MPHOSPH9 (M-phase phosphoprotein 9)

Gene

• Entrez ID: 10198
• Gene name: M-phase phosphoprotein 9
• Gene symbol: MPHOSPH9
• Synonyms (NCBI Gene): MPP-9, MPP9
• Chromosome: 12
• Chromosome location: 12q24.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002676	hsa-miR-124-3p	Microarray	15685193
MIRT019557	hsa-miR-340-5p	Sequencing	20371350
MIRT020231	hsa-miR-130b-3p	Sequencing	20371350
MIRT002676	hsa-miR-124-3p	Microarray;Other	15685193
MIRT031174	hsa-miR-19b-3p	Sequencing	20371350
MIRT046416	hsa-miR-15b-5p	CLASH	23622248
MIRT1156120	hsa-miR-130a	CLIP-seq
MIRT1156121	hsa-miR-130b	CLIP-seq
MIRT1156122	hsa-miR-19a	CLIP-seq
MIRT1156123	hsa-miR-19b	CLIP-seq
MIRT1156124	hsa-miR-301a	CLIP-seq
MIRT1156125	hsa-miR-301b	CLIP-seq
MIRT1156126	hsa-miR-3163	CLIP-seq
MIRT1156127	hsa-miR-323-3p	CLIP-seq
MIRT1156128	hsa-miR-3666	CLIP-seq
MIRT1156129	hsa-miR-3944-5p	CLIP-seq
MIRT1156130	hsa-miR-4282	CLIP-seq
MIRT1156131	hsa-miR-4295	CLIP-seq
MIRT1156132	hsa-miR-4473	CLIP-seq
MIRT1156133	hsa-miR-4477a	CLIP-seq
MIRT1156134	hsa-miR-454	CLIP-seq
MIRT1156135	hsa-miR-4671-3p	CLIP-seq
MIRT1156136	hsa-miR-4789-5p	CLIP-seq
MIRT1156137	hsa-miR-671-5p	CLIP-seq
MIRT1156138	hsa-miR-944	CLIP-seq
MIRT2044656	hsa-miR-3152-5p	CLIP-seq
MIRT2044657	hsa-miR-340	CLIP-seq
MIRT2044658	hsa-miR-345	CLIP-seq
MIRT2044659	hsa-miR-4256	CLIP-seq
MIRT2044660	hsa-miR-4493	CLIP-seq
MIRT2044661	hsa-miR-4762-3p	CLIP-seq
MIRT2044662	hsa-miR-4774-3p	CLIP-seq
MIRT1156126	hsa-miR-3163	CLIP-seq
MIRT2044657	hsa-miR-340	CLIP-seq
MIRT2273902	hsa-miR-3668	CLIP-seq
MIRT2273903	hsa-miR-4773	CLIP-seq
MIRT2273904	hsa-miR-4796-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005794	Component	Golgi apparatus	IDA	8885239
GO:0005814	Component	Centriole	IBA	21873635
GO:0005814	Component	Centriole	IDA	23644468
GO:0016020	Component	Membrane	HDA	19946888

Other IDs

• MIM: 605501
• HGNC: 7215
• e!Ensembl: ENSG00000051825

Protein

• UniProt ID: Q99550
• Protein name: M-phase phosphoprotein 9
• Protein function: Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergo
• Sequence:

  MEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGT
  VEVLTSLMQELQNSGKTDSELWKNCETRWLQLFNLVEKQCQEQIVAQQEQFHNQIQHIQE
  EIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQE
  MSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLV
  DGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQK
  LKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDS
  GTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRE
  NKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVL
  EPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVY
  TITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLK
  EKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSR
  VRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDL
  EEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQI
  SDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSI
  FTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALK
  ELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLP
  PSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDT
  VPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWE
  KNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGG
  RITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL

• Sequence length: 1183

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	30664745
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	24509480
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	19525953
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203, 28991256, 29483656, 26198764, 25056061, 28540026, 30285260

Unknown
Disease term	Disease name	Evidence	References	Source
Multiple Sclerosis	Multiple Sclerosis			GWAS
Diabetes	Diabetes			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Uterine Fibroids	Uterine Fibroids			GWAS
Asthma	Asthma			GWAS
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Diabetes Mellitus Type 2	Associate	25799151
Lymphoma Non Hodgkin	Associate	33951297
Multiple Sclerosis	Associate	20546594
Neoplasms	Stimulate	33174370
Neuroblastoma	Associate	20444257
Stomach Neoplasms	Stimulate	33174370
Tourette Syndrome	Associate	35354918
Venous Thromboembolism	Associate	31420334