Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	10260
Gene name	DENN domain containing 4A
Gene symbol	DENND4A
Synonyms (NCBI Gene)	IRLBMYCPBP
Chromosome	15
Chromosome location	15q22.31
Summary	This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may

Show/Hide all (66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050274	hsa-miR-25-3p	CLASH	23622248
MIRT040677	hsa-miR-92b-3p	CLASH	23622248
MIRT932385	hsa-miR-1231	CLIP-seq
MIRT932386	hsa-miR-1273e	CLIP-seq
MIRT932387	hsa-miR-1299	CLIP-seq
MIRT932388	hsa-miR-139-5p	CLIP-seq
MIRT932389	hsa-miR-15a	CLIP-seq
MIRT932390	hsa-miR-15b	CLIP-seq
MIRT932391	hsa-miR-16	CLIP-seq
MIRT932392	hsa-miR-195	CLIP-seq
MIRT932393	hsa-miR-2964a-5p	CLIP-seq
MIRT932394	hsa-miR-3120-5p	CLIP-seq
MIRT932395	hsa-miR-3145-3p	CLIP-seq
MIRT932396	hsa-miR-3166	CLIP-seq
MIRT932397	hsa-miR-3201	CLIP-seq
MIRT932398	hsa-miR-320e	CLIP-seq
MIRT932399	hsa-miR-3671	CLIP-seq
MIRT932400	hsa-miR-3682-5p	CLIP-seq
MIRT932401	hsa-miR-3686	CLIP-seq
MIRT932402	hsa-miR-3920	CLIP-seq
MIRT932403	hsa-miR-424	CLIP-seq
MIRT932404	hsa-miR-4288	CLIP-seq
MIRT932405	hsa-miR-4327	CLIP-seq
MIRT932406	hsa-miR-4524	CLIP-seq
MIRT932407	hsa-miR-4652-3p	CLIP-seq
MIRT932408	hsa-miR-4682	CLIP-seq
MIRT932409	hsa-miR-4720-3p	CLIP-seq
MIRT932410	hsa-miR-4742-3p	CLIP-seq
MIRT932411	hsa-miR-4760-3p	CLIP-seq
MIRT932412	hsa-miR-4760-5p	CLIP-seq
MIRT932413	hsa-miR-4778-5p	CLIP-seq
MIRT932414	hsa-miR-4782-5p	CLIP-seq
MIRT932415	hsa-miR-4791	CLIP-seq
MIRT932416	hsa-miR-4804-3p	CLIP-seq
MIRT932417	hsa-miR-497	CLIP-seq
MIRT932418	hsa-miR-499a-5p	CLIP-seq
MIRT932419	hsa-miR-503	CLIP-seq
MIRT932420	hsa-miR-516b	CLIP-seq
MIRT932421	hsa-miR-543	CLIP-seq
MIRT932422	hsa-miR-579	CLIP-seq
MIRT932423	hsa-miR-607	CLIP-seq
MIRT932424	hsa-miR-626	CLIP-seq
MIRT932425	hsa-miR-627	CLIP-seq
MIRT932426	hsa-miR-632	CLIP-seq
MIRT932427	hsa-miR-646	CLIP-seq
MIRT932428	hsa-miR-664	CLIP-seq
MIRT932429	hsa-miR-922	CLIP-seq
MIRT932430	hsa-miR-924	CLIP-seq
MIRT932431	hsa-miR-1289	CLIP-seq
MIRT932389	hsa-miR-15a	CLIP-seq
MIRT932390	hsa-miR-15b	CLIP-seq
MIRT932391	hsa-miR-16	CLIP-seq
MIRT932392	hsa-miR-195	CLIP-seq
MIRT932396	hsa-miR-3166	CLIP-seq
MIRT932432	hsa-miR-3198	CLIP-seq
MIRT932399	hsa-miR-3671	CLIP-seq
MIRT932433	hsa-miR-3976	CLIP-seq
MIRT932403	hsa-miR-424	CLIP-seq
MIRT932434	hsa-miR-4294	CLIP-seq
MIRT932435	hsa-miR-4309	CLIP-seq
MIRT932406	hsa-miR-4524	CLIP-seq
MIRT932417	hsa-miR-497	CLIP-seq
MIRT932419	hsa-miR-503	CLIP-seq
MIRT932423	hsa-miR-607	CLIP-seq
MIRT932427	hsa-miR-646	CLIP-seq
MIRT932429	hsa-miR-922	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	NAS	8056341
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	15161933, 28514442, 33961781, 35271311, 36931259
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	8056341
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0032483	Process	Regulation of Rab protein signal transduction	IBA

MIM	HGNC	e!Ensembl
600382	24321	ENSG00000174485

Q7Z401

Protein name

C-myc promoter-binding protein (DENN domain-containing protein 4A)

Protein function

Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like e

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03456	uDENN	210 → 275	uDENN domain	Domain
PF02141	DENN	308 → 492	DENN (AEX-3) domain	Family
PF03455	dDENN	599 → 648	dDENN domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regul

Sequence

MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP
QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII
QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT
IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK
SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI
HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP
PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA
LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV
RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN
KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV
KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG
IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS
GGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQN
SSSIVRLTGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETN
LQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTL
DIGKPPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVAT
QNPKRIQRMNSSFSVKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSA
RRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPV
RLTKSKSYTKSEEKPRDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLR
NSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHEL
EGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQN
YAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRR
PGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENF
CTRSIQIPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDS
LGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFR
RLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWN
AHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLY
REILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGE
PYL

Sequence length

1863

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

DENND4A (DENN domain containing 4A)