Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1017
Gene name Gene Name - the full gene name approved by the HGNC.	Cyclin dependent kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CDK2
Synonyms (NCBI Gene) Gene synonyms aliases	CDKN2, p33(CDK2)
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004283	hsa-miR-124-3p	Luciferase reporter assay, Western blot	19404929
MIRT004764	hsa-miR-103a-3p	Luciferase reporter assay, qRT-PCR, Western blot	20886090
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005461	hsa-miR-885-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21233845
MIRT006766	hsa-miR-372-3p	FACS, GFP reporter assay, qRT-PCR, Western blot	21646351
MIRT006766	hsa-miR-372-3p	FACS, GFP reporter assay, qRT-PCR, Western blot	21646351
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT020948	hsa-miR-155-5p	Proteomics	18668040
MIRT004283	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT030063	hsa-miR-26b-5p	Microarray	19088304
MIRT047445	hsa-miR-10b-5p	CLASH	23622248
MIRT046257	hsa-miR-23b-3p	CLASH	23622248
MIRT044112	hsa-miR-361-5p	CLASH	23622248
MIRT053070	hsa-miR-223-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24137330
MIRT006766	hsa-miR-372-3p	Luciferase reporter assay, Western blot, qRT-PCR	23479742
MIRT053775	hsa-miR-302a-3p	ChIP-seq, Flow, Microarray, qRT-PCR, Western blot	24861464
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT732203	hsa-miR-200c-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26248649
MIRT732203	hsa-miR-200c-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26248649
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	26701625
MIRT513331	hsa-miR-2909	PAR-CLIP	26701625
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	26701625
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	26701625
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	26701625
MIRT570129	hsa-miR-4492	PAR-CLIP	26701625
MIRT570128	hsa-miR-4498	PAR-CLIP	26701625
MIRT513338	hsa-miR-4784	PAR-CLIP	26701625
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	26701625
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	26701625
MIRT513340	hsa-miR-5186	PAR-CLIP	26701625
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	26701625
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	26701625
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	26701625
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	26701625
MIRT570126	hsa-miR-762	PAR-CLIP	26701625
MIRT513334	hsa-miR-765	PAR-CLIP	26701625
MIRT513336	hsa-miR-766-5p	PAR-CLIP	26701625
MIRT735447	hsa-miR-335-3p	qRT-PCR	32165872
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT755832	hsa-miR-646	Western blotting, qRT-PCR, in vitro cullelar assays, Flow cytometry	37155307
MIRT880948	hsa-miR-18a	CLIP-seq
