STAM2 (signal transducing adaptor molecule 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10254 |
| Gene name | Signal transducing adaptor molecule 2 |
| Gene symbol | STAM2 |
| Synonyms (NCBI Gene) |
HbpSTAM2ASTAM2B
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| Chromosome | 2 |
| Chromosome location | 2q23.3 |
| Summary | The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, |
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miRNA
miRNA information provided by mirtarbase database.
497
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O75886 | ||||||||||||||||||||
| Protein name | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | ||||||||||||||||||||
| Protein function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involv | ||||||||||||||||||||
| PDB | 1X2Q , 1X5B , 2L0T , 5CRV , 5IXF | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10899310}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 525 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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