Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10154
Gene name Gene Name - the full gene name approved by the HGNC.	Plexin C1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLXNC1
Synonyms (NCBI Gene) Gene synonyms aliases	CD232, PLXN-C1, VESPR
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q22
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate

Show/Hide all(102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016344	hsa-miR-193b-3p	Microarray	20304954
MIRT017321	hsa-miR-335-5p	Microarray	18185580
MIRT029051	hsa-miR-26b-5p	Microarray	19088304
MIRT622677	hsa-miR-299-5p	HITS-CLIP	23824327
MIRT622676	hsa-miR-8485	HITS-CLIP	23824327
MIRT622675	hsa-miR-603	HITS-CLIP	23824327
MIRT622674	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622673	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622672	hsa-miR-4719	HITS-CLIP	23824327
MIRT136439	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT136440	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT622677	hsa-miR-299-5p	HITS-CLIP	23824327
MIRT622676	hsa-miR-8485	HITS-CLIP	23824327
MIRT622675	hsa-miR-603	HITS-CLIP	23824327
MIRT622674	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622673	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622672	hsa-miR-4719	HITS-CLIP	23824327
MIRT1243915	hsa-let-7a	CLIP-seq
MIRT1243916	hsa-let-7b	CLIP-seq
MIRT1243917	hsa-let-7c	CLIP-seq
MIRT1243918	hsa-let-7d	CLIP-seq
MIRT1243919	hsa-let-7e	CLIP-seq
MIRT1243920	hsa-let-7f	CLIP-seq
MIRT1243921	hsa-let-7g	CLIP-seq
MIRT1243922	hsa-let-7i	CLIP-seq
MIRT1243923	hsa-miR-1294	CLIP-seq
MIRT1243924	hsa-miR-202	CLIP-seq
MIRT1243925	hsa-miR-21	CLIP-seq
MIRT1243926	hsa-miR-371b-3p	CLIP-seq
MIRT1243927	hsa-miR-4276	CLIP-seq
MIRT1243928	hsa-miR-4458	CLIP-seq
MIRT1243929	hsa-miR-4500	CLIP-seq
MIRT1243930	hsa-miR-4796-3p	CLIP-seq
MIRT1243931	hsa-miR-485-3p	CLIP-seq
MIRT1243932	hsa-miR-520g	CLIP-seq
MIRT1243933	hsa-miR-520h	CLIP-seq
MIRT1243934	hsa-miR-590-5p	CLIP-seq
MIRT1243935	hsa-miR-656	CLIP-seq
MIRT1243936	hsa-miR-98	CLIP-seq
MIRT2072081	hsa-miR-374c	CLIP-seq
MIRT2072082	hsa-miR-605	CLIP-seq
MIRT2072083	hsa-miR-655	CLIP-seq
MIRT2072084	hsa-miR-659	CLIP-seq
MIRT2299132	hsa-miR-15a	CLIP-seq
MIRT2299133	hsa-miR-15b	CLIP-seq
MIRT2299134	hsa-miR-16	CLIP-seq
MIRT2299135	hsa-miR-195	CLIP-seq
MIRT2299136	hsa-miR-424	CLIP-seq
MIRT2299137	hsa-miR-4468	CLIP-seq
MIRT2299138	hsa-miR-497	CLIP-seq
MIRT2299139	hsa-miR-545	CLIP-seq
MIRT2299140	hsa-miR-548p	CLIP-seq
MIRT2392725	hsa-miR-3065-5p	CLIP-seq
MIRT2392726	hsa-miR-409-3p	CLIP-seq
MIRT2392727	hsa-miR-421	CLIP-seq
MIRT2392728	hsa-miR-4684-3p	CLIP-seq
MIRT2432204	hsa-miR-3121-5p	CLIP-seq
MIRT2432205	hsa-miR-501-5p	CLIP-seq
MIRT1243915	hsa-let-7a	CLIP-seq
MIRT1243916	hsa-let-7b	CLIP-seq
MIRT1243917	hsa-let-7c	CLIP-seq
MIRT1243918	hsa-let-7d	CLIP-seq
MIRT1243919	hsa-let-7e	CLIP-seq
MIRT1243920	hsa-let-7f	CLIP-seq
MIRT1243921	hsa-let-7g	CLIP-seq
MIRT1243922	hsa-let-7i	CLIP-seq
MIRT1243923	hsa-miR-1294	CLIP-seq
MIRT2596004	hsa-miR-193a-3p	CLIP-seq
MIRT2596005	hsa-miR-193b	CLIP-seq
MIRT1243924	hsa-miR-202	CLIP-seq
MIRT1243925	hsa-miR-21	CLIP-seq
MIRT2596006	hsa-miR-2114	CLIP-seq
MIRT2596007	hsa-miR-221	CLIP-seq
MIRT2596008	hsa-miR-222	CLIP-seq
MIRT2596009	hsa-miR-3064-3p	CLIP-seq
MIRT2596010	hsa-miR-30a	CLIP-seq
MIRT2596011	hsa-miR-30b	CLIP-seq
MIRT2596012	hsa-miR-30c	CLIP-seq
MIRT2596013	hsa-miR-30d	CLIP-seq
MIRT2596014	hsa-miR-30e	CLIP-seq
MIRT2596015	hsa-miR-3176	CLIP-seq
MIRT2596016	hsa-miR-323-3p	CLIP-seq
MIRT2596017	hsa-miR-335	CLIP-seq
MIRT2596018	hsa-miR-3606	CLIP-seq
MIRT2596019	hsa-miR-3607-3p	CLIP-seq
MIRT2596020	hsa-miR-3686	CLIP-seq
MIRT2596021	hsa-miR-3922-3p	CLIP-seq
MIRT1243927	hsa-miR-4276	CLIP-seq
MIRT2596022	hsa-miR-4292	CLIP-seq
MIRT2596023	hsa-miR-4308	CLIP-seq
MIRT2596024	hsa-miR-4312	CLIP-seq
MIRT1243928	hsa-miR-4458	CLIP-seq
MIRT1243929	hsa-miR-4500	CLIP-seq
MIRT2596025	hsa-miR-4790-5p	CLIP-seq
MIRT1243931	hsa-miR-485-3p	CLIP-seq
MIRT1243934	hsa-miR-590-5p	CLIP-seq
MIRT2596026	hsa-miR-630	CLIP-seq
MIRT2596027	hsa-miR-643	CLIP-seq
MIRT2596028	hsa-miR-7	CLIP-seq
MIRT2596029	hsa-miR-892b	CLIP-seq
MIRT2596030	hsa-miR-921	CLIP-seq
MIRT1243936	hsa-miR-98	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA	21873635
GO:0005102	Function	Signaling receptor binding	TAS	9586637
GO:0005515	Function	Protein binding	IPI	20727575
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007155	Process	Cell adhesion	TAS	9586637
GO:0007162	Process	Negative regulation of cell adhesion	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0017154	Function	Semaphorin receptor activity	IBA	21873635
GO:0030334	Process	Regulation of cell migration	IBA	21873635
GO:0043087	Process	Regulation of GTPase activity	IBA	21873635
GO:0050772	Process	Positive regulation of axonogenesis	IBA	21873635
GO:1902287	Process	Semaphorin-plexin signaling pathway involved in axon guidance	IBA	21873635

MIM	HGNC	e!Ensembl
604259	9106	ENSG00000136040

Protein

UniProt ID

O60486

Protein name

Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232)

Protein function

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and I

PDB

3KUZ , 3NVN , 3NVQ , 6VXK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01437	PSI	454 → 507	Plexin repeat	Family
PF01833	TIG	663 → 750	IPT/TIG domain	Domain
PF01833	TIG	754 → 840	IPT/TIG domain	Domain
PF08337	Plexin_cytopl	1012 → 1535	Plexin cytoplasmic RasGAP domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in heart, brain, lung, spleen and placenta. {ECO:0000269|PubMed:9586637}.

Sequence

MEVSRRKAPPRPPRPAAPLPLLAYLLALAAPGRGADEPVWRSEQAIGAIAASQEDGVFVA
SGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGAAGLG
GLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVA
ATYVLPEPETASRCNPAASDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLW
NGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQASLDCGHGHPDGRRLLLSSSLV
EALDVWAGVFSAAAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESHCKEGDQP
ERVQPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIK
EETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSLQR
CTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVD
SSRELCQNKSQPNRTCTCSIPTRATYKDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPA
CVETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPKENKGNRTNQALQ
VFYIKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMK
FSLPSSRKEMKDVCIQFDGGNCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFD
VIDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRTNVTVKLRVQDTYLDCGTLQY
REDPRFTGYRVESEVDTELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQ
DLTTILCKIKGIKTASTIANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIF
AAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKH
FALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFS
VKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNW
MSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVA
LNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLEL
QMGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHC
HLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRA
PFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDG
CLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEM
EEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFD
EKKKCKWM

Sequence length

1568

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		Other semaphorin interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	30595370
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912 View all (22 more)	30595370

Show/Hide Unknown Diseases (11)

Disease term	Disease name	Evidence	References	Source
Unknown
Endometriosis	Endometriosis		20864642	ClinVar
Alopecia Areata	Alopecia Areata			GWAS
Mental Depression	Mental Depression			GWAS
Eczema	Eczema			GWAS
Neuroticism	Neuroticism			GWAS
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Asthma	Asthma			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Psoriasis	Psoriasis			GWAS
Dermatitis	Dermatitis			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma	Associate	30327758
Carcinoma Hepatocellular	Stimulate	30327758
Colitis Ulcerative	Associate	39596507
Hemangioma	Associate	19349369
Inflammation	Associate	34535017
Inflammation	Stimulate	37853395
Melanoma	Inhibit	18987670
Neoplasm Metastasis	Associate	18987670
Neoplasms	Inhibit	18987670
Neoplasms	Associate	19462467
Neoplasms Basal Cell	Associate	25921176
Neoplasms Squamous Cell	Associate	25921176
Neuroblastoma	Associate	36419120
Osteoarthritis	Associate	37853395
Thyroid Cancer Papillary	Associate	31317324
Urinary Bladder Neoplasms	Associate	25921176

PLXNC1 (plexin C1)