Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10147
Gene name	SURP and G-patch domain containing 2
Gene symbol	SUGP2
Synonyms (NCBI Gene)	SFRS14SRFS14
Chromosome	19
Chromosome location	19p13.11
Summary	This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

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Show/Hide all (202)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051552	hsa-let-7e-5p	CLASH	23622248
MIRT046029	hsa-miR-125b-5p	CLASH	23622248
MIRT042295	hsa-miR-484	CLASH	23622248
MIRT1402529	hsa-miR-1200	CLIP-seq
MIRT1402530	hsa-miR-122	CLIP-seq
MIRT1402531	hsa-miR-1254	CLIP-seq
MIRT1402532	hsa-miR-1282	CLIP-seq
MIRT1402533	hsa-miR-129-5p	CLIP-seq
MIRT1402534	hsa-miR-1297	CLIP-seq
MIRT1402535	hsa-miR-1343	CLIP-seq
MIRT1402536	hsa-miR-183	CLIP-seq
MIRT1402537	hsa-miR-185	CLIP-seq
MIRT1402538	hsa-miR-2110	CLIP-seq
MIRT1402539	hsa-miR-26a	CLIP-seq
MIRT1402540	hsa-miR-26b	CLIP-seq
MIRT1402541	hsa-miR-3116	CLIP-seq
MIRT1402542	hsa-miR-3180-5p	CLIP-seq
MIRT1402543	hsa-miR-342-5p	CLIP-seq
MIRT1402544	hsa-miR-3622b-5p	CLIP-seq
MIRT1402545	hsa-miR-3657	CLIP-seq
MIRT1402546	hsa-miR-3692	CLIP-seq
MIRT1402547	hsa-miR-3919	CLIP-seq
MIRT1402548	hsa-miR-4252	CLIP-seq
MIRT1402549	hsa-miR-4257	CLIP-seq
MIRT1402550	hsa-miR-4271	CLIP-seq
MIRT1402551	hsa-miR-4306	CLIP-seq
MIRT1402552	hsa-miR-4324	CLIP-seq
MIRT1402553	hsa-miR-4438	CLIP-seq
MIRT1402554	hsa-miR-4465	CLIP-seq
MIRT1402555	hsa-miR-4488	CLIP-seq
MIRT1402556	hsa-miR-4639-5p	CLIP-seq
MIRT1402557	hsa-miR-4641	CLIP-seq
MIRT1402558	hsa-miR-4644	CLIP-seq
MIRT1402559	hsa-miR-4651	CLIP-seq
MIRT1402560	hsa-miR-4664-5p	CLIP-seq
MIRT1402561	hsa-miR-4667-5p	CLIP-seq
MIRT1402562	hsa-miR-4669	CLIP-seq
MIRT1402563	hsa-miR-4695-3p	CLIP-seq
MIRT1402564	hsa-miR-4697-5p	CLIP-seq
MIRT1402565	hsa-miR-4700-5p	CLIP-seq
MIRT1402566	hsa-miR-4707-3p	CLIP-seq
MIRT1402567	hsa-miR-4707-5p	CLIP-seq
MIRT1402568	hsa-miR-4713-3p	CLIP-seq
MIRT1402569	hsa-miR-4717-3p	CLIP-seq
MIRT1402570	hsa-miR-4725-3p	CLIP-seq
MIRT1402571	hsa-miR-4731-5p	CLIP-seq
MIRT1402572	hsa-miR-4735-5p	CLIP-seq
MIRT1402573	hsa-miR-4756-3p	CLIP-seq
MIRT1402574	hsa-miR-4772-3p	CLIP-seq
MIRT1402575	hsa-miR-4775	CLIP-seq
MIRT1402576	hsa-miR-4781-5p	CLIP-seq
MIRT1402577	hsa-miR-4794	CLIP-seq
MIRT1402578	hsa-miR-499-3p	CLIP-seq
MIRT1402579	hsa-miR-499a-3p	CLIP-seq
MIRT1402580	hsa-miR-500a	CLIP-seq
MIRT1402581	hsa-miR-5095	CLIP-seq
MIRT1402582	hsa-miR-512-3p	CLIP-seq
MIRT1402583	hsa-miR-516b	CLIP-seq
MIRT1402584	hsa-miR-520a-5p	CLIP-seq
MIRT1402585	hsa-miR-525-5p	CLIP-seq
