CDH18 (cadherin 18)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 1016
Gene name Cadherin 18
Gene symbol CDH18
Synonyms (NCBI Gene)
CDH14CDH14LCDH24
Chromosome 5
Chromosome location 5p14.3
Summary This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membra
miRNA miRNA information provided by mirtarbase database.
6
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (6)
miRTarBase ID miRNA Experiments Reference
MIRT051690 hsa-let-7e-5p CLASH 23622248
MIRT2197344 hsa-miR-198 CLIP-seq
MIRT2197345 hsa-miR-3691-3p CLIP-seq
MIRT2197346 hsa-miR-4267 CLIP-seq
MIRT2197347 hsa-miR-4277 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0005912 Component Adherens junction IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603019 1757 ENSG00000145526
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13634
Protein name Cadherin-18 (Cadherin-14)
Protein function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00028 Cadherin 58 → 150 Cadherin domain Domain
PF00028 Cadherin 164 → 259 Cadherin domain Domain
PF00028 Cadherin 273 → 374 Cadherin domain Domain
PF00028 Cadherin 388 → 479 Cadherin domain Domain
PF00028 Cadherin 492 → 589 Cadherin domain Domain
PF01049 Cadherin_C 637 → 784 Cadherin cytoplasmic region Family
Sequence
Sequence length 790
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Adherens junctions interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CDH18-related disorder Likely benign rs751281107, rs142033128 RCV003927339
RCV003926829
Childhood apraxia of speech Uncertain significance rs17285716 RCV000755134
Show/Hide Text Mining Associations (13)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35242247
Apraxias Associate 27120335
Carcinogenesis Associate 37025097
Endometrial Hyperplasia Associate 37780629
Endometrial Neoplasms Associate 37780629
Heart Defects Congenital Associate 30342662
Lymphoma Associate 34166375
Metabolic Syndrome Associate 23628382, 30852652
Migraine Disorders Associate 34380431
Moyamoya Disease Associate 39238003