CDK2AP2 (cyclin dependent kinase 2 associated protein 2)

Gene

• Entrez ID: 10263
• Gene name: Cyclin dependent kinase 2 associated protein 2
• Gene symbol: CDK2AP2
• Synonyms (NCBI Gene): DOC-1R, DOC1R, p14
• Chromosome: 11
• Chromosome location: 11q13.2
• Summary: This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030237	hsa-miR-26b-5p	Microarray	19088304
MIRT044773	hsa-miR-320a	CLASH	23622248
MIRT560939	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT560938	hsa-miR-2392	PAR-CLIP	20371350
MIRT560937	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT560936	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT560935	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT560934	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT560933	hsa-miR-3666	PAR-CLIP	20371350
MIRT560932	hsa-miR-4295	PAR-CLIP	20371350
MIRT560931	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT560930	hsa-miR-4436a	PAR-CLIP	20371350
MIRT560929	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT560928	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT560927	hsa-miR-8069	PAR-CLIP	20371350
MIRT560926	hsa-miR-891b	PAR-CLIP	20371350
MIRT560925	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT560924	hsa-miR-1193	PAR-CLIP	20371350
MIRT560939	hsa-miR-4700-3p	PAR-CLIP	20371350
MIRT560938	hsa-miR-2392	PAR-CLIP	20371350
MIRT560937	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT560936	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT560935	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT560934	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT560933	hsa-miR-3666	PAR-CLIP	20371350
MIRT560932	hsa-miR-4295	PAR-CLIP	20371350
MIRT560931	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT560930	hsa-miR-4436a	PAR-CLIP	20371350
MIRT560929	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT560928	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT560927	hsa-miR-8069	PAR-CLIP	20371350
MIRT560926	hsa-miR-891b	PAR-CLIP	20371350
MIRT560925	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT560924	hsa-miR-1193	PAR-CLIP	20371350
MIRT881061	hsa-miR-1184	CLIP-seq
MIRT881062	hsa-miR-1197	CLIP-seq
MIRT881063	hsa-miR-1205	CLIP-seq
MIRT881064	hsa-miR-1207-5p	CLIP-seq
MIRT881065	hsa-miR-130a	CLIP-seq
MIRT881066	hsa-miR-130b	CLIP-seq
MIRT881067	hsa-miR-1321	CLIP-seq
MIRT881068	hsa-miR-135a	CLIP-seq
MIRT881069	hsa-miR-135b	CLIP-seq
MIRT881070	hsa-miR-1914	CLIP-seq
MIRT881071	hsa-miR-24	CLIP-seq
MIRT881072	hsa-miR-301a	CLIP-seq
MIRT881073	hsa-miR-301b	CLIP-seq
MIRT881074	hsa-miR-302a	CLIP-seq
MIRT881075	hsa-miR-302b	CLIP-seq
MIRT881076	hsa-miR-302c	CLIP-seq
MIRT881077	hsa-miR-302d	CLIP-seq
MIRT881078	hsa-miR-302e	CLIP-seq
MIRT881079	hsa-miR-3158-5p	CLIP-seq
MIRT881080	hsa-miR-3163	CLIP-seq
MIRT881081	hsa-miR-3194-3p	CLIP-seq
MIRT881082	hsa-miR-3202	CLIP-seq
MIRT881083	hsa-miR-3656	CLIP-seq
