Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10204
Gene name	Nuclear transport factor 2
Gene symbol	NUTF2
Synonyms (NCBI Gene)	NTF-2NTF2PP15
Chromosome	16
Chromosome location	16q22.1
Summary	This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts wi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050639	hsa-miR-19b-3p	CLASH	23622248
MIRT041259	hsa-miR-193b-3p	CLASH	23622248
MIRT036033	hsa-miR-1301-3p	CLASH	23622248
MIRT343777	hsa-miR-4282	PAR-CLIP	21572407
MIRT545700	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT545699	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT545698	hsa-miR-2681-3p	PAR-CLIP	21572407
MIRT545697	hsa-miR-96-3p	PAR-CLIP	21572407
MIRT343773	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT343779	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT545696	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT545695	hsa-miR-5701	PAR-CLIP	21572407
MIRT545694	hsa-miR-3658	PAR-CLIP	21572407
MIRT545693	hsa-miR-2113	PAR-CLIP	21572407
MIRT545692	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT545691	hsa-miR-203b-3p	PAR-CLIP	21572407
MIRT343777	hsa-miR-4282	PAR-CLIP	21572407
MIRT545700	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT545699	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT545698	hsa-miR-2681-3p	PAR-CLIP	21572407
MIRT545697	hsa-miR-96-3p	PAR-CLIP	21572407
MIRT343773	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT343779	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT545696	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT545695	hsa-miR-5701	PAR-CLIP	21572407
MIRT545694	hsa-miR-3658	PAR-CLIP	21572407
MIRT545693	hsa-miR-2113	PAR-CLIP	21572407
MIRT545692	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT545691	hsa-miR-203b-3p	PAR-CLIP	21572407
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT1200278	hsa-miR-1256	CLIP-seq
MIRT1200279	hsa-miR-1264	CLIP-seq
MIRT1200280	hsa-miR-1273g	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200283	hsa-miR-199a-3p	CLIP-seq
MIRT1200284	hsa-miR-199b-3p	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200288	hsa-miR-2681	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT1200290	hsa-miR-3124-3p	CLIP-seq
MIRT1200291	hsa-miR-3129-5p	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200294	hsa-miR-33a	CLIP-seq
MIRT1200295	hsa-miR-33b	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200297	hsa-miR-3910	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT1200303	hsa-miR-450b-5p	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT1200309	hsa-miR-507	CLIP-seq
MIRT1200310	hsa-miR-557	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT1200315	hsa-miR-936	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT1200279	hsa-miR-1264	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200283	hsa-miR-199a-3p	CLIP-seq
MIRT1200284	hsa-miR-199b-3p	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT1200290	hsa-miR-3124-3p	CLIP-seq
MIRT1200291	hsa-miR-3129-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200294	hsa-miR-33a	CLIP-seq
MIRT1200295	hsa-miR-33b	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200297	hsa-miR-3910	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT1200303	hsa-miR-450b-5p	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT1200309	hsa-miR-507	CLIP-seq
MIRT1200310	hsa-miR-557	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT1200315	hsa-miR-936	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT1200279	hsa-miR-1264	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200283	hsa-miR-199a-3p	CLIP-seq
MIRT1200284	hsa-miR-199b-3p	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT1200290	hsa-miR-3124-3p	CLIP-seq
MIRT1200291	hsa-miR-3129-5p	CLIP-seq
MIRT2286329	hsa-miR-3135	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200297	hsa-miR-3910	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT2286330	hsa-miR-4261	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT2286331	hsa-miR-4496	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT2286332	hsa-miR-515-3p	CLIP-seq
MIRT2286333	hsa-miR-519e	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2286334	hsa-miR-765	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT1200315	hsa-miR-936	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2584292	hsa-miR-1224-3p	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT2584293	hsa-miR-1260	CLIP-seq
MIRT2584294	hsa-miR-1260b	CLIP-seq
MIRT2584295	hsa-miR-1280	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT2584296	hsa-miR-1291	CLIP-seq
MIRT2584297	hsa-miR-1321	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT2286329	hsa-miR-3135	CLIP-seq
MIRT2584298	hsa-miR-3145-3p	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT2584299	hsa-miR-3173-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT2286330	hsa-miR-4261	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT2584300	hsa-miR-4419a	CLIP-seq
