Gene Gene information from NCBI Gene database.
Entrez ID 10193
Gene name Ring finger protein 41
Gene symbol RNF41
Synonyms (NCBI Gene)
FLRFNRDP1SBBI03
Chromosome 12
Chromosome location 12q13.3
Summary This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in mult
miRNA miRNA information provided by mirtarbase database.
942
miRTarBase ID miRNA Experiments Reference
MIRT020324 hsa-miR-130b-3p Sequencing 20371350
MIRT025017 hsa-miR-183-5p Sequencing 20371350
MIRT025964 hsa-miR-7-5p Sequencing 20371350
MIRT031241 hsa-miR-19b-3p Sequencing 20371350
MIRT044633 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IDA 14765125, 18541373
GO:0000209 Process Protein polyubiquitination IEA
GO:0000209 Process Protein polyubiquitination IEA
GO:0004842 Function Ubiquitin-protein transferase activity IDA 14765125, 18541373, 24105792
GO:0004842 Function Ubiquitin-protein transferase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620051 18401 ENSG00000181852
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H4P4
Protein name E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
Protein function Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interfe
PDB 2FZP , 2GWF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 17 55 Domain
PF08941 USP8_interact 137 315 USP8 interacting Domain
Tissue specificity TISSUE SPECIFICITY: Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}.
Sequence
Sequence length 317
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis   Downregulation of ERBB2:ERBB3 signaling
Antigen processing: Ubiquitination & Proteasome degradation