TH2LCRR (T helper type 2 locus control region associated RNA)

Gene

• Entrez ID: 101927761
• Gene name: T helper type 2 locus control region associated RNA
• Gene symbol: TH2LCRR
• Synonyms (NCBI Gene): TH2-LCR
• Chromosome: 5
• Chromosome location: 5q31.1

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	30787463
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25865352, 23886662, 25574825, 26482879
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	22190364
Nijmegen breakage syndrome-like disorder	Nijmegen Breakage Syndrome-Like Disorder	rs121912628, rs397507177, rs104895046, rs587780150, rs587780154, rs377260382, rs587781904, rs587781930, rs587782078, rs587782090, rs587782543, rs587782895, rs786203485, rs760146707, rs764122619, rs786203655, rs373428259, rs587781327, rs786201789, rs786201897, rs786203805, rs786202187, rs750586158, rs778555849, rs149201802, rs748086984, rs876659255, rs876659005, rs876660957, rs587780147, rs876660364, rs368980595, rs775069541, rs762648843, rs745797941, rs761168506, rs876658770, rs749466673, rs878854799, rs1060501941, rs1060501970, rs766315644, rs1060501936, rs1458900761, rs587781454, rs995265408, rs1060501954, rs1060501942, rs377429225, rs772468452, rs1554099888, rs765484171, rs1554101314, rs1247689593, rs1236278956, rs764968413, rs587781742, rs1554099106, rs142947311, rs1554098250, rs748536322, rs773761143, rs765975825, rs1554099320, rs761837416, rs1554099776, rs1554100940, rs1339714611, rs1554096791, rs1561634357, rs1561635887, rs753950483, rs1561647410, rs1561639636, rs1561661777, rs758641567, rs1580997203, rs1580987798, rs1580987375, rs1750646869, rs757261714, rs1581004859, rs1751171297
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	20953187, 25903422, 26626624, 19169254, 23143594

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma, Childhood asthma		20159242, 20860503, 21907864, 22561531, 29273806, 31619474, 27611488, 24241537	ClinVar, GWAS
Alopecia Areata	Alopecia Areata			GWAS
Eczema	Eczema			GWAS
Allergic Sensitization	Allergic Sensitization			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Psoriasis vulgaris	Psoriasis vulgaris			GWAS
Crohn Disease	Crohn Disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Associate	34967552
Dermatitis Atopic	Associate	28364410
Diabetes Mellitus Type 2	Associate	37356726
Neoplasms	Associate	34967552
Neuromyelitis Optica	Associate	38091807
Severe Acute Respiratory Syndrome	Associate	23521898
Spinal Muscular Atrophies of Childhood	Associate	23521898