GPA33 (glycoprotein A33)

Gene

• Entrez ID: 10223
• Gene name: Glycoprotein A33
• Gene symbol: GPA33
• Synonyms (NCBI Gene): A33
• Chromosome: 1
• Chromosome location: 1q24.1
• Summary: The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosyla

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1028031	hsa-miR-1281	CLIP-seq
MIRT1028032	hsa-miR-1286	CLIP-seq
MIRT1028033	hsa-miR-1294	CLIP-seq
MIRT1028034	hsa-miR-1298	CLIP-seq
MIRT1028035	hsa-miR-185	CLIP-seq
MIRT1028036	hsa-miR-193a-3p	CLIP-seq
MIRT1028037	hsa-miR-193b	CLIP-seq
MIRT1028038	hsa-miR-2110	CLIP-seq
MIRT1028039	hsa-miR-214	CLIP-seq
MIRT1028040	hsa-miR-27a	CLIP-seq
MIRT1028041	hsa-miR-27b	CLIP-seq
MIRT1028042	hsa-miR-3619-5p	CLIP-seq
MIRT1028043	hsa-miR-3676	CLIP-seq
MIRT1028044	hsa-miR-3914	CLIP-seq
MIRT1028045	hsa-miR-4254	CLIP-seq
MIRT1028046	hsa-miR-4271	CLIP-seq
MIRT1028047	hsa-miR-4291	CLIP-seq
MIRT1028048	hsa-miR-4292	CLIP-seq
MIRT1028049	hsa-miR-4306	CLIP-seq
MIRT1028050	hsa-miR-4308	CLIP-seq
MIRT1028051	hsa-miR-4436a	CLIP-seq
MIRT1028052	hsa-miR-4642	CLIP-seq
MIRT1028053	hsa-miR-4644	CLIP-seq
MIRT1028054	hsa-miR-4681	CLIP-seq
MIRT1028055	hsa-miR-4700-3p	CLIP-seq
MIRT1028056	hsa-miR-4720-5p	CLIP-seq
MIRT1028057	hsa-miR-4722-5p	CLIP-seq
MIRT1028058	hsa-miR-4725-3p	CLIP-seq
MIRT1028059	hsa-miR-4799-3p	CLIP-seq
MIRT1028060	hsa-miR-513a-5p	CLIP-seq
MIRT1028061	hsa-miR-576-3p	CLIP-seq
MIRT1028062	hsa-miR-664	CLIP-seq
MIRT1028063	hsa-miR-761	CLIP-seq
MIRT1028064	hsa-miR-873	CLIP-seq
MIRT1028065	hsa-miR-885-3p	CLIP-seq
MIRT1028066	hsa-miR-892b	CLIP-seq
MIRT1028067	hsa-miR-922	CLIP-seq
MIRT2004957	hsa-miR-1	CLIP-seq
MIRT1028032	hsa-miR-1286	CLIP-seq
MIRT2004958	hsa-miR-206	CLIP-seq
MIRT2004959	hsa-miR-3127-5p	CLIP-seq
MIRT2004960	hsa-miR-3158-3p	CLIP-seq
MIRT2004961	hsa-miR-3673	CLIP-seq
MIRT1028044	hsa-miR-3914	CLIP-seq
MIRT2004962	hsa-miR-4270	CLIP-seq
MIRT1028051	hsa-miR-4436a	CLIP-seq
MIRT2004963	hsa-miR-4441	CLIP-seq
MIRT1028057	hsa-miR-4722-5p	CLIP-seq
MIRT2004964	hsa-miR-613	CLIP-seq
MIRT1028064	hsa-miR-873	CLIP-seq
MIRT1028032	hsa-miR-1286	CLIP-seq
MIRT1028044	hsa-miR-3914	CLIP-seq
MIRT1028057	hsa-miR-4722-5p	CLIP-seq
MIRT1028064	hsa-miR-873	CLIP-seq
MIRT1028032	hsa-miR-1286	CLIP-seq
MIRT1028044	hsa-miR-3914	CLIP-seq
MIRT1028057	hsa-miR-4722-5p	CLIP-seq
MIRT1028064	hsa-miR-873	CLIP-seq
MIRT2541631	hsa-miR-103a	CLIP-seq
MIRT2541632	hsa-miR-107	CLIP-seq
MIRT2541633	hsa-miR-1914	CLIP-seq
MIRT2541634	hsa-miR-1915	CLIP-seq
MIRT1028039	hsa-miR-214	CLIP-seq
MIRT2541635	hsa-miR-2861	CLIP-seq
MIRT1028042	hsa-miR-3619-5p	CLIP-seq
MIRT2541636	hsa-miR-3918	CLIP-seq
MIRT2541637	hsa-miR-3944-5p	CLIP-seq
MIRT2541638	hsa-miR-4433	CLIP-seq
MIRT2541639	hsa-miR-4481	CLIP-seq
MIRT2541640	hsa-miR-4512	CLIP-seq
MIRT2541641	hsa-miR-4685-5p	CLIP-seq
MIRT1028057	hsa-miR-4722-5p	CLIP-seq
MIRT2541642	hsa-miR-4745-5p	CLIP-seq
MIRT1028063	hsa-miR-761	CLIP-seq
MIRT2541631	hsa-miR-103a	CLIP-seq
MIRT2541632	hsa-miR-107	CLIP-seq
MIRT2541633	hsa-miR-1914	CLIP-seq
MIRT2541634	hsa-miR-1915	CLIP-seq
MIRT1028039	hsa-miR-214	CLIP-seq
MIRT2541635	hsa-miR-2861	CLIP-seq
MIRT1028042	hsa-miR-3619-5p	CLIP-seq
MIRT2541636	hsa-miR-3918	CLIP-seq
MIRT2541637	hsa-miR-3944-5p	CLIP-seq
MIRT2541638	hsa-miR-4433	CLIP-seq
MIRT2541639	hsa-miR-4481	CLIP-seq
MIRT2541640	hsa-miR-4512	CLIP-seq
MIRT2541641	hsa-miR-4685-5p	CLIP-seq
MIRT1028057	hsa-miR-4722-5p	CLIP-seq
MIRT2541642	hsa-miR-4745-5p	CLIP-seq
MIRT1028063	hsa-miR-761	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KLF4	Activation	19551868

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9012807
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	TAS	9012807
GO:0070062	Component	Extracellular exosome	HDA	11487543

Other IDs

• MIM: 602171
• HGNC: 4445
• e!Ensembl: ENSG00000143167

Protein

• UniProt ID: Q99795
• Protein name: Cell surface A33 antigen (Glycoprotein A33)
• Protein function: May play a role in cell-cell recognition and signaling.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	25 → 138	Immunoglobulin V-set domain	Domain
  PF13927	Ig_3	143 → 215		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
• Sequence:

  MVGKMWPVLWTLCAVRVTVDAISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDK
  LLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVS
  LMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNI
  LNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNVALYVG
  IAVGVVAALIIIGIIIYCCCCRGKDDNTEDKEDARPNREAYEEPPEQLRELSREREEEDD
  YRQEEQRSTGRESPDHLDQ

• Sequence length: 319