MIRT1402586	hsa-miR-544b	CLIP-seq
MIRT1402587	hsa-miR-550a	CLIP-seq
MIRT1402588	hsa-miR-552	CLIP-seq
MIRT1402589	hsa-miR-590-3p	CLIP-seq
MIRT1402590	hsa-miR-608	CLIP-seq
MIRT1402591	hsa-miR-661	CLIP-seq
MIRT1402592	hsa-miR-671-3p	CLIP-seq
MIRT1402593	hsa-miR-759	CLIP-seq
MIRT1402594	hsa-miR-764	CLIP-seq
MIRT1402595	hsa-miR-922	CLIP-seq
MIRT1402596	hsa-miR-1238	CLIP-seq
MIRT1402597	hsa-miR-137	CLIP-seq
MIRT1402598	hsa-miR-194	CLIP-seq
MIRT1402599	hsa-miR-217	CLIP-seq
MIRT1402600	hsa-miR-25	CLIP-seq
MIRT1402601	hsa-miR-32	CLIP-seq
MIRT1402602	hsa-miR-337-5p	CLIP-seq
MIRT1402603	hsa-miR-363	CLIP-seq
MIRT1402604	hsa-miR-3646	CLIP-seq
MIRT1402605	hsa-miR-367	CLIP-seq
MIRT1402606	hsa-miR-4719	CLIP-seq
MIRT1402607	hsa-miR-4729	CLIP-seq
MIRT1402578	hsa-miR-499-3p	CLIP-seq
MIRT1402579	hsa-miR-499a-3p	CLIP-seq
MIRT1402608	hsa-miR-645	CLIP-seq
MIRT1402609	hsa-miR-891a	CLIP-seq
MIRT1402610	hsa-miR-92a	CLIP-seq
MIRT1402611	hsa-miR-92b	CLIP-seq
MIRT2120756	hsa-miR-1825	CLIP-seq
MIRT2120757	hsa-miR-199a-5p	CLIP-seq
MIRT2120758	hsa-miR-199b-5p	CLIP-seq
MIRT1402608	hsa-miR-645	CLIP-seq
MIRT1402530	hsa-miR-122	CLIP-seq
MIRT1402534	hsa-miR-1297	CLIP-seq
MIRT1402539	hsa-miR-26a	CLIP-seq
MIRT1402540	hsa-miR-26b	CLIP-seq
MIRT2342754	hsa-miR-3135b	CLIP-seq
MIRT1402544	hsa-miR-3622b-5p	CLIP-seq
MIRT2342755	hsa-miR-3652	CLIP-seq
MIRT2342756	hsa-miR-371-5p	CLIP-seq
MIRT1402547	hsa-miR-3919	CLIP-seq
MIRT2342757	hsa-miR-4430	CLIP-seq
MIRT1402554	hsa-miR-4465	CLIP-seq
MIRT1402563	hsa-miR-4695-3p	CLIP-seq
MIRT1402567	hsa-miR-4707-5p	CLIP-seq
MIRT1402573	hsa-miR-4756-3p	CLIP-seq
MIRT1402574	hsa-miR-4772-3p	CLIP-seq
MIRT1402592	hsa-miR-671-3p	CLIP-seq
MIRT1402594	hsa-miR-764	CLIP-seq
MIRT2395413	hsa-miR-1207-5p	CLIP-seq
MIRT2395414	hsa-miR-1237	CLIP-seq
MIRT2395415	hsa-miR-3179	CLIP-seq
MIRT2395416	hsa-miR-4436b-3p	CLIP-seq
MIRT2395417	hsa-miR-4645-5p	CLIP-seq
MIRT2395418	hsa-miR-4673	CLIP-seq
MIRT2395419	hsa-miR-4685-5p	CLIP-seq
MIRT2395420	hsa-miR-4763-3p	CLIP-seq
MIRT2395421	hsa-miR-486-3p	CLIP-seq
MIRT2395422	hsa-miR-885-3p	CLIP-seq
MIRT1402533	hsa-miR-129-5p	CLIP-seq
MIRT1402534	hsa-miR-1297	CLIP-seq
MIRT2460786	hsa-miR-1976	CLIP-seq
MIRT1402539	hsa-miR-26a	CLIP-seq
MIRT1402540	hsa-miR-26b	CLIP-seq
MIRT2460787	hsa-miR-3149	CLIP-seq
MIRT2460788	hsa-miR-411	CLIP-seq
MIRT2460789	hsa-miR-4279	CLIP-seq
MIRT1402554	hsa-miR-4465	CLIP-seq
MIRT1402567	hsa-miR-4707-5p	CLIP-seq
MIRT2460790	hsa-miR-4722-3p	CLIP-seq
MIRT1402572	hsa-miR-4735-5p	CLIP-seq
MIRT1402575	hsa-miR-4775	CLIP-seq
