Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	10249
Gene name	Glycine-N-acyltransferase
Gene symbol	GLYAT
Synonyms (NCBI Gene)	ACGNATCATGAT
Chromosome	11
Chromosome location	11q12.1
Summary	The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA`s. Two transcript variants encoding different isoform

101

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miRTarBase ID	miRNA	Experiments	Reference
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT679250	hsa-miR-5693	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT679249	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT678450	hsa-miR-498	HITS-CLIP	23824327
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT679250	hsa-miR-5693	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT679249	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT678450	hsa-miR-498	HITS-CLIP	23824327
MIRT1022090	hsa-miR-1289	CLIP-seq
MIRT1022091	hsa-miR-142-5p	CLIP-seq
MIRT1022092	hsa-miR-185	CLIP-seq
MIRT1022093	hsa-miR-3149	CLIP-seq
MIRT1022094	hsa-miR-3198	CLIP-seq
MIRT1022095	hsa-miR-340	CLIP-seq
MIRT1022096	hsa-miR-4294	CLIP-seq
MIRT1022097	hsa-miR-4306	CLIP-seq
MIRT1022098	hsa-miR-4309	CLIP-seq
MIRT1022099	hsa-miR-4464	CLIP-seq
MIRT1022100	hsa-miR-4503	CLIP-seq
MIRT1022101	hsa-miR-4644	CLIP-seq
MIRT1022102	hsa-miR-4722-5p	CLIP-seq
MIRT1022103	hsa-miR-4748	CLIP-seq
MIRT1022104	hsa-miR-4768-3p	CLIP-seq
MIRT1022105	hsa-miR-494	CLIP-seq
MIRT1022106	hsa-miR-548m	CLIP-seq
MIRT1022107	hsa-miR-924	CLIP-seq
MIRT1022108	hsa-miR-1183	CLIP-seq
MIRT1022109	hsa-miR-1343	CLIP-seq
MIRT1022110	hsa-miR-28-5p	CLIP-seq
MIRT1022111	hsa-miR-3074-5p	CLIP-seq
MIRT1022112	hsa-miR-3139	CLIP-seq
MIRT1022113	hsa-miR-3690	CLIP-seq
MIRT1022114	hsa-miR-4254	CLIP-seq
MIRT1022115	hsa-miR-4733-5p	CLIP-seq
MIRT1022116	hsa-miR-4742-3p	CLIP-seq
MIRT1022117	hsa-miR-708	CLIP-seq
MIRT1022118	hsa-miR-889	CLIP-seq
MIRT2539805	hsa-miR-3689a-5p	CLIP-seq
MIRT2539806	hsa-miR-3689b	CLIP-seq
MIRT2539807	hsa-miR-3689e	CLIP-seq
MIRT2539808	hsa-miR-3689f	CLIP-seq
MIRT2539809	hsa-miR-513a-3p	CLIP-seq
MIRT2539810	hsa-miR-944	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	22475485
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005739	Component	Mitochondrion	TAS	9202629
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006544	Process	Glycine metabolic process	IBA
GO:0006544	Process	Glycine metabolic process	IDA	22475485
GO:0006544	Process	Glycine metabolic process	ISS
GO:0006637	Process	Acyl-CoA metabolic process	TAS	7802672
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0009636	Process	Response to toxic substance	IEA
GO:0009636	Process	Response to toxic substance	TAS	9202629
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016746	Function	Acyltransferase activity	TAS	9202629
GO:0032787	Process	Monocarboxylic acid metabolic process	ISS
GO:0047961	Function	Glycine N-acyltransferase activity	IBA
GO:0047961	Function	Glycine N-acyltransferase activity	IDA	22475485
GO:0047961	Function	Glycine N-acyltransferase activity	IEA
GO:0047962	Function	Glycine N-benzoyltransferase activity	IBA
GO:0047962	Function	Glycine N-benzoyltransferase activity	IDA	22475485
GO:0047962	Function	Glycine N-benzoyltransferase activity	IEA
GO:0047962	Function	Glycine N-benzoyltransferase activity	ISS
GO:0047962	Function	Glycine N-benzoyltransferase activity	TAS
GO:1901787	Process	Benzoyl-CoA metabolic process	IDA	22475485

MIM	HGNC	e!Ensembl
607424	13734	ENSG00000149124

Q6IB77

Protein name

Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1

Protein function

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06021	Gly_acyl_tr_N	2 → 206	Aralkyl acyl-CoA:amino acid N-acyltransferase	Family
PF08444	Gly_acyl_tr_C	207 → 295	Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269|PubMed:22475485}.

Sequence

MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCP
QEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAA
IKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPNGGKPKAINQEMFKLSSMDVTHAHL
VNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLH
GLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL

Sequence length

296

Interactions

View interactions

	Reactome
			Conjugation of salicylate with glycine Conjugation of benzoate with glycine

GLYAT (glycine-N-acyltransferase)