MIRT880949	hsa-miR-18b	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT880951	hsa-miR-4735-3p	CLIP-seq
MIRT880952	hsa-miR-4761-5p	CLIP-seq
MIRT880953	hsa-miR-520d-5p	CLIP-seq
MIRT880954	hsa-miR-616	CLIP-seq
MIRT880955	hsa-miR-1293	CLIP-seq
MIRT880956	hsa-miR-3129-3p	CLIP-seq
MIRT880957	hsa-miR-3153	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT880959	hsa-miR-3165	CLIP-seq
MIRT880960	hsa-miR-3179	CLIP-seq
MIRT880961	hsa-miR-3199	CLIP-seq
MIRT880962	hsa-miR-3612	CLIP-seq
MIRT880963	hsa-miR-3942-5p	CLIP-seq
MIRT880964	hsa-miR-3975	CLIP-seq
MIRT880965	hsa-miR-4443	CLIP-seq
MIRT880966	hsa-miR-4483	CLIP-seq
MIRT880967	hsa-miR-4515	CLIP-seq
MIRT880968	hsa-miR-4652-5p	CLIP-seq
MIRT880969	hsa-miR-4703-5p	CLIP-seq
MIRT880970	hsa-miR-4716-3p	CLIP-seq
MIRT880971	hsa-miR-548t	CLIP-seq
MIRT880972	hsa-miR-625	CLIP-seq
MIRT880973	hsa-miR-650	CLIP-seq
MIRT880974	hsa-miR-660	CLIP-seq
MIRT1960974	hsa-miR-1224-3p	CLIP-seq
MIRT1960975	hsa-miR-1263	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT1960976	hsa-miR-3622a-3p	CLIP-seq
MIRT1960977	hsa-miR-3622b-3p	CLIP-seq
MIRT1960978	hsa-miR-3651	CLIP-seq
MIRT1960979	hsa-miR-4756-3p	CLIP-seq
MIRT1960980	hsa-miR-4762-5p	CLIP-seq
MIRT1960981	hsa-miR-509-3p	CLIP-seq
MIRT1960982	hsa-miR-548al	CLIP-seq
MIRT2197677	hsa-miR-124	CLIP-seq
MIRT2197678	hsa-miR-200b	CLIP-seq
MIRT2197679	hsa-miR-200c	CLIP-seq
MIRT2197680	hsa-miR-214	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT2197681	hsa-miR-3188	CLIP-seq
MIRT2197682	hsa-miR-3619-5p	CLIP-seq
MIRT2197683	hsa-miR-3652	CLIP-seq
MIRT2197684	hsa-miR-3659	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197686	hsa-miR-3714	CLIP-seq
MIRT2197687	hsa-miR-3910	CLIP-seq
MIRT2197688	hsa-miR-3926	CLIP-seq
MIRT2197689	hsa-miR-3938	CLIP-seq
MIRT2197690	hsa-miR-429	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197692	hsa-miR-4430	CLIP-seq
MIRT2197693	hsa-miR-4459	CLIP-seq
MIRT2197694	hsa-miR-4477b	CLIP-seq
MIRT2197695	hsa-miR-451b	CLIP-seq
MIRT2197696	hsa-miR-4658	CLIP-seq
MIRT2197697	hsa-miR-4695-5p	CLIP-seq
MIRT2197698	hsa-miR-4713-3p	CLIP-seq
MIRT2197699	hsa-miR-4715-5p	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT2197700	hsa-miR-4722-5p	CLIP-seq
MIRT2197701	hsa-miR-4724-5p	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197703	hsa-miR-4742-3p	CLIP-seq
MIRT2197704	hsa-miR-506	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197706	hsa-miR-519a	CLIP-seq
MIRT2197707	hsa-miR-519b-3p	CLIP-seq
MIRT2197708	hsa-miR-519c-3p	CLIP-seq
MIRT2197709	hsa-miR-548s	CLIP-seq
MIRT2197710	hsa-miR-571	CLIP-seq
MIRT2197711	hsa-miR-574-5p	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197713	hsa-miR-630	CLIP-seq
MIRT2197714	hsa-miR-647	CLIP-seq
MIRT2197715	hsa-miR-761	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq

