Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	1017
Gene name	Cyclin dependent kinase 2
Gene symbol	CDK2
Synonyms (NCBI Gene)	CDKN2p33(CDK2)
Chromosome	12
Chromosome location	12q13.2
Summary	This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004283	hsa-miR-124-3p	Luciferase reporter assayWestern blot	19404929
MIRT004764	hsa-miR-103a-3p	Luciferase reporter assayqRT-PCRWestern blot	20886090
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assayMicroarrayNorthern blotWestern blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assayMicroarrayNorthern blotWestern blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assayMicroarrayNorthern blotWestern blot	21062975
MIRT005461	hsa-miR-885-5p	Luciferase reporter assayNorthern blotqRT-PCRWestern blot	21233845
MIRT006766	hsa-miR-372-3p	FACSGFP reporter assayqRT-PCRWestern blot	21646351
MIRT006766	hsa-miR-372-3p	FACSGFP reporter assayqRT-PCRWestern blot	21646351
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT020948	hsa-miR-155-5p	Proteomics	18668040
MIRT004283	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT030063	hsa-miR-26b-5p	Microarray	19088304
MIRT047445	hsa-miR-10b-5p	CLASH	23622248
MIRT046257	hsa-miR-23b-3p	CLASH	23622248
MIRT044112	hsa-miR-361-5p	CLASH	23622248
MIRT053070	hsa-miR-223-3p	FlowLuciferase reporter assayqRT-PCRWestern blot	24137330
MIRT006766	hsa-miR-372-3p	Luciferase reporter assayWestern blotqRT-PCR	23479742
MIRT053775	hsa-miR-302a-3p	ChIP-seqFlowMicroarrayqRT-PCRWestern blot	24861464
MIRT054309	hsa-miR-29a-3p	qRT-PCRWestern blot	25889078
MIRT054309	hsa-miR-29a-3p	qRT-PCRWestern blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT054309	hsa-miR-29a-3p	qRT-PCRWestern blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT731124	hsa-miR-638	qRT-PCRLuciferase reporter assayWestern blot	25451924
MIRT731124	hsa-miR-638	qRT-PCRLuciferase reporter assayWestern blot	25451924
MIRT731124	hsa-miR-638	qRT-PCRLuciferase reporter assayWestern blot	25451924
MIRT731124	hsa-miR-638	qRT-PCRLuciferase reporter assayWestern blot	25451924
MIRT732203	hsa-miR-200c-3p	ImmunohistochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot	26248649
MIRT732203	hsa-miR-200c-3p	ImmunohistochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot	26248649
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assayqRT-PCRWestern blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assayqRT-PCRWestern blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assayqRT-PCRWestern blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assayqRT-PCRWestern blot	27475256
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	26701625
MIRT513331	hsa-miR-2909	PAR-CLIP	26701625
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	26701625
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	26701625
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	26701625
MIRT570129	hsa-miR-4492	PAR-CLIP	26701625
MIRT570128	hsa-miR-4498	PAR-CLIP	26701625
MIRT513338	hsa-miR-4784	PAR-CLIP	26701625
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	26701625
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	26701625
MIRT513340	hsa-miR-5186	PAR-CLIP	26701625
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	26701625
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	26701625
