KLRG1 (killer cell lectin like receptor G1)

Gene

• Entrez ID: 10219
• Gene name: Killer cell lectin like receptor G1
• Gene symbol: KLRG1
• Synonyms (NCBI Gene): 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE
• Chromosome: 12
• Chromosome location: 12p13.31
• Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT036992	hsa-miR-877-3p	CLASH	23622248
MIRT1099389	hsa-miR-103b	CLIP-seq
MIRT1099390	hsa-miR-1184	CLIP-seq
MIRT1099391	hsa-miR-150	CLIP-seq
MIRT1099392	hsa-miR-1915	CLIP-seq
MIRT1099393	hsa-miR-3135b	CLIP-seq
MIRT1099394	hsa-miR-3200-5p	CLIP-seq
MIRT1099395	hsa-miR-365	CLIP-seq
MIRT1099396	hsa-miR-3652	CLIP-seq
MIRT1099397	hsa-miR-371-5p	CLIP-seq
MIRT1099398	hsa-miR-4251	CLIP-seq
MIRT1099399	hsa-miR-4329	CLIP-seq
MIRT1099400	hsa-miR-4418	CLIP-seq
MIRT1099401	hsa-miR-4420	CLIP-seq
MIRT1099402	hsa-miR-4430	CLIP-seq
MIRT1099403	hsa-miR-4713-5p	CLIP-seq
MIRT1099404	hsa-miR-4726-3p	CLIP-seq
MIRT1099405	hsa-miR-4729	CLIP-seq
MIRT1099406	hsa-miR-509-3-5p	CLIP-seq
MIRT1099407	hsa-miR-509-5p	CLIP-seq
MIRT1099408	hsa-miR-532-3p	CLIP-seq
MIRT1099409	hsa-miR-539	CLIP-seq
MIRT1099410	hsa-miR-633	CLIP-seq
MIRT1099389	hsa-miR-103b	CLIP-seq
MIRT1099391	hsa-miR-150	CLIP-seq
MIRT1099392	hsa-miR-1915	CLIP-seq
MIRT1099393	hsa-miR-3135b	CLIP-seq
MIRT1099396	hsa-miR-3652	CLIP-seq
MIRT1099402	hsa-miR-4430	CLIP-seq
MIRT1099403	hsa-miR-4713-5p	CLIP-seq
MIRT1099404	hsa-miR-4726-3p	CLIP-seq
MIRT1099408	hsa-miR-532-3p	CLIP-seq
MIRT1099389	hsa-miR-103b	CLIP-seq
MIRT1099390	hsa-miR-1184	CLIP-seq
MIRT2258177	hsa-miR-1343	CLIP-seq
MIRT1099391	hsa-miR-150	CLIP-seq
MIRT1099392	hsa-miR-1915	CLIP-seq
MIRT1099393	hsa-miR-3135b	CLIP-seq
MIRT1099396	hsa-miR-3652	CLIP-seq
MIRT1099397	hsa-miR-371-5p	CLIP-seq
MIRT2258178	hsa-miR-378g	CLIP-seq
MIRT2258179	hsa-miR-4307	CLIP-seq
MIRT2258180	hsa-miR-431	CLIP-seq
MIRT1099400	hsa-miR-4418	CLIP-seq
MIRT1099402	hsa-miR-4430	CLIP-seq
MIRT2258181	hsa-miR-4437	CLIP-seq
MIRT2258182	hsa-miR-455-3p	CLIP-seq
MIRT2258183	hsa-miR-4670-5p	CLIP-seq
MIRT2258184	hsa-miR-4674	CLIP-seq
MIRT1099403	hsa-miR-4713-5p	CLIP-seq
MIRT2258185	hsa-miR-4716-5p	CLIP-seq
MIRT1099404	hsa-miR-4726-3p	CLIP-seq
MIRT1099406	hsa-miR-509-3-5p	CLIP-seq
MIRT1099407	hsa-miR-509-5p	CLIP-seq
MIRT1099408	hsa-miR-532-3p	CLIP-seq
MIRT1099389	hsa-miR-103b	CLIP-seq
MIRT1099391	hsa-miR-150	CLIP-seq
MIRT1099392	hsa-miR-1915	CLIP-seq
MIRT1099393	hsa-miR-3135b	CLIP-seq
MIRT1099396	hsa-miR-3652	CLIP-seq
MIRT1099400	hsa-miR-4418	CLIP-seq
MIRT1099402	hsa-miR-4430	CLIP-seq
MIRT1099403	hsa-miR-4713-5p	CLIP-seq
MIRT1099404	hsa-miR-4726-3p	CLIP-seq
MIRT1099406	hsa-miR-509-3-5p	CLIP-seq
MIRT1099407	hsa-miR-509-5p	CLIP-seq
MIRT1099408	hsa-miR-532-3p	CLIP-seq
MIRT1099389	hsa-miR-103b	CLIP-seq
MIRT1099390	hsa-miR-1184	CLIP-seq
MIRT1099397	hsa-miR-371-5p	CLIP-seq
MIRT1099400	hsa-miR-4418	CLIP-seq
MIRT1099406	hsa-miR-509-3-5p	CLIP-seq
MIRT1099407	hsa-miR-509-5p	CLIP-seq
MIRT1099389	hsa-miR-103b	CLIP-seq
MIRT1099390	hsa-miR-1184	CLIP-seq
MIRT1099397	hsa-miR-371-5p	CLIP-seq
MIRT1099400	hsa-miR-4418	CLIP-seq
MIRT1099406	hsa-miR-509-3-5p	CLIP-seq
MIRT1099407	hsa-miR-509-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 32296183, 32814053
GO:0005886	Component	Plasma membrane	IEA
GO:0006954	Process	Inflammatory response	TAS	9842918
GO:0006968	Process	Cellular defense response	TAS	9842918
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9842918
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9842918
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030246	Function	Carbohydrate binding	TAS	9765598
GO:0038023	Function	Signaling receptor activity	TAS	9765598
GO:0045087	Process	Innate immune response	IEA

Other IDs

• MIM: 604874
• HGNC: 6380
• e!Ensembl: ENSG00000139187

Protein

• UniProt ID: Q96E93
• Protein name: Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)
• Protein function: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expressio
• PDB: 3FF7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00059	Lectin_C	92 → 186	Lectin C-type domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. {ECO:0000269|PubMed:15879103, ECO:0000269|PubMed:9842918}.
• Sequence:

  MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALGLLTAVLLSVLLYQWIL
  CQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMS
  LLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPL
  HWVCKKCPFADQALF

• Sequence length: 195