Gene Gene information from NCBI Gene database.
Entrez ID 10217
Gene name CTD small phosphatase like
Gene symbol CTDSPL
Synonyms (NCBI Gene)
C3orf8HYA22PSR1RBSP3SCP3
Chromosome 3
Chromosome location 3p22.2
miRNA miRNA information provided by mirtarbase database.
431
miRTarBase ID miRNA Experiments Reference
MIRT006765 hsa-miR-100-5p Luciferase reporter assayNorthern blotqRT-PCRWestern blot 21643017
MIRT006765 hsa-miR-100-5p Luciferase reporter assayNorthern blotqRT-PCRWestern blot 21643017
MIRT006765 hsa-miR-100-5p Luciferase reporter assayNorthern blotqRT-PCRWestern blot 21643017
MIRT006765 hsa-miR-100-5p Luciferase reporter assayNorthern blotqRT-PCRWestern blot 21643017
MIRT022910 hsa-miR-124-3p Microarray 18668037
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0005515 Function Protein binding IPI 16882717, 32296183
GO:0005634 Component Nucleus IEA
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608592 16890 ENSG00000144677
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15194
Protein name CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22)
Protein function Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-term
PDB 2HHL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03031 NIF 107 267 NLI interacting factor-like phosphatase Family
Tissue specificity TISSUE SPECIFICITY: Expression is restricted to non-neuronal tissues. {ECO:0000269|PubMed:15681389}.
Sequence
MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPP
SSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHS
SFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVAD
LLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQS
WFDDMTDTELLDLIPFFEGLSREDDVY
SMLHRLCNR
Sequence length 276
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 19016758
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 31774910, 37629167
★☆☆☆☆
Found in Text Mining only
Carcinoma Associate 15051889
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Inhibit 20193080
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 22491060, 31774910
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 24977159, 37629167
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Inhibit 20193080
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Associate 22491060, 23478628
★☆☆☆☆
Found in Text Mining only
Head and Neck Neoplasms Associate 20412120, 29624473, 29672635
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Associate 21643017
★☆☆☆☆
Found in Text Mining only