Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10161
Gene name	Lysophosphatidic acid receptor 6
Gene symbol	LPAR6
Synonyms (NCBI Gene)	ARWH1HYPT8LAH3LPA-6P2RY5P2Y5
Chromosome	13
Chromosome location	13q14.2
Summary	The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the revers

Show/Hide all (12)

miRTarBase ID	miRNA	Experiments	Reference
MIRT736565	hsa-miR-595	Western blottingMicroarrayqRT-PCR	22101077
MIRT1115496	hsa-miR-1252	CLIP-seq
MIRT1115497	hsa-miR-128	CLIP-seq
MIRT1115498	hsa-miR-27a	CLIP-seq
MIRT1115499	hsa-miR-27b	CLIP-seq
MIRT1115500	hsa-miR-5096	CLIP-seq
MIRT1115501	hsa-miR-513a-5p	CLIP-seq
MIRT1115497	hsa-miR-128	CLIP-seq
MIRT1115498	hsa-miR-27a	CLIP-seq
MIRT1115499	hsa-miR-27b	CLIP-seq
MIRT1115500	hsa-miR-5096	CLIP-seq
MIRT1115501	hsa-miR-513a-5p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001835	Process	Blastocyst hatching	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18297070
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0070915	Function	Lysophosphatidic acid receptor activity	IBA

MIM	HGNC	e!Ensembl
609239	15520	ENSG00000139679

P43657

Protein name

Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor)

Protein function

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.

PDB

9ITB , 9ITE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	34 → 291	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at lo

Sequence

MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLA
MSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVY
PFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTY
LSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCF
CFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQN
SIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA

Sequence length

344

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Pathways in cancer		G alpha (q) signalling events P2Y receptors

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hypotrichosis 8	Pathogenic; Likely pathogenic	rs2138204557, rs121434306, rs121434307, rs121434308, rs121434309, rs2542261609, rs879255262, rs2542256275, rs2542255397, rs1948803416, rs759807882, rs2542254523, rs1566212378	RCV002250094 RCV000001898 RCV003234534 RCV000001902 RCV000001903 RCV002465046 RCV000239380 RCV003234610 RCV003234611 RCV003234612 RCV003237403 RCV004585197 RCV000723282
Wooly hair, autosomal recessive 1, with or without hypotrichosis	Likely pathogenic; Pathogenic	rs121434307	RCV000001901

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
LPAR6-related disorder	Likely benign	rs944321155	RCV003939465
Retinoblastoma	Benign	rs1236830240, rs1275629547, rs1344531248, rs1458608158, rs1200570253, rs1404056158, rs1198561901	RCV000989123 RCV000989124 RCV000989125 RCV000989126 RCV000989127 RCV000989128 RCV000989129

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	34769557
Breast Neoplasms	Associate	17047088, 37372960
Breast Neoplasms	Inhibit	34510318
Carcinogenesis	Associate	18475256
Carcinoma Hepatocellular	Associate	27583415, 29211777, 31236404
Carcinoma Squamous Cell	Associate	29211777
Crohn Disease	Associate	19253308
Hair Diseases	Associate	18803659
Hypotrichosis	Associate	18803659, 19365138, 22385360, 25119526
Hypotrichosis Localized Autosomal Recessive 1	Associate	32336749
Inflammation	Associate	19253308
Inflammatory Bowel Diseases	Associate	19253308
Lung Neoplasms	Associate	34769557
Microvascular Angina	Stimulate	27583415
Neoplasm Metastasis	Inhibit	34510318
Neoplasms	Associate	17702869, 29211777, 34769557, 37372960, 38354460
Neoplasms	Inhibit	18475256, 34510318
Neoplasms Adipose Tissue	Associate	38354460
Ovarian Neoplasms	Associate	17047088
Prostatic Neoplasms	Associate	29211777
Urethral Neoplasms	Associate	18475256
Urinary Bladder Neoplasms	Stimulate	18475256
Woolly Hair Autosomal Recessive	Associate	18803659, 22385360, 22592156
Woolly hair congenital	Associate	18803659, 19365138, 22385360

LPAR6 (lysophosphatidic acid receptor 6)