MEI4 (meiotic double-stranded break formation protein 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
101928601
Gene name Gene Name - the full gene name approved by the HGNC.
Meiotic double-stranded break formation protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MEI4
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q14.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(10)
miRTarBase ID miRNA Experiments Reference
MIRT740506 hsa-miR-7109-3p HITS-CLIP 19536157
MIRT740507 hsa-miR-3614-3p HITS-CLIP 19536157
MIRT740508 hsa-miR-617 HITS-CLIP 19536157
MIRT740509 hsa-miR-6505-3p HITS-CLIP 19536157
MIRT740510 hsa-miR-3164 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0000800 Component Lateral element IBA 21873635
GO:0000800 Component Lateral element ISS
GO:0005515 Function Protein binding IPI 32296183
GO:0006310 Process DNA recombination IEA
GO:0007129 Process Homologous chromosome pairing at meiosis IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
618417 43638 ENSG00000269964
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID A8MW99
Protein name Meiosis-specific protein MEI4
Protein function Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13971 Mei4 1 → 378 Meiosis-specific protein Mei4 Family
Sequence
Sequence length 385
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 21725308
Show/Hide Unknown Diseases (7)
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Sjogren-Larsson Syndrome Sjogren-Larsson Syndrome GWAS
Drusen Drusen GWAS
Hypertension Hypertension GWAS