MSLN (mesothelin)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 10232
Gene name Mesothelin
Gene symbol MSLN
Synonyms (NCBI Gene)
MPFSMRP
Chromosome 16
Chromosome location 16p13.3
Summary This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone m
miRNA miRNA information provided by mirtarbase database.
10
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (10)
miRTarBase ID miRNA Experiments Reference
MIRT019192 hsa-miR-335-5p Microarray 18185580
MIRT1161721 hsa-miR-1184 CLIP-seq
MIRT1161722 hsa-miR-1205 CLIP-seq
MIRT1161723 hsa-miR-187 CLIP-seq
MIRT1161724 hsa-miR-1909 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (4)
Transcription factor Regulation Reference
NAB1 Unknown 23025254
RFX1 Unknown 23025254
TEAD1 Activation 17909009
ZNF24 Unknown 23025254
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 14676194, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0005794 Component Golgi apparatus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601051 7371 ENSG00000102854
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13421
Protein name Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]
Protein function Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
PDB 4F3F , 7U8C , 7U9J , 7UED , 8CX3 , 8CXC , 8CYH , 8CZ8 , 8FSL , 8VM1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06060 Mesothelin 1 → 629 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269|PubMed:168
Sequence
Sequence length 630
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
EBV-positive nodal T- and NK-cell lymphoma Likely benign rs2544227544 RCV004557812
Show/Hide Text Mining Associations (75)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 22237988, 24639398
Adenocarcinoma Mucinous Associate 27062033
Adenocarcinoma of Lung Associate 26028668, 32648573
Alzheimer Disease Associate 40471493
Asbestosis Associate 32187018, 35987988
Astrocytoma Associate 18347077
Barrett Esophagus Associate 22237988
Bile Duct Neoplasms Associate 23064529
Brain Neoplasms Associate 36656512
Breast Neoplasms Associate 18245228, 18381931, 22418702, 22906263, 25193277, 25506917, 26172299, 31354732, 33418877, 35616135, 37747033