MIRT1402577	hsa-miR-4794	CLIP-seq
MIRT2460791	hsa-miR-483-5p	CLIP-seq
MIRT1402589	hsa-miR-590-3p	CLIP-seq
MIRT1402592	hsa-miR-671-3p	CLIP-seq
MIRT1402533	hsa-miR-129-5p	CLIP-seq
MIRT2460787	hsa-miR-3149	CLIP-seq
MIRT2460788	hsa-miR-411	CLIP-seq
MIRT1402572	hsa-miR-4735-5p	CLIP-seq
MIRT1402575	hsa-miR-4775	CLIP-seq
MIRT1402577	hsa-miR-4794	CLIP-seq
MIRT2460791	hsa-miR-483-5p	CLIP-seq
MIRT1402589	hsa-miR-590-3p	CLIP-seq
MIRT1402529	hsa-miR-1200	CLIP-seq
MIRT1402530	hsa-miR-122	CLIP-seq
MIRT1402533	hsa-miR-129-5p	CLIP-seq
MIRT1402534	hsa-miR-1297	CLIP-seq
MIRT2636514	hsa-miR-181a	CLIP-seq
MIRT2636515	hsa-miR-181b	CLIP-seq
MIRT2636516	hsa-miR-181c	CLIP-seq
MIRT2636517	hsa-miR-181d	CLIP-seq
MIRT1402536	hsa-miR-183	CLIP-seq
MIRT1402537	hsa-miR-185	CLIP-seq
MIRT2460786	hsa-miR-1976	CLIP-seq
MIRT1402538	hsa-miR-2110	CLIP-seq
MIRT1402539	hsa-miR-26a	CLIP-seq
MIRT1402540	hsa-miR-26b	CLIP-seq
MIRT2342754	hsa-miR-3135b	CLIP-seq
MIRT2460787	hsa-miR-3149	CLIP-seq
MIRT1402544	hsa-miR-3622b-5p	CLIP-seq
MIRT2342755	hsa-miR-3652	CLIP-seq
MIRT1402547	hsa-miR-3919	CLIP-seq
MIRT2460788	hsa-miR-411	CLIP-seq
MIRT2636518	hsa-miR-4262	CLIP-seq
MIRT1402550	hsa-miR-4271	CLIP-seq
MIRT2460789	hsa-miR-4279	CLIP-seq
MIRT1402551	hsa-miR-4306	CLIP-seq
MIRT1402552	hsa-miR-4324	CLIP-seq
MIRT2342757	hsa-miR-4430	CLIP-seq
MIRT1402554	hsa-miR-4465	CLIP-seq
MIRT1402558	hsa-miR-4644	CLIP-seq
MIRT1402561	hsa-miR-4667-5p	CLIP-seq
MIRT1402565	hsa-miR-4700-5p	CLIP-seq
MIRT1402566	hsa-miR-4707-3p	CLIP-seq
MIRT1402567	hsa-miR-4707-5p	CLIP-seq
MIRT2460790	hsa-miR-4722-3p	CLIP-seq
MIRT1402570	hsa-miR-4725-3p	CLIP-seq
MIRT1402571	hsa-miR-4731-5p	CLIP-seq
MIRT1402572	hsa-miR-4735-5p	CLIP-seq
MIRT1402573	hsa-miR-4756-3p	CLIP-seq
MIRT1402575	hsa-miR-4775	CLIP-seq
MIRT1402576	hsa-miR-4781-5p	CLIP-seq
MIRT1402577	hsa-miR-4794	CLIP-seq
MIRT2460791	hsa-miR-483-5p	CLIP-seq
MIRT1402581	hsa-miR-5095	CLIP-seq
MIRT1402582	hsa-miR-512-3p	CLIP-seq
MIRT1402583	hsa-miR-516b	CLIP-seq
MIRT1402586	hsa-miR-544b	CLIP-seq
MIRT1402588	hsa-miR-552	CLIP-seq
MIRT1402589	hsa-miR-590-3p	CLIP-seq
MIRT1402592	hsa-miR-671-3p	CLIP-seq
MIRT1402593	hsa-miR-759	CLIP-seq
MIRT1402595	hsa-miR-922	CLIP-seq
MIRT1402533	hsa-miR-129-5p	CLIP-seq
MIRT2460787	hsa-miR-3149	CLIP-seq
MIRT2460788	hsa-miR-411	CLIP-seq
MIRT1402572	hsa-miR-4735-5p	CLIP-seq
MIRT1402575	hsa-miR-4775	CLIP-seq
MIRT1402577	hsa-miR-4794	CLIP-seq
MIRT2460791	hsa-miR-483-5p	CLIP-seq
MIRT1402589	hsa-miR-590-3p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016604	Component	Nuclear body	IDA

