MSLN (mesothelin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10232
Gene name Gene Name - the full gene name approved by the HGNC.
Mesothelin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MSLN
Synonyms (NCBI Gene) Gene synonyms aliases
MPF, SMRP
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone m
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(10)
miRTarBase ID miRNA Experiments Reference
MIRT019192 hsa-miR-335-5p Microarray 18185580
MIRT1161721 hsa-miR-1184 CLIP-seq
MIRT1161722 hsa-miR-1205 CLIP-seq
MIRT1161723 hsa-miR-187 CLIP-seq
MIRT1161724 hsa-miR-1909 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(4)
Transcription factor Regulation Reference
NAB1 Unknown 23025254
RFX1 Unknown 23025254
TEAD1 Activation 17909009
ZNF24 Unknown 23025254
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 14676194, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0005794 Component Golgi apparatus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
601051 7371 ENSG00000102854
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Q13421
Protein name Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]
Protein function Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
PDB 4F3F , 7U8C , 7U9J , 7UED , 8CX3 , 8CXC , 8CYH , 8CZ8 , 8FSL , 8VM1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06060 Mesothelin 1 → 629 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269|PubMed:168
Sequence
Sequence length 630
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
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