NAMPT (nicotinamide phosphoribosyltransferase)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10135 |
| Gene name | Nicotinamide phosphoribosyltransferase |
| Gene symbol | NAMPT |
| Synonyms (NCBI Gene) |
1110035O14RikPBEFPBEF1VFVISFATIN
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| Chromosome | 7 |
| Chromosome location | 7q22.3 |
| Summary | This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic |
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miRNA
miRNA information provided by mirtarbase database.
586
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
4
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P43490 | |||||||||||||||
| Protein name | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | |||||||||||||||
| Protein function | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The s | |||||||||||||||
| PDB | 2E5B , 2E5C , 2E5D , 2GVG , 2GVJ , 3DGR , 3DHD , 3DHF , 3DKJ , 3DKL , 4JNM , 4JR5 , 4KFN , 4KFO , 4KFP , 4L4L , 4L4M , 4LTS , 4LV9 , 4LVA , 4LVB , 4LVD , 4LVF , 4LVG , 4LWW , 4M6P , 4M6Q , 4N9B , 4N9C , 4N9D , 4N9E , 4O0Z , 4O10 , 4O12 , 4O13 , 4O14 , 4O15 , 4O16 , 4O17 , 4O18 , 4O19 , 4O1A , 4O1B , 4O1C , 4O1D , 4O28 , 4WQ6 , 5KIT , 5LX3 , 5LX5 , 5NSD | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. | |||||||||||||||
| Sequence |
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| Sequence length | 491 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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