Transcription factors

Show/Hide all(9)

Transcription factor	Regulation	Reference
ARNT	Repression	21544813
DDIT3	Unknown	20017906
E2F4	Unknown	22447046
GLI1	Activation	20647328
IRF1	Repression	22200613
KAT2B	Repression	19525977
MITF	Unknown	15607961
MYC	Unknown	21384303
TP53	Repression	12732645

Show/Hide all(99)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA
GO:0000082	Process	G1/S transition of mitotic cell cycle	IEA
GO:0000082	Process	G1/S transition of mitotic cell cycle	NAS	9840943, 15838514
GO:0000086	Process	G2/M transition of mitotic cell cycle	NAS	1653904
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IDA	1312467, 8692841
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IEA
GO:0000723	Process	Telomere maintenance	IDA	28216226
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000793	Component	Condensed chromosome	IEA
GO:0000805	Component	X chromosome	IEA
GO:0000806	Component	Y chromosome	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11953320
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IGI	26996940
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IDA	21596315, 28216226
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	2227411, 7630397, 8242750, 8521818, 8601310, 8684460, 8756328, 8756624, 9840943, 10330164, 11463386, 11980914, 12244298, 12361598, 12839962, 12941338, 15107404, 15178429, 15189033, 15232106, 15239650, 15530371, 15611625, 15890360, 16061792, 16209941, 16326706, 16327805, 16431923, 167
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10767298
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IDA	8245034
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10767298
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IDA	21262353
GO:0005768	Component	Endosome	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	TAS	19238148
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006260	Process	DNA replication	TAS	19238148
GO:0006281	Process	DNA repair	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006468	Process	Protein phosphorylation	IDA	12944431, 28666995
GO:0006468	Process	Protein phosphorylation	IMP	29203878
GO:0006813	Process	Potassium ion transport	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007099	Process	Centriole replication	IMP	26297806
GO:0007165	Process	Signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IEP	9054499
GO:0007346	Process	Regulation of mitotic cell cycle	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	10767298
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	IBA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0015030	Component	Cajal body	IDA	10995387
GO:0015030	Component	Cajal body	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	23184662
GO:0019904	Function	Protein domain specific binding	IPI	8876165, 15024385
GO:0030332	Function	Cyclin binding	IBA
GO:0030332	Function	Cyclin binding	IDA	1653904, 23781148
GO:0030332	Function	Cyclin binding	IEA
GO:0030332	Function	Cyclin binding	IPI	1312467, 15024385
GO:0031453	Process	Positive regulation of heterochromatin formation	IDA	20935635
GO:0031571	Process	Mitotic G1 DNA damage checkpoint signaling	TAS	21319273
GO:0031848	Process	Protection from non-homologous end joining at telomere	IDA	28216226
GO:0032298	Process	Positive regulation of DNA-templated DNA replication initiation	IEA
GO:0035173	Function	Histone kinase activity	IDA	8692841
GO:0043247	Process	Telomere maintenance in response to DNA damage	IDA	28216226
GO:0043247	Process	Telomere maintenance in response to DNA damage	IDA	28216226
GO:0043687	Process	Post-translational protein modification	IDA	11746698
GO:0045740	Process	Positive regulation of DNA replication	TAS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051298	Process	Centrosome duplication	TAS	19238148
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	TAS	19238148
GO:0071732	Process	Cellular response to nitric oxide	TAS	20079829
GO:0090398	Process	Cellular senescence	TAS
GO:0097123	Component	Cyclin A1-CDK2 complex	IEA
GO:0097123	Component	Cyclin A1-CDK2 complex	NAS	12244298
GO:0097124	Component	Cyclin A2-CDK2 complex	IDA	1312467, 8684460, 8876165, 11746698, 15024385
GO:0097124	Component	Cyclin A2-CDK2 complex	IEA
GO:0097124	Component	Cyclin A2-CDK2 complex	IPI	12244298
GO:0097134	Component	Cyclin E1-CDK2 complex	IEA
GO:0097134	Component	Cyclin E1-CDK2 complex	IPI	8756624
GO:0097135	Component	Cyclin E2-CDK2 complex	IEA
GO:0097135	Component	Cyclin E2-CDK2 complex	IPI	15232106
GO:0097472	Function	Cyclin-dependent protein kinase activity	IDA	1312467, 24670654, 28666995
GO:0097472	Function	Cyclin-dependent protein kinase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1905784	Process	Regulation of anaphase-promoting complex-dependent catabolic process	TAS

MIM	HGNC	e!Ensembl
116953	1771	ENSG00000123374

Protein

UniProt ID

P24941

Protein name

Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)

Protein function

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431,

PDB

1AQ1 , 1B38 , 1B39 , 1BUH , 1CKP , 1DI8 , 1DM2 , 1E1V , 1E1X , 1E9H , 1F5Q , 1FIN , 1FQ1 , 1FVT , 1FVV , 1G5S , 1GIH , 1GII , 1GIJ , 1GY3 , 1GZ8 , 1H00 , 1H01 , 1H07 , 1H08 , 1H0V , 1H0W , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1HCK , 1HCL , 1JST , 1JSU , 1JSV , 1JVP , 1KE5 , 1KE6 , 1KE7 , 1KE8 , 1KE9 , 1OGU , 1OI9 , 1OIQ , 1OIR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	4 → 286	Protein kinase domain	Domain

Sequence

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Sequence length

298

Interactions

View interactions

	KEGG		Reactome
	FoxO signaling pathway Cell cycle Oocyte meiosis p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Progesterone-mediated oocyte maturation Cushing syndrome Hepatitis C Hepatitis B Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Prostate cancer Small cell lung cancer Gastric cancer		G0 and Early G1 Activation of ATR in response to replication stress Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle Transcriptional regulation of granulopoiesis