MIM	HGNC	e!Ensembl
607993	18641	ENSG00000064607

Q8IX01

Protein name

SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)

Protein function

May play a role in mRNA splicing.

PDB

1X4P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01805	Surp	785 → 837	Surp module	Family
PF01585	G-patch	1011 → 1055	G-patch domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in adult testis, and in fetal brain and kidney. {ECO:0000269|PubMed:12594045}.

Sequence

MAARRITQETFDAVLQEKAKRYHMDASGEAVSETLQFKAQDLLRAVPRSRAEMYDDVHSD
GRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSYFRKECGRDLEFSHSDSRD
QVIGHRKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQEYSFGPSAVLGDFGSSRLIE
KECLEKESRDYDVDHPGEADSVLRGGSQVQARGRALNIVDQEGSLLGKGETQGLLTAKGG
VGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTPSPDVTLGTNPGTEDIQFPIQKIPL
GLDLKNLRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETE
TCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFE
IIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSL
ALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGC
PLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLSDAVPQRADHRVVGTIDQLVKRVIEG
SLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRA
MLYSRAVRNLKKKLLPWQRRGLLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGL
SQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASGPSPKPAGVDISEAPQTSSPCPSADI
DMKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFELCPS
ICFTSSPHNLHTGGGDTTGSQESPVDLMEGEAEFEDEPPPREAELESPEVMPEEEDEDDE
DGGEEAPAPGGAGKSEGSTPADGLPGEAAEDDLAGAPALSQASSGTCFPRKRISSKSLKV
GMIPAPKRVCLIQEPKVHEPVRIAYDRPRGRPMSKKKKPKDLDFAQQKLTDKNLGFQMLQ
KMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGADGQEHKEDTFDVFRQRMMQMYRHKRA
NK

Sequence length

1082

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
FAMILIAL HYPERLIPIDEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Diabetes Mellitus	Associate	34583728	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemochromatosis	Associate	34583728	★★★★★ ★☆☆☆☆ Found in Text Mining only
Iron Overload	Associate	34583728	★★★★★ ★☆☆☆☆ Found in Text Mining only

SUGP2 (SURP and G-patch domain containing 2)