Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10248
Gene name	POP7 ribonuclease P/MRP subunit
Gene symbol	POP7
Synonyms (NCBI Gene)	0610037N12RikRPP2RPP20
Chromosome	7
Chromosome location	7q22.1

164

Show/Hide all (164)

miRTarBase ID	miRNA	Experiments	Reference
MIRT545072	hsa-miR-4704-5p	HITS-CLIP	21572407
MIRT545071	hsa-miR-1197	HITS-CLIP	21572407
MIRT102151	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT102153	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT102152	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT102156	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT102161	hsa-miR-3666	HITS-CLIP	21572407
MIRT102160	hsa-miR-4295	HITS-CLIP	21572407
MIRT102154	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT545070	hsa-miR-8076	HITS-CLIP	21572407
MIRT545069	hsa-miR-183-5p	HITS-CLIP	21572407
MIRT102164	hsa-miR-6080	HITS-CLIP	21572407
MIRT545068	hsa-miR-3117-5p	HITS-CLIP	21572407
MIRT102157	hsa-miR-1290	HITS-CLIP	21572407
MIRT102162	hsa-miR-4671-3p	HITS-CLIP	21572407
MIRT545067	hsa-miR-6083	HITS-CLIP	21572407
MIRT545072	hsa-miR-4704-5p	PAR-CLIP	20371350
MIRT545071	hsa-miR-1197	PAR-CLIP	20371350
MIRT102151	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT102153	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT102152	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT102156	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT102161	hsa-miR-3666	PAR-CLIP	20371350
MIRT102160	hsa-miR-4295	PAR-CLIP	20371350
MIRT102154	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT545070	hsa-miR-8076	PAR-CLIP	20371350
MIRT545069	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT560920	hsa-miR-4436a	PAR-CLIP	20371350
MIRT560919	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT102164	hsa-miR-6080	PAR-CLIP	20371350
MIRT545068	hsa-miR-3117-5p	PAR-CLIP	20371350
MIRT560918	hsa-miR-1286	PAR-CLIP	20371350
MIRT102157	hsa-miR-1290	PAR-CLIP	20371350
MIRT102162	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT545067	hsa-miR-6083	PAR-CLIP	20371350
MIRT545072	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT545071	hsa-miR-1197	PAR-CLIP	21572407
MIRT102151	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT102153	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT102152	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT102156	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT102161	hsa-miR-3666	PAR-CLIP	21572407
MIRT102160	hsa-miR-4295	PAR-CLIP	21572407
MIRT102154	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT545070	hsa-miR-8076	PAR-CLIP	21572407
MIRT545069	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT102164	hsa-miR-6080	PAR-CLIP	21572407
MIRT545068	hsa-miR-3117-5p	PAR-CLIP	21572407
MIRT102157	hsa-miR-1290	PAR-CLIP	21572407
MIRT102162	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT545067	hsa-miR-6083	PAR-CLIP	21572407
MIRT545071	hsa-miR-1197	PAR-CLIP	27292025
MIRT102157	hsa-miR-1290	PAR-CLIP	27292025
MIRT102151	hsa-miR-130a-3p	PAR-CLIP	27292025
MIRT102153	hsa-miR-130b-3p	PAR-CLIP	27292025
MIRT545069	hsa-miR-183-5p	PAR-CLIP	27292025
MIRT102152	hsa-miR-301a-3p	PAR-CLIP	27292025
MIRT102156	hsa-miR-301b-3p	PAR-CLIP	27292025
MIRT545068	hsa-miR-3117-5p	PAR-CLIP	27292025
MIRT102161	hsa-miR-3666	PAR-CLIP	27292025
MIRT102160	hsa-miR-4295	PAR-CLIP	27292025
MIRT102154	hsa-miR-454-3p	PAR-CLIP	27292025
MIRT102162	hsa-miR-4671-3p	PAR-CLIP	27292025
MIRT545072	hsa-miR-4704-5p	PAR-CLIP	27292025
MIRT102164	hsa-miR-6080	PAR-CLIP	27292025
MIRT545067	hsa-miR-6083	PAR-CLIP	27292025
MIRT545070	hsa-miR-8076	PAR-CLIP	27292025
MIRT545072	hsa-miR-4704-5p	HITS-CLIP	21572407
MIRT545071	hsa-miR-1197	HITS-CLIP	21572407
MIRT102151	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT102153	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT102152	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT102156	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT102161	hsa-miR-3666	HITS-CLIP	21572407
MIRT102160	hsa-miR-4295	HITS-CLIP	21572407
MIRT102154	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT545070	hsa-miR-8076	HITS-CLIP	21572407
MIRT545069	hsa-miR-183-5p	HITS-CLIP	21572407
MIRT102164	hsa-miR-6080	HITS-CLIP	21572407
MIRT545068	hsa-miR-3117-5p	HITS-CLIP	21572407
MIRT102157	hsa-miR-1290	HITS-CLIP	21572407
MIRT102162	hsa-miR-4671-3p	HITS-CLIP	21572407
MIRT545067	hsa-miR-6083	HITS-CLIP	21572407
MIRT545072	hsa-miR-4704-5p	PAR-CLIP	20371350
MIRT545071	hsa-miR-1197	PAR-CLIP	20371350
MIRT102151	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT102153	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT102152	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT102156	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT102161	hsa-miR-3666	PAR-CLIP	20371350
MIRT102160	hsa-miR-4295	PAR-CLIP	20371350
