FRY (FRY microtubule binding protein)

Gene

• Entrez ID: 10129
• Gene name: FRY microtubule binding protein
• Gene symbol: FRY
• Synonyms (NCBI Gene): 13CDNA73, 214K23.2, C13orf14, CG003, bA207N4.2, bA37E23.1
• Chromosome: 13
• Chromosome location: 13q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021767	hsa-miR-132-3p	Microarray	17612493
MIRT640658	hsa-miR-3133	HITS-CLIP	23824327
MIRT640657	hsa-miR-186-5p	HITS-CLIP	23824327
MIRT640656	hsa-miR-4744	HITS-CLIP	23824327
MIRT640655	hsa-miR-4509	HITS-CLIP	23824327
MIRT640654	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT640653	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT640652	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT527951	hsa-miR-548a-5p	PAR-CLIP	22012620
MIRT527950	hsa-miR-548ab	PAR-CLIP	22012620
MIRT527949	hsa-miR-548ad-5p	PAR-CLIP	22012620
MIRT527948	hsa-miR-548ae-5p	PAR-CLIP	22012620
MIRT527947	hsa-miR-548ak	PAR-CLIP	22012620
MIRT527946	hsa-miR-548am-5p	PAR-CLIP	22012620
MIRT527945	hsa-miR-548ap-5p	PAR-CLIP	22012620
MIRT527944	hsa-miR-548aq-5p	PAR-CLIP	22012620
MIRT527943	hsa-miR-548ar-5p	PAR-CLIP	22012620
MIRT527942	hsa-miR-548as-5p	PAR-CLIP	22012620
MIRT527941	hsa-miR-548au-5p	PAR-CLIP	22012620
MIRT527940	hsa-miR-548ay-5p	PAR-CLIP	22012620
MIRT527939	hsa-miR-548b-5p	PAR-CLIP	22012620
MIRT527938	hsa-miR-548bb-5p	PAR-CLIP	22012620
MIRT527937	hsa-miR-548c-5p	PAR-CLIP	22012620
MIRT527936	hsa-miR-548d-5p	PAR-CLIP	22012620
MIRT527935	hsa-miR-548h-5p	PAR-CLIP	22012620
MIRT527934	hsa-miR-548i	PAR-CLIP	22012620
MIRT527933	hsa-miR-548j-5p	PAR-CLIP	22012620
MIRT527932	hsa-miR-548o-5p	PAR-CLIP	22012620
MIRT527931	hsa-miR-548w	PAR-CLIP	22012620
MIRT527930	hsa-miR-548y	PAR-CLIP	22012620
MIRT527929	hsa-miR-559	PAR-CLIP	22012620
MIRT527928	hsa-miR-4517	PAR-CLIP	22012620
MIRT527927	hsa-miR-802	PAR-CLIP	22012620
MIRT527926	hsa-miR-425-5p	PAR-CLIP	22012620
MIRT527925	hsa-miR-3973	PAR-CLIP	22012620
MIRT527924	hsa-miR-3913-3p	PAR-CLIP	22012620
MIRT527923	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT640658	hsa-miR-3133	HITS-CLIP	23824327
MIRT640657	hsa-miR-186-5p	HITS-CLIP	23824327
MIRT640656	hsa-miR-4744	HITS-CLIP	23824327
MIRT640655	hsa-miR-4509	HITS-CLIP	23824327
MIRT640654	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT640653	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT640652	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT527951	hsa-miR-548a-5p	PAR-CLIP	22012620
MIRT527950	hsa-miR-548ab	PAR-CLIP	22012620
MIRT527949	hsa-miR-548ad-5p	PAR-CLIP	22012620
MIRT527948	hsa-miR-548ae-5p	PAR-CLIP	22012620
MIRT527947	hsa-miR-548ak	PAR-CLIP	22012620
MIRT527946	hsa-miR-548am-5p	PAR-CLIP	22012620
MIRT527945	hsa-miR-548ap-5p	PAR-CLIP	22012620
MIRT527944	hsa-miR-548aq-5p	PAR-CLIP	22012620
MIRT527943	hsa-miR-548ar-5p	PAR-CLIP	22012620
MIRT527942	hsa-miR-548as-5p	PAR-CLIP	22012620
MIRT527941	hsa-miR-548au-5p	PAR-CLIP	22012620
