Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10224
Gene name	Zinc finger protein 443
Gene symbol	ZNF443
Synonyms (NCBI Gene)	ZK1
Chromosome	19
Chromosome location	19p13.2
Summary	Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supp

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Show/Hide all (239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024834	hsa-miR-215-5p	Microarray	19074876
MIRT026465	hsa-miR-192-5p	Microarray	19074876
MIRT695263	hsa-miR-5700	HITS-CLIP	23313552
MIRT695262	hsa-miR-4678	HITS-CLIP	23313552
MIRT695261	hsa-miR-4461	HITS-CLIP	23313552
MIRT695260	hsa-miR-4305	HITS-CLIP	23313552
MIRT695259	hsa-let-7a-5p	HITS-CLIP	23313552
MIRT695258	hsa-let-7b-5p	HITS-CLIP	23313552
MIRT695257	hsa-let-7c-5p	HITS-CLIP	23313552
MIRT695256	hsa-let-7d-5p	HITS-CLIP	23313552
MIRT695255	hsa-let-7e-5p	HITS-CLIP	23313552
MIRT695254	hsa-let-7f-5p	HITS-CLIP	23313552
MIRT695253	hsa-let-7g-5p	HITS-CLIP	23313552
MIRT695252	hsa-let-7i-5p	HITS-CLIP	23313552
MIRT695251	hsa-miR-4458	HITS-CLIP	23313552
MIRT695250	hsa-miR-4500	HITS-CLIP	23313552
MIRT695249	hsa-miR-98-5p	HITS-CLIP	23313552
MIRT695248	hsa-miR-202-3p	HITS-CLIP	23313552
MIRT695247	hsa-miR-6076	HITS-CLIP	23313552
MIRT695246	hsa-miR-6797-3p	HITS-CLIP	23313552
MIRT695245	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT695244	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT695243	hsa-miR-3672	HITS-CLIP	23313552
MIRT695242	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT695241	hsa-miR-7856-5p	HITS-CLIP	23313552
MIRT695263	hsa-miR-5700	HITS-CLIP	23313552
MIRT695262	hsa-miR-4678	HITS-CLIP	23313552
MIRT695261	hsa-miR-4461	HITS-CLIP	23313552
MIRT695260	hsa-miR-4305	HITS-CLIP	23313552
MIRT695259	hsa-let-7a-5p	HITS-CLIP	23313552
MIRT695258	hsa-let-7b-5p	HITS-CLIP	23313552
MIRT695257	hsa-let-7c-5p	HITS-CLIP	23313552
MIRT695256	hsa-let-7d-5p	HITS-CLIP	23313552
MIRT695255	hsa-let-7e-5p	HITS-CLIP	23313552
MIRT695254	hsa-let-7f-5p	HITS-CLIP	23313552
MIRT695253	hsa-let-7g-5p	HITS-CLIP	23313552
MIRT695252	hsa-let-7i-5p	HITS-CLIP	23313552
MIRT695251	hsa-miR-4458	HITS-CLIP	23313552
MIRT695250	hsa-miR-4500	HITS-CLIP	23313552
MIRT695249	hsa-miR-98-5p	HITS-CLIP	23313552
MIRT695248	hsa-miR-202-3p	HITS-CLIP	23313552
MIRT695247	hsa-miR-6076	HITS-CLIP	23313552
MIRT695246	hsa-miR-6797-3p	HITS-CLIP	23313552
MIRT695245	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT695244	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT695243	hsa-miR-3672	HITS-CLIP	23313552
MIRT695242	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT695241	hsa-miR-7856-5p	HITS-CLIP	23313552
MIRT1525096	hsa-let-7a	CLIP-seq
MIRT1525097	hsa-let-7b	CLIP-seq
MIRT1525098	hsa-let-7c	CLIP-seq
MIRT1525099	hsa-let-7d	CLIP-seq
MIRT1525100	hsa-let-7e	CLIP-seq
MIRT1525101	hsa-let-7f	CLIP-seq
MIRT1525102	hsa-let-7g	CLIP-seq
MIRT1525103	hsa-let-7i	CLIP-seq
MIRT1525104	hsa-miR-1182	CLIP-seq
MIRT1525105	hsa-miR-1243	CLIP-seq
MIRT1525106	hsa-miR-1284	CLIP-seq
MIRT1525107	hsa-miR-1287	CLIP-seq
MIRT1525108	hsa-miR-153	CLIP-seq
MIRT1525109	hsa-miR-181a	CLIP-seq
MIRT1525110	hsa-miR-181b	CLIP-seq
MIRT1525111	hsa-miR-181c	CLIP-seq