MIRT102154	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT545070	hsa-miR-8076	PAR-CLIP	20371350
MIRT545069	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT560920	hsa-miR-4436a	PAR-CLIP	20371350
MIRT560919	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT102164	hsa-miR-6080	PAR-CLIP	20371350
MIRT545068	hsa-miR-3117-5p	PAR-CLIP	20371350
MIRT560918	hsa-miR-1286	PAR-CLIP	20371350
MIRT102157	hsa-miR-1290	PAR-CLIP	20371350
MIRT102162	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT545067	hsa-miR-6083	PAR-CLIP	20371350
MIRT545072	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT545071	hsa-miR-1197	PAR-CLIP	21572407
MIRT102151	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT102153	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT102152	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT102156	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT102161	hsa-miR-3666	PAR-CLIP	21572407
MIRT102160	hsa-miR-4295	PAR-CLIP	21572407
MIRT102154	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT545070	hsa-miR-8076	PAR-CLIP	21572407
MIRT545069	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT102164	hsa-miR-6080	PAR-CLIP	21572407
MIRT545068	hsa-miR-3117-5p	PAR-CLIP	21572407
MIRT102157	hsa-miR-1290	PAR-CLIP	21572407
MIRT102162	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT545067	hsa-miR-6083	PAR-CLIP	21572407
MIRT1250237	hsa-miR-1207-5p	CLIP-seq
MIRT1250238	hsa-miR-1245b-5p	CLIP-seq
MIRT1250239	hsa-miR-130a	CLIP-seq
MIRT1250240	hsa-miR-130b	CLIP-seq
MIRT1250241	hsa-miR-1587	CLIP-seq
MIRT1250242	hsa-miR-183	CLIP-seq
MIRT1250243	hsa-miR-2115	CLIP-seq
MIRT1250244	hsa-miR-301a	CLIP-seq
MIRT1250245	hsa-miR-301b	CLIP-seq
MIRT1250246	hsa-miR-3142	CLIP-seq
MIRT1250247	hsa-miR-329	CLIP-seq
MIRT1250248	hsa-miR-362-3p	CLIP-seq
MIRT1250249	hsa-miR-3663-5p	CLIP-seq
MIRT1250250	hsa-miR-3941	CLIP-seq
MIRT1250251	hsa-miR-454	CLIP-seq
MIRT1250252	hsa-miR-4650-5p	CLIP-seq
MIRT1250253	hsa-miR-4666-5p	CLIP-seq
MIRT1250254	hsa-miR-4674	CLIP-seq
MIRT1250255	hsa-miR-4685-5p	CLIP-seq
MIRT1250256	hsa-miR-4712-5p	CLIP-seq
MIRT1250257	hsa-miR-4736	CLIP-seq
MIRT1250258	hsa-miR-4763-3p	CLIP-seq
MIRT1250259	hsa-miR-4802-3p	CLIP-seq
MIRT1250260	hsa-miR-600	CLIP-seq
MIRT1250261	hsa-miR-603	CLIP-seq
MIRT1250262	hsa-miR-760	CLIP-seq
MIRT1250263	hsa-miR-770-5p	CLIP-seq
MIRT1250242	hsa-miR-183	CLIP-seq
MIRT1250247	hsa-miR-329	CLIP-seq
MIRT1250248	hsa-miR-362-3p	CLIP-seq
MIRT1250249	hsa-miR-3663-5p	CLIP-seq
MIRT2073901	hsa-miR-3664-3p	CLIP-seq
MIRT1250250	hsa-miR-3941	CLIP-seq
MIRT2073902	hsa-miR-4301	CLIP-seq
MIRT2073903	hsa-miR-4476	CLIP-seq
MIRT2073904	hsa-miR-4493	CLIP-seq
MIRT2073905	hsa-miR-4637	CLIP-seq
MIRT1250253	hsa-miR-4666-5p	CLIP-seq
MIRT1250259	hsa-miR-4802-3p	CLIP-seq
MIRT2073906	hsa-miR-510	CLIP-seq
MIRT2073907	hsa-miR-582-3p	CLIP-seq
MIRT1250260	hsa-miR-600	CLIP-seq
MIRT1250261	hsa-miR-603	CLIP-seq
MIRT1250262	hsa-miR-760	CLIP-seq
MIRT2073908	hsa-miR-873	CLIP-seq
MIRT2073906	hsa-miR-510	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000172	Component	Ribonuclease MRP complex	IDA	16723659
GO:0000172	Component	Ribonuclease MRP complex	IEA
GO:0001682	Process	TRNA 5'-leader removal	IDA	16723659, 30454648
GO:0001682	Process	TRNA 5'-leader removal	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0004526	Function	Ribonuclease P activity	IDA	30454648
GO:0004526	Function	Ribonuclease P activity	IEA
GO:0005515	Function	Protein binding	IPI	14715275, 15096576, 25416956, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005655	Component	Nucleolar ribonuclease P complex	IEA
GO:0005730	Component	Nucleolus	IDA	20215441
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IBA
GO:0008033	Process	TRNA processing	IEA
GO:0030681	Component	Multimeric ribonuclease P complex	IDA	16723659, 30454648
GO:0033204	Function	Ribonuclease P RNA binding	IDA	16723659, 20215441, 30454648

MIM	HGNC	e!Ensembl
606113	19949	ENSG00000172336

O75817

Protein name

Ribonuclease P protein subunit p20 (RNaseP protein p20) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7)

Protein function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed

PDB

6AHR , 6AHU , 6CWX , 6LT7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12328	Rpp20	32 → 133	Rpp20 subunit of nuclear RNase MRP and P	Family

Sequence

MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGA
RGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREP
LTRIRNNSAIHIRVFRVTPK

Sequence length

140

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		tRNA processing in the nucleus

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Stimulate	35579257	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	35579257	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	35579257	★★★★★ ★☆☆☆☆ Found in Text Mining only

POP7 (POP7 ribonuclease P/MRP subunit)