Gene Gene information from NCBI Gene database.
Entrez ID 10231
Gene name Regulator of calcineurin 2
Gene symbol RCAN2
Synonyms (NCBI Gene)
CSP2DSCR1L1MCIP2RCN2ZAKI-4ZAKI4
Chromosome 6
Chromosome location 6p12.3
Summary This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the
miRNA miRNA information provided by mirtarbase database.
572
miRTarBase ID miRNA Experiments Reference
MIRT713224 hsa-miR-513b-3p HITS-CLIP 19536157
MIRT713223 hsa-miR-6777-3p HITS-CLIP 19536157
MIRT713222 hsa-miR-6511a-3p HITS-CLIP 19536157
MIRT713221 hsa-miR-6511b-3p HITS-CLIP 19536157
MIRT713220 hsa-miR-6509-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
GO:0006950 Process Response to stress IEA
GO:0006979 Process Response to oxidative stress IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604876 3041 ENSG00000172348
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14206
Protein name Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4)
Protein function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04847 Calcipressin 20 191 Calcipressin Family
Tissue specificity TISSUE SPECIFICITY: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas.
Sequence
Sequence length 197
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Thyroid hormone signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinogenesis Associate 36879212
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 36879212
★☆☆☆☆
Found in Text Mining only
Coxa Magna Associate 33542623
★☆☆☆☆
Found in Text Mining only
Down Syndrome Associate 33231770
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Associate 20008143
★☆☆☆☆
Found in Text Mining only
Glioma Associate 37918583
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 33231770
★☆☆☆☆
Found in Text Mining only
Pancreatitis Chronic Associate 36879212
★☆☆☆☆
Found in Text Mining only