MIRT1525112	hsa-miR-181d	CLIP-seq
MIRT1525113	hsa-miR-1912	CLIP-seq
MIRT1525114	hsa-miR-202	CLIP-seq
MIRT1525115	hsa-miR-214	CLIP-seq
MIRT1525116	hsa-miR-217	CLIP-seq
MIRT1525117	hsa-miR-27a	CLIP-seq
MIRT1525118	hsa-miR-27b	CLIP-seq
MIRT1525119	hsa-miR-302a	CLIP-seq
MIRT1525120	hsa-miR-302b	CLIP-seq
MIRT1525121	hsa-miR-302c	CLIP-seq
MIRT1525122	hsa-miR-302d	CLIP-seq
MIRT1525123	hsa-miR-302e	CLIP-seq
MIRT1525124	hsa-miR-3130-5p	CLIP-seq
MIRT1525125	hsa-miR-3135b	CLIP-seq
MIRT1525126	hsa-miR-3200-5p	CLIP-seq
MIRT1525127	hsa-miR-323b-3p	CLIP-seq
MIRT1525128	hsa-miR-338-5p	CLIP-seq
MIRT1525129	hsa-miR-3619-5p	CLIP-seq
MIRT1525130	hsa-miR-3647-3p	CLIP-seq
MIRT1525131	hsa-miR-3654	CLIP-seq
MIRT1525132	hsa-miR-372	CLIP-seq
MIRT1525133	hsa-miR-373	CLIP-seq
MIRT1525134	hsa-miR-374a	CLIP-seq
MIRT1525135	hsa-miR-374b	CLIP-seq
MIRT1525136	hsa-miR-376c	CLIP-seq
MIRT1525137	hsa-miR-3938	CLIP-seq
MIRT1525138	hsa-miR-3978	CLIP-seq
MIRT1525139	hsa-miR-4262	CLIP-seq
MIRT1525140	hsa-miR-4275	CLIP-seq
MIRT1525141	hsa-miR-4284	CLIP-seq
MIRT1525142	hsa-miR-433	CLIP-seq
MIRT1525143	hsa-miR-4418	CLIP-seq
MIRT1525144	hsa-miR-448	CLIP-seq
MIRT1525145	hsa-miR-4482	CLIP-seq
MIRT1525146	hsa-miR-4530	CLIP-seq
MIRT1525147	hsa-miR-4666-3p	CLIP-seq
MIRT1525148	hsa-miR-4704-5p	CLIP-seq
MIRT1525149	hsa-miR-4724-5p	CLIP-seq
MIRT1525150	hsa-miR-4738-3p	CLIP-seq
MIRT1525151	hsa-miR-4773	CLIP-seq
MIRT1525152	hsa-miR-4781-3p	CLIP-seq
MIRT1525153	hsa-miR-509-3-5p	CLIP-seq
MIRT1525154	hsa-miR-509-5p	CLIP-seq
MIRT1525155	hsa-miR-512-3p	CLIP-seq
MIRT1525156	hsa-miR-513a-5p	CLIP-seq
MIRT1525157	hsa-miR-515-5p	CLIP-seq
MIRT1525158	hsa-miR-520a-3p	CLIP-seq
MIRT1525159	hsa-miR-520b	CLIP-seq
MIRT1525160	hsa-miR-520c-3p	CLIP-seq
MIRT1525161	hsa-miR-520d-3p	CLIP-seq
MIRT1525162	hsa-miR-520e	CLIP-seq
MIRT1525163	hsa-miR-520f	CLIP-seq
MIRT1525164	hsa-miR-606	CLIP-seq
MIRT1525165	hsa-miR-761	CLIP-seq
MIRT1525166	hsa-miR-875-3p	CLIP-seq
MIRT1525167	hsa-miR-943	CLIP-seq
MIRT1525168	hsa-miR-98	CLIP-seq
MIRT1525096	hsa-let-7a	CLIP-seq
MIRT1525097	hsa-let-7b	CLIP-seq
MIRT1525098	hsa-let-7c	CLIP-seq
MIRT1525099	hsa-let-7d	CLIP-seq
MIRT1525100	hsa-let-7e	CLIP-seq
MIRT1525101	hsa-let-7f	CLIP-seq
MIRT1525102	hsa-let-7g	CLIP-seq
MIRT1525103	hsa-let-7i	CLIP-seq
MIRT1525104	hsa-miR-1182	CLIP-seq
MIRT1525114	hsa-miR-202	CLIP-seq
MIRT1525117	hsa-miR-27a	CLIP-seq
MIRT1525118	hsa-miR-27b	CLIP-seq
MIRT1525119	hsa-miR-302a	CLIP-seq
MIRT1525120	hsa-miR-302b	CLIP-seq
MIRT1525121	hsa-miR-302c	CLIP-seq
MIRT1525122	hsa-miR-302d	CLIP-seq
MIRT1525123	hsa-miR-302e	CLIP-seq
MIRT1525128	hsa-miR-338-5p	CLIP-seq
MIRT1525132	hsa-miR-372	CLIP-seq
MIRT1525133	hsa-miR-373	CLIP-seq
MIRT1525134	hsa-miR-374a	CLIP-seq
MIRT1525135	hsa-miR-374b	CLIP-seq
MIRT1525136	hsa-miR-376c	CLIP-seq
MIRT1525137	hsa-miR-3938	CLIP-seq
MIRT1525140	hsa-miR-4275	CLIP-seq
MIRT1525141	hsa-miR-4284	CLIP-seq
MIRT1525142	hsa-miR-433	CLIP-seq
MIRT1525147	hsa-miR-4666-3p	CLIP-seq
MIRT1525148	hsa-miR-4704-5p	CLIP-seq
MIRT1525151	hsa-miR-4773	CLIP-seq
MIRT1525152	hsa-miR-4781-3p	CLIP-seq
MIRT1525156	hsa-miR-513a-5p	CLIP-seq
MIRT1525157	hsa-miR-515-5p	CLIP-seq
