TRAP1 (TNF receptor associated protein 1)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10131
Gene name Gene Name - the full gene name approved by the HGNC.
TNF receptor associated protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRAP1
Synonyms (NCBI Gene) Gene synonyms aliases
HSP 75, HSP75, HSP90L, TRAP-1
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stres
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs113476582 T>A,C Conflicting-interpretations-of-pathogenicity Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(42)
miRTarBase ID miRNA Experiments Reference
MIRT031812 hsa-miR-16-5p Proteomics 18668040
MIRT049372 hsa-miR-92a-3p qRT-PCR 23622248
MIRT031812 hsa-miR-16-5p CLASH 23622248
MIRT050940 hsa-miR-17-5p CLASH 23622248
MIRT050345 hsa-miR-25-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005164 Function Tumor necrosis factor receptor binding NAS 7876093
GO:0005515 Function Protein binding IPI 17579517, 23564345, 23747254, 29128334
GO:0005524 Function ATP binding IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606219 16264 ENSG00000126602
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q12931
Protein name Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
Protein function Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance betw
PDB 4Z1F , 4Z1G , 4Z1H , 4Z1I , 5F3K , 5F5R , 5HPH , 5Y3N , 5Y3O , 6XG6 , 7C04 , 7C05 , 7C7B , 7C7C , 7KCK , 7KCL , 7KCM , 7KLU , 7KLV , 7U8U , 7U8V , 7U8W , 7U8X , 7ULK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02518 HATPase_c 108 → 260 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Domain
PF00183 HSP90 288 → 704 Hsp90 protein Family
Tissue specificity TISSUE SPECIFICITY: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other ty
Sequence
Sequence length 704
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Parkinson disease
Pathways of neurodegeneration - multiple diseases 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Congenital anomalies of kidney and urinary tract Cakut rs267606865, rs121908436, rs281875326, rs879255515, rs75462234, rs869320679, rs760905589, rs797045022, rs869320624, rs745597204, rs1114167358, rs1555879360, rs1577330805, rs1008555507 24152966
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 21364753
Vacterl association VATER/VACTERL ASSOCIATION rs752504125, rs869320684, rs776556963 24152966
Show/Hide Unknown Diseases (5)
Unknown
Disease term Disease name Evidence References Source
Crohn disease Crohn Disease 31039275 ClinVar
Gout Gout GWAS
Sclerosing Cholangitis Sclerosing Cholangitis GWAS
Asthma Asthma GWAS
Show/Hide Text Mining Associations (47)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32092740
Adenoma Stimulate 28177905
Breast Neoplasms Associate 23735188, 33145341
Carcinogenesis Associate 23747254, 26464709, 27662365
Carcinoma in Situ Stimulate 28177905
Carcinoma Non Small Cell Lung Associate 24567527
Carcinoma Ovarian Epithelial Associate 26408177
Chronic Pain Associate 26022780
Colitis Ulcerative Associate 20828217
Colitis Ulcerative Stimulate 25493016