579894	hsa-miR-4310	CLIP-seq
MIRT2579895	hsa-miR-450b-5p	CLIP-seq
MIRT2579896	hsa-miR-4530	CLIP-seq
MIRT1180738	hsa-miR-4635	CLIP-seq
MIRT1180741	hsa-miR-4709-3p	CLIP-seq
MIRT2579899	hsa-miR-518a-5p	CLIP-seq
MIRT2579900	hsa-miR-527	CLIP-seq
MIRT1180760	hsa-miR-548o	CLIP-seq
MIRT1180767	hsa-miR-606	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	8649828
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	8649828
GO:0005515	Function	Protein binding	IPI	24550280, 30126976, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	8649828
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21373644
GO:0043547	Process	Positive regulation of GTPase activity	IMP	21373644
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051451	Process	Myoblast migration	IEA
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	21373644
GO:0071479	Process	Cellular response to ionizing radiation	IDA	21373644

Other IDs

• MIM: 606450
• HGNC: 14592
• e!Ensembl: ENSG00000173848

Protein

• UniProt ID: Q7Z628
• Protein name: Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
• Protein function: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:2
• PDB: 3EO2, 4XH9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	178 → 354	RhoGEF domain	Domain
  PF00169	PH	375 → 501	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8649828}.
• Sequence:

  MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPN
  WDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTI
  QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIY
  EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT
  KPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSR
  KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES
  ECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNE
  RHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHT
  LQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRAST
  VSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV

• Sequence length: 596

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Clear cell carcinoma of kidney	Benign	rs78693452	RCV005906009
Ependymoma	Uncertain significance	rs1554818513	RCV000577843
Gastric cancer	Uncertain significance	rs199808307	RCV005939336
Long QT syndrome	Likely benign	rs796052153	RCV000190140
Malignant tumor of esophagus	Benign	rs78693452	RCV005906008
Ovarian serous cystadenocarcinoma	Benign	rs78693452	RCV005906011
Sarcoma	Benign	rs78693452	RCV005906010
Thymoma	Benign	rs78693452	RCV005906012
Thyroid cancer, nonmedullary, 1	Benign	rs78693452	RCV005906013
Uterine corpus endometrial carcinoma	Benign	rs78693452	RCV005906014

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	32420320
Attention Deficit Disorder with Hyperactivity	Associate	20039948
Barrett Esophagus	Stimulate	23945136
Breast Neoplasms	Associate	19124484, 23380069, 23689132, 24897521, 30332929
Carcinoma Hepatocellular	Associate	20590388, 24885292, 27216880, 31128017, 32641699, 36458010
Carcinoma Non Small Cell Lung	Associate	32420320
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	25041463
Lung Neoplasms	Associate	32420320, 33955315
Neoplasm Metastasis	Associate	19124484, 20590388, 30332929
Neoplasms	Associate	18827818, 20590388, 23689132, 23945136, 30332929, 31046876, 32420320, 34957935
Personality Disorders	Associate	19124484
Precursor Cell Lymphoblastic Leukemia Lymphoma	Stimulate	31046876
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	34957935
Stomach Neoplasms	Associate	16552434, 21284875, 23945136
Stomach Neoplasms	Stimulate	18827818