Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10120
Gene name Gene Name - the full gene name approved by the HGNC.
Actin related protein 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACTR1B
Synonyms (NCBI Gene) Gene synonyms aliases
ARP1B, CTRN2, PC3
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PC3
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, inc
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026412 hsa-miR-192-5p Microarray 19074876
MIRT048557 hsa-miR-100-5p CLASH 23622248
MIRT044201 hsa-miR-99b-5p CLASH 23622248
MIRT764387 hsa-miR-1205 CLIP-seq
MIRT764388 hsa-miR-1224-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 12857853, 26638075, 32814053
GO:0005524 Function ATP binding IEA
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IDA
GO:0005813 Component Centrosome IDA 21399614
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605144 168 ENSG00000115073
Protein
UniProt ID P42025
Protein name Beta-centractin (Actin-related protein 1B) (ARP1B)
Protein function Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00022 Actin 7 376 Actin Family
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Motor proteins
Amyotrophic lateral sclerosis
Huntington disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection
  MHC class II antigen presentation
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 31089142
Colorectal cancer Colorectal Carcinoma, Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
31089142
Colorectal neoplasms Colorectal Neoplasms, Malignant neoplasm of large intestine rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
31089142
Unknown
Disease term Disease name Evidence References Source
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA