Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	10148
Gene name	Epstein-Barr virus induced 3
Gene symbol	EBI3
Synonyms (NCBI Gene)	IL-27BIL27BIL35B
Chromosome	19
Chromosome location	19p13.3
Summary	This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin

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miRTarBase ID	miRNA	Experiments	Reference
MIRT042869	hsa-miR-324-3p	CLASH	23622248
MIRT496548	hsa-miR-508-5p	PAR-CLIP	22291592
MIRT496547	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT496546	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT496545	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT496544	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT496543	hsa-miR-940	PAR-CLIP	22291592
MIRT496542	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496541	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496540	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496539	hsa-miR-4690-3p	PAR-CLIP	22291592
MIRT496538	hsa-miR-5685	PAR-CLIP	22291592
MIRT496537	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496536	hsa-miR-766-3p	PAR-CLIP	22291592
MIRT496535	hsa-miR-6069	PAR-CLIP	22291592
MIRT496534	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496533	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT496548	hsa-miR-508-5p	PAR-CLIP	22291592
MIRT496547	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT496546	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT496545	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT496544	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT496543	hsa-miR-940	PAR-CLIP	22291592
MIRT496542	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496541	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496540	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496539	hsa-miR-4690-3p	PAR-CLIP	22291592
MIRT496538	hsa-miR-5685	PAR-CLIP	22291592
MIRT496537	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496536	hsa-miR-766-3p	PAR-CLIP	22291592
MIRT496535	hsa-miR-6069	PAR-CLIP	22291592
MIRT496534	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496533	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT951411	hsa-miR-15a	CLIP-seq
MIRT951412	hsa-miR-15b	CLIP-seq
MIRT951413	hsa-miR-16	CLIP-seq
MIRT951414	hsa-miR-195	CLIP-seq
MIRT951415	hsa-miR-214	CLIP-seq
MIRT951416	hsa-miR-330-3p	CLIP-seq
MIRT951417	hsa-miR-3619-5p	CLIP-seq
MIRT951418	hsa-miR-424	CLIP-seq
MIRT951419	hsa-miR-4291	CLIP-seq
MIRT951420	hsa-miR-4660	CLIP-seq
MIRT951421	hsa-miR-497	CLIP-seq
MIRT951422	hsa-miR-545	CLIP-seq
MIRT951423	hsa-miR-761	CLIP-seq
MIRT951424	hsa-miR-922	CLIP-seq
MIRT1981821	hsa-miR-2467-5p	CLIP-seq
MIRT1981822	hsa-miR-3123	CLIP-seq
MIRT1981823	hsa-miR-3188	CLIP-seq
MIRT1981824	hsa-miR-3925-5p	CLIP-seq
MIRT1981825	hsa-miR-3975	CLIP-seq
MIRT1981826	hsa-miR-4649-3p	CLIP-seq
MIRT1981827	hsa-miR-4738-3p	CLIP-seq
MIRT1981828	hsa-miR-485-5p	CLIP-seq
MIRT1981826	hsa-miR-4649-3p	CLIP-seq

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Transcription factor	Regulation	Reference
NFKB1	Activation	9733827
NFKBIA	Repression	9733827
RELA	Activation	9733827

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0004896	Function	Cytokine receptor activity	IEA
GO:0004896	Function	Cytokine receptor activity	IPI	9342359
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	9342359, 20974977
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	8551575
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	TAS	8551575
GO:0006959	Process	Humoral immune response	TAS	8551575
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0032729	Process	Positive regulation of type II interferon production	TAS	14743498
GO:0042088	Process	T-helper 1 type immune response	TAS	14743498
GO:0042098	Process	T cell proliferation	IBA
GO:0042098	Process	T cell proliferation	IEA
GO:0045523	Function	Interleukin-27 receptor binding	IBA
GO:0045523	Function	Interleukin-27 receptor binding	IEA
GO:0046641	Process	Positive regulation of alpha-beta T cell proliferation	TAS	14743498

MIM	HGNC	e!Ensembl
605816	3129	ENSG00000105246

Q14213

Protein name

Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)

Protein function

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimula

PDB

7U7N , 7ZXK , 8D85 , 8XWY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	130 → 215	Fibronectin type III domain	Domain

Sequence

MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPV
SFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVP
FITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRV
GPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK

Sequence length

229

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Th17 cell differentiation		Interleukin-35 Signalling Interleukin-27 signaling

EBI3 (Epstein-Barr virus induced 3)