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (137)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abortion Habitual	Associate	32938693
Acquired Immunodeficiency Syndrome	Associate	12970448
Adenocarcinoma	Associate	9764589
Adenocarcinoma of Lung	Associate	27356570, 30867372, 34880385, 38232915
Aneuploidy	Associate	23321641
Anophthalmia with pulmonary hypoplasia	Associate	39358545
Aortic Dissection	Associate	36818541
Arthritis Rheumatoid	Associate	19404929, 21676922
Astrocytoma	Associate	27172220
Ataxia Telangiectasia	Associate	26429916
Bone Marrow Diseases	Associate	19201832
Breast Neoplasms	Associate	10757805, 10991938, 10995786, 11337496, 12379472, 17055492, 17671085, 18060053, 18236071, 19242061, 21821547, 22108518, 22948662, 23185313, 23285007 View all (17 more)
Carcinogenesis	Associate	11884622, 12684894, 24386425, 26701206, 28760857
Carcinoid Tumor	Inhibit	26008974
Carcinoma Embryonal	Associate	19259937
Carcinoma Hepatocellular	Associate	10884382, 15298730, 25292023, 27782152, 28333141, 28742201, 29782647, 35694386, 35958019, 36047102, 36069218
Carcinoma Large Cell	Associate	9736045
Carcinoma Merkel Cell	Associate	31694959
Carcinoma Non Small Cell Lung	Associate	10817513, 31378747, 32373965, 40682474, 9708810
Carcinoma Pancreatic Ductal	Stimulate	35445726
Carcinoma Renal Cell	Associate	19473483, 25443276, 30675171, 34595849, 37464398, 39199428
Carcinoma Small Cell	Associate	9736045
Carcinoma Squamous Cell	Associate	11710944, 27356570, 34738627, 9736045
Carcinoma Transitional Cell	Associate	10408858
Cardiomyopathies	Associate	32196466, 32631246
Cell Transformation Neoplastic	Associate	24086649
Cholangiocarcinoma	Associate	22972485
Chondrosarcoma	Associate	26555773
Chromosomal Instability	Associate	28760857
Classical Lissencephalies and Subcortical Band Heterotopias	Associate	26121641
Colonic Neoplasms	Associate	16177568
Colorectal Neoplasms	Associate	16437675, 24550143, 29386092, 35039060, 37919073, 7779716
COVID 19	Associate	36575184
Cytomegalovirus Infections	Associate	25870074
Death	Associate	18236071, 9579547
DNA Virus Infections	Associate	31649026
Down Syndrome	Associate	10757805, 30763715
Drug Hypersensitivity	Associate	29229598
Drug Related Side Effects and Adverse Reactions	Associate	15840769, 23305945
Dysplastic Nevus Syndrome	Associate	9579547
Endocrine System Diseases	Associate	33098638
Endometrial Hyperplasia	Stimulate	19631369
Endometrial Neoplasms	Associate	12684894
Epilepsy Idiopathic Generalized	Stimulate	26537625
Epilepsy Idiopathic Generalized	Associate	30675171
Epstein Barr Virus Infections	Inhibit	23534755
Esophageal Squamous Cell Carcinoma	Associate	10390005, 27496804
Fever	Stimulate	15204521
Gallbladder Neoplasms	Associate	29513793
Glioblastoma	Associate	17960384, 32678261, 32781747, 34716726, 35982032, 37936247
Glioma	Associate	18492260, 27613831, 32851798, 37936247
Glomerulonephritis IGA	Associate	15208647
Glomerulonephritis Membranous	Associate	28760550
Head and Neck Neoplasms	Associate	29229598
Heart Failure	Associate	39351221
Hereditary Breast and Ovarian Cancer Syndrome	Associate	26598692, 28678584
HIV Infections	Associate	15531588, 17083724, 31551335, 34233649
Hodgkin Disease	Associate	12393683
Hyperglycemia	Stimulate	12379472
Hypoxia	Inhibit	10471034
Hypoxia	Associate	14511370
Hypoxia Brain	Associate	34599215
Infections	Inhibit	10662629
Infectious Mononucleosis	Associate	28155194
Inflammation	Associate	36042612, 39351221
Inflammatory Breast Neoplasms	Associate	28107181
Influenza Human	Associate	37758692
Intervertebral Disc Degeneration	Associate	32271397
Islet cell tumor syndrome	Associate	30914061
Kidney Diseases	Associate	15208647
Kidney Neoplasms	Associate	24272084
Laryngeal Neoplasms	Associate	28269752