MIRT881084	hsa-miR-3664-3p	CLIP-seq
MIRT881085	hsa-miR-3677-5p	CLIP-seq
MIRT881086	hsa-miR-3689d	CLIP-seq
MIRT881087	hsa-miR-3714	CLIP-seq
MIRT881088	hsa-miR-372	CLIP-seq
MIRT881089	hsa-miR-373	CLIP-seq
MIRT881090	hsa-miR-3907	CLIP-seq
MIRT881091	hsa-miR-3945	CLIP-seq
MIRT881092	hsa-miR-4270	CLIP-seq
MIRT881093	hsa-miR-4284	CLIP-seq
MIRT881094	hsa-miR-4434	CLIP-seq
MIRT881095	hsa-miR-4441	CLIP-seq
MIRT881096	hsa-miR-4446-3p	CLIP-seq
MIRT881097	hsa-miR-4457	CLIP-seq
MIRT881098	hsa-miR-4473	CLIP-seq
MIRT881099	hsa-miR-4477a	CLIP-seq
MIRT881100	hsa-miR-4493	CLIP-seq
MIRT881101	hsa-miR-4516	CLIP-seq
MIRT881102	hsa-miR-454	CLIP-seq
MIRT881103	hsa-miR-4646-5p	CLIP-seq
MIRT881104	hsa-miR-4650-5p	CLIP-seq
MIRT881105	hsa-miR-4656	CLIP-seq
MIRT881106	hsa-miR-4663	CLIP-seq
MIRT881107	hsa-miR-4664-3p	CLIP-seq
MIRT881108	hsa-miR-4671-3p	CLIP-seq
MIRT881109	hsa-miR-4688	CLIP-seq
MIRT881110	hsa-miR-4731-3p	CLIP-seq
MIRT881111	hsa-miR-4731-5p	CLIP-seq
MIRT881112	hsa-miR-4739	CLIP-seq
MIRT881113	hsa-miR-4743	CLIP-seq
MIRT881114	hsa-miR-4747-5p	CLIP-seq
MIRT881115	hsa-miR-4749-3p	CLIP-seq
MIRT881116	hsa-miR-4753-5p	CLIP-seq
MIRT881117	hsa-miR-4755-3p	CLIP-seq
MIRT881118	hsa-miR-4756-5p	CLIP-seq
MIRT881119	hsa-miR-4761-3p	CLIP-seq
MIRT881120	hsa-miR-4763-3p	CLIP-seq
MIRT881121	hsa-miR-4766-3p	CLIP-seq
MIRT881122	hsa-miR-4796-3p	CLIP-seq
MIRT881123	hsa-miR-4801	CLIP-seq
MIRT881124	hsa-miR-512-3p	CLIP-seq
MIRT881125	hsa-miR-520a-3p	CLIP-seq
MIRT881126	hsa-miR-520b	CLIP-seq
MIRT881127	hsa-miR-520c-3p	CLIP-seq
MIRT881128	hsa-miR-520d-3p	CLIP-seq
MIRT881129	hsa-miR-520e	CLIP-seq
MIRT881130	hsa-miR-520g	CLIP-seq
MIRT881131	hsa-miR-520h	CLIP-seq
MIRT881132	hsa-miR-541	CLIP-seq
MIRT881133	hsa-miR-548p	CLIP-seq
MIRT881134	hsa-miR-577	CLIP-seq
MIRT881135	hsa-miR-654-5p	CLIP-seq
MIRT881136	hsa-miR-889	CLIP-seq
MIRT881137	hsa-miR-940	CLIP-seq
MIRT1921453	hsa-miR-4254	CLIP-seq
MIRT881061	hsa-miR-1184	CLIP-seq
MIRT881063	hsa-miR-1205	CLIP-seq
MIRT881065	hsa-miR-130a	CLIP-seq
MIRT881066	hsa-miR-130b	CLIP-seq
MIRT1960995	hsa-miR-1343	CLIP-seq
MIRT881072	hsa-miR-301a	CLIP-seq
MIRT881073	hsa-miR-301b	CLIP-seq
MIRT1960996	hsa-miR-3144-5p	CLIP-seq
MIRT881079	hsa-miR-3158-5p	CLIP-seq
MIRT1960997	hsa-miR-3189-3p	CLIP-seq
MIRT881081	hsa-miR-3194-3p	CLIP-seq
MIRT881083	hsa-miR-3656	CLIP-seq
MIRT881085	hsa-miR-3677-5p	CLIP-seq
MIRT1960998	hsa-miR-3690	CLIP-seq
MIRT881090	hsa-miR-3907	CLIP-seq
MIRT1921453	hsa-miR-4254	CLIP-seq
MIRT881092	hsa-miR-4270	CLIP-seq
MIRT881094	hsa-miR-4434	CLIP-seq
MIRT881095	hsa-miR-4441	CLIP-seq
MIRT881098	hsa-miR-4473	CLIP-seq
MIRT1960999	hsa-miR-4475	CLIP-seq
MIRT881100	hsa-miR-4493	CLIP-seq
MIRT881101	hsa-miR-4516	CLIP-seq
MIRT881102	hsa-miR-454	CLIP-seq
MIRT881108	hsa-miR-4671-3p	CLIP-seq
MIRT1961000	hsa-miR-4715-3p	CLIP-seq
MIRT881113	hsa-miR-4743	CLIP-seq
MIRT881116	hsa-miR-4753-5p	CLIP-seq
MIRT1961001	hsa-miR-483-3p	CLIP-seq