MIRT527940	hsa-miR-548ay-5p	PAR-CLIP	22012620
MIRT527939	hsa-miR-548b-5p	PAR-CLIP	22012620
MIRT527938	hsa-miR-548bb-5p	PAR-CLIP	22012620
MIRT527937	hsa-miR-548c-5p	PAR-CLIP	22012620
MIRT527936	hsa-miR-548d-5p	PAR-CLIP	22012620
MIRT527935	hsa-miR-548h-5p	PAR-CLIP	22012620
MIRT527934	hsa-miR-548i	PAR-CLIP	22012620
MIRT527933	hsa-miR-548j-5p	PAR-CLIP	22012620
MIRT527932	hsa-miR-548o-5p	PAR-CLIP	22012620
MIRT527931	hsa-miR-548w	PAR-CLIP	22012620
MIRT527930	hsa-miR-548y	PAR-CLIP	22012620
MIRT527929	hsa-miR-559	PAR-CLIP	22012620
MIRT527928	hsa-miR-4517	PAR-CLIP	22012620
MIRT527927	hsa-miR-802	PAR-CLIP	22012620
MIRT527926	hsa-miR-425-5p	PAR-CLIP	22012620
MIRT527925	hsa-miR-3973	PAR-CLIP	22012620
MIRT527924	hsa-miR-3913-3p	PAR-CLIP	22012620
MIRT527923	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT1005271	hsa-miR-1227	CLIP-seq
MIRT1005272	hsa-miR-1272	CLIP-seq
MIRT1005273	hsa-miR-132	CLIP-seq
MIRT1005274	hsa-miR-146a	CLIP-seq
MIRT1005275	hsa-miR-146b-5p	CLIP-seq
MIRT1005276	hsa-miR-185	CLIP-seq
MIRT1005277	hsa-miR-2113	CLIP-seq
MIRT1005278	hsa-miR-212	CLIP-seq
MIRT1005279	hsa-miR-221	CLIP-seq
MIRT1005280	hsa-miR-222	CLIP-seq
MIRT1005281	hsa-miR-3064-3p	CLIP-seq
MIRT1005282	hsa-miR-3140-3p	CLIP-seq
MIRT1005283	hsa-miR-3173-3p	CLIP-seq
MIRT1005284	hsa-miR-3925-5p	CLIP-seq
MIRT1005285	hsa-miR-4306	CLIP-seq
MIRT1005286	hsa-miR-4419a	CLIP-seq
MIRT1005287	hsa-miR-4428	CLIP-seq
MIRT1005288	hsa-miR-4477b	CLIP-seq
MIRT1005289	hsa-miR-4510	CLIP-seq
MIRT1005290	hsa-miR-4644	CLIP-seq
MIRT1005291	hsa-miR-4727-5p	CLIP-seq
MIRT1005292	hsa-miR-4769-3p	CLIP-seq
MIRT1005293	hsa-miR-4773	CLIP-seq
MIRT1005294	hsa-miR-548v	CLIP-seq
MIRT1005295	hsa-miR-582-5p	CLIP-seq
MIRT1005296	hsa-miR-591	CLIP-seq
MIRT1005297	hsa-miR-600	CLIP-seq
MIRT1005298	hsa-miR-622	CLIP-seq
MIRT1997926	hsa-miR-23a	CLIP-seq
MIRT1997927	hsa-miR-23b	CLIP-seq
MIRT1997928	hsa-miR-23c	CLIP-seq
MIRT1997929	hsa-miR-4717-3p	CLIP-seq
MIRT1997930	hsa-miR-548ae	CLIP-seq
MIRT1997931	hsa-miR-548aj	CLIP-seq
MIRT1997932	hsa-miR-548am	CLIP-seq
MIRT1997933	hsa-miR-548x	CLIP-seq
MIRT2231522	hsa-miR-1253	CLIP-seq
MIRT1997926	hsa-miR-23a	CLIP-seq
MIRT1997927	hsa-miR-23b	CLIP-seq
MIRT1997928	hsa-miR-23c	CLIP-seq
MIRT2231523	hsa-miR-3189-5p	CLIP-seq
MIRT1997929	hsa-miR-4717-3p	CLIP-seq
MIRT2231524	hsa-miR-4757-3p	CLIP-seq
MIRT2231525	hsa-miR-4758-3p	CLIP-seq
MIRT1997926	hsa-miR-23a	CLIP-seq
MIRT1997927	hsa-miR-23b	CLIP-seq
MIRT1997928	hsa-miR-23c	CLIP-seq
MIRT1997929	hsa-miR-4717-3p	CLIP-seq
MIRT2535383	hsa-miR-1257	CLIP-seq
MIRT2535384	hsa-miR-125a-3p	CLIP-seq
MIRT2535385	hsa-miR-1279	CLIP-seq
MIRT2535386	hsa-miR-1283	CLIP-seq
MIRT2535387	hsa-miR-1291	CLIP-seq
MIRT2535388	hsa-miR-141	CLIP-seq
MIRT1005274	hsa-miR-146a	CLIP-seq
MIRT1005275	hsa-miR-146b-5p	CLIP-seq
MIRT1005276	hsa-miR-185	CLIP-seq
MIRT2535389	hsa-miR-200a	CLIP-seq
MIRT2535390	hsa-miR-205	CLIP-seq
MIRT2535391	hsa-miR-214	CLIP-seq
MIRT2535392	hsa-miR-2277-3p	CLIP-seq
MIRT2535393	hsa-miR-3163	CLIP-seq
MIRT1005283	hsa-miR-3173-3p	CLIP-seq
MIRT2535394	hsa-miR-328	CLIP-seq
MIRT2535395	hsa-miR-3611	CLIP-seq
MIRT2535396	hsa-miR-3619-5p	CLIP-seq
MIRT2535397	hsa-miR-3653	CLIP-seq
MIRT2535398	hsa-miR-3658	CLIP-seq
MIRT2535399	hsa-miR-3673	CLIP-seq
MIRT1005284	hsa-miR-3925-5p	CLIP-seq
MIRT2535400	hsa-miR-3941	CLIP-seq
MIRT2535401	hsa-miR-425	CLIP-seq
MIRT2535402	hsa-miR-4282	CLIP-seq
MIRT2535403	hsa-miR-4291	CLIP-seq
MIRT1005285	hsa-miR-4306	CLIP-seq
MIRT2535404	hsa-miR-4310	CLIP-seq
MIRT1005287	hsa-miR-4428	CLIP-seq
MIRT1005288	hsa-miR-4477b	CLIP-seq
MIRT2535405	hsa-miR-4643	CLIP-seq
MIRT1005290	hsa-miR-4644	CLIP-seq
MIRT2535406	hsa-miR-466	CLIP-seq
MIRT2535407	hsa-miR-4672	CLIP-seq
MIRT2535408	hsa-miR-4684-5p	CLIP-seq
MIRT2535409	hsa-miR-4768-5p	CLIP-seq
MIRT2535410	hsa-miR-4789-3p	CLIP-seq
MIRT2535411	hsa-miR-4793-5p	CLIP-seq
MIRT2535412	hsa-miR-489	CLIP-seq
MIRT2535413	hsa-miR-548al	CLIP-seq
MIRT2535414	hsa-miR-548h	CLIP-seq
MIRT2535415	hsa-miR-548j	CLIP-seq
MIRT2535416	hsa-miR-548u	CLIP-seq
MIRT2535417	hsa-miR-552	CLIP-seq
MIRT2535418	hsa-miR-581	CLIP-seq
MIRT2535419	hsa-miR-656	CLIP-seq
MIRT2535420	hsa-miR-761	CLIP-seq
MIRT2535421	hsa-miR-890	CLIP-seq
MIRT2535422	hsa-miR-922	CLIP-seq
MIRT2535383	hsa-miR-1257	CLIP-seq
MIRT2535384	hsa-miR-125a-3p	CLIP-seq
MIRT2535386	hsa-miR-1283	CLIP-seq
MIRT2535387	hsa-miR-1291	CLIP-seq
MIRT2535388	hsa-miR-141	CLIP-seq
MIRT1005274	hsa-miR-146a	CLIP-seq
MIRT1005275	hsa-miR-146b-5p	CLIP-seq
MIRT1005276	hsa-miR-185	CLIP-seq
MIRT2535389	hsa-miR-200a	CLIP-seq
MIRT2535392	hsa-miR-2277-3p	CLIP-seq
MIRT1005283	hsa-miR-3173-3p	CLIP-seq
MIRT2535394	hsa-miR-328	CLIP-seq
MIRT2535395	hsa-miR-3611	CLIP-seq
MIRT2535397	hsa-miR-3653	CLIP-seq
MIRT2535398	hsa-miR-3658	CLIP-seq
MIRT2535399	hsa-miR-3673	CLIP-seq
MIRT1005284	hsa-miR-3925-5p	CLIP-seq
MIRT2535400	hsa-miR-3941	CLIP-seq
MIRT1005285	hsa-miR-4306	CLIP-seq
MIRT2535404	hsa-miR-4310	CLIP-seq
MIRT1005287	hsa-miR-4428	CLIP-seq
MIRT1005288	hsa-miR-4477b	CLIP-seq
MIRT2535405	hsa-miR-4643	CLIP-seq
MIRT1005290	hsa-miR-4644	CLIP-seq
MIRT2535406	hsa-miR-466	CLIP-seq
MIRT2535407	hsa-miR-4672	CLIP-seq
MIRT2535408	hsa-miR-4684-5p	CLIP-seq
MIRT2535409	hsa-miR-4768-5p	CLIP-seq
MIRT2535410	hsa-miR-4789-3p	CLIP-seq
MIRT2535413	hsa-miR-548al	CLIP-seq
MIRT2535416	hsa-miR-548u	CLIP-seq
MIRT2535417	hsa-miR-552	CLIP-seq
MIRT2535418	hsa-miR-581	CLIP-seq
MIRT2535419	hsa-miR-656	CLIP-seq
MIRT2535421	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA
GO:0000902	Process	Cell morphogenesis	IEA
GO:0000922	Component	Spindle pole	IEA
GO:0004857	Function	Enzyme inhibitor activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005938	Component	Cell cortex	IBA
GO:0030427	Component	Site of polarized growth	IBA
GO:0031175	Process	Neuron projection development	IBA
GO:1904428	Process	Negative regulation of tubulin deacetylation	IEA

Other IDs

• MIM: 614818
• HGNC: 20367
• e!Ensembl: ENSG00000073910

Protein

• UniProt ID: Q5TBA9
• Protein name: Protein furry homolog
• Protein function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14222	MOR2-PAG1_N	165 → 697	Cell morphogenesis N-terminal	Family
  PF14228	MOR2-PAG1_mid	1191 → 1378	Cell morphogenesis central region	Family
  PF14228	MOR2-PAG1_mid	1399 → 1526	Cell morphogenesis central region	Family
  PF14228	MOR2-PAG1_mid	1632 → 1705	Cell morphogenesis central region	Family
  PF14228	MOR2-PAG1_mid	1771 → 1905	Cell morphogenesis central region	Family
  PF14225	MOR2-PAG1_C	2042 → 2295	Cell morphogenesis C-terminal	Family

• Sequence:

  MASQQDSGFFEISIKYLLKSWSNTSPVGNGYIKPPVPPASGTHREKGPPTMLPINVDPDS
  KPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYC
  LPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLI
  EVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKF
  PAVKKKFMAELKELRHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHY
  FLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLA
  LYPLVTCLLCVSQKQLFLNRWHIFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKC
  ESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLC
  VGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSK
  TLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKP
  KIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWRE
  DVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNSELIA
  NGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFIALGQPEDD
  DRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHNVDLQWLVEWNAVLVNSHYDVKSPSH
  VWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAK
  KTSTAGSGDNYVTLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIG
  TPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENK
  KRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAEN
  DKEVEILKDIRAHFSAMVANLIQCVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTP
  LDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQ
  LGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLN
  LVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLA
  LLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSS
  PSSPEDEVKDREGDVTASHGLRGNGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWN
  ALANNEKWSNNLRITLQFLISLCGVSSDTVLLPYIKKVAIYLCRNNTIQTMEELLFELQQ
  TEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQENFPDAEENKILKESDE
  RFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCW
  APLVDYLPETITPRGPLHRCNIAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRP
  EVFEHSKKLLLHLLIALSCNSNFHSIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDF
  LREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDVDTAAETDEKANKLIEFLT
  TRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFKDSKSGFHLEHQLSEVALQTALA
  SSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVD
  NLSDCLKNSDLLTVLSRSSSPDLSSSSKLTASRKSTGQLNMNPGTTSGNTATAERSRHQR
  SFSVPKKFGVIDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNL
  LATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQLKWADFSGL
  QQLLLKGFTSLTTTDLTLQLFSLLTPVSKISMVDASHAIGFPLNVLCLLPQLIQHFENPN
  QFCKDIAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADIT
  LNMVTYLAELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSVHW
  REALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSASKELPGKTLDFHFDISETPII
  GRRYDELQNSSGRDGKPRAMAVTRSTSSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHV
  LSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRD
  FDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDMQILEERQLSGSTPSLNKMHHEDSD
  ESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTACDSTPAEPHSFNTRMSSFDASL
  PDMNNLQISEGSKAEAVREEEDTTVHEDDLSSSINELPAAFECSDSFSLDMTEGEEKGNR
  ALDQFTLASFGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCA
  VYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDA
  ETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDS
  EEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSMPELLNMSRELSDLKKHLKEASA
  VIAADPLYSDGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSS
  DDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLT
  TFLPDSSVSGTSL

• Sequence length: 3013