MIRT1525158	hsa-miR-520a-3p	CLIP-seq
MIRT1525159	hsa-miR-520b	CLIP-seq
MIRT1525160	hsa-miR-520c-3p	CLIP-seq
MIRT1525161	hsa-miR-520d-3p	CLIP-seq
MIRT1525162	hsa-miR-520e	CLIP-seq
MIRT1525168	hsa-miR-98	CLIP-seq
MIRT1525096	hsa-let-7a	CLIP-seq
MIRT1525097	hsa-let-7b	CLIP-seq
MIRT1525098	hsa-let-7c	CLIP-seq
MIRT1525099	hsa-let-7d	CLIP-seq
MIRT1525100	hsa-let-7e	CLIP-seq
MIRT1525101	hsa-let-7f	CLIP-seq
MIRT1525102	hsa-let-7g	CLIP-seq
MIRT1525103	hsa-let-7i	CLIP-seq
MIRT1525104	hsa-miR-1182	CLIP-seq
MIRT1525105	hsa-miR-1243	CLIP-seq
MIRT1525106	hsa-miR-1284	CLIP-seq
MIRT1525107	hsa-miR-1287	CLIP-seq
MIRT1525109	hsa-miR-181a	CLIP-seq
MIRT1525110	hsa-miR-181b	CLIP-seq
MIRT1525111	hsa-miR-181c	CLIP-seq
MIRT1525112	hsa-miR-181d	CLIP-seq
MIRT1525113	hsa-miR-1912	CLIP-seq
MIRT1525114	hsa-miR-202	CLIP-seq
MIRT2378140	hsa-miR-203	CLIP-seq
MIRT1525115	hsa-miR-214	CLIP-seq
MIRT1525116	hsa-miR-217	CLIP-seq
MIRT2378141	hsa-miR-24	CLIP-seq
MIRT1525117	hsa-miR-27a	CLIP-seq
MIRT1525118	hsa-miR-27b	CLIP-seq
MIRT1525119	hsa-miR-302a	CLIP-seq
MIRT1525120	hsa-miR-302b	CLIP-seq
MIRT1525121	hsa-miR-302c	CLIP-seq
MIRT1525122	hsa-miR-302d	CLIP-seq
MIRT1525123	hsa-miR-302e	CLIP-seq
MIRT1525124	hsa-miR-3130-5p	CLIP-seq
MIRT1525125	hsa-miR-3135b	CLIP-seq
MIRT2378142	hsa-miR-3163	CLIP-seq
MIRT1525126	hsa-miR-3200-5p	CLIP-seq
MIRT1525127	hsa-miR-323b-3p	CLIP-seq
MIRT2378143	hsa-miR-340	CLIP-seq
MIRT1525129	hsa-miR-3619-5p	CLIP-seq
MIRT1525130	hsa-miR-3647-3p	CLIP-seq
MIRT1525131	hsa-miR-3654	CLIP-seq
MIRT1525132	hsa-miR-372	CLIP-seq
MIRT1525133	hsa-miR-373	CLIP-seq
MIRT1525138	hsa-miR-3978	CLIP-seq
MIRT1525139	hsa-miR-4262	CLIP-seq
MIRT1525140	hsa-miR-4275	CLIP-seq
MIRT1525141	hsa-miR-4284	CLIP-seq
MIRT1525143	hsa-miR-4418	CLIP-seq
MIRT1525145	hsa-miR-4482	CLIP-seq
MIRT1525146	hsa-miR-4530	CLIP-seq
MIRT2378144	hsa-miR-4638-3p	CLIP-seq
MIRT1525148	hsa-miR-4704-5p	CLIP-seq
MIRT1525149	hsa-miR-4724-5p	CLIP-seq
MIRT1525150	hsa-miR-4738-3p	CLIP-seq
MIRT2378145	hsa-miR-4766-5p	CLIP-seq
MIRT1525153	hsa-miR-509-3-5p	CLIP-seq
MIRT1525154	hsa-miR-509-5p	CLIP-seq
MIRT1525155	hsa-miR-512-3p	CLIP-seq
MIRT1525156	hsa-miR-513a-5p	CLIP-seq
MIRT1525158	hsa-miR-520a-3p	CLIP-seq
MIRT1525159	hsa-miR-520b	CLIP-seq
MIRT1525160	hsa-miR-520c-3p	CLIP-seq
MIRT1525161	hsa-miR-520d-3p	CLIP-seq
MIRT1525162	hsa-miR-520e	CLIP-seq
MIRT1525163	hsa-miR-520f	CLIP-seq
MIRT1525164	hsa-miR-606	CLIP-seq
MIRT2378146	hsa-miR-616	CLIP-seq
MIRT1525165	hsa-miR-761	CLIP-seq
MIRT1525166	hsa-miR-875-3p	CLIP-seq
MIRT1525167	hsa-miR-943	CLIP-seq
MIRT1525168	hsa-miR-98	CLIP-seq
MIRT1525104	hsa-miR-1182	CLIP-seq
MIRT2696027	hsa-miR-1260	CLIP-seq
MIRT2696028	hsa-miR-1260b	CLIP-seq
MIRT2696029	hsa-miR-188-3p	CLIP-seq
MIRT1525117	hsa-miR-27a	CLIP-seq
MIRT1525118	hsa-miR-27b	CLIP-seq
MIRT2696030	hsa-miR-3156-3p	CLIP-seq
MIRT2696031	hsa-miR-3160-5p	CLIP-seq
MIRT1525156	hsa-miR-513a-5p	CLIP-seq
MIRT1525157	hsa-miR-515-5p	CLIP-seq
MIRT2696032	hsa-miR-587	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006915	Process	Apoptotic process	TAS	9731181
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
606697	20878	ENSG00000180855

Q9Y2A4

Protein name

Zinc finger protein 443 (Krueppel-type zinc finger protein ZK1)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	3 → 43	KRAB box	Family
PF00096	zf-C2H2	169 → 190	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	225 → 247	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	253 → 275	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	309 → 331	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	337 → 359	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	365 → 387	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	393 → 415	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	421 → 443	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	449 → 471	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	504 → 526	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	532 → 554	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	588 → 610	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	616 → 641		Domain
PF13912	zf-C2H2_6	649 → 671		Domain

Sequence

MASVALEDVAVNFTREEWALLGPCQKNLYKDVMQETIRNLDCVVMKWKDQNIEDQYRYPR
KNLRCRMLERFVESKDGTQCGETSSQIQDSIVTKNTLPGVGPCESSMRGEKVMGHSSLNC
YIRVGAGHKPHEYHECGEKPDTHKQRGKAFSYHNSFQTHERLHTGKKPYDCKECGKSFSS
LGNLQRHMAVQRGDGPYKCKLCGKAFFWPSLLHMHERTHTGEKPYECKQCSKAFSFYSSY
LRHERTHTGEKPYECKQCSKAFPFYSSYLRHERTHTGEKPYKCKQCSKAFPDSSSCLIHE
RTHTGEKPYTCKQCGKAFSVSGSLQRHETTHSAEKPYACQQCGKAFHHLGSFQRHMIRHT
GNGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGKALSHRSSFRSHMIMHTGDGP
HKCKVCGKAFVYPSVFQRHERTHTAEKPYKCKQCGKAYRISSSLRRHETTHTGEKPYKCK
LGKACIDFCSFQNHKTTHTGEKPYECKECGKAFSRFRYLSRHKRTHTGEKPYECKTCRKA
FGHYDNLKVHERIHSGEKPYECKECGKAFSWLTCFLRHERIHMREKSYECPQCGKAFTHS
RFLQGHEKTHTGENPYECKECGKAFASLSSLHRHKKTHWKKTHTGENPYECKECGKAFAS
LSSLHRHKKTH

Sequence length

671

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Squamous Cell Carcinoma of Head and Neck	Associate	23817087, 31698994	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF443 (zinc finger protein 443)