MIRT1961002	hsa-miR-619	CLIP-seq
MIRT1961003	hsa-miR-659	CLIP-seq
MIRT1961004	hsa-miR-711	CLIP-seq
MIRT881061	hsa-miR-1184	CLIP-seq
MIRT881062	hsa-miR-1197	CLIP-seq
MIRT881063	hsa-miR-1205	CLIP-seq
MIRT881064	hsa-miR-1207-5p	CLIP-seq
MIRT2197716	hsa-miR-1275	CLIP-seq
MIRT2197717	hsa-miR-1293	CLIP-seq
MIRT881065	hsa-miR-130a	CLIP-seq
MIRT881066	hsa-miR-130b	CLIP-seq
MIRT881067	hsa-miR-1321	CLIP-seq
MIRT1960995	hsa-miR-1343	CLIP-seq
MIRT881068	hsa-miR-135a	CLIP-seq
MIRT881069	hsa-miR-135b	CLIP-seq
MIRT2197718	hsa-miR-141	CLIP-seq
MIRT881070	hsa-miR-1914	CLIP-seq
MIRT2197719	hsa-miR-198	CLIP-seq
MIRT2197720	hsa-miR-200a	CLIP-seq
MIRT881071	hsa-miR-24	CLIP-seq
MIRT2197721	hsa-miR-2467-5p	CLIP-seq
MIRT881072	hsa-miR-301a	CLIP-seq
MIRT881073	hsa-miR-301b	CLIP-seq
MIRT881074	hsa-miR-302a	CLIP-seq
MIRT881075	hsa-miR-302b	CLIP-seq
MIRT881076	hsa-miR-302c	CLIP-seq
MIRT881077	hsa-miR-302d	CLIP-seq
MIRT881078	hsa-miR-302e	CLIP-seq
MIRT1960996	hsa-miR-3144-5p	CLIP-seq
MIRT2197722	hsa-miR-3151	CLIP-seq
MIRT881079	hsa-miR-3158-5p	CLIP-seq
MIRT2197723	hsa-miR-3173-3p	CLIP-seq
MIRT2197724	hsa-miR-3175	CLIP-seq
MIRT1960997	hsa-miR-3189-3p	CLIP-seq
MIRT2197725	hsa-miR-3191	CLIP-seq
MIRT881081	hsa-miR-3194-3p	CLIP-seq
MIRT2197726	hsa-miR-3197	CLIP-seq
MIRT2197727	hsa-miR-3199	CLIP-seq
MIRT881082	hsa-miR-3202	CLIP-seq
MIRT2197728	hsa-miR-3649	CLIP-seq
MIRT881083	hsa-miR-3656	CLIP-seq
MIRT881084	hsa-miR-3664-3p	CLIP-seq
MIRT881085	hsa-miR-3677-5p	CLIP-seq
MIRT881086	hsa-miR-3689d	CLIP-seq
MIRT1960998	hsa-miR-3690	CLIP-seq
MIRT2197729	hsa-miR-370	CLIP-seq
MIRT881087	hsa-miR-3714	CLIP-seq
MIRT881088	hsa-miR-372	CLIP-seq
MIRT881089	hsa-miR-373	CLIP-seq
MIRT881090	hsa-miR-3907	CLIP-seq
MIRT1921453	hsa-miR-4254	CLIP-seq
MIRT2197730	hsa-miR-4265	CLIP-seq
MIRT881092	hsa-miR-4270	CLIP-seq
MIRT881093	hsa-miR-4284	CLIP-seq
MIRT2197731	hsa-miR-4296	CLIP-seq
MIRT2197732	hsa-miR-4322	CLIP-seq
MIRT881094	hsa-miR-4434	CLIP-seq
MIRT881095	hsa-miR-4441	CLIP-seq
MIRT881096	hsa-miR-4446-3p	CLIP-seq
MIRT2197733	hsa-miR-4447	CLIP-seq
MIRT881097	hsa-miR-4457	CLIP-seq
MIRT2197734	hsa-miR-4472	CLIP-seq
MIRT881098	hsa-miR-4473	CLIP-seq
MIRT1960999	hsa-miR-4475	CLIP-seq
MIRT2197735	hsa-miR-4483	CLIP-seq
MIRT881100	hsa-miR-4493	CLIP-seq
MIRT881101	hsa-miR-4516	CLIP-seq
MIRT2197736	hsa-miR-4525	CLIP-seq
MIRT881102	hsa-miR-454	CLIP-seq
MIRT881103	hsa-miR-4646-5p	CLIP-seq
MIRT2197737	hsa-miR-4648	CLIP-seq
MIRT2197738	hsa-miR-4649-3p	CLIP-seq
MIRT881104	hsa-miR-4650-5p	CLIP-seq
MIRT2197739	hsa-miR-4652-5p	CLIP-seq
MIRT881105	hsa-miR-4656	CLIP-seq
MIRT881106	hsa-miR-4663	CLIP-seq
MIRT881107	hsa-miR-4664-3p	CLIP-seq
MIRT2197740	hsa-miR-4665-5p	CLIP-seq
MIRT881108	hsa-miR-4671-3p	CLIP-seq
MIRT881109	hsa-miR-4688	CLIP-seq
MIRT2197741	hsa-miR-4695-5p	CLIP-seq
MIRT2197742	hsa-miR-4723-5p	CLIP-seq
MIRT881110	hsa-miR-4731-3p	CLIP-seq
