Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10135
Gene name Gene Name - the full gene name approved by the HGNC.
Nicotinamide phosphoribosyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NAMPT
Synonyms (NCBI Gene) Gene synonyms aliases
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005102 hsa-miR-155-5p Microarray 19193853
MIRT031598 hsa-miR-16-5p Proteomics 18668040
MIRT053226 hsa-miR-34a-5p Luciferase reporter assay, Western blot 23834033
MIRT437686 hsa-miR-223-3p Microarray, qRT-PCR 22815788
MIRT438241 hsa-miR-26b-5p Luciferase reporter assay, qRT-PCR, Western blot 23922874
Transcription factors
Transcription factor Regulation Reference
CLOCK Activation 19299583
JUN Activation 16701870
NFKB1 Activation 16701870
RELA Activation 16701870
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity TAS 8289818
GO:0005515 Function Protein binding IPI 18486613, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608764 30092 ENSG00000105835
Protein
UniProt ID P43490
Protein name Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)
Protein function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The s
PDB 2E5B , 2E5C , 2E5D , 2GVG , 2GVJ , 3DGR , 3DHD , 3DHF , 3DKJ , 3DKL , 4JNM , 4JR5 , 4KFN , 4KFO , 4KFP , 4L4L , 4L4M , 4LTS , 4LV9 , 4LVA , 4LVB , 4LVD , 4LVF , 4LVG , 4LWW , 4M6P , 4M6Q , 4N9B , 4N9C , 4N9D , 4N9E , 4O0Z , 4O10 , 4O12 , 4O13 , 4O14 , 4O15 , 4O16 , 4O17 , 4O18 , 4O19 , 4O1A , 4O1B , 4O1C , 4O1D , 4O28 , 4WQ6 , 5KIT , 5LX3 , 5LX5 , 5NSD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18127 DUF5598 10 116 Domain of unknown function (DUF5598) Domain
PF04095 NAPRTase 188 466 Nicotinate phosphoribosyltransferase (NAPRTase) family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Sequence
Sequence length 491
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nicotinate and nicotinamide metabolism
Metabolic pathways
NOD-like receptor signaling pathway
  BMAL1:CLOCK,NPAS2 activates circadian gene expression
Nicotinamide salvaging
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