Gene Gene information from NCBI Gene database.
Entrez ID 10135
Gene name Nicotinamide phosphoribosyltransferase
Gene symbol NAMPT
Synonyms (NCBI Gene)
1110035O14RikPBEFPBEF1VFVISFATIN
Chromosome 7
Chromosome location 7q22.3
Summary This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic
miRNA miRNA information provided by mirtarbase database.
586
miRTarBase ID miRNA Experiments Reference
MIRT005102 hsa-miR-155-5p Microarray 19193853
MIRT031598 hsa-miR-16-5p Proteomics 18668040
MIRT053226 hsa-miR-34a-5p Luciferase reporter assayWestern blot 23834033
MIRT437686 hsa-miR-223-3p MicroarrayqRT-PCR 22815788
MIRT438241 hsa-miR-26b-5p Luciferase reporter assayqRT-PCRWestern blot 23922874
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
CLOCK Activation 19299583
JUN Activation 16701870
NFKB1 Activation 16701870
RELA Activation 16701870
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity TAS 8289818
GO:0005515 Function Protein binding IPI 18486613, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608764 30092 ENSG00000105835
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P43490
Protein name Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)
Protein function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The s
PDB 2E5B , 2E5C , 2E5D , 2GVG , 2GVJ , 3DGR , 3DHD , 3DHF , 3DKJ , 3DKL , 4JNM , 4JR5 , 4KFN , 4KFO , 4KFP , 4L4L , 4L4M , 4LTS , 4LV9 , 4LVA , 4LVB , 4LVD , 4LVF , 4LVG , 4LWW , 4M6P , 4M6Q , 4N9B , 4N9C , 4N9D , 4N9E , 4O0Z , 4O10 , 4O12 , 4O13 , 4O14 , 4O15 , 4O16 , 4O17 , 4O18 , 4O19 , 4O1A , 4O1B , 4O1C , 4O1D , 4O28 , 4WQ6 , 5KIT , 5LX3 , 5LX5 , 5NSD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18127 DUF5598 10 116 Domain of unknown function (DUF5598) Domain
PF04095 NAPRTase 188 466 Nicotinate phosphoribosyltransferase (NAPRTase) family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Sequence
Sequence length 491
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nicotinate and nicotinamide metabolism
Metabolic pathways
NOD-like receptor signaling pathway
  BMAL1:CLOCK,NPAS2 activates circadian gene expression
Nicotinamide salvaging