RNF41 (ring finger protein 41)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10193 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Ring finger protein 41 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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RNF41 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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FLRF, NRDP1, SBBI03 |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q13.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in mult |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q9H4P4 | |||||||||||||||
| Protein name | E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) | |||||||||||||||
| Protein function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interfe | |||||||||||||||
| PDB | 2FZP , 2GWF | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}. | |||||||||||||||
| Sequence |
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| Sequence length | 317 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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