|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10135
|
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Nicotinamide phosphoribosyltransferase |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
NAMPT |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN |
|
Chromosome
Chromosome number
|
7 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7q22.3 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic |
| UniProt ID |
P43490
|
| Protein name |
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) |
| Protein function |
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The s |
| PDB |
2E5B
,
2E5C
,
2E5D
,
2GVG
,
2GVJ
,
3DGR
,
3DHD
,
3DHF
,
3DKJ
,
3DKL
,
4JNM
,
4JR5
,
4KFN
,
4KFO
,
4KFP
,
4L4L
,
4L4M
,
4LTS
,
4LV9
,
4LVA
,
4LVB
,
4LVD
,
4LVF
,
4LVG
,
4LWW
,
4M6P
,
4M6Q
,
4N9B
,
4N9C
,
4N9D
,
4N9E
,
4O0Z
,
4O10
,
4O12
,
4O13
,
4O14
,
4O15
,
4O16
,
4O17
,
4O18
,
4O19
,
4O1A
,
4O1B
,
4O1C
,
4O1D
,
4O28
,
4WQ6
,
5KIT
,
5LX3
,
5LX5
,
5NSD
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
|
PF18127
|
DUF5598 |
10 → 116 |
Domain of unknown function (DUF5598) |
Domain |
|
PF04095
|
NAPRTase |
188 → 466 |
Nicotinate phosphoribosyltransferase (NAPRTase) family |
Family |
|
| Tissue specificity |
TISSUE SPECIFICITY: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. |
| Sequence |
|
| Sequence length |
491 |
| Interactions |
View interactions
|