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	26701625
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	26701625
MIRT570126	hsa-miR-762	PAR-CLIP	26701625
MIRT513334	hsa-miR-765	PAR-CLIP	26701625
MIRT513336	hsa-miR-766-5p	PAR-CLIP	26701625
MIRT735447	hsa-miR-335-3p	qRT-PCR	32165872
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT755832	hsa-miR-646	Western blottingqRT-PCRin vitro cullelar assaysFlow cytometry	37155307
MIRT880948	hsa-miR-18a	CLIP-seq
MIRT880949	hsa-miR-18b	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT880951	hsa-miR-4735-3p	CLIP-seq
MIRT880952	hsa-miR-4761-5p	CLIP-seq
MIRT880953	hsa-miR-520d-5p	CLIP-seq
MIRT880954	hsa-miR-616	CLIP-seq
MIRT880955	hsa-miR-1293	CLIP-seq
MIRT880956	hsa-miR-3129-3p	CLIP-seq
MIRT880957	hsa-miR-3153	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT880959	hsa-miR-3165	CLIP-seq
MIRT880960	hsa-miR-3179	CLIP-seq
MIRT880961	hsa-miR-3199	CLIP-seq
MIRT880962	hsa-miR-3612	CLIP-seq
MIRT880963	hsa-miR-3942-5p	CLIP-seq
MIRT880964	hsa-miR-3975	CLIP-seq
MIRT880965	hsa-miR-4443	CLIP-seq
MIRT880966	hsa-miR-4483	CLIP-seq
MIRT880967	hsa-miR-4515	CLIP-seq
MIRT880968	hsa-miR-4652-5p	CLIP-seq
MIRT880969	hsa-miR-4703-5p	CLIP-seq
MIRT880970	hsa-miR-4716-3p	CLIP-seq
MIRT880971	hsa-miR-548t	CLIP-seq
MIRT880972	hsa-miR-625	CLIP-seq
MIRT880973	hsa-miR-650	CLIP-seq
MIRT880974	hsa-miR-660	CLIP-seq
MIRT1960974	hsa-miR-1224-3p	CLIP-seq
MIRT1960975	hsa-miR-1263	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT1960976	hsa-miR-3622a-3p	CLIP-seq
MIRT1960977	hsa-miR-3622b-3p	CLIP-seq
MIRT1960978	hsa-miR-3651	CLIP-seq
MIRT1960979	hsa-miR-4756-3p	CLIP-seq
MIRT1960980	hsa-miR-4762-5p	CLIP-seq
MIRT1960981	hsa-miR-509-3p	CLIP-seq
MIRT1960982	hsa-miR-548al	CLIP-seq
MIRT2197677	hsa-miR-124	CLIP-seq
MIRT2197678	hsa-miR-200b	CLIP-seq
MIRT2197679	hsa-miR-200c	CLIP-seq
MIRT2197680	hsa-miR-214	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT2197681	hsa-miR-3188	CLIP-seq
MIRT2197682	hsa-miR-3619-5p	CLIP-seq
MIRT2197683	hsa-miR-3652	CLIP-seq
MIRT2197684	hsa-miR-3659	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197686	hsa-miR-3714	CLIP-seq
MIRT2197687	hsa-miR-3910	CLIP-seq
MIRT2197688	hsa-miR-3926	CLIP-seq
MIRT2197689	hsa-miR-3938	CLIP-seq
MIRT2197690	hsa-miR-429	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197692	hsa-miR-4430	CLIP-seq
MIRT2197693	hsa-miR-4459	CLIP-seq
MIRT2197694	hsa-miR-4477b	CLIP-seq
MIRT2197695	hsa-miR-451b	CLIP-seq
MIRT2197696	hsa-miR-4658	CLIP-seq
MIRT2197697	hsa-miR-4695-5p	CLIP-seq
MIRT2197698	hsa-miR-4713-3p	CLIP-seq
MIRT2197699	hsa-miR-4715-5p	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT2197700	hsa-miR-4722-5p	CLIP-seq
MIRT2197701	hsa-miR-4724-5p	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197703	hsa-miR-4742-3p	CLIP-seq
MIRT2197704	hsa-miR-506	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197706	hsa-miR-519a	CLIP-seq
MIRT2197707	hsa-miR-519b-3p	CLIP-seq
MIRT2197708	hsa-miR-519c-3p	CLIP-seq
MIRT2197709	hsa-miR-548s	CLIP-seq
MIRT2197710	hsa-miR-571	CLIP-seq
MIRT2197711	hsa-miR-574-5p	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197713	hsa-miR-630	CLIP-seq
MIRT2197714	hsa-miR-647	CLIP-seq
MIRT2197715	hsa-miR-761	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq

Show/Hide all (9)

Transcription factor	Regulation	Reference
ARNT	Repression	21544813
DDIT3	Unknown	20017906
E2F4	Unknown	22447046
GLI1	Activation	20647328
IRF1	Repression	22200613
KAT2B	Repression	19525977
MITF	Unknown	15607961
MYC	Unknown	21384303
TP53	Repression	12732645

Show/Hide all (99)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA
GO:0000082	Process	G1/S transition of mitotic cell cycle	IEA
GO:0000082	Process	G1/S transition of mitotic cell cycle	NAS	9840943, 15838514
GO:0000086	Process	G2/M transition of mitotic cell cycle	NAS	1653904
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IDA	1312467, 8692841
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IEA
GO:0000723	Process	Telomere maintenance	IDA	28216226
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000793	Component	Condensed chromosome	IEA
GO:0000805	Component	X chromosome	IEA
GO:0000806	Component	Y chromosome	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11953320
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IGI	26996940
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IDA	21596315, 28216226
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	2227411, 7630397, 8242750, 8521818, 8601310, 8684460, 8756328, 8756624, 9840943, 10330164, 11463386, 11980914, 12244298, 12361598, 12839962, 12941338, 15107404, 15178429, 15189033, 15232106, 15239650, 15530371, 15611625, 15890360, 16061792, 16209941, 16326706, 16327805, 16431923, 167
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10767298
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IDA	8245034
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10767298
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IDA	21262353
GO:0005768	Component	Endosome	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	TAS	19238148
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006260	Process	DNA replication	TAS	19238148
GO:0006281	Process	DNA repair	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006468	Process	Protein phosphorylation	IDA	12944431, 28666995
GO:0006468	Process	Protein phosphorylation	IMP	29203878
GO:0006813	Process	Potassium ion transport	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007099	Process	Centriole replication	IMP	26297806
GO:0007165	Process	Signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IEP	9054499
GO:0007346	Process	Regulation of mitotic cell cycle	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	10767298
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	IBA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0015030	Component	Cajal body	IDA	10995387
GO:0015030	Component	Cajal body	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	23184662
GO:0019904	Function	Protein domain specific binding	IPI	8876165, 15024385
GO:0030332	Function	Cyclin binding	IBA
GO:0030332	Function	Cyclin binding	IDA	1653904, 23781148
GO:0030332	Function	Cyclin binding	IEA
GO:0030332	Function	Cyclin binding	IPI	1312467, 15024385
GO:0031453	Process	Positive regulation of heterochromatin formation	IDA	20935635
GO:0031571	Process	Mitotic G1 DNA damage checkpoint signaling	TAS	21319273
GO:0031848	Process	Protection from non-homologous end joining at telomere	IDA	28216226
GO:0032298	Process	Positive regulation of DNA-templated DNA replication initiation	IEA
GO:0035173	Function	Histone kinase activity	IDA	8692841
GO:0043247	Process	Telomere maintenance in response to DNA damage	IDA	28216226
GO:0043247	Process	Telomere maintenance in response to DNA damage	IDA	28216226
GO:0043687	Process	Post-translational protein modification	IDA	11746698
GO:0045740	Process	Positive regulation of DNA replication	TAS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051298	Process	Centrosome duplication	TAS	19238148
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	TAS	19238148
GO:0071732	Process	Cellular response to nitric oxide	TAS	20079829
GO:0090398	Process	Cellular senescence	TAS
GO:0097123	Component	Cyclin A1-CDK2 complex	IEA
GO:0097123	Component	Cyclin A1-CDK2 complex	NAS	12244298
GO:0097124	Component	Cyclin A2-CDK2 complex	IDA	1312467, 8684460, 8876165, 11746698, 15024385
GO:0097124	Component	Cyclin A2-CDK2 complex	IEA
GO:0097124	Component	Cyclin A2-CDK2 complex	IPI	12244298
GO:0097134	Component	Cyclin E1-CDK2 complex	IEA
GO:0097134	Component	Cyclin E1-CDK2 complex	IPI	8756624
GO:0097135	Component	Cyclin E2-CDK2 complex	IEA
GO:0097135	Component	Cyclin E2-CDK2 complex	IPI	15232106
GO:0097472	Function	Cyclin-dependent protein kinase activity	IDA	1312467, 24670654, 28666995
GO:0097472	Function	Cyclin-dependent protein kinase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1905784	Process	Regulation of anaphase-promoting complex-dependent catabolic process	TAS

MIM	HGNC	e!Ensembl
116953	1771	ENSG00000123374

P24941

Protein name

Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)

Protein function

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431,

PDB

1AQ1 , 1B38 , 1B39 , 1BUH , 1CKP , 1DI8 , 1DM2 , 1E1V , 1E1X , 1E9H , 1F5Q , 1FIN , 1FQ1 , 1FVT , 1FVV , 1G5S , 1GIH , 1GII , 1GIJ , 1GY3 , 1GZ8 , 1H00 , 1H01 , 1H07 , 1H08 , 1H0V , 1H0W , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1HCK , 1HCL , 1JST , 1JSU , 1JSV , 1JVP , 1KE5 , 1KE6 , 1KE7 , 1KE8 , 1KE9 , 1OGU , 1OI9 , 1OIQ , 1OIR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	4 → 286	Protein kinase domain	Domain

Sequence

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Sequence length

298

Interactions

View interactions

	KEGG		Reactome
	FoxO signaling pathway Cell cycle Oocyte meiosis p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Progesterone-mediated oocyte maturation Cushing syndrome Hepatitis C Hepatitis B Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Prostate cancer Small cell lung cancer Gastric cancer		G0 and Early G1 Activation of ATR in response to replication stress Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle Transcriptional regulation of granulopoiesis

CDK2 (cyclin dependent kinase 2)