MIRT881111	hsa-miR-4731-5p	CLIP-seq
MIRT2197743	hsa-miR-4736	CLIP-seq
MIRT881112	hsa-miR-4739	CLIP-seq
MIRT881113	hsa-miR-4743	CLIP-seq
MIRT881114	hsa-miR-4747-5p	CLIP-seq
MIRT881115	hsa-miR-4749-3p	CLIP-seq
MIRT881116	hsa-miR-4753-5p	CLIP-seq
MIRT881117	hsa-miR-4755-3p	CLIP-seq
MIRT881118	hsa-miR-4756-5p	CLIP-seq
MIRT881120	hsa-miR-4763-3p	CLIP-seq
MIRT881121	hsa-miR-4766-3p	CLIP-seq
MIRT881122	hsa-miR-4796-3p	CLIP-seq
MIRT881123	hsa-miR-4801	CLIP-seq
MIRT1961001	hsa-miR-483-3p	CLIP-seq
MIRT2197744	hsa-miR-491-5p	CLIP-seq
MIRT881124	hsa-miR-512-3p	CLIP-seq
MIRT881125	hsa-miR-520a-3p	CLIP-seq
MIRT881126	hsa-miR-520b	CLIP-seq
MIRT881127	hsa-miR-520c-3p	CLIP-seq
MIRT881128	hsa-miR-520d-3p	CLIP-seq
MIRT881129	hsa-miR-520e	CLIP-seq
MIRT2197745	hsa-miR-520f	CLIP-seq
MIRT881130	hsa-miR-520g	CLIP-seq
MIRT881131	hsa-miR-520h	CLIP-seq
MIRT881132	hsa-miR-541	CLIP-seq
MIRT881133	hsa-miR-548p	CLIP-seq
MIRT881134	hsa-miR-577	CLIP-seq
MIRT2197746	hsa-miR-618	CLIP-seq
MIRT2197747	hsa-miR-625	CLIP-seq
MIRT2197748	hsa-miR-637	CLIP-seq
MIRT2197749	hsa-miR-639	CLIP-seq
MIRT881135	hsa-miR-654-5p	CLIP-seq
MIRT1961003	hsa-miR-659	CLIP-seq
MIRT1961004	hsa-miR-711	CLIP-seq
MIRT2197750	hsa-miR-720	CLIP-seq
MIRT881137	hsa-miR-940	CLIP-seq
MIRT881065	hsa-miR-130a	CLIP-seq
MIRT881066	hsa-miR-130b	CLIP-seq
MIRT881072	hsa-miR-301a	CLIP-seq
MIRT881073	hsa-miR-301b	CLIP-seq
MIRT881094	hsa-miR-4434	CLIP-seq
MIRT881098	hsa-miR-4473	CLIP-seq
MIRT881100	hsa-miR-4493	CLIP-seq
MIRT881101	hsa-miR-4516	CLIP-seq
MIRT881102	hsa-miR-454	CLIP-seq
MIRT881107	hsa-miR-4664-3p	CLIP-seq
MIRT881108	hsa-miR-4671-3p	CLIP-seq
MIRT881116	hsa-miR-4753-5p	CLIP-seq
MIRT881132	hsa-miR-541	CLIP-seq
MIRT881135	hsa-miR-654-5p	CLIP-seq
MIRT1960997	hsa-miR-3189-3p	CLIP-seq
MIRT1921453	hsa-miR-4254	CLIP-seq
MIRT1961000	hsa-miR-4715-3p	CLIP-seq
MIRT1961001	hsa-miR-483-3p	CLIP-seq
MIRT1961002	hsa-miR-619	CLIP-seq
MIRT1961003	hsa-miR-659	CLIP-seq
MIRT1960995	hsa-miR-1343	CLIP-seq
MIRT1960997	hsa-miR-3189-3p	CLIP-seq
MIRT1960998	hsa-miR-3690	CLIP-seq
MIRT1921453	hsa-miR-4254	CLIP-seq
MIRT1961000	hsa-miR-4715-3p	CLIP-seq
MIRT1961001	hsa-miR-483-3p	CLIP-seq
MIRT1961002	hsa-miR-619	CLIP-seq
MIRT1961003	hsa-miR-659	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14985111, 23781148, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	33283408
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0005874	Component	Microtubule	ISS
GO:0016581	Component	NuRD complex	IDA	33283408
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IBA
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IEA
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	ISS
GO:2000035	Process	Regulation of stem cell division	IEA
GO:2000035	Process	Regulation of stem cell division	ISS
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IBA
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IMP	23781148

Other IDs

• MIM: 620061
• HGNC: 30833
• e!Ensembl: ENSG00000167797

Protein

• UniProt ID: O75956
• Protein name: Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R)
• Protein function: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by
• PDB: 2M1L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09806	CDK2AP	59 → 125	Cyclin-dependent kinase 2-associated protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10082655}.
• Sequence:

  MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQ
  AMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAET
  ERNART

• Sequence length: 126

Pathways

KEGG:

ATP-dependent chromatin remodeling

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs144468375	RCV005905278
Adrenocortical carcinoma, hereditary	Benign	rs144468375	RCV005905282
Cervical cancer	Benign	rs144468375	RCV005905283
Clear cell carcinoma of kidney	Benign	rs144468375	RCV005905284
Colon adenocarcinoma	Benign	rs144468375	RCV005905277
Colorectal cancer	Benign	rs144468375	RCV005905287
Hepatocellular carcinoma	Benign	rs144468375	RCV005905279
Lung cancer	Benign	rs144468375	RCV005905293
Lymphoma	Benign	rs144468375	RCV005905289
Malignant lymphoma, large B-cell, diffuse	Benign	rs144468375	RCV005905286
Malignant tumor of esophagus	Benign	rs144468375	RCV005905280
Melanoma	Benign	rs144468375	RCV005905292
Nonpapillary renal cell carcinoma	Benign	rs144468375	RCV005905281
Sarcoma	Benign	rs144468375	RCV005905288
Thymoma	Benign	rs144468375	RCV005905290
Thyroid cancer, nonmedullary, 1	Benign	rs144468375	RCV005905291
Uterine corpus endometrial carcinoma	Benign	rs144468375	RCV005905294
Uveal melanoma	Benign	rs144468375	RCV005905285

Associations from Text Mining
Disease Name	Relationship Type	References
Neoplasms	Inhibit	23781148