Leiomyoma	Associate	10854234, 30015921
Leiomyosarcoma	Associate	10854234
Leukemia	Associate	24520316, 25451924, 8704231
Leukemia Lymphocytic Chronic B Cell	Associate	15059135
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	10973491
Leukemia Myeloid	Associate	16115123
Leukemia Myeloid Acute	Associate	25844667
Leukoencephalopathy Progressive Multifocal	Associate	12970448
Li Fraumeni Syndrome	Associate	10389970
Lung Diseases	Associate	24671051
Lung Neoplasms	Associate	19633068, 27356570, 33148075, 9708810, 9736045
Lupus Erythematosus Systemic	Associate	24151513
Lymphatic Metastasis	Associate	24386425
Lymphoma	Associate	10851086
Lymphoma B Cell	Associate	16765349
Lymphoma Large B Cell Diffuse	Associate	16704435, 40615583
Lymphoma Mantle Cell	Associate	19594747
Lymphoma Primary Effusion	Associate	16150942
Lymphoma T Cell Cutaneous	Associate	26244872
Lymphoproliferative Disorders	Associate	16449999
Medulloblastoma	Associate	29511348, 29984917, 30678435
Melanoma	Associate	11253137, 11442760, 15607961, 21559390, 23349796, 25980496, 27903987, 29507054, 30385854, 30792348, 33450548, 7589260, 8562340, 9579547
Melanoma Cutaneous Malignant	Stimulate	11253137
Melanoma Cutaneous Malignant	Associate	37401304, 8562340
Microcephaly	Stimulate	26297806
Mouth Neoplasms	Associate	11267947
Multiple Myeloma	Associate	10851086, 27319807, 32060401, 37012388, 9207463
Muscular Dystrophy Duchenne	Associate	34922439
Myocardial Infarction	Associate	18925945
Myopathies Structural Congenital	Stimulate	36069218
Nasopharyngeal Carcinoma	Associate	35303867
Neoplasm Metastasis	Associate	11253137, 26474427, 30237499, 8562340
Neoplasms	Associate	10079269, 10389970, 10390005, 11253137, 12393683, 12419181, 12676582, 16618721, 18276582, 19460940, 19525400, 19633068, 20147522, 20423616, 20504322 View all (40 more)
Neoplasms	Inhibit	10207115, 22471733, 9738978
Neoplasms	Stimulate	15990281, 29896817
Neoplasms Cystic Mucinous and Serous	Associate	27480179
Neuroblastoma	Associate	17273780, 19525400, 28246384, 33016930, 33277872, 35655142, 37813883
Odontogenic Tumors	Associate	28512636
Osteosarcoma	Associate	10234573, 12676582, 30389712, 33963544
Ovarian Neoplasms	Associate	15075339, 19258477, 21424700, 32415712, 32622365, 35843311
Pancreatic Neoplasms	Associate	19460940, 21898405, 9579547
Personality Disorders	Associate	16618721
Polycystic Ovary Syndrome	Associate	19631369
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	8704231
Prostatic Neoplasms	Associate	19017637, 20147522, 21867506, 29767250, 31300540, 35430569
Prostatic Neoplasms Castration Resistant	Associate	25271736
Renal Insufficiency	Associate	24997640, 39351221
Retinoblastoma	Associate	8641969
Rhabdomyosarcoma	Associate	16899113
Sarcoma	Associate	20017906
Sarcoma Ewing	Associate	18271016, 31649026
Skin Neoplasms	Associate	33450548
Small Cell Lung Carcinoma	Stimulate	26008974
Small Cell Lung Carcinoma	Associate	9421477
Spastic paraplegia 11 autosomal recessive	Associate	10408858
Squamous Cell Carcinoma of Head and Neck	Associate	17217620, 19596857, 24386425, 25275298, 27285764, 29229598, 30468474, 34599215, 36768994, 37178584
Stomach Neoplasms	Associate	22320960, 27465546, 27496804, 27983933, 29896817, 31399040, 37848946, 8797888
Tertiary Lymphoid Structures	Associate	11267947
Thyroid Neoplasms	Associate	10510327, 24289643, 35968508
Triple Negative Breast Neoplasms	Associate	24970653, 36998242
Urinary Bladder Neoplasms	Associate	25136960, 30145203, 30237499, 9738978
Uterine Cervical Neoplasms	Associate	12676582, 21646351, 26041102, 34284793, 35246013
Virus Diseases	Associate	17108053
Wilms Tumor	Associate	32214060
Wolf Hirschhorn Syndrome	Associate	27285764

CDK2 (cyclin dependent kinase 2)