MIRT2584301	hsa-miR-4481	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT2286331	hsa-miR-4496	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT2584302	hsa-miR-4510	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT2584303	hsa-miR-4739	CLIP-seq
MIRT2584304	hsa-miR-4745-5p	CLIP-seq
MIRT2584305	hsa-miR-4747-5p	CLIP-seq
MIRT2584306	hsa-miR-4756-5p	CLIP-seq
MIRT2584307	hsa-miR-4779	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT2286332	hsa-miR-515-3p	CLIP-seq
MIRT2584308	hsa-miR-516b	CLIP-seq
MIRT2286333	hsa-miR-519e	CLIP-seq
MIRT2584309	hsa-miR-579	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2286334	hsa-miR-765	CLIP-seq
MIRT2584310	hsa-miR-767-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq
MIRT2584292	hsa-miR-1224-3p	CLIP-seq
MIRT1200275	hsa-miR-1231	CLIP-seq
MIRT1200276	hsa-miR-1245b-3p	CLIP-seq
MIRT1200277	hsa-miR-1247	CLIP-seq
MIRT2584293	hsa-miR-1260	CLIP-seq
MIRT2584294	hsa-miR-1260b	CLIP-seq
MIRT2584295	hsa-miR-1280	CLIP-seq
MIRT1200281	hsa-miR-1285	CLIP-seq
MIRT2584296	hsa-miR-1291	CLIP-seq
MIRT2584297	hsa-miR-1321	CLIP-seq
MIRT1200282	hsa-miR-1827	CLIP-seq
MIRT1200285	hsa-miR-205	CLIP-seq
MIRT1200286	hsa-miR-223	CLIP-seq
MIRT1200287	hsa-miR-2278	CLIP-seq
MIRT1200289	hsa-miR-28-3p	CLIP-seq
MIRT2584298	hsa-miR-3145-3p	CLIP-seq
MIRT1200292	hsa-miR-3160-5p	CLIP-seq
MIRT2584299	hsa-miR-3173-5p	CLIP-seq
MIRT1200293	hsa-miR-3187-5p	CLIP-seq
MIRT1200296	hsa-miR-378g	CLIP-seq
MIRT1200298	hsa-miR-3940-5p	CLIP-seq
MIRT2286330	hsa-miR-4261	CLIP-seq
MIRT1200299	hsa-miR-4279	CLIP-seq
MIRT1200300	hsa-miR-4316	CLIP-seq
MIRT2584300	hsa-miR-4419a	CLIP-seq
MIRT2584301	hsa-miR-4481	CLIP-seq
MIRT1200301	hsa-miR-4486	CLIP-seq
MIRT2286331	hsa-miR-4496	CLIP-seq
MIRT1200302	hsa-miR-4507	CLIP-seq
MIRT2584302	hsa-miR-4510	CLIP-seq
MIRT1200304	hsa-miR-4539	CLIP-seq
MIRT1200305	hsa-miR-4697-3p	CLIP-seq
MIRT1200306	hsa-miR-4710	CLIP-seq
MIRT1200307	hsa-miR-4713-5p	CLIP-seq
MIRT2584303	hsa-miR-4739	CLIP-seq
MIRT2584304	hsa-miR-4745-5p	CLIP-seq
MIRT2584305	hsa-miR-4747-5p	CLIP-seq
MIRT2584306	hsa-miR-4756-5p	CLIP-seq
MIRT2584307	hsa-miR-4779	CLIP-seq
MIRT1200308	hsa-miR-494	CLIP-seq
MIRT2686718	hsa-miR-503	CLIP-seq
MIRT2286332	hsa-miR-515-3p	CLIP-seq
MIRT2584308	hsa-miR-516b	CLIP-seq
MIRT2286333	hsa-miR-519e	CLIP-seq
MIRT2686719	hsa-miR-532-3p	CLIP-seq
MIRT2584309	hsa-miR-579	CLIP-seq
MIRT1200311	hsa-miR-612	CLIP-seq
MIRT1200312	hsa-miR-654-3p	CLIP-seq
MIRT2286334	hsa-miR-765	CLIP-seq
MIRT2584310	hsa-miR-767-3p	CLIP-seq
MIRT2686720	hsa-miR-885-3p	CLIP-seq
MIRT1200313	hsa-miR-891b	CLIP-seq
MIRT1200314	hsa-miR-9	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	7744965, 18266911, 19098896, 24855949, 25416956, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005640	Component	Nuclear outer membrane	IEA
GO:0005643	Component	Nuclear pore	IEA
GO:0005654	Component	Nucleoplasm	IDA	10679025
GO:0005654	Component	Nucleoplasm	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	7744965, 10679025
GO:0005829	Component	Cytosol	IEA
GO:0006606	Process	Protein import into nucleus	IBA
GO:0006606	Process	Protein import into nucleus	IDA	7744965, 10679025
GO:0006606	Process	Protein import into nucleus	IEA
GO:0006611	Process	Protein export from nucleus	IDA	16449645
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0017056	Function	Structural constituent of nuclear pore	IDA	7744965, 10679025
GO:0031267	Function	Small GTPase binding	IDA	10679025
GO:0031267	Function	Small GTPase binding	IPI	18266911
GO:0031965	Component	Nuclear membrane	ISS
GO:0042802	Function	Identical protein binding	IPI	19098896, 25416956
GO:0044613	Component	Nuclear pore central transport channel	IBA
GO:0051028	Process	MRNA transport	IEA
GO:0061608	Function	Nuclear import signal receptor activity	IBA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0090204	Process	Protein localization to nuclear pore	ISS

MIM	HGNC	e!Ensembl
605813	13722	ENSG00000102898

P61970

Protein name

Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15)

Protein function

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated

PDB

1GY5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02136	NTF2	10 → 121	Nuclear transport factor 2 (NTF2) domain	Domain

Sequence

MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLP
FQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFR
LALHNFG

Sequence length

127

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HIV INFECTIONS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
CADASIL	Associate	35409031	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular Disorders	Associate	35409031	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Complications	Associate	35806251	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Associate	35806251	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35155672	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Stimulate	35155672	★★★★★ ★☆☆☆☆ Found in Text Mining only

NUTF2 (nuclear transport factor 2)