Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10204
Gene name Gene Name - the full gene name approved by the HGNC.	Nuclear transport factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NUTF2
Synonyms (NCBI Gene) Gene synonyms aliases	NTF-2, NTF2, PP15
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts wi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050639	hsa-miR-19b-3p	CLASH	23622248
MIRT041259	hsa-miR-193b-3p	CLASH	23622248
MIRT036033	hsa-miR-1301-3p	CLASH	23622248
MIRT343777	hsa-miR-4282	PAR-CLIP	21572407
MIRT545700	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT545699	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT545698	hsa-miR-2681-3p	PAR-CLIP	21572407
MIRT545697	hsa-miR-96-3p	PAR-CLIP	21572407
MIRT343773	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT343779	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT545696	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT545695	hsa-miR-5701	PAR-CLIP	21572407
MIRT545694	hsa-miR-3658	PAR-CLIP	21572407
MIRT545693	hsa-miR-2113	PAR-CLIP	21572407
MIRT545692	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT545691	hsa-miR-203b-3p	PAR-CLIP	21572407
MIRT343777	hsa-miR-4282	PAR-CLIP	21572407
MIRT545700	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT545699	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT545698	hsa-miR-2681-3p	PAR-CLIP	21572407
MIRT545697	hsa-miR-96-3p	PAR-CLIP	21572407
MIRT343773	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT343779	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT545696	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT545695	hsa-miR-5701	PAR-CLIP	21572407
MIRT545694	hsa-miR-3658	PAR-CLIP	21572407
MIRT545693	hsa-miR-2113	PAR-CLIP	21572407
MIRT545692	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT545691	hsa-miR-203b-3p	PAR-CLIP	21572407
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT1200278	hsa-miR-1256	CLIP-seq
MIRT1200279	hsa-miR-1264	CLIP-seq
MIRT1200280	hsa-miR-1273g	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200283	hsa-miR-199a-3p	CLIP-seq
MIRT1200284	hsa-miR-199b-3p	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200288	hsa-miR-2681	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT1200290	hsa-miR-3124-3p	CLIP-seq
MIRT1200291	hsa-miR-3129-5p	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200294	hsa-miR-33a	CLIP-seq
MIRT1200295	hsa-miR-33b	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200297	hsa-miR-3910	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT1200303	hsa-miR-450b-5p	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT1200309	hsa-miR-507	CLIP-seq
MIRT1200310	hsa-miR-557	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT1200315	hsa-miR-936	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT1200279	hsa-miR-1264	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200283	hsa-miR-199a-3p	CLIP-seq
MIRT1200284	hsa-miR-199b-3p	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT1200290	hsa-miR-3124-3p	CLIP-seq
MIRT1200291	hsa-miR-3129-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200294	hsa-miR-33a	CLIP-seq
MIRT1200295	hsa-miR-33b	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200297	hsa-miR-3910	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT1200303	hsa-miR-450b-5p	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT1200309	hsa-miR-507	CLIP-seq
MIRT1200310	hsa-miR-557	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT1200315	hsa-miR-936	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT1200279	hsa-miR-1264	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200283	hsa-miR-199a-3p	CLIP-seq
MIRT1200284	hsa-miR-199b-3p	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT1200290	hsa-miR-3124-3p	CLIP-seq
MIRT1200291	hsa-miR-3129-5p	CLIP-seq
MIRT2286329	hsa-miR-3135	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200297	hsa-miR-3910	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT2286330	hsa-miR-4261	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT2286331	hsa-miR-4496	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT2286332	hsa-miR-515-3p	CLIP-seq
MIRT2286333	hsa-miR-519e	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2286334	hsa-miR-765	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT1200315	hsa-miR-936	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2584292	hsa-miR-1224-3p	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT2584293	hsa-miR-1260	CLIP-seq
MIRT2584294	hsa-miR-1260b	CLIP-seq
MIRT2584295	hsa-miR-1280	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT2584296	hsa-miR-1291	CLIP-seq
MIRT2584297	hsa-miR-1321	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT2286329	hsa-miR-3135	CLIP-seq
MIRT2584298	hsa-miR-3145-3p	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT2584299	hsa-miR-3173-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT2286330	hsa-miR-4261	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT2584300	hsa-miR-4419a	CLIP-seq
MIRT2584301	hsa-miR-4481	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT2286331	hsa-miR-4496	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT2584302	hsa-miR-4510	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT2584303	hsa-miR-4739	CLIP-seq
MIRT2584304	hsa-miR-4745-5p	CLIP-seq
MIRT2584305	hsa-miR-4747-5p	CLIP-seq
MIRT2584306	hsa-miR-4756-5p	CLIP-seq
MIRT2584307	hsa-miR-4779	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT2286332	hsa-miR-515-3p	CLIP-seq
MIRT2584308	hsa-miR-516b	CLIP-seq
MIRT2286333	hsa-miR-519e	CLIP-seq
MIRT2584309	hsa-miR-579	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2286334	hsa-miR-765	CLIP-seq
MIRT2584310	hsa-miR-767-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT2584292	hsa-miR-1224-3p	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT2584293	hsa-miR-1260	CLIP-seq
MIRT2584294	hsa-miR-1260b	CLIP-seq
MIRT2584295	hsa-miR-1280	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT2584296	hsa-miR-1291	CLIP-seq
MIRT2584297	hsa-miR-1321	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT2584298	hsa-miR-3145-3p	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT2584299	hsa-miR-3173-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT2286330	hsa-miR-4261	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT2584300	hsa-miR-4419a	CLIP-seq
MIRT2584301	hsa-miR-4481	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT2286331	hsa-miR-4496	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT2584302	hsa-miR-4510	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT2584303	hsa-miR-4739	CLIP-seq
MIRT2584304	hsa-miR-4745-5p	CLIP-seq
MIRT2584305	hsa-miR-4747-5p	CLIP-seq
MIRT2584306	hsa-miR-4756-5p	CLIP-seq
MIRT2584307	hsa-miR-4779	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT2686718	hsa-miR-503	CLIP-seq
MIRT2286332	hsa-miR-515-3p	CLIP-seq
MIRT2584308	hsa-miR-516b	CLIP-seq
MIRT2286333	hsa-miR-519e	CLIP-seq
MIRT2686719	hsa-miR-532-3p	CLIP-seq
MIRT2584309	hsa-miR-579	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2286334	hsa-miR-765	CLIP-seq
MIRT2584310	hsa-miR-767-3p	CLIP-seq
MIRT2686720	hsa-miR-885-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	7744965, 18266911, 19098896, 24855949, 25416956, 28514442, 31515488, 32296183
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005640	Component	Nuclear outer membrane	IEA
GO:0005654	Component	Nucleoplasm	IDA	10679025
GO:0005829	Component	Cytosol	IDA	7744965, 10679025
GO:0006606	Process	Protein import into nucleus	IBA	21873635
GO:0006606	Process	Protein import into nucleus	IDA	7744965, 10679025
GO:0006611	Process	Protein export from nucleus	IDA	16449645
GO:0006913	Process	Nucleocytoplasmic transport	IBA	21873635
GO:0017056	Function	Structural constituent of nuclear pore	IDA	7744965, 10679025
GO:0031267	Function	Small GTPase binding	IDA	10679025
GO:0031267	Function	Small GTPase binding	IPI	18266911
GO:0031965	Component	Nuclear membrane	ISS
GO:0042307	Process	Positive regulation of protein import into nucleus	IEA
GO:0042802	Function	Identical protein binding	IPI	19098896, 25416956
GO:0044613	Component	Nuclear pore central transport channel	IBA	21873635
GO:0051028	Process	MRNA transport	IEA
GO:0061608	Function	Nuclear import signal receptor activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0090204	Process	Protein localization to nuclear pore	ISS
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	IEA

MIM	HGNC	e!Ensembl
605813	13722	ENSG00000102898

Protein

UniProt ID

P61970

Protein name

Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15)

Protein function

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated

PDB

1GY5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02136	NTF2	10 → 121	Nuclear transport factor 2 (NTF2) domain	Domain

Sequence

MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLP
FQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFR
LALHNFG

Sequence length

127

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Coronary heart disease	Coronary heart disease	21347282	ClinVar
Alzheimer disease	Alzheimer disease		GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
CADASIL	Associate	35409031
Cerebrovascular Disorders	Associate	35409031
Diabetes Complications	Associate	35806251
Insulin Resistance	Associate	35806251
Neoplasms	Associate	35155672
Squamous Cell Carcinoma of Head and Neck	Stimulate	35155672

NUTF2 